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- Antibody Data
- Antigen structure
- References [15]
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- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 14067-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14067-1-AP, RRID:AB_2225559
- Product name
- CCP1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CCP1 antibody (Cat. #14067-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references CCP1, a Regulator of Tubulin Post-Translational Modifications, Potentially Plays an Essential Role in Cerebellar Development.
[Expression of TUBB4B in mouse primary spermatocyte GC-2 cells and its regulatory effect on NF-κB and MAPK signaling pathway].
Pathogenic role of delta 2 tubulin in bortezomib-induced peripheral neuropathy.
Nucleolin reorganization and nucleolar stress in Purkinje cells of mutant PCD mice.
CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in pcd mice.
Deletion of exons encoding carboxypeptidase domain of Nna1 results in Purkinje cell degeneration (pcd) phenotype.
Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.
Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis.
Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration.
Increase in α-tubulin modifications in the neuronal processes of hippocampal neurons in both kainic acid-induced epileptic seizure and Alzheimer's disease.
Bioinformatics Data Mining Approach Suggests Coexpression of AGTPBP1 with an ALS-linked Gene C9orf72.
AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation.
Functional segregation and emerging role of cilia-related cytosolic carboxypeptidases (CCPs).
Cytosolic carboxypeptidase 1 is involved in processing α- and β-tubulin.
Abnormal sperm development in pcd(3J)-/- mice: the importance of Agtpbp1 in spermatogenesis.
Pang B, Araki A, Zhou L, Takebayashi H, Harada T, Kadota K
International journal of molecular sciences 2023 Mar 10;24(6)
International journal of molecular sciences 2023 Mar 10;24(6)
[Expression of TUBB4B in mouse primary spermatocyte GC-2 cells and its regulatory effect on NF-κB and MAPK signaling pathway].
Liu T, Wang W, Zhang T, Liu S, Bian Y, Zhang C, Xiao R
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Jun 20;43(6):1002-1009
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Jun 20;43(6):1002-1009
Pathogenic role of delta 2 tubulin in bortezomib-induced peripheral neuropathy.
Pero ME, Meregalli C, Qu X, Shin GJ, Kumar A, Shorey M, Rolls MM, Tanji K, Brannagan TH, Alberti P, Fumagalli G, Monza L, Grueber WB, Cavaletti G, Bartolini F
Proceedings of the National Academy of Sciences of the United States of America 2021 Jan 26;118(4)
Proceedings of the National Academy of Sciences of the United States of America 2021 Jan 26;118(4)
Nucleolin reorganization and nucleolar stress in Purkinje cells of mutant PCD mice.
Baltanás FC, Berciano MT, Tapia O, Narcis JO, Lafarga V, Díaz D, Weruaga E, Santos E, Lafarga M
Neurobiology of disease 2019 Jul;127:312-322
Neurobiology of disease 2019 Jul;127:312-322
CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in pcd mice.
Gilmore-Hall S, Kuo J, Ward JM, Zahra R, Morrison RS, Perkins G, La Spada AR
The Journal of cell biology 2019 Jan 7;218(1):206-219
The Journal of cell biology 2019 Jan 7;218(1):206-219
Deletion of exons encoding carboxypeptidase domain of Nna1 results in Purkinje cell degeneration (pcd) phenotype.
Zhou L, Hossain MI, Yamazaki M, Abe M, Natsume R, Konno K, Kageyama S, Komatsu M, Watanabe M, Sakimura K, Takebayashi H
Journal of neurochemistry 2018 Nov;147(4):557-572
Journal of neurochemistry 2018 Nov;147(4):557-572
Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.
Ye B, Liu B, Hao L, Zhu X, Yang L, Wang S, Xia P, Du Y, Meng S, Huang G, Qin X, Wang Y, Yan X, Li C, Hao J, Zhu P, He L, Tian Y, Fan Z
Nature communications 2018 Mar 28;9(1):1261
Nature communications 2018 Mar 28;9(1):1261
Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis.
Silva CG, Peyre E, Adhikari MH, Tielens S, Tanco S, Van Damme P, Magno L, Krusy N, Agirman G, Magiera MM, Kessaris N, Malgrange B, Andrieux A, Janke C, Nguyen L
Cell 2018 Feb 22;172(5):1063-1078.e19
Cell 2018 Feb 22;172(5):1063-1078.e19
Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration.
Shashi V, Magiera MM, Klein D, Zaki M, Schoch K, Rudnik-Schöneborn S, Norman A, Lopes Abath Neto O, Dusl M, Yuan X, Bartesaghi L, De Marco P, Alfares AA, Marom R, Arold ST, Guzmán-Vega FJ, Pena LD, Smith EC, Steinlin M, Babiker MO, Mohassel P, Foley AR, Donkervoort S, Kaur R, Ghosh PS, Stanley V, Musaev D, Nava C, Mignot C, Keren B, Scala M, Tassano E, Picco P, Doneda P, Fiorillo C, Issa MY, Alassiri A, Alahmad A, Gerard A, Liu P, Yang Y, Ertl-Wagner B, Kranz PG, Wentzensen IM, Stucka R, Stong N, Allen AS, Goldstein DB, Undiagnosed Diseases Network, Schoser B, Rösler KM, Alfadhel M, Capra V, Chrast R, Strom TM, Kamsteeg EJ, Bönnemann CG, Gleeson JG, Martini R, Janke C, Senderek J
The EMBO journal 2018 Dec 3;37(23)
The EMBO journal 2018 Dec 3;37(23)
Increase in α-tubulin modifications in the neuronal processes of hippocampal neurons in both kainic acid-induced epileptic seizure and Alzheimer's disease.
Vu HT, Akatsu H, Hashizume Y, Setou M, Ikegami K
Scientific reports 2017 Jan 9;7:40205
Scientific reports 2017 Jan 9;7:40205
Bioinformatics Data Mining Approach Suggests Coexpression of AGTPBP1 with an ALS-linked Gene C9orf72.
Kitano S, Kino Y, Yamamoto Y, Takitani M, Miyoshi J, Ishida T, Saito Y, Arima K, Satoh J
Journal of central nervous system disease 2015;7:15-26
Journal of central nervous system disease 2015;7:15-26
AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation.
Herms A, Bosch M, Reddy BJ, Schieber NL, Fajardo A, Rupérez C, Fernández-Vidal A, Ferguson C, Rentero C, Tebar F, Enrich C, Parton RG, Gross SP, Pol A
Nature communications 2015 May 27;6:7176
Nature communications 2015 May 27;6:7176
Functional segregation and emerging role of cilia-related cytosolic carboxypeptidases (CCPs).
Rodríguez de la Vega Otazo M, Lorenzo J, Tort O, Avilés FX, Bautista JM
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Feb;27(2):424-31
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Feb;27(2):424-31
Cytosolic carboxypeptidase 1 is involved in processing α- and β-tubulin.
Berezniuk I, Vu HT, Lyons PJ, Sironi JJ, Xiao H, Burd B, Setou M, Angeletti RH, Ikegami K, Fricker LD
The Journal of biological chemistry 2012 Feb 24;287(9):6503-17
The Journal of biological chemistry 2012 Feb 24;287(9):6503-17
Abnormal sperm development in pcd(3J)-/- mice: the importance of Agtpbp1 in spermatogenesis.
Kim N, Xiao R, Choi H, Jo H, Kim JH, Uhm SJ, Park C
Molecules and cells 2011 Jan;31(1):39-48
Molecules and cells 2011 Jan;31(1):39-48
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A549 cells were subjected to SDS PAGE followed by western blot with 14067-1-AP(CCP1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-CCP1 (IP:14067-1-AP, 3ug; Detection:14067-1-AP 1:1000) with mouse testis tissue lysate 10000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 14067-1-AP(CCP1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CCP1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CCP1. This antibody recognizes human,mouse,rat antigen. The CCP1 antibody has been validated for the following applications: ELISA, IHC, WB, IP analysis.
