15168-1-AP

antibody from Proteintech Group

Targeting: SIGMAR1 OPRS1, SR-BP1

Provider product page for 15168-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [37]
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Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 15168-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#15168-1-AP, RRID:AB_2301712
Product name: SIGMAR1 antibody
Antibody type: Polyclonal
Description: KD/KO validated SIGMAR1 antibody (Cat. #15168-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SIGMAR1 protein structure - 15168-1-AP shown in red.

Submitted references Central role of Sigma-1 receptor in ochratoxin A-induced ferroptosis.

Chen W, Han L, Yang R, Wang H, Yao S, Deng H, Liu S, Zhou Y, Shen XL
Archives of toxicology 2024 Oct;98(10):3323-3336

CGI1746 targets σ(1)R to modulate ferroptosis through mitochondria-associated membranes.

Zhang Z, Zhou H, Gu W, Wei Y, Mou S, Wang Y, Zhang J, Zhong Q
Nature chemical biology 2024 Jun;20(6):699-709

Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a male mouse model of head-and-neck cancer.

Barr J, Walz A, Restaino AC, Amit M, Barclay SM, Vichaya EG, Spanos WC, Dantzer R, Talbot S, Vermeer PD
bioRxiv : the preprint server for biology 2024 Jun 7;

The classical D1 dopamine receptor antagonist SCH23390 is a functional sigma-1 receptor allosteric modulator.

Zhang GF, Zhu KL, Li Q, Zhang Y, Waddington JL, Du XD, Zhen XC
Acta pharmacologica Sinica 2024 Aug;45(8):1582-1590

Specific detection and deletion of the sigma-1 receptor widely expressed in neurons and glial cells in vivo.

Liu Q, Guo Q, Fang LP, Yao H, Scheller A, Kirchhoff F, Huang W
Journal of neurochemistry 2023 Mar;164(6):764-785

Regenerative peripheral nerve interface prevents neuroma formation after peripheral nerve transection.

Wang Z, Yi XZ, Yu AX
Neural regeneration research 2023 Apr;18(4):814-818

Autophagy-mediated circHIPK2 promotes lipopolysaccharide-induced astrocytic inflammation via SIGMAR1.

Huang R, Cai L, Ma X, Shen K
International immunopharmacology 2023 Apr;117:109907

Nerve-End Capping Treatment with a Polyglycolic Acid Conduit for Rat Sciatic Neuroma: A Preliminary Report.

Onode E, Uemura T, Hama S, Yokoi T, Okada M, Takamatsu K, Nakamura H
Journal of reconstructive microsurgery 2022 Nov;38(9):711-720

A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease.

Shang Y, Sun X, Chen X, Wang Q, Wang EJ, Miller E, Xu R, Pieper AA, Qi X
Acta neuropathologica 2022 Nov;144(5):911-938

A new insight on peripheral nerve repair: the technique of internal nerve splinting.

Luo X, Li B, Zhang D, Chen H, Zhou X, Yao C, Raza MA, Wang L, Tang N, Zheng G, Yan H
Journal of neurosurgery 2022 Nov 1;137(5):1406-1417

Sigma‑1 receptor overexpression promotes proliferation and ameliorates cell apoptosis in β‑cells.

Ke M, Lin F, Wang H, He G, Feng J, Song L, Xu Y, Liu J
Molecular medicine reports 2022 May;25(5)

ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models.

Zhao Y, Hu D, Wang R, Sun X, Ropelewski P, Hubler Z, Lundberg K, Wang Q, Adams DJ, Xu R, Qi X
Nature communications 2022 Mar 2;13(1):1121

Allosteric Modulation of the Sigma-1 Receptor Elicits Antipsychotic-like Effects.

Chen J, Li G, Qin P, Chen J, Ye N, Waddington JL, Zhen X
Schizophrenia bulletin 2022 Mar 1;48(2):474-484

Sigma-1 receptor activation alleviates blood-brain barrier disruption post cerebral ischemia stroke by stimulating the GDNF-GFRα1-RET pathway.

Liu D, Yang L, Liu P, Ji X, Qi X, Wang Z, Chi T, Zou L
Experimental neurology 2022 Jan;347:113867

Serine palmitoyltransferase assembles at ER-mitochondria contact sites.

Aaltonen MJ, Alecu I, König T, Bennett SA, Shoubridge EA
Life science alliance 2022 Feb;5(2)

PACS2-TRPV1 axis is required for ER-mitochondrial tethering during ER stress and lung fibrosis.

Knoell J, Chillappagari S, Knudsen L, Korfei M, Dartsch R, Jonigk D, Kuehnel MP, Hoetzenecker K, Guenther A, Mahavadi P
Cellular and molecular life sciences : CMLS 2022 Feb 25;79(3):151

Veratramine ameliorates pain symptoms in rats with diabetic peripheral neuropathy by inhibiting activation of the SIGMAR1-NMDAR pathway.

Zhang Y, Ye G, Chen Y, Sheng C, Wang J, Kong L, Yuan L, Lin C
Pharmaceutical biology 2022 Dec;60(1):2145-2154

NCS1 overexpression restored mitochondrial activity and behavioral alterations in a zebrafish model of Wolfram syndrome.

Crouzier L, Richard EM, Diez C, Denus M, Peyrel A, Alzaeem H, Cubedo N, Delaunay T, Maurice T, Delprat B
Molecular therapy. Methods & clinical development 2022 Dec 8;27:295-308

Morphological, behavioral and cellular analyses revealed different phenotypes in Wolfram syndrome wfs1a and wfs1b zebrafish mutant lines.

Crouzier L, Richard EM, Diez C, Alzaeem H, Denus M, Cubedo N, Delaunay T, Glendenning E, Baxendale S, Liévens JC, Whitfield TT, Maurice T, Delprat B
Human molecular genetics 2022 Aug 23;31(16):2711-2727

Sigma-1 receptor regulates mitophagy in dopaminergic neurons and contributes to dopaminergic protection.

Wang M, Wan C, He T, Han C, Zhu K, Waddington JL, Zhen X
Neuropharmacology 2021 Sep 15;196:108360

Nerve capping treatment using a bioabsorbable nerve conduit with open or closed end for rat sciatic neuroma.

Hama S, Uemura T, Onode E, Yokoi T, Okada M, Takamatsu K, Nakamura H
Clinical neurology and neurosurgery 2021 Oct;209:106920

Sigma-1 Receptor Is Critical for Mitochondrial Activity and Unfolded Protein Response in Larval Zebrafish.

Crouzier L, Denus M, Richard EM, Tavernier A, Diez C, Cubedo N, Maurice T, Delprat B
International journal of molecular sciences 2021 Oct 13;22(20)

Sulforaphane Balances Ca(2+) Homeostasis Injured by Excessive Fat via Mitochondria-Associated Membrane (MAM).

Tian S, Lei P, Zhang J, Sun Y, Li B, Shan Y
Molecular nutrition & food research 2021 Jul;65(14):e2001076

Sigma receptor knockdown augments dysfunction and apoptosis of beta cells induced by palmitate.

Ke M, He G, Wang H, Cheng S, Xu Y
Experimental biology and medicine (Maywood, N.J.) 2021 Jul;246(13):1491-1499

The role of Mfn2 in the structure and function of endoplasmic reticulum-mitochondrial tethering in vivo.

Han S, Zhao F, Hsia J, Ma X, Liu Y, Torres S, Fujioka H, Zhu X
Journal of cell science 2021 Jul 1;134(13)

Sigma-1 Receptor Activation Suppresses Microglia M1 Polarization via Regulating Endoplasmic Reticulum-Mitochondria Contact and Mitochondrial Functions in Stress-Induced Hypertension Rats.

Ooi K, Hu L, Feng Y, Han C, Ren X, Qian X, Huang H, Chen S, Shi Q, Lin H, Wang J, Zhu D, Wang R, Xia C
Molecular neurobiology 2021 Dec;58(12):6625-6646

Dexmedetomidine inhibits neuronal apoptosis by inducing Sigma-1 receptor signaling in cerebral ischemia-reperfusion injury.

Zhai M, Liu C, Li Y, Zhang P, Yu Z, Zhu H, Zhang L, Zhang Q, Wang J, Wang J
Aging 2019 Nov 4;11(21):9556-9568

Cocaine-induced release of CXCL10 from pericytes regulates monocyte transmigration into the CNS.

Niu F, Liao K, Hu G, Sil S, Callen S, Guo ML, Yang L, Buch S
The Journal of cell biology 2019 Feb 4;218(2):700-721

DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1.

Liu Y, Ma X, Fujioka H, Liu J, Chen S, Zhu X
Proceedings of the National Academy of Sciences of the United States of America 2019 Dec 10;116(50):25322-25328

Protective effect of a novel sigma-1 receptor agonist is associated with reduced endoplasmic reticulum stress in stroke male mice.

Morihara R, Yamashita T, Liu X, Nakano Y, Fukui Y, Sato K, Ohta Y, Hishikawa N, Shang J, Abe K
Journal of neuroscience research 2018 Oct;96(10):1707-1716

Systematic In-Depth Proteomic Analysis of Mitochondria-Associated Endoplasmic Reticulum Membranes in Mouse and Human Testes.

Wang X, Wen Y, Dong J, Cao C, Yuan S
Proteomics 2018 Jul;18(14):e1700478

Sigma-1 Receptor Plays a Negative Modulation on N-type Calcium Channel.

Zhang K, Zhao Z, Lan L, Wei X, Wang L, Liu X, Yan H, Zheng J
Frontiers in pharmacology 2017;8:302

An Increase of Sigma-1 Receptor in the Penumbra Neuron after Acute Ischemic Stroke.

Zhang X, Wu F, Jiao Y, Tang T, Yang L, Lu C, Zhang Y, Zhang Y, Bai Y, Chao J, Teng G, Yao H
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2017 Sep;26(9):1981-1987

ALS-Associated Endoplasmic Reticulum Proteins in Denervated Skeletal Muscle: Implications for Motor Neuron Disease Pathology.

Jesse CM, Bushuven E, Tripathi P, Chandrasekar A, Simon CM, Drepper C, Yamoah A, Dreser A, Katona I, Johann S, Beyer C, Wagner S, Grond M, Nikolin S, Anink J, Troost D, Sendtner M, Goswami A, Weis J
Brain pathology (Zurich, Switzerland) 2017 Nov;27(6):781-794

Sigma-1 receptor agonist increases axon outgrowth of hippocampal neurons via voltage-gated calcium ions channels.

Li D, Zhang SZ, Yao YH, Xiang Y, Ma XY, Wei XL, Yan HT, Liu XY
CNS neuroscience & therapeutics 2017 Dec;23(12):930-939

Transactivation of TrkB by Sigma-1 receptor mediates cocaine-induced changes in dendritic spine density and morphology in hippocampal and cortical neurons.

Ka M, Kook YH, Liao K, Buch S, Kim WY
Cell death & disease 2016 Oct 13;7(10):e2414

Hereditary spastic paraplegia-linked REEP1 modulates endoplasmic reticulum/mitochondria contacts.

Lim Y, Cho IT, Schoel LJ, Cho G, Golden JA
Annals of neurology 2015 Nov;78(5):679-96

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse kidney tissue were subjected to SDS PAGE followed by western blot with 15168-1-AP(SIGMAR1 antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SIGMAR1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SIGMAR1. This antibody recognizes human,mouse,rat antigen. The SIGMAR1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 15168-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human liver cancer using 15168-1-AP(SIGMAR1 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue