FXYD4

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. FXYD4, originally named CHIF for channel-inducing factor, has been shown to modulate the properties of the Na,K-ATPase, as has FXYD2, also known as the gamma subunit of the Na,K-ATPase, and FXYD7. Transmembrane topology has been established for FXYD4 and two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. Alternatively spliced transcript variants encoding the same protein have been found. [provided by RefSeq, May 2010]

Description

FXYD domain containing ion transport regulator 4

Tissue specificity

Tissue enriched (kidney)

Subcell location

Cytosol

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Transporters

Chromosome

10 (43371636 - 43376335)

Ensembl ID

ENSG00000150201  (ver. 103.38)

Orthologs

Mouse Fxyd4: ENSMUSG00000004988

UniProt

P59646

neXtProt

NX_P59646

Human splice variants
Mouse splice variants

Protein structure