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- References [20]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 15168-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15168-1-AP, RRID:AB_2301712
- Product name
- SIGMAR1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SIGMAR1 antibody (Cat. #15168-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Sigma-1 receptor activation alleviates blood-brain barrier disruption post cerebral ischemia stroke by stimulating the GDNF-GFRα1-RET pathway.
Serine palmitoyltransferase assembles at ER-mitochondria contact sites.
Sigma-1 receptor regulates mitophagy in dopaminergic neurons and contributes to dopaminergic protection.
Nerve capping treatment using a bioabsorbable nerve conduit with open or closed end for rat sciatic neuroma.
Sigma-1 Receptor Is Critical for Mitochondrial Activity and Unfolded Protein Response in Larval Zebrafish.
Sulforaphane Balances Ca2+ Homeostasis Injured by Excessive Fat via Mitochondria-Associated Membrane (MAM).
Sigma receptor knockdown augments dysfunction and apoptosis of beta cells induced by palmitate.
The role of Mfn2 in the structure and function of endoplasmic reticulum-mitochondrial tethering in vivo.
Sigma-1 Receptor Activation Suppresses Microglia M1 Polarization via Regulating Endoplasmic Reticulum-Mitochondria Contact and Mitochondrial Functions in Stress-Induced Hypertension Rats.
Dexmedetomidine inhibits neuronal apoptosis by inducing Sigma-1 receptor signaling in cerebral ischemia-reperfusion injury.
Cocaine-induced release of CXCL10 from pericytes regulates monocyte transmigration into the CNS.
DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1.
Protective effect of a novel sigma-1 receptor agonist is associated with reduced endoplasmic reticulum stress in stroke male mice.
Systematic In-Depth Proteomic Analysis of Mitochondria-Associated Endoplasmic Reticulum Membranes in Mouse and Human Testes.
Sigma-1 Receptor Plays a Negative Modulation on N-type Calcium Channel.
An Increase of Sigma-1 Receptor in the Penumbra Neuron after Acute Ischemic Stroke.
ALS-Associated Endoplasmic Reticulum Proteins in Denervated Skeletal Muscle: Implications for Motor Neuron Disease Pathology.
Sigma-1 receptor agonist increases axon outgrowth of hippocampal neurons via voltage-gated calcium ions channels.
Transactivation of TrkB by Sigma-1 receptor mediates cocaine-induced changes in dendritic spine density and morphology in hippocampal and cortical neurons.
Hereditary spastic paraplegia-linked REEP1 modulates endoplasmic reticulum/mitochondria contacts.
Liu D, Yang L, Liu P, Ji X, Qi X, Wang Z, Chi T, Zou L
Experimental neurology 2022 Jan;347:113867
Experimental neurology 2022 Jan;347:113867
Serine palmitoyltransferase assembles at ER-mitochondria contact sites.
Aaltonen MJ, Alecu I, König T, Bennett SA, Shoubridge EA
Life science alliance 2022 Feb;5(2)
Life science alliance 2022 Feb;5(2)
Sigma-1 receptor regulates mitophagy in dopaminergic neurons and contributes to dopaminergic protection.
Wang M, Wan C, He T, Han C, Zhu K, Waddington JL, Zhen X
Neuropharmacology 2021 Sep 15;196:108360
Neuropharmacology 2021 Sep 15;196:108360
Nerve capping treatment using a bioabsorbable nerve conduit with open or closed end for rat sciatic neuroma.
Hama S, Uemura T, Onode E, Yokoi T, Okada M, Takamatsu K, Nakamura H
Clinical neurology and neurosurgery 2021 Oct;209:106920
Clinical neurology and neurosurgery 2021 Oct;209:106920
Sigma-1 Receptor Is Critical for Mitochondrial Activity and Unfolded Protein Response in Larval Zebrafish.
Crouzier L, Denus M, Richard EM, Tavernier A, Diez C, Cubedo N, Maurice T, Delprat B
International journal of molecular sciences 2021 Oct 13;22(20)
International journal of molecular sciences 2021 Oct 13;22(20)
Sulforaphane Balances Ca2+ Homeostasis Injured by Excessive Fat via Mitochondria-Associated Membrane (MAM).
Tian S, Lei P, Zhang J, Sun Y, Li B, Shan Y
Molecular nutrition & food research 2021 Jul;65(14):e2001076
Molecular nutrition & food research 2021 Jul;65(14):e2001076
Sigma receptor knockdown augments dysfunction and apoptosis of beta cells induced by palmitate.
Ke M, He G, Wang H, Cheng S, Xu Y
Experimental biology and medicine (Maywood, N.J.) 2021 Jul;246(13):1491-1499
Experimental biology and medicine (Maywood, N.J.) 2021 Jul;246(13):1491-1499
The role of Mfn2 in the structure and function of endoplasmic reticulum-mitochondrial tethering in vivo.
Han S, Zhao F, Hsia J, Ma X, Liu Y, Torres S, Fujioka H, Zhu X
Journal of cell science 2021 Jul 1;134(13)
Journal of cell science 2021 Jul 1;134(13)
Sigma-1 Receptor Activation Suppresses Microglia M1 Polarization via Regulating Endoplasmic Reticulum-Mitochondria Contact and Mitochondrial Functions in Stress-Induced Hypertension Rats.
Ooi K, Hu L, Feng Y, Han C, Ren X, Qian X, Huang H, Chen S, Shi Q, Lin H, Wang J, Zhu D, Wang R, Xia C
Molecular neurobiology 2021 Dec;58(12):6625-6646
Molecular neurobiology 2021 Dec;58(12):6625-6646
Dexmedetomidine inhibits neuronal apoptosis by inducing Sigma-1 receptor signaling in cerebral ischemia-reperfusion injury.
Zhai M, Liu C, Li Y, Zhang P, Yu Z, Zhu H, Zhang L, Zhang Q, Wang J, Wang J
Aging 2019 Nov 4;11(21):9556-9568
Aging 2019 Nov 4;11(21):9556-9568
Cocaine-induced release of CXCL10 from pericytes regulates monocyte transmigration into the CNS.
Niu F, Liao K, Hu G, Sil S, Callen S, Guo ML, Yang L, Buch S
The Journal of cell biology 2019 Feb 4;218(2):700-721
The Journal of cell biology 2019 Feb 4;218(2):700-721
DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1.
Liu Y, Ma X, Fujioka H, Liu J, Chen S, Zhu X
Proceedings of the National Academy of Sciences of the United States of America 2019 Dec 10;116(50):25322-25328
Proceedings of the National Academy of Sciences of the United States of America 2019 Dec 10;116(50):25322-25328
Protective effect of a novel sigma-1 receptor agonist is associated with reduced endoplasmic reticulum stress in stroke male mice.
Morihara R, Yamashita T, Liu X, Nakano Y, Fukui Y, Sato K, Ohta Y, Hishikawa N, Shang J, Abe K
Journal of neuroscience research 2018 Oct;96(10):1707-1716
Journal of neuroscience research 2018 Oct;96(10):1707-1716
Systematic In-Depth Proteomic Analysis of Mitochondria-Associated Endoplasmic Reticulum Membranes in Mouse and Human Testes.
Wang X, Wen Y, Dong J, Cao C, Yuan S
Proteomics 2018 Jul;18(14):e1700478
Proteomics 2018 Jul;18(14):e1700478
Sigma-1 Receptor Plays a Negative Modulation on N-type Calcium Channel.
Zhang K, Zhao Z, Lan L, Wei X, Wang L, Liu X, Yan H, Zheng J
Frontiers in pharmacology 2017;8:302
Frontiers in pharmacology 2017;8:302
An Increase of Sigma-1 Receptor in the Penumbra Neuron after Acute Ischemic Stroke.
Zhang X, Wu F, Jiao Y, Tang T, Yang L, Lu C, Zhang Y, Zhang Y, Bai Y, Chao J, Teng G, Yao H
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2017 Sep;26(9):1981-1987
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2017 Sep;26(9):1981-1987
ALS-Associated Endoplasmic Reticulum Proteins in Denervated Skeletal Muscle: Implications for Motor Neuron Disease Pathology.
Jesse CM, Bushuven E, Tripathi P, Chandrasekar A, Simon CM, Drepper C, Yamoah A, Dreser A, Katona I, Johann S, Beyer C, Wagner S, Grond M, Nikolin S, Anink J, Troost D, Sendtner M, Goswami A, Weis J
Brain pathology (Zurich, Switzerland) 2017 Nov;27(6):781-794
Brain pathology (Zurich, Switzerland) 2017 Nov;27(6):781-794
Sigma-1 receptor agonist increases axon outgrowth of hippocampal neurons via voltage-gated calcium ions channels.
Li D, Zhang SZ, Yao YH, Xiang Y, Ma XY, Wei XL, Yan HT, Liu XY
CNS neuroscience & therapeutics 2017 Dec;23(12):930-939
CNS neuroscience & therapeutics 2017 Dec;23(12):930-939
Transactivation of TrkB by Sigma-1 receptor mediates cocaine-induced changes in dendritic spine density and morphology in hippocampal and cortical neurons.
Ka M, Kook YH, Liao K, Buch S, Kim WY
Cell death & disease 2016 Oct 13;7(10):e2414
Cell death & disease 2016 Oct 13;7(10):e2414
Hereditary spastic paraplegia-linked REEP1 modulates endoplasmic reticulum/mitochondria contacts.
Lim Y, Cho IT, Schoel LJ, Cho G, Golden JA
Annals of neurology 2015 Nov;78(5):679-96
Annals of neurology 2015 Nov;78(5):679-96
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse kidney tissue were subjected to SDS PAGE followed by western blot with 15168-1-AP(SIGMAR1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SIGMAR1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SIGMAR1. This antibody recognizes human,mouse,rat antigen. The SIGMAR1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 15168-1-AP(SIGMAR1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
