orb154220

antibody from Biorbyt

Targeting: SOS1 GF1, GINGF, HGF

Western blot (Data presented on provider website)

Antibody Data

Product number

orb154220

Provider

Biorbyt

Product name

SOS1 antibody

Antibody type

Polyclonal

Description

Rabbit polyclonal antibody to SOS1. Son of sevenless (SOS) was first identified in Drosophila as a guanine nucleotide exchange factor (GEF) for Ras acting downstream of the Sevenless receptor (1). Two closely related homologs of Drosophila SOS are found in mammalian cells: SOS1 and SOS2 (2). SOS1 consists of histone folds, Dbl (DH) and pleckstrin (PH) homology domains, a Ras exchange motif (REM), and Cdc25 homology and polyproline domains (3). SOS1 binds to GRB2, NCK, and other adaptor proteins, and plays an important role in ERK activation downstream of protein tyrosine kinase receptor (RTK). Research studies have identified mutations in the corresponding SOS1 gene of patients with Noonan syndrome, a developmental disorder characterized by short stature, facial dysmorphia, and congenital heart defects

Reactivity

Human, Mouse, Rat

Conjugate

Unconjugated

Isotype

IgG

Vial size

50 ul

Storage

Store at -20°C. Avoid freeze / thaw cycles.