APR06575G

CENPO antibody from Leading Biology
CENP-O, MGC11266
Western blot
Recommended by provider

Antibody data

Product number
APR06575G
Provider
Leading Biology
Product name
CENPO Antibody
Provider product page
Leading Biology - APR06575G
Antibody type
Polyclonal
Description
CENPO Antibody: Accurate chromosome segregation during mitosis requires a kinetochore to assemble correctly at the centromere of each chromatid and form a dynamic interface with the microtubules of the mitotic spindle. The kinetochore assembly includes the multisubunit CENP-H/I complex which can be divided into three functional classes based on phenotype analysis. One of these classes is referred to as the CENP-O class of proteins of which CENPO is the exemplar. These proteins form a stable complex with each other and are required for proper kinetochore function and for recovery from mitotic spindle damage. CENPO has also been shown to be an auto-antigen in a small population of anti-centromere antibodies- (ACA-) positive patients with sclerodoma.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Storage
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.