66087-1-Ig

antibody from Proteintech Group

Targeting: UBE2C UBCH10

Provider product page for 66087-1-Ig

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [17]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 66087-1-Ig - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#66087-1-Ig, RRID:AB_11232220
Product name: UBE2C antibody
Antibody type: Monoclonal
Description: UBE2C antibody (Cat. #66087-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 1C12H8
Vial size: 20ul, 150ul

UBE2C protein structure - 66087-1-Ig shown in red.

Submitted references Integrating multiple key molecules in uveal melanoma to uncover metastatic and immune microenvironment-related gene signatures.

Guo YM, Bai ZP, Wang JQ, Huang J, Wei JH, Han YJ, Liu Y, Ye L
International journal of ophthalmology 2026;19(1):11-24

Multiomics Profiling Reveals Distinct Immunosuppression and Metabolic Dysregulation in Aggressive Subtypes of Thyroid Cancer.

Gui S, Huang K, Qiang J, Chen Y, Gan M, Jiang Z, Qian J, Yi C, Ding Y, Jiang H, Zheng F, Lei W, Jin L, Zhang X, Fang H, Wang M
Molecular & cellular proteomics : MCP 2026 Mar;25(3):101513

Integrating spatial and single-cell transcriptomics analysis reveals MYCN-UBE2C-TFRC signaling endows ferroptosis resistance in neuroectodermal tumors.

Yang J, He M, Liao Q, Mengjiang R, Li Y, Zong C, Zhu T, He F, Chai P, Jia R, Wen X, Fan X, Fan J
Science China. Life sciences 2026 Mar 26;

Exploring the carcinogenic potential of bisphenol A in lung adenocarcinoma: molecular mechanisms, key gene insights, and immune microenvironment impacts.

Chen H, Jiang T, Yang Y, Cai G, Jiang Y, Ouyang W
Frontiers in immunology 2025;16:1647807

UBE2C regulating the lung carcinoma progression via inhibiting ubiquitin-proteasomal degradation to increase MMP9 protein stability.

Zhao J, Dai J, Zhou N, Liu D, Wang D, Miao S, Liang C, An D, Jiang J, Gong K, Wu Y
Genes & genomics 2025 Jun;47(6):651-662

UBE2C: a potential therapeutic target and prognostic biomarker for prostate cancer patients.

Li S, Liu Y, Wu X, Zhang Q, Yuan W
Functional & integrative genomics 2025 Jul 25;25(1):159

Exploring Potential Biomarkers and Molecular Mechanisms of Cutaneous Squamous Cell Carcinoma Based on Bioinformatics.

Qi J, Guo Q, Bai J, Liang X, Zhu W, Li C, Xie F
OncoTargets and therapy 2024;17:841-856

UBE2C orchestrates bone formation through stabilization of SMAD1/5.

Zhang H, Du Y, Lu D, Wang X, Li Y, Qing J, Zhang Y, Liu H, Lv L, Zhang X, Liu Y, Zhou Y, Zhang P
Bone 2024 Oct;187:117175

Shared and distinct mechanisms of UBA1 inactivation across different diseases.

Collins JC, Magaziner SJ, English M, Hassan B, Chen X, Balanda N, Anderson M, Lam A, Fernandez-Pol S, Kwong B, Greenberg PL, Terrier B, Likhite ME, Kosmider O, Wang Y, Samara NL, Walters KJ, Beck DB, Werner A
The EMBO journal 2024 May;43(10):1919-1946

Distinctive multicellular immunosuppressive hubs confer different intervention strategies for left- and right-sided colon cancers.

Liu B, Li S, Cheng Y, Song P, Xu M, Li Z, Shao W, Xin J, Fu Z, Gu D, Du M, Zhang Z, Wang M
Cell reports. Medicine 2024 Jun 18;5(6):101589

Shared and Distinct Mechanisms of UBA1 Inactivation Across Different Diseases.

Ubiquitin-specific peptidase 14 maintains estrogen receptor α stability via its deubiquitination activity in endometrial cancer.

Su Y, Zeng K, Liu S, Wu Y, Wang C, Wang S, Lin L, Zou R, Sun G, Luan R, Zhou B, Bai Y, Niu J, Zhang Y, Zhao Y
The Journal of biological chemistry 2023 Jan;299(1):102734

LINC01194 recruits NUMA1 to promote ubiquitination of RYR2 to enhance malignant progression in triple-negative breast cancer.

Zhai D, Zhang M, Li Y, Bi J, Kuang X, Shan Z, Shao N, Lin Y
Cancer letters 2022 Sep 28;544:215797

N-glycosylation of GDF15 abolishes its inhibitory effect on EGFR in AR inhibitor-resistant prostate cancer cells.

Wang R, Wen P, Yang G, Feng Y, Mi Y, Wang X, Zhu S, Chen YQ
Cell death & disease 2022 Jul 19;13(7):626

PRPF6 promotes androgen receptor/androgen receptor-variant 7 actions in castration-resistant prostate cancer cells.

Liu W, Wang C, Wang S, Zeng K, Wei S, Sun N, Sun G, Wang M, Zou R, Liu W, Lin L, Song H, Jin Z, Zhao Y
International journal of biological sciences 2021;17(1):188-203

Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition.

Hong AL, Tseng YY, Wala JA, Kim WJ, Kynnap BD, Doshi MB, Kugener G, Sandoval GJ, Howard TP, Li J, Yang X, Tillgren M, Ghandi M, Sayeed A, Deasy R, Ward A, McSteen B, Labella KM, Keskula P, Tracy A, Connor C, Clinton CM, Church AJ, Crompton BD, Janeway KA, Van Hare B, Sandak D, Gjoerup O, Bandopadhayay P, Clemons PA, Schreiber SL, Root DE, Gokhale PC, Chi SN, Mullen EA, Roberts CW, Kadoch C, Beroukhim R, Ligon KL, Boehm JS, Hahn WC
eLife 2019 Mar 12;8

Silencing ubiquitin-conjugating enzyme 2C inhibits proliferation and epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma.

Wang X, Yin L, Yang L, Zheng Y, Liu S, Yang J, Cui H, Wang H
The FEBS journal 2019 Dec;286(24):4889-4909

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HEK-293 cells were subjected to SDS PAGE followed by western blot with 66087-1-Ig( UBE2C Antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using UBE2C antibody 66087-1-lg at 1:25 dilution and Rhodamine-labeled goat anti-mouse IgG (red).
Sample type: cell line