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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [11]
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- Product number
- 14186-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- UPP1 antibody
- Antibody type
- Polyclonal
- Description
- UPP1 antibody (Cat. #14186-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The dysregulation of UPP1 incurred by METTL3 regulates the malignancy of esophageal squamous cell carcinoma in an m(6)A-YTHDC1-KLF5-mediated manner.
Targeting plasticity in the pyrimidine synthesis pathway potentiates macrophage-mediated phagocytosis in pancreatic cancer models.
The protection of UCK2 protein stability by GART maintains pyrimidine salvage synthesis for HCC growth under glucose limitation.
Lysine Methyltransferase 5C (KMT5C) Suppresses Oral Squamous Cell Carcinoma Progression by Epigenetic Regulation of Uridine Phosphorylase 1 Expression.
UPP1 and AHSA1 as emerging biomarkers and targets in pancreatic cancer: A proteomic approach.
Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAF(V600E)-induced growth arrest in melanocytes.
UPP1 is a dual biomarker of prognosis and immune microenvironment in IDH wild-type glioblastoma.
p53 activation enhances the sensitivity of non-small cell lung cancer to the combination of SH003 and docetaxel by inhibiting de novo pyrimidine synthesis.
UPP1 promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment.
SH2 Domain-Containing Phosphatase 2 Inhibition Attenuates Osteoarthritis by Maintaining Homeostasis of Cartilage Metabolism via the Docking Protein 1/Uridine Phosphorylase 1/Uridine Cascade.
Pharmacological inhibition of catalase induces peroxisome leakage and suppression of LPS induced inflammatory response in Raw 264.7 cell.
Chen J, Zhu ZX, Yang PJ, Deng F, Li PF, Zhu ZF, Xu X, Wu WJ, Shen WG
Cellular signalling 2026 Jan;137:112201
Cellular signalling 2026 Jan;137:112201
Targeting plasticity in the pyrimidine synthesis pathway potentiates macrophage-mediated phagocytosis in pancreatic cancer models.
Zhao J, Li X, Li X, Ren P, Wu Y, Gong H, Wu L, Huang J, Wang S, Guo Z, Chen M, Zeng Z, Pan D
The Journal of clinical investigation 2025 Nov 17;135(22)
The Journal of clinical investigation 2025 Nov 17;135(22)
The protection of UCK2 protein stability by GART maintains pyrimidine salvage synthesis for HCC growth under glucose limitation.
Sha N, Zhou B, Hou G, Xi Z, Wang W, Yan M, He J, Zhou Y, Xia Q, Jiang Y, Zhao Q
Oncogene 2025 May;44(16):1078-1092
Oncogene 2025 May;44(16):1078-1092
Lysine Methyltransferase 5C (KMT5C) Suppresses Oral Squamous Cell Carcinoma Progression by Epigenetic Regulation of Uridine Phosphorylase 1 Expression.
Zhang L, Zhang A, Wang Y, Liu Y, Liu F
Laboratory investigation; a journal of technical methods and pathology 2025 May;105(5):104106
Laboratory investigation; a journal of technical methods and pathology 2025 May;105(5):104106
UPP1 and AHSA1 as emerging biomarkers and targets in pancreatic cancer: A proteomic approach.
Zhu K, Hu H, Tao Y, Yang Z, Li H
Biomolecules & biomedicine 2025 May 9;25(11):2466-2480
Biomolecules & biomedicine 2025 May 9;25(11):2466-2480
Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAF(V600E)-induced growth arrest in melanocytes.
McGrail K, Granado-Martínez P, Orsenigo R, Caratù G, Nieto P, Heyn H, Ferrer B, Hernández-Losa J, Muñoz-Couselo E, García-Patos V, Recio JA
Oncogene 2025 Jun;44(21):1592-1608
Oncogene 2025 Jun;44(21):1592-1608
UPP1 is a dual biomarker of prognosis and immune microenvironment in IDH wild-type glioblastoma.
Qian K, Jia Z, Cai Q, Jiang T, Gan L, Yang J, Cen X, Zhao Y, Di Z, Ma C, Lin X
Scientific reports 2025 Aug 28;15(1):31677
Scientific reports 2025 Aug 28;15(1):31677
p53 activation enhances the sensitivity of non-small cell lung cancer to the combination of SH003 and docetaxel by inhibiting de novo pyrimidine synthesis.
Choi YJ, Lee K, Lee SY, Kwon Y, Woo J, Jeon CY, Ko SG
Cancer cell international 2024 May 4;24(1):156
Cancer cell international 2024 May 4;24(1):156
UPP1 promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment.
Li Y, Jiang M, Aye L, Luo L, Zhang Y, Xu F, Wei Y, Peng D, He X, Gu J, Yu X, Li G, Ge D, Lu C
Nature communications 2024 Feb 8;15(1):1200
Nature communications 2024 Feb 8;15(1):1200
SH2 Domain-Containing Phosphatase 2 Inhibition Attenuates Osteoarthritis by Maintaining Homeostasis of Cartilage Metabolism via the Docking Protein 1/Uridine Phosphorylase 1/Uridine Cascade.
Liu Q, Zhai L, Han M, Shi D, Sun Z, Peng S, Wang M, Zhang C, Gao J, Yan W, Jiang Q, Chen D, Xu Q, Tan M, Sun Y
Arthritis & rheumatology (Hoboken, N.J.) 2022 Mar;74(3):462-474
Arthritis & rheumatology (Hoboken, N.J.) 2022 Mar;74(3):462-474
Pharmacological inhibition of catalase induces peroxisome leakage and suppression of LPS induced inflammatory response in Raw 264.7 cell.
Mu Y, Maharjan Y, Kumar Dutta R, Wei X, Kim JH, Son J, Park C, Park R
PloS one 2021;16(2):e0245799
PloS one 2021;16(2):e0245799
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