15168-1-AP

antibody from Proteintech Group

Targeting: SIGMAR1 OPRS1, SR-BP1

Provider product page for 15168-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [64]
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Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 15168-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#15168-1-AP, RRID:AB_2301712
Product name: SIGMAR1 antibody
Antibody type: Polyclonal
Description: KD/KO validated SIGMAR1 antibody (Cat. #15168-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SIGMAR1 protein structure - 15168-1-AP shown in red.

Submitted references Cannabidiol attenuates methamphetamine-induced psychosis via anti-oxidative stress: σ1R-mediated mitochondrial dysfunction as a critical pathway.

Liu L, Wang C, Tian Y, Yin Y, Rao M, Tao H, Luo C, Li J, Zeng X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158015

Purification of murine cortex mitochondria using a modified magnetic bead isolation method.

Josic E, Ujevic A, Puljko B, Maček Hrvat N, Lipovcic A, Kalanj-Bognar S, Mlinac-Jerkovic K
MethodsX 2026 Jun;16:103871

A Novel YTHDF2/SIGMAR1 Axis in Astrocytes Regulates Neuroinflammation and Cognitive Impairment in Diabetic Encephalopathy.

Xu F, Zhang H, Chen X, Duan C, Gu Q, Hu J
Inflammation 2026 Jan 16;49(1):55

Cannabidiol alleviates methamphetamine-induced autophagy and oxidative stress by suppressing sigma 1 receptor expression.

Li Y, Liu L, Miao L, Zhang Y, Li XD, Sun T, Zeng XF, Huang J, Liu JX
Cellular signalling 2026 Feb;138:112280

Role of Sigma-1 Receptors in the Paraventricular Nucleus and Myocardium during Cirrhotic Cardiomyopathy in Rats.

Yu A, Li Y, Li J, Deng S
Molecular neurobiology 2026 Feb 21;63(1)

CLCC1 governs ER bilayer equilibration to maintain lipid homeostasis.

Wu L, Wang J, Wang Y, Yang J, Yao Y, Wang Y, Huang D, Hu Y, Xu X, Wang R, Du W, Shi Y, Li Q, Liu L, Zhu Y, Li S, Chen FJ, Zhang X, Wang X, Guo Q, Xu L, Li P, Chen XW
Nature 2026 Apr;652(8109):471-480

Sigma-1 Receptor Rescues Autophagy Through AMPK/mTOR Signaling Pathway in Sepsis-Induced Acute Kidney Injury.

Jiang W, Zhang J, Zhang Y, Huang Z
International journal of general medicine 2025;18:1917-1931

Cardioprotective effect of Yiqi Huoxue decoction on post-myocardial infarction injury mediated by Ca(2+) flux through MAMs.

Li Y, Du T, Zhang Y, Lu Y, Li X, Xie W, Guo S
Frontiers in cardiovascular medicine 2025;12:1596757

Sigma-1 receptor activation by PRE-084 attenuates sepsis-associated encephalopathy by targeting microglial p38 MAPK-mediated neuroinflammation and neuronal endoplasmic reticulum stress.

Zeng X, Kang W, Zhou Q, Pan X, Wang L
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Sep 4;74(1):117

Perfluorohexane sulfonate (PFHxS) induces liver cytotoxicity by activating autophagy and endoplasmic reticulum stress-regulated mitochondrial pathway apoptosis.

Chen W, Liu S, Zhou Y, Liu B, Wang W, Chen C, Lou Z, Shen XL
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Oct;204:115657

Social and contextual memory impairments induced by Amyloid-β oligomers are rescued by Sigma-1 receptor activation.

Djebari S, Jiménez-Herrera R, Iborra-Lázaro G, Jiménez-Díaz L, Navarro-López JD
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Mar;184:117914

Activating Sig-1R inhibits microvascular permeability by reducing LRRK2 expression in lipopolysaccharide-induced acute lung injury.

Lin B, Li Y, Yao Y, Yu B, Ke P, Wang T, Qiu W, Weng L, Shi M, Guo C, Chen Z, Zeng Z, Wang X, Lin X, Li T, Gao Y
Free radical biology & medicine 2025 Jan;226:96-108

Calcium-mediated mitochondrial fission and mitophagy drive glycolysis to facilitate arterivirus proliferation.

Sun Z, Ma Z, Cao W, Jiang C, Guo L, Liu K, Gao Y, Bai J, Pi J, Jiang P, Liu X
PLoS pathogens 2025 Jan;21(1):e1012872

SA4503 Mitigates Adriamycin-Induced Nephropathy via Sigma-1 Receptor in Animal and Cell-Based Models.

Tagashira H, Chida S, Bhuiyan MS, Fukunaga K, Numata T
Pharmaceuticals (Basel, Switzerland) 2025 Jan 27;18(2)

Sigma-1 receptor activation ameliorates age-related postoperative cognitive dysfunction by attenuating endoplasmic reticulum stress and neuroinflammation.

Hao Y, Hao R, Lu K, He Y, Xu Z
International immunopharmacology 2025 Dec 10;167:115677

The EMC acts as a chaperone for membrane proteins.

Klose CJ, Meighen-Berger KM, Kulke M, Parr M, Steigenberger B, Zacharias M, Frishman D, Feige MJ
Nature communications 2025 Aug 2;16(1):7097

Sigma-1 receptor agonist PRE-084 increases BDNF by activating the ERK/CREB pathway to rescue learning and memory impairment caused by type II diabetes.

Shi L, Wang M, Yu R, An Y, Wang X, Zhang Y, Shi Y, Han C, Liu J
Behavioural brain research 2025 Apr 27;484:115493

SIGMAR1 screened by a GPCR-related classifier regulates endoplasmic reticulum stress in bladder cancer.

Zhuang J, Wang Y, Wu X, Peng Z, Huang Z, Zhao C, Shen B
Journal of translational medicine 2025 Apr 10;23(1):417

Inactivation of mitochondrial MUL1 E3 ubiquitin ligase deregulates mitophagy and prevents diet-induced obesity in mice.

Cilenti L, Di Gregorio J, Mahar R, Liu F, Ambivero CT, Periasamy M, Merritt ME, Zervos AS
Frontiers in molecular biosciences 2024;11:1397565

Spastin regulates ER-mitochondrial contact sites and mitochondrial homeostasis.

Raby A, Missiroli S, Sanatine P, Langui D, Pansiot J, Beaude N, Vezzana L, Saleh R, Marinello M, Laforge M, Pinton P, Buj-Bello A, Burgo A
iScience 2024 Sep 20;27(9):110683

Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer.

Barr J, Walz A, Restaino AC, Amit M, Barclay SM, Vichaya EG, Spanos WC, Dantzer R, Talbot S, Vermeer PD
eLife 2024 Sep 20;13

Central role of Sigma-1 receptor in ochratoxin A-induced ferroptosis.

Chen W, Han L, Yang R, Wang H, Yao S, Deng H, Liu S, Zhou Y, Shen XL
Archives of toxicology 2024 Oct;98(10):3323-3336

GRP75-dependent mitochondria-ER contacts ensure cell survival during early mouse thymocyte development.

Zhao F, Cui Z, Wang P, Zhao Z, Zhu K, Bai Y, Jin X, Wang L, Lu L
Developmental cell 2024 Oct 7;59(19):2643-2658.e7

Readdressing the Localization of Apolipoprotein E (APOE) in Mitochondria-Associated Endoplasmic Reticulum (ER) Membranes (MAMs): An Investigation of the Hepatic Protein-Protein Interactions of APOE with the Mitochondrial Proteins Lon Protease (LONP1), Mitochondrial Import Receptor Subunit TOM40 (TOMM40) and Voltage-Dependent Anion-Selective Channel 1 (VDAC1).

Rueter J, Rimbach G, Bilke S, Tholey A, Huebbe P
International journal of molecular sciences 2024 Oct 1;25(19)

CGI1746 targets σ(1)R to modulate ferroptosis through mitochondria-associated membranes.

Zhang Z, Zhou H, Gu W, Wei Y, Mou S, Wang Y, Zhang J, Zhong Q
Nature chemical biology 2024 Jun;20(6):699-709

Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a male mouse model of head-and-neck cancer.

Barr J, Walz A, Restaino AC, Amit M, Barclay SM, Vichaya EG, Spanos WC, Dantzer R, Talbot S, Vermeer PD
bioRxiv : the preprint server for biology 2024 Jun 7;

Multiscale photocatalytic proximity labeling reveals cell surface neighbors on and between cells.

Lin Z, Schaefer K, Lui I, Yao Z, Fossati A, Swaney DL, Palar A, Sali A, Wells JA
Science (New York, N.Y.) 2024 Jul 19;385(6706):eadl5763

Sigma-1 receptor exerts protective effects on ameliorating nephrolithiasis by modulating endoplasmic reticulum-mitochondrion association and inhibiting endoplasmic reticulum stress-induced apoptosis in renal tubular epithelial cells.

Ke H, Su X, Dong C, He Z, Song Q, Song C, Zhou J, Liao W, Wang C, Yang S, Xiong Y
Redox report : communications in free radical research 2024 Dec;29(1):2391139

The classical D1 dopamine receptor antagonist SCH23390 is a functional sigma-1 receptor allosteric modulator.

Zhang GF, Zhu KL, Li Q, Zhang Y, Waddington JL, Du XD, Zhen XC
Acta pharmacologica Sinica 2024 Aug;45(8):1582-1590

SIGMAR1 targets AMPK/ULK1 pathway to inhibit SH-SY5Y cell apoptosis by regulating endoplasmic reticulum stress and autophagy.

Kong M, Chen Z, Lin Z, Yin P, Zhao Q
Functional & integrative genomics 2024 Aug 7;24(4):134

Sigma-1 receptor recruits LC3 mRNA to ER-associated omegasomes to promote localized LC3 translation enabling functional autophagy.

Knupp J, Chen YJ, Wang E, Arvan P, Tsai B
Cell reports 2024 Aug 27;43(8):114619

Specific detection and deletion of the sigma-1 receptor widely expressed in neurons and glial cells in vivo.

Liu Q, Guo Q, Fang LP, Yao H, Scheller A, Kirchhoff F, Huang W
Journal of neurochemistry 2023 Mar;164(6):764-785

Regenerative peripheral nerve interface prevents neuroma formation after peripheral nerve transection.

Wang Z, Yi XZ, Yu AX
Neural regeneration research 2023 Apr;18(4):814-818

Autophagy-mediated circHIPK2 promotes lipopolysaccharide-induced astrocytic inflammation via SIGMAR1.

Huang R, Cai L, Ma X, Shen K
International immunopharmacology 2023 Apr;117:109907

Nerve-End Capping Treatment with a Polyglycolic Acid Conduit for Rat Sciatic Neuroma: A Preliminary Report.

Onode E, Uemura T, Hama S, Yokoi T, Okada M, Takamatsu K, Nakamura H
Journal of reconstructive microsurgery 2022 Nov;38(9):711-720

A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease.

Shang Y, Sun X, Chen X, Wang Q, Wang EJ, Miller E, Xu R, Pieper AA, Qi X
Acta neuropathologica 2022 Nov;144(5):911-938

A new insight on peripheral nerve repair: the technique of internal nerve splinting.

Luo X, Li B, Zhang D, Chen H, Zhou X, Yao C, Raza MA, Wang L, Tang N, Zheng G, Yan H
Journal of neurosurgery 2022 Nov 1;137(5):1406-1417

Sigma‑1 receptor overexpression promotes proliferation and ameliorates cell apoptosis in β‑cells.

Ke M, Lin F, Wang H, He G, Feng J, Song L, Xu Y, Liu J
Molecular medicine reports 2022 May;25(5)

ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models.

Zhao Y, Hu D, Wang R, Sun X, Ropelewski P, Hubler Z, Lundberg K, Wang Q, Adams DJ, Xu R, Qi X
Nature communications 2022 Mar 2;13(1):1121

Allosteric Modulation of the Sigma-1 Receptor Elicits Antipsychotic-like Effects.

Chen J, Li G, Qin P, Chen J, Ye N, Waddington JL, Zhen X
Schizophrenia bulletin 2022 Mar 1;48(2):474-484

Sigma-1 receptor activation alleviates blood-brain barrier disruption post cerebral ischemia stroke by stimulating the GDNF-GFRα1-RET pathway.

Liu D, Yang L, Liu P, Ji X, Qi X, Wang Z, Chi T, Zou L
Experimental neurology 2022 Jan;347:113867

Serine palmitoyltransferase assembles at ER-mitochondria contact sites.

Aaltonen MJ, Alecu I, König T, Bennett SA, Shoubridge EA
Life science alliance 2022 Feb;5(2)

PACS2-TRPV1 axis is required for ER-mitochondrial tethering during ER stress and lung fibrosis.

Knoell J, Chillappagari S, Knudsen L, Korfei M, Dartsch R, Jonigk D, Kuehnel MP, Hoetzenecker K, Guenther A, Mahavadi P
Cellular and molecular life sciences : CMLS 2022 Feb 25;79(3):151

Veratramine ameliorates pain symptoms in rats with diabetic peripheral neuropathy by inhibiting activation of the SIGMAR1-NMDAR pathway.

Zhang Y, Ye G, Chen Y, Sheng C, Wang J, Kong L, Yuan L, Lin C
Pharmaceutical biology 2022 Dec;60(1):2145-2154

NCS1 overexpression restored mitochondrial activity and behavioral alterations in a zebrafish model of Wolfram syndrome.

Crouzier L, Richard EM, Diez C, Denus M, Peyrel A, Alzaeem H, Cubedo N, Delaunay T, Maurice T, Delprat B
Molecular therapy. Methods & clinical development 2022 Dec 8;27:295-308

Morphological, behavioral and cellular analyses revealed different phenotypes in Wolfram syndrome wfs1a and wfs1b zebrafish mutant lines.

Crouzier L, Richard EM, Diez C, Alzaeem H, Denus M, Cubedo N, Delaunay T, Glendenning E, Baxendale S, Liévens JC, Whitfield TT, Maurice T, Delprat B
Human molecular genetics 2022 Aug 23;31(16):2711-2727

Sigma-1 receptor regulates mitophagy in dopaminergic neurons and contributes to dopaminergic protection.

Wang M, Wan C, He T, Han C, Zhu K, Waddington JL, Zhen X
Neuropharmacology 2021 Sep 15;196:108360

Nerve capping treatment using a bioabsorbable nerve conduit with open or closed end for rat sciatic neuroma.

Hama S, Uemura T, Onode E, Yokoi T, Okada M, Takamatsu K, Nakamura H
Clinical neurology and neurosurgery 2021 Oct;209:106920

Sigma-1 Receptor Is Critical for Mitochondrial Activity and Unfolded Protein Response in Larval Zebrafish.

Crouzier L, Denus M, Richard EM, Tavernier A, Diez C, Cubedo N, Maurice T, Delprat B
International journal of molecular sciences 2021 Oct 13;22(20)

Sulforaphane Balances Ca(2+) Homeostasis Injured by Excessive Fat via Mitochondria-Associated Membrane (MAM).

Tian S, Lei P, Zhang J, Sun Y, Li B, Shan Y
Molecular nutrition & food research 2021 Jul;65(14):e2001076

Sigma receptor knockdown augments dysfunction and apoptosis of beta cells induced by palmitate.

Ke M, He G, Wang H, Cheng S, Xu Y
Experimental biology and medicine (Maywood, N.J.) 2021 Jul;246(13):1491-1499

The role of Mfn2 in the structure and function of endoplasmic reticulum-mitochondrial tethering in vivo.

Han S, Zhao F, Hsia J, Ma X, Liu Y, Torres S, Fujioka H, Zhu X
Journal of cell science 2021 Jul 1;134(13)

Sigma-1 Receptor Activation Suppresses Microglia M1 Polarization via Regulating Endoplasmic Reticulum-Mitochondria Contact and Mitochondrial Functions in Stress-Induced Hypertension Rats.

Ooi K, Hu L, Feng Y, Han C, Ren X, Qian X, Huang H, Chen S, Shi Q, Lin H, Wang J, Zhu D, Wang R, Xia C
Molecular neurobiology 2021 Dec;58(12):6625-6646

Dexmedetomidine inhibits neuronal apoptosis by inducing Sigma-1 receptor signaling in cerebral ischemia-reperfusion injury.

Zhai M, Liu C, Li Y, Zhang P, Yu Z, Zhu H, Zhang L, Zhang Q, Wang J, Wang J
Aging 2019 Nov 4;11(21):9556-9568

Cocaine-induced release of CXCL10 from pericytes regulates monocyte transmigration into the CNS.

Niu F, Liao K, Hu G, Sil S, Callen S, Guo ML, Yang L, Buch S
The Journal of cell biology 2019 Feb 4;218(2):700-721

DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1.

Liu Y, Ma X, Fujioka H, Liu J, Chen S, Zhu X
Proceedings of the National Academy of Sciences of the United States of America 2019 Dec 10;116(50):25322-25328

Protective effect of a novel sigma-1 receptor agonist is associated with reduced endoplasmic reticulum stress in stroke male mice.

Morihara R, Yamashita T, Liu X, Nakano Y, Fukui Y, Sato K, Ohta Y, Hishikawa N, Shang J, Abe K
Journal of neuroscience research 2018 Oct;96(10):1707-1716

Systematic In-Depth Proteomic Analysis of Mitochondria-Associated Endoplasmic Reticulum Membranes in Mouse and Human Testes.

Wang X, Wen Y, Dong J, Cao C, Yuan S
Proteomics 2018 Jul;18(14):e1700478

Sigma-1 Receptor Plays a Negative Modulation on N-type Calcium Channel.

Zhang K, Zhao Z, Lan L, Wei X, Wang L, Liu X, Yan H, Zheng J
Frontiers in pharmacology 2017;8:302

An Increase of Sigma-1 Receptor in the Penumbra Neuron after Acute Ischemic Stroke.

Zhang X, Wu F, Jiao Y, Tang T, Yang L, Lu C, Zhang Y, Zhang Y, Bai Y, Chao J, Teng G, Yao H
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2017 Sep;26(9):1981-1987

ALS-Associated Endoplasmic Reticulum Proteins in Denervated Skeletal Muscle: Implications for Motor Neuron Disease Pathology.

Jesse CM, Bushuven E, Tripathi P, Chandrasekar A, Simon CM, Drepper C, Yamoah A, Dreser A, Katona I, Johann S, Beyer C, Wagner S, Grond M, Nikolin S, Anink J, Troost D, Sendtner M, Goswami A, Weis J
Brain pathology (Zurich, Switzerland) 2017 Nov;27(6):781-794

Sigma-1 receptor agonist increases axon outgrowth of hippocampal neurons via voltage-gated calcium ions channels.

Li D, Zhang SZ, Yao YH, Xiang Y, Ma XY, Wei XL, Yan HT, Liu XY
CNS neuroscience & therapeutics 2017 Dec;23(12):930-939

Transactivation of TrkB by Sigma-1 receptor mediates cocaine-induced changes in dendritic spine density and morphology in hippocampal and cortical neurons.

Ka M, Kook YH, Liao K, Buch S, Kim WY
Cell death & disease 2016 Oct 13;7(10):e2414

Hereditary spastic paraplegia-linked REEP1 modulates endoplasmic reticulum/mitochondria contacts.

Lim Y, Cho IT, Schoel LJ, Cho G, Golden JA
Annals of neurology 2015 Nov;78(5):679-96

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse kidney tissue were subjected to SDS PAGE followed by western blot with 15168-1-AP(SIGMAR1 antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SIGMAR1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SIGMAR1. This antibody recognizes human,mouse,rat antigen. The SIGMAR1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 15168-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human liver cancer using 15168-1-AP(SIGMAR1 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue