FRMD3

The protein encoded by this gene is a single pass membrane protein primarily found in ovaries. A similar protein in erythrocytes helps determine the shape of red blood cells, but the function of the encoded protein has not been determined. There is some evidence that this is a tumor suppressor gene, and there is also evidence linking defects in this gene to susceptibility to diabetic nephropathy in type 1 diabetes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Description

FERM domain containing 3

Tissue specificity

Tissue enhanced (heart muscle, skeletal muscle, tongue)

Subcell location

Golgi apparatus, Plasma membrane

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9 (83242990 - 83538546)

Ensembl ID

ENSG00000172159  (ver. 103.38)

Orthologs

Mouse Frmd3: ENSMUSG00000049122

UniProt

A2A2Y4

neXtProt

NX_A2A2Y4

Human splice variants
Mouse splice variants

Protein structure