Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- PA2195 - Provider product page
- Provider
- Boster Biological Technology
- Product name
- Anti-Leupaxin/LPXN Antibody
- Antibody type
- Polyclonal
- Description
- Polyclonal antibody for LEUPAXIN/LPXN detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. LEUPAXIN/LPXN information: Molecular Weight: 43332 MW; Subcellular Localization: Cytoplasm. Cell junction, focal adhesion. Nucleus. Cytoplasm, perinuclear region . Cell projection, podosome. Cell membrane. Shuttles between the cytoplasm and nucleus. Recruited to the cell membrane following B- cell antigen receptor (BCR) cross-linking in B-cells. Enhanced focal adhesion kinase activity (PTK2/FAK) attenuates its nuclear accumulation and limits its ability to enhance serum response factor (SRF)-dependent gene transcription. Targeting to focal adhesions is essential for its tyrosine phosphorylation in response to bombesin; Tissue Specificity: Macrophages, monocytes and osteoclasts (at protein level). Strongly expressed in cells and tissues of hematopoietic origin. Highest expression in lymphoid tissues such as spleen, lymph node, thymus and appendix and in the vascular smooth muscle. Lower levels in bone marrow and fetal liver. Also expressed in peripheral blood lymphocytes and a number of hematopoietic cell lines. Very low levels found in epithelial cell lines. Expressed in prostate cancer (PCa) cells and its expression intensity is directly linked to PCa progression.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Vial size
- 100μg/vial
- Concentration
- Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
- Storage
- At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquoted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
- Handling
- Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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Supportive validation
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- Boster Biological Technology (provider)
- Main image
- Experimental details
- Anti-Leupaxin antibody, PA2195, Western blottingLane 1: Rat Thymus Tissue LysateLane 2: JURKAT Cell Lysate
- Additional image