Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-B123 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Anti-RAGE (V Domain) monoclonal antibody, clone 3B22
- Antibody type
- Monoclonal
- Description
- Advanced glycosylation end product-specific receptor (AGER, RAGE) mediates interactions of advanced glycosylation end products (AGE), nonenzymatically glycosylated proteins. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. RAGE acts as a receptor for amyloid beta peptide and contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane in cortical neurons. The V domain binds multiple ligands that elicit sustained inflammation associated with diabetes, cancer, Alzheimer's, multiple sclerosis, and other diseases.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 3B22
- Vial size
- 100_g
- Storage
- -20°C
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