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- References [12]
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- Immunohistochemistry [1]
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- Product number
- 12639-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12639-1-AP, RRID:AB_2289669
- Product name
- APPL1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated APPL1 antibody (Cat. #12639-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references PEPITEM Regulates the Synovial Microenvironment During Immune-Mediated Inflammatory Arthritis to Limit Disease.
Increased neuronal expression of the early endosomal adaptor APPL1 replicates Alzheimer's Disease-related endosomal and synaptic dysfunction with cholinergic neurodegeneration.
Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Alzheimer's Disease-Related Endosomal and Synaptic Dysfunction with Cholinergic Neurodegeneration.
The Role of Human Adiponectin Receptor 1 in 2-Ethylhexyl Diphenyl Phosphate Induced Lipid Metabolic Disruption.
Rejuvenation of leukocyte trafficking in aged mice through PEPITEM intervention.
DDAH1/ADMA Regulates Adiponectin Resistance in Cerebral Ischemia via the ROS/FOXO1/APR1 Pathway.
Naringin Promotes Skeletal Muscle Fiber Remodeling by the AdipoR1-APPL1-AMPK Signaling Pathway.
Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease.
Myosin VI maintains the actin-dependent organization of the tubulobulbar complexes required for endocytosis during mouse spermiogenesis†‡.
Endocytosis is required for CXC chemokine receptor type 4 (CXCR4)-mediated Akt activation and antiapoptotic signaling.
ESCRT-0 marks an APPL1-independent transit route for EGFR between the cell surface and the EEA1-positive early endosome.
Characterization and distribution of adaptor protein containing a PH domain, PTB domain and leucine zipper motif (APPL1) in Alzheimer's disease hippocampus: an immunohistochemical study.
Wahid M, Kemble S, Abudu O, Saviano A, Mahony C, Lewis JW, Nicholson TA, Schettino A, Marigliano N, Frost K, Begum J, Urbanowski AM, Limo M, Jha R, Jarquin SM, Pezhman L, Degan AEA, Anderson AE, Smith CG, Batki A, Adams H, Caso F, Scarpa R, McInnes I, Siebert S, Pratt AG, Filer A, Raza K, Croft AP, Chimen M, de Cogan F, Rainger GE, Iqbal AJ, Maione F, McGettrick HM
Arthritis & rheumatology (Hoboken, N.J.) 2026 Apr 13;
Arthritis & rheumatology (Hoboken, N.J.) 2026 Apr 13;
Increased neuronal expression of the early endosomal adaptor APPL1 replicates Alzheimer's Disease-related endosomal and synaptic dysfunction with cholinergic neurodegeneration.
Jiang Y, Sachdeva K, Goulbourne CN, Berg MJ, Peddy J, Stavrides PH, Pensalfini A, Pawlik M, Malampati S, Whyte L, Basavarajappa BS, Shivakumar S, Bleiwas C, Smiley JF, Mathews PM, Nixon RA
bioRxiv : the preprint server for biology 2025 May 8;
bioRxiv : the preprint server for biology 2025 May 8;
Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Alzheimer's Disease-Related Endosomal and Synaptic Dysfunction with Cholinergic Neurodegeneration.
Jiang Y, Sachdeva K, Goulbourne CN, Berg MJ, Peddy J, Stavrides PH, Pensalfini A, Pawlik M, Malampati S, Whyte L, Basavarajappa BS, Subbanna S, Bleiwas C, Smiley JF, Mathews PM, Nixon RA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2025 Jul 16;45(29)
The Journal of neuroscience : the official journal of the Society for Neuroscience 2025 Jul 16;45(29)
The Role of Human Adiponectin Receptor 1 in 2-Ethylhexyl Diphenyl Phosphate Induced Lipid Metabolic Disruption.
Feng J, Ma X, Liu Y, Shi X, Jin L, Le Y, Zhang Q, Wang C
Environmental science & technology 2024 Oct 15;58(41):18190-18201
Environmental science & technology 2024 Oct 15;58(41):18190-18201
Rejuvenation of leukocyte trafficking in aged mice through PEPITEM intervention.
Hopkin SJ, Nathan P, Pezhman L, Begum J, Manning JE, Quinn LM, Rainger GE, McGettrick HM, Iqbal AJ, Chimen M
npj aging 2024 Jul 18;10(1):33
npj aging 2024 Jul 18;10(1):33
DDAH1/ADMA Regulates Adiponectin Resistance in Cerebral Ischemia via the ROS/FOXO1/APR1 Pathway.
Zhao Y, Zhang M, Dou Y, Du K, Liu X, Zhao Y
Oxidative medicine and cellular longevity 2022;2022:2350857
Oxidative medicine and cellular longevity 2022;2022:2350857
Naringin Promotes Skeletal Muscle Fiber Remodeling by the AdipoR1-APPL1-AMPK Signaling Pathway.
Li P, Zhang S, Song H, Traore SS, Li J, Raubenheimer D, Cui Z, Kou G
Journal of agricultural and food chemistry 2021 Oct 13;69(40):11890-11899
Journal of agricultural and food chemistry 2021 Oct 13;69(40):11890-11899
Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease.
Pensalfini A, Kim S, Subbanna S, Bleiwas C, Goulbourne CN, Stavrides PH, Jiang Y, Lee JH, Darji S, Pawlik M, Huo C, Peddy J, Berg MJ, Smiley JF, Basavarajappa BS, Nixon RA
Cell reports 2020 Nov 24;33(8):108420
Cell reports 2020 Nov 24;33(8):108420
Myosin VI maintains the actin-dependent organization of the tubulobulbar complexes required for endocytosis during mouse spermiogenesis†‡.
Zakrzewski P, Suwińska A, Lenartowski R, Rędowicz MJ, Buss F, Lenartowska M
Biology of reproduction 2020 Apr 15;102(4):863-875
Biology of reproduction 2020 Apr 15;102(4):863-875
Endocytosis is required for CXC chemokine receptor type 4 (CXCR4)-mediated Akt activation and antiapoptotic signaling.
English EJ, Mahn SA, Marchese A
The Journal of biological chemistry 2018 Jul 20;293(29):11470-11480
The Journal of biological chemistry 2018 Jul 20;293(29):11470-11480
ESCRT-0 marks an APPL1-independent transit route for EGFR between the cell surface and the EEA1-positive early endosome.
Flores-Rodriguez N, Kenwright DA, Chung PH, Harrison AW, Stefani F, Waigh TA, Allan VJ, Woodman PG
Journal of cell science 2015 Feb 15;128(4):755-67
Journal of cell science 2015 Feb 15;128(4):755-67
Characterization and distribution of adaptor protein containing a PH domain, PTB domain and leucine zipper motif (APPL1) in Alzheimer's disease hippocampus: an immunohistochemical study.
Ogawa A, Yamazaki Y, Nakamori M, Takahashi T, Kurashige T, Hiji M, Nagano Y, Yamawaki T, Matsumoto M
Brain research 2013 Feb 4;1494:118-24
Brain research 2013 Feb 4;1494:118-24
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 12639-1-AP(APPL1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The APPL1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human APPL1. This antibody recognizes human, mouse, rat antigen. The APPL1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
