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Learn13954-1-AP
antibody from Proteintech Group
Targeting: CHEK2
bA444G7, CDS1, CHK2, HuCds1, PP1425, RAD53
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [29]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 13954-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13954-1-AP, RRID:AB_10598159
- Product name
- CHEK2 antibody
- Antibody type
- Polyclonal
- Description
- CHEK2 antibody (Cat. #13954-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references MRE11A: a novel negative regulator of human DNA mismatch repair.
Development and validation of a novel anoikis-related gene signature in clear cell renal cell carcinoma.
Hexavalent chromium caused DNA damage repair and apoptosis via the PI3K/AKT/FOXO1 pathway triggered by oxidative stress in the lung of rat.
RIG-I Promotes Tumorigenesis and Confers Radioresistance of Esophageal Squamous Cell Carcinoma by Regulating DUSP6.
C11orf54 promotes DNA repair via blocking CMA-mediated degradation of HIF1A.
DON entry into the nucleus induces DNA damage, apoptosis and cycle arrest in GES-1 cells.
ATM deficiency aggravates the progression of liver fibrosis induced by carbon tetrachloride in mice.
TRIM24 is critical for the cellular response to DNA double-strand breaks through regulating the recruitment of MRN complex.
CHEK2 is a potential prognostic biomarker associated with immune infiltration in clear cell renal cell carcinoma.
ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway.
Damaged DNA Is an Early Event of Neurodegeneration in Induced Pluripotent Stem Cell-Derived Motoneurons with UBQLN2(P497H) Mutation.
An RNAi screen of RNA helicases identifies eIF4A3 as a regulator of embryonic stem cell identity.
Single-cell profiling-guided combination therapy of c-Fos and histone deacetylase inhibitors in diffuse large B-cell lymphoma.
G-quadruplex DNA structures in human stem cells and differentiation.
Comparable radiation sensitivity in p53 wild-type and p53 deficient tumor cells associated with different cell death modalities.
HDAC6 inhibitor ACY1215 inhibits the activation of NLRP3 inflammasome in acute liver failure by regulating the ATM/F-actin signalling pathway.
TiO(2) Nanoparticles Caused DNA Damage in Lung and Extra-Pulmonary Organs Through ROS-Activated FOXO3a Signaling Pathway After Intratracheal Administration in Rats.
Azidothymidine (AZT) Inhibits Proliferation of Human Ovarian Cancer Cells by Regulating Cell Cycle Progression.
Novel SAHA‑bendamustine hybrid NL‑101 in combination with daunorubicin synergistically suppresses acute myeloid leukemia.
Rice protein reduces DNA damage by activating the p53 pathway and stimulating endogenous antioxidant response in growing and adult rats.
A novel alkylating deacetylase inhibitor molecule EDO-S101 in combination with cytarabine synergistically enhances apoptosis of acute myeloid leukemia cells.
High PARP-1 expression predicts poor survival in acute myeloid leukemia and PARP-1 inhibitor and SAHA-bendamustine hybrid inhibitor combination treatment synergistically enhances anti-tumor effects.
Anthocyanins from Black Chokeberry (Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain.
The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD.
Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver.
UBE2D3 gene overexpression increases radiosensitivity of EC109 esophageal cancer cells in vitro and in vivo.
Paper-based microreactor array for rapid screening of cell signaling cascades.
Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells.
Probing the cell death signaling pathway of HepG2 cell line induced by copper-1,10-phenanthroline complex.
Du D, Yang Y, Zhang Y, Wang G, Chen L, Guan X, Rasmussen LJ, Liu D
Cellular & molecular biology letters 2024 Mar 14;29(1):37
Cellular & molecular biology letters 2024 Mar 14;29(1):37
Development and validation of a novel anoikis-related gene signature in clear cell renal cell carcinoma.
Wu Q, Sun Y, Qin X, Li M, Huang S, Wang X, Weng G
Frontiers in oncology 2023;13:1211103
Frontiers in oncology 2023;13:1211103
Hexavalent chromium caused DNA damage repair and apoptosis via the PI3K/AKT/FOXO1 pathway triggered by oxidative stress in the lung of rat.
Zhang L, Li N, Zhang X, Wu H, Yu S
Ecotoxicology and environmental safety 2023 Nov 15;267:115622
Ecotoxicology and environmental safety 2023 Nov 15;267:115622
RIG-I Promotes Tumorigenesis and Confers Radioresistance of Esophageal Squamous Cell Carcinoma by Regulating DUSP6.
Li L, Lv L, Xu JC, He Q, Chang N, Cui YY, Tao ZC, Zhu T, Qian LT
International journal of molecular sciences 2023 Mar 15;24(6)
International journal of molecular sciences 2023 Mar 15;24(6)
C11orf54 promotes DNA repair via blocking CMA-mediated degradation of HIF1A.
Tan J, Wang W, Liu X, Xu J, Che Y, Liu Y, Hu J, Hu L, Li J, Zhou Q
Communications biology 2023 Jun 5;6(1):606
Communications biology 2023 Jun 5;6(1):606
DON entry into the nucleus induces DNA damage, apoptosis and cycle arrest in GES-1 cells.
Hou S, Cheng Y, Wang Z, Xia L, Wang J, Wang H, Sun J, Ma J, Yan Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113531
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113531
ATM deficiency aggravates the progression of liver fibrosis induced by carbon tetrachloride in mice.
Li M, Yang Z, Song Z, Bo C, Wang S, Jia Q
Toxicology 2023 Jan 15;484:153397
Toxicology 2023 Jan 15;484:153397
TRIM24 is critical for the cellular response to DNA double-strand breaks through regulating the recruitment of MRN complex.
Wang Y, Yao Y, Wei Q, Long S, Chen Y, Xie J, Tan R, Jiang W, Zhang Q, Wu D, Xiao S, Wan F, Fu K
Oncogene 2023 Feb;42(8):586-600
Oncogene 2023 Feb;42(8):586-600
CHEK2 is a potential prognostic biomarker associated with immune infiltration in clear cell renal cell carcinoma.
Wu Q, Fang C, Wang X, Huang S, Weng G
Scientific reports 2023 Dec 11;13(1):21928
Scientific reports 2023 Dec 11;13(1):21928
ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway.
Wen X, Chen S, Chen X, Qiu H, Wang W, Zhang N, Liu W, Wang T, Ding X, Zhang L
Frontiers in oncology 2022;12:887068
Frontiers in oncology 2022;12:887068
Damaged DNA Is an Early Event of Neurodegeneration in Induced Pluripotent Stem Cell-Derived Motoneurons with UBQLN2(P497H) Mutation.
Zhang Y, Zeng B, Gu A, Kang Q, Zhao M, Peng G, Zhou M, Liu W, Liu M, Ding L, Liang D, Liu X, Liu M
International journal of molecular sciences 2022 Sep 26;23(19)
International journal of molecular sciences 2022 Sep 26;23(19)
An RNAi screen of RNA helicases identifies eIF4A3 as a regulator of embryonic stem cell identity.
Li D, Yang J, Malik V, Huang Y, Huang X, Zhou H, Wang J
Nucleic acids research 2022 Nov 28;50(21):12462-12479
Nucleic acids research 2022 Nov 28;50(21):12462-12479
Single-cell profiling-guided combination therapy of c-Fos and histone deacetylase inhibitors in diffuse large B-cell lymphoma.
Wang L, Wu Z, Xia Y, Lu X, Li J, Fan L, Qiao C, Qiu H, Gu D, Xu W, Li J, Jin H
Clinical and translational medicine 2022 May;12(5):e798
Clinical and translational medicine 2022 May;12(5):e798
G-quadruplex DNA structures in human stem cells and differentiation.
Zyner KG, Simeone A, Flynn SM, Doyle C, Marsico G, Adhikari S, Portella G, Tannahill D, Balasubramanian S
Nature communications 2022 Jan 10;13(1):142
Nature communications 2022 Jan 10;13(1):142
Comparable radiation sensitivity in p53 wild-type and p53 deficient tumor cells associated with different cell death modalities.
Li P, Liu X, Zhao T, Li F, Wang Q, Zhang P, Hirayama R, Chen W, Jin X, Zheng X, Wang Z, Li Q
Cell death discovery 2021 Jul 20;7(1):184
Cell death discovery 2021 Jul 20;7(1):184
HDAC6 inhibitor ACY1215 inhibits the activation of NLRP3 inflammasome in acute liver failure by regulating the ATM/F-actin signalling pathway.
Chen Q, Wang Y, Jiao F, Cao P, Shi C, Pei M, Wang L, Gong Z
Journal of cellular and molecular medicine 2021 Aug;25(15):7218-7228
Journal of cellular and molecular medicine 2021 Aug;25(15):7218-7228
TiO(2) Nanoparticles Caused DNA Damage in Lung and Extra-Pulmonary Organs Through ROS-Activated FOXO3a Signaling Pathway After Intratracheal Administration in Rats.
Han B, Pei Z, Shi L, Wang Q, Li C, Zhang B, Su X, Zhang N, Zhou L, Zhao B, Niu Y, Zhang R
International journal of nanomedicine 2020;15:6279-6294
International journal of nanomedicine 2020;15:6279-6294
Azidothymidine (AZT) Inhibits Proliferation of Human Ovarian Cancer Cells by Regulating Cell Cycle Progression.
Hsieh Y, Tseng JJ
Anticancer research 2020 Oct;40(10):5517-5527
Anticancer research 2020 Oct;40(10):5517-5527
Novel SAHA‑bendamustine hybrid NL‑101 in combination with daunorubicin synergistically suppresses acute myeloid leukemia.
Jin J, Li X, Guo W, Li F, Huang J, Huang X, Pan J, Huang S, Ye W, Ling Q, Jin J
Oncology reports 2020 Jul;44(1):273-282
Oncology reports 2020 Jul;44(1):273-282
Rice protein reduces DNA damage by activating the p53 pathway and stimulating endogenous antioxidant response in growing and adult rats.
Liang M, Li H, Wang Z, Cai L, Yang L
Journal of the science of food and agriculture 2019 Oct;99(13):6097-6107
Journal of the science of food and agriculture 2019 Oct;99(13):6097-6107
A novel alkylating deacetylase inhibitor molecule EDO-S101 in combination with cytarabine synergistically enhances apoptosis of acute myeloid leukemia cells.
Jin J, Mao S, Li F, Li X, Huang X, Yu M, Guo W, Jin J
Medical oncology (Northwood, London, England) 2019 Aug 1;36(9):77
Medical oncology (Northwood, London, England) 2019 Aug 1;36(9):77
High PARP-1 expression predicts poor survival in acute myeloid leukemia and PARP-1 inhibitor and SAHA-bendamustine hybrid inhibitor combination treatment synergistically enhances anti-tumor effects.
Li X, Li C, Jin J, Wang J, Huang J, Ma Z, Huang X, He X, Zhou Y, Xu Y, Yu M, Huang S, Yan X, Li F, Pan J, Wang Y, Yu Y, Jin J
EBioMedicine 2018 Dec;38:47-56
EBioMedicine 2018 Dec;38:47-56
Anthocyanins from Black Chokeberry (Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain.
Wei J, Zhang G, Zhang X, Xu D, Gao J, Fan J, Zhou Z
Journal of agricultural and food chemistry 2017 Jul 26;65(29):5973-5984
Journal of agricultural and food chemistry 2017 Jul 26;65(29):5973-5984
The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD.
Yang J, Qiao L, Zeng Z, Wang J, Zhu T, Wei J, Wu M, Ye S, Huang X, Ma D, Liu R, Gao Q
Toxicology letters 2017 Jan 4;265:131-139
Toxicology letters 2017 Jan 4;265:131-139
Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver.
Wei J, Zhang G, Zhang X, Xu D, Gao J, Fan J
Plant foods for human nutrition (Dordrecht, Netherlands) 2017 Dec;72(4):425-431
Plant foods for human nutrition (Dordrecht, Netherlands) 2017 Dec;72(4):425-431
UBE2D3 gene overexpression increases radiosensitivity of EC109 esophageal cancer cells in vitro and in vivo.
Gao X, Wang W, Yang H, Wu L, He Z, Zhou S, Zhao H, Fu Z, Zhou F, Zhou Y
Oncotarget 2016 May 31;7(22):32543-53
Oncotarget 2016 May 31;7(22):32543-53
Paper-based microreactor array for rapid screening of cell signaling cascades.
Huang CH, Lei KF, Tsang NM
Lab on a chip 2016 Aug 7;16(15):2911-20
Lab on a chip 2016 Aug 7;16(15):2911-20
Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells.
Song X, Li L, Shi Q, Lehmler HJ, Fu J, Su C, Xia X, Song E, Song Y
Chemical research in toxicology 2015 Nov 16;28(11):2160-9
Chemical research in toxicology 2015 Nov 16;28(11):2160-9
Probing the cell death signaling pathway of HepG2 cell line induced by copper-1,10-phenanthroline complex.
Wu J, Chen W, Yin Y, Zheng Z, Zou G
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2014 Jun;27(3):445-58
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2014 Jun;27(3):445-58
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Chk2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Chk2. This antibody recognizes human,mouse,rat antigen. The Chk2 antibody has been validated for the following applications: ELISA, WB analysis.
