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- Antigen structure
- References [18]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 11630-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11630-1-AP, RRID:AB_2101525
- Product name
- MIG6; ERRFI1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MIG6; ERRFI1 antibody (Cat. #11630-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references METTL14 affects UVB-induced human dermal fibroblasts photoaging via miR-100-3p biogenesis in an m(6)A-dependent manner.
Selumetinib overcomes gefitinib primary and acquired resistance by regulating MIG6/STAT3 in NSCLC.
MIG6 loss confers resistance to ALK/ROS1 inhibitors in NSCLC through EGFR activation by low-dose EGF.
Androgen-Induced MIG6 Regulates Phosphorylation of Retinoblastoma Protein and AKT to Counteract Non-Genomic AR Signaling in Prostate Cancer Cells.
Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways.
p52Shc regulates the sustainability of ERK activation in a RAF-independent manner.
ERRFI1 induces apoptosis of hepatocellular carcinoma cells in response to tryptophan deficiency.
MIG-6 is essential for promoting glucose metabolic reprogramming and tumor growth in triple-negative breast cancer.
Altered Expression of Three EGFR Posttranslational Regulators MDGI, MIG6, and EIG121 in Invasive Breast Carcinomas.
AAV-Mig-6 Increase the Efficacy of TAE in VX2 Rabbit Model, Is Associated With JNK Mediated Autophagy.
CBP/p300 antagonises EGFR-Ras-Erk signalling and suppresses increased Ras-Erk signalling-induced tumour formation in mice.
Profiling of protein-protein interactions via single-molecule techniques predicts the dependence of cancers on growth-factor receptors.
RNA-binding protein SAMD4 regulates skeleton development through translational inhibition of Mig6 expression.
Mig-6 is down-regulated in HCC and inhibits the proliferation of HCC cells via the P-ERK/Cyclin D1 pathway.
Mitogen-inducible gene-6 partly mediates the inhibitory effects of prenatal dexamethasone exposure on endochondral ossification in long bones of fetal rats.
A genome landscape of SRSF3-regulated splicing events and gene expression in human osteosarcoma U2OS cells.
Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation.
Downregulation of Mig-6 in nonsmall-cell lung cancer is associated with EGFR signaling.
Chen L, Hu Y, Zhang M, Liu L, Ma J, Xu Z, Zhang J, Gu H, Chen K
Aging cell 2024 May;23(5):e14123
Aging cell 2024 May;23(5):e14123
Selumetinib overcomes gefitinib primary and acquired resistance by regulating MIG6/STAT3 in NSCLC.
Song X, Wang L, Tang W, Yuan L, Liu Q, Li J, Fan D
Archives of pharmacal research 2023 Dec;46(11-12):924-938
Archives of pharmacal research 2023 Dec;46(11-12):924-938
MIG6 loss confers resistance to ALK/ROS1 inhibitors in NSCLC through EGFR activation by low-dose EGF.
Kondo N, Utsumi T, Shimizu Y, Takemoto A, Oh-Hara T, Uchibori K, Subat-Motoshi S, Ninomiya H, Takeuchi K, Nishio M, Miyazaki Y, Katayama R
JCI insight 2023 Dec 22;8(24)
JCI insight 2023 Dec 22;8(24)
Androgen-Induced MIG6 Regulates Phosphorylation of Retinoblastoma Protein and AKT to Counteract Non-Genomic AR Signaling in Prostate Cancer Cells.
Schomann T, Mirzakhani K, Kallenbach J, Lu J, Rasa SMM, Neri F, Baniahmad A
Biomolecules 2022 Jul 29;12(8)
Biomolecules 2022 Jul 29;12(8)
Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways.
Fu NJ, Xi RY, Shi XK, Li RZ, Zhang ZH, Li LY, Zhang GL, Wang F
Toxicology and applied pharmacology 2022 Apr 15;441:115988
Toxicology and applied pharmacology 2022 Apr 15;441:115988
p52Shc regulates the sustainability of ERK activation in a RAF-independent manner.
Yoshizawa R, Umeki N, Yamamoto A, Okada M, Murata M, Sako Y
Molecular biology of the cell 2021 Sep 1;32(19):1838-1848
Molecular biology of the cell 2021 Sep 1;32(19):1838-1848
ERRFI1 induces apoptosis of hepatocellular carcinoma cells in response to tryptophan deficiency.
Cui M, Liu D, Xiong W, Wang Y, Mi J
Cell death discovery 2021 Oct 4;7(1):274
Cell death discovery 2021 Oct 4;7(1):274
MIG-6 is essential for promoting glucose metabolic reprogramming and tumor growth in triple-negative breast cancer.
He J, Li CF, Lee HJ, Shin DH, Chern YJ, Pereira De Carvalho B, Chan CH
EMBO reports 2021 May 5;22(5):e50781
EMBO reports 2021 May 5;22(5):e50781
Altered Expression of Three EGFR Posttranslational Regulators MDGI, MIG6, and EIG121 in Invasive Breast Carcinomas.
Meseure D, Drak Alsibai K, Vacher S, Hatem R, Nicolas A, Callens C, Lerebours F, Bieche I
Analytical cellular pathology (Amsterdam) 2020;2020:9268236
Analytical cellular pathology (Amsterdam) 2020;2020:9268236
AAV-Mig-6 Increase the Efficacy of TAE in VX2 Rabbit Model, Is Associated With JNK Mediated Autophagy.
Li Z, Tian Y, Qu L, Mao J, Zhong H
Journal of Cancer 2019;10(4):1060-1069
Journal of Cancer 2019;10(4):1060-1069
CBP/p300 antagonises EGFR-Ras-Erk signalling and suppresses increased Ras-Erk signalling-induced tumour formation in mice.
Ichise T, Yoshida N, Ichise H
The Journal of pathology 2019 Sep;249(1):39-51
The Journal of pathology 2019 Sep;249(1):39-51
Profiling of protein-protein interactions via single-molecule techniques predicts the dependence of cancers on growth-factor receptors.
Lee HW, Choi B, Kang HN, Kim H, Min A, Cha M, Ryu JY, Park S, Sohn J, Shin K, Yun MR, Han JY, Shon MJ, Jeong C, Chung J, Lee SH, Im SA, Cho BC, Yoon TY
Nature biomedical engineering 2018 Apr;2(4):239-253
Nature biomedical engineering 2018 Apr;2(4):239-253
RNA-binding protein SAMD4 regulates skeleton development through translational inhibition of Mig6 expression.
Niu N, Xiang JF, Yang Q, Wang L, Wei Z, Chen LL, Yang L, Zou W
Cell discovery 2017;3:16050
Cell discovery 2017;3:16050
Mig-6 is down-regulated in HCC and inhibits the proliferation of HCC cells via the P-ERK/Cyclin D1 pathway.
Li Z, Qu L, Luo W, Tian Y, Zhai H, Xu K, Zhong H
Experimental and molecular pathology 2017 Jun;102(3):492-499
Experimental and molecular pathology 2017 Jun;102(3):492-499
Mitogen-inducible gene-6 partly mediates the inhibitory effects of prenatal dexamethasone exposure on endochondral ossification in long bones of fetal rats.
Zhang X, Shang-Guan Y, Ma J, Hu H, Wang L, Magdalou J, Chen L, Wang H
British journal of pharmacology 2016 Jul;173(14):2250-62
British journal of pharmacology 2016 Jul;173(14):2250-62
A genome landscape of SRSF3-regulated splicing events and gene expression in human osteosarcoma U2OS cells.
Ajiro M, Jia R, Yang Y, Zhu J, Zheng ZM
Nucleic acids research 2016 Feb 29;44(4):1854-70
Nucleic acids research 2016 Feb 29;44(4):1854-70
Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation.
Staal B, Williams BO, Beier F, Vande Woude GF, Zhang YW
Proceedings of the National Academy of Sciences of the United States of America 2014 Feb 18;111(7):2590-5
Proceedings of the National Academy of Sciences of the United States of America 2014 Feb 18;111(7):2590-5
Downregulation of Mig-6 in nonsmall-cell lung cancer is associated with EGFR signaling.
Li Z, Dong Q, Wang Y, Qu L, Qiu X, Wang E
Molecular carcinogenesis 2012 Jul;51(7):522-34
Molecular carcinogenesis 2012 Jul;51(7):522-34
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 11630-1-AP(MIG6; ERRFI1 antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MIG6; ERRFI1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MIG6; ERRFI1. This antibody recognizes human,mouse,rat antigen. The MIG6; ERRFI1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
