24895-1-AP

antibody from Proteintech Group

Targeting: PTGER4 EP4

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

24895-1-AP

Provider

Proteintech Group

Product name

PTGER4 antibody

Antibody type

Polyclonal

Description

PTGER4 antibody (Cat. #24895-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Endogenous Ceramide 24:1 Constrains Th17-Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling.

Liu H, Aili A, Kuang Z, Cao L, Li Z, Shang Y, Ge Y, Hu T, Sun Y, Zhao W, Jin R, Chang C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 13;:e20695

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Rebamipide Induces Hair Regeneration Through EP4-Driven Lipid Metabolism Remodeling.

Feng C, Dong H, Jiang D, Gao Y, Gu X, Diao W, Zhou Y, Xu D, Li R, Wu L
International journal of molecular sciences 2025 Oct 18;26(20)

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Macrophage EP4 Deficiency Drives Atherosclerosis Progression via CD36-Mediated Lipid Uptake and M1 Polarization.

Tang X, Chen Q, Guo M, Wen Y, Jia C, Bu Y, Wang T, Zhang Y, Tang W
Cells 2025 Jul 4;14(13)

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Hyperoxia-activated Nrf2 regulates ferroptosis in intestinal epithelial cells and intervenes in inflammatory reaction through COX-2/PGE2/EP2 pathway.

Liu Y, Li T, Niu C, Yuan Z, Sun S, Liu D
Molecular medicine (Cambridge, Mass.) 2025 Jan 3;31(1):1

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Rab23 GTPase and IFT43 regulate the trafficking of prostaglandin E receptor 4 to primary cilia.

Chen Y, Zhou Y, Qi Y, Miao T, Shi J, Jin D, Zhong TP
Communications biology 2025 Dec 10;9(1):33

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Abnormal mitochondrial iron metabolism damages alveolar type II epithelial cells involved in bleomycin-induced pulmonary fibrosis.

Shao M, Cheng H, Li X, Qiu Y, Zhang Y, Chang Y, Fu J, Shen M, Xu X, Feng D, Han Y, Yue S, Zhou Y, Luo Z
Theranostics 2024;14(7):2687-2705

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Gabapentin alleviates peripheral nerve sensitization induced by inflammatory arthritis via ionotropic glutamate receptor NR2B subunit.

Meng Y, Tan M, Yan Jiang X, Wang T, Li Shen H
Neuroscience 2024 Sep 25;556:1-13

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PTGER4 signaling regulates class IIa HDAC function and SPINK4 mRNA levels in rectal epithelial cells.

Anbazhagan M, Sharma G, Murthy S, Maddipatla SC, Kolachala VL, Dodd A, Randunne A, Cutler DJ, Kugathasan S, Matthews JD
Cell communication and signaling : CCS 2024 Oct 13;22(1):493

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Sensory nerve EP4 facilitates heterotopic ossification by regulating angiogenesis-coupled bone formation.

Lin R, Lin H, Zhu C, Zeng J, Hou J, Xu T, Tan Y, Zhou X, Ma Y, Yang M, Wei K, Yu B, Wu H, Cui Z
Journal of orthopaedic translation 2024 Nov;49:325-338

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Cellular senescence and metabolic reprogramming model based on bulk/single-cell RNA sequencing reveals PTGER4 as a therapeutic target for ccRCC.

Zhou L, Zeng Y, Liu Y, Du K, Luo Y, Dai Y, Pan W, Zhang L, Zhang L, Tian F, Gu C
BMC cancer 2024 Apr 11;24(1):451

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New, potent, small molecule agonists of tyrosine kinase receptors attenuate dry eye disease.

Yu Z, Joy S, Mi T, Yazdanpanah G, Burgess K, de Paiva CS
Frontiers in medicine 2022;9:937142

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In Silico, In Vitro, and In Vivo Analysis of Tanshinone IIA and Cryptotanshinone from Salvia miltiorrhiza as Modulators of Cyclooxygenase-2/mPGES-1/Endothelial Prostaglandin EP3 Pathway.

Saviano A, De Vita S, Chini MG, Marigliano N, Lauro G, Casillo GM, Raucci F, Iorizzi M, Hofstetter RK, Fischer K, Koeberle A, Werz O, Maione F, Bifulco G
Biomolecules 2022 Jan 7;12(1)

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The Prostaglandin E2 Receptor EP4 Promotes Vascular Neointimal Hyperplasia through Translational Control of Tenascin C via the cAPM/PKA/mTORC1/rpS6 Pathway.

Xu H, Fang B, Bao C, Mao X, Zhu C, Ye L, Liu Q, Li Y, Du C, Qi H, Zhang X, Guan Y
Cells 2022 Aug 31;11(17)

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Prostaglandin E2 accelerated recovery of chemotherapy-induced intestinal damage by increasing expression of cyclin D.

Yue M, Shao L, Cheng J, Fan Y, Cai X, Li H, Li M, Zhang X, Fu A, Huang Y, Nie C, Long F, Chen H, Zhu Q, Zeng H
Experimental cell research 2020 Mar 15;388(2):111819

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Endothelial cell prostaglandin E2 receptor EP4 is essential for blood pressure homeostasis.

Xu H, Fang B, Du S, Wang S, Li Q, Jia X, Bao C, Ye L, Sui X, Qian L, Luan Z, Yang G, Zheng F, Wang N, Chen L, Zhang X, Guan Y
JCI insight 2020 Jul 9;5(13)

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Correlative Study on Impaired Prostaglandin E2 Regulation in Epicardial Adipose Tissue and its Role in Maladaptive Cardiac Remodeling via EPAC2 and ST2 Signaling in Overweight Cardiovascular Disease Subjects.

Vianello E, Dozio E, Bandera F, Froldi M, Micaglio E, Lamont J, Tacchini L, Schmitz G, Corsi Romanelli MM
International journal of molecular sciences 2020 Jan 14;21(2)

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Inhibition of prostaglandin E2 receptor 4 by lnc000908 to promote the endothelial-mesenchymal transition participation in cardiac remodelling.

Chen X, Ge W, Hu J, Dong T, Yao H, Chen L, Geng B, Zhou H
Journal of cellular and molecular medicine 2019 Sep;23(9):6355-6367

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Antibiotic pretreatment alleviates liver transplant damage in mice and humans.

Nakamura K, Kageyama S, Ito T, Hirao H, Kadono K, Aziz A, Dery KJ, Everly MJ, Taura K, Uemoto S, Farmer DG, Kaldas FM, Busuttil RW, Kupiec-Weglinski JW
The Journal of clinical investigation 2019 Jul 22;129(8):3420-3434

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Meloxicam Improves Cognitive Impairment of Diabetic Rats through COX2-PGE2-EPs-cAMP/pPKA Pathway.

Li H, Luo Y, Xu Y, Yang L, Hu C, Chen Q, Yang Y, Ma J, Zhang J, Xia H, Li Y, Yang J
Molecular pharmaceutics 2018 Sep 4;15(9):4121-4131