66823-1-Ig

antibody from Proteintech Group

Targeting: OGT FLJ23071, HRNT1, MGC22921, O-GLCNAC, OGT1

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

66823-1-Ig

Provider

Proteintech Group

Product name

OGT antibody

Antibody type

Monoclonal

Description

OGT antibody (Cat. #66823-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse, rat, pig and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat, Porcine

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

2B2A6

Vial size

20ul, 150ul

References

Submitted references

Lipotoxic hepatocyte-derived UBQLN1-enriched small extracellular vesicles activate hepatic stellate cells to promote hepatic fibrosis.

Yang F, Chen Y, Wang Y, Zheng G, Abouelnazar F, Fan L, Wang Y, Yan Y
Autophagy 2026 Mar 13;:1-23

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Galactose treatment rescues neuromuscular junction transmission in glutamine-fructose-6-phosphate transaminase 1 (Gfpt1) deficient mice.

Holland SH, Carmona-Martinez R, O'Neil D, Ho K, O'Connor K, Azuma Y, Roos A, Spendiff S, Lochmüller H
Human molecular genetics 2025 Oct 14;34(21):1765-1779

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High-Glucose Microenvironment Accelerates Malignant Progression Via O-GlcNAcylation in Oral Squamous Cell Carcinoma.

Zhu Z, Ren W, Yan X, Li S, Zheng J, Zhi K, Gao L
International dental journal 2025 Dec;75(6):103897

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Astragalus Polysaccharide Enhances O-GlcNAcylation Through OGT to Improve Intervertebral Disc Degeneration in Rats.

Tan H, Fang C, Tan Y, Wang Z, Zhou Y, Li X
Journal of cellular and molecular medicine 2025 Dec;29(23):e70940

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O-GlcNAcylation of hexokinase 2 modulates mitochondrial dynamics and enhances the progression of lung cancer.

Panpan SI, Wei GE, Kaiming WU, Zhang R
Molecular and cellular biochemistry 2025 Apr;480(4):2633-2643

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LIMA1 O-GlcNAcylation Promotes Hepatic Lipid Deposition through Inducing β-catenin-Regulated FASn Expression in Metabolic Dysfunction-Associated Steatotic Liver Disease.

Yang F, Chen Y, Zheng G, Gu K, Fan L, Li T, Zhu L, Yan Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2415941

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TRIM65/NF2/YAP1 Signaling Coordinately Orchestrates Metabolic and Immune Advantages in Hepatocellular Carcinoma.

Bian Z, Xu C, Wang X, Zhang B, Xiao Y, Liu L, Zhao S, Huang N, Yang F, Zhang Y, Xue S, Wang X, Pan Q, Sun F
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(35):e2402578

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Senegenin suppresses hepatocellular carcinoma by regulating O-GlcNAcylation.

Zhang X, Wang LQ, Liu ZY
World journal of gastrointestinal oncology 2024 Sep 15;16(9):3994-4005

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A Deficiency in Glutamine-Fructose-6-Phosphate Transaminase 1 (Gfpt1) in Skeletal Muscle Results in Reduced Glycosylation of the Delta Subunit of the Nicotinic Acetylcholine Receptor (AChRδ).

Holland SH, Carmona-Martinez R, O'Connor K, O'Neil D, Roos A, Spendiff S, Lochmüller H
Biomolecules 2024 Oct 3;14(10)

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Chromatin-associated OGT promotes the malignant progression of hepatocellular carcinoma by activating ZNF263.

Wang L, Li G, Zhou Z, Ge C, Chen Q, Liu Y, Zhang N, Zhang K, Niu M, Li W, Zhong X, Wu S, Zhang J, Liu Y
Oncogene 2023 Jul;42(30):2329-2346

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O-GlcNAcylation promotes topoisomerase IIα catalytic activity in breast cancer chemoresistance.

Liu Y, Yu K, Zhang K, Niu M, Chen Q, Liu Y, Wang L, Zhang N, Li W, Zhong X, Li G, Wu S, Zhang J, Liu Y
EMBO reports 2023 Jul 5;24(7):e56458

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The deubiquitinase EIF3H promotes hepatocellular carcinoma progression by stabilizing OGT and inhibiting ferroptosis.

Tang J, Long G, Li X, Zhou L, Zhou Y, Wu Z
Cell communication and signaling : CCS 2023 Aug 9;21(1):198

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FOXA1 O-GlcNAcylation-mediated transcriptional switch governs metastasis capacity in breast cancer.

Liu Y, Yu K, Kong X, Zhang K, Wang L, Zhang N, Chen Q, Niu M, Li W, Zhong X, Wu S, Zhang J, Liu Y
Science advances 2023 Aug 18;9(33):eadg7112

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Histone methyltransferase Dot1L recruits O-GlcNAc transferase to target chromatin sites to regulate histone O-GlcNAcylation.

Xu B, Zhang C, Jiang A, Zhang X, Liang F, Wang X, Li D, Liu C, Liu X, Xia J, Li Y, Wang Y, Yang Z, Chen J, Zhou Y, Chen L, Sun H
The Journal of biological chemistry 2022 Jul;298(7):102115