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LearnPAB18147
antibody from Abnova Corporation
Targeting: CHEK2
bA444G7, CDS1, CHK2, HuCds1, PP1425, RAD53
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- PAB18147 - Provider product page
- Provider
- Abnova Corporation
- Proper citation
- Abnova Corporation Cat#PAB18147, RRID:AB_10716779
- Product name
- CHEK2 polyclonal antibody
- Antibody type
- Polyclonal
- Description
- Rabbit polyclonal antibody raised against synthetic peptide of CHEK2.
- Storage
- Store at -20°C.Aliquot to avoid repeated freezing and thawing.
Submitted references Promyelocytic leukemia activates Chk2 by mediating Chk2 autophosphorylation.
Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation.
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.
Yang S, Jeong JH, Brown AL, Lee CH, Pandolfi PP, Chung JH, Kim MK
The Journal of biological chemistry 2006 Sep 8;281(36):26645-54
The Journal of biological chemistry 2006 Sep 8;281(36):26645-54
Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation.
Schwarz JK, Lovly CM, Piwnica-Worms H
Molecular cancer research : MCR 2003 Jun;1(8):598-609
Molecular cancer research : MCR 2003 Jun;1(8):598-609
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.
Hirao A, Cheung A, Duncan G, Girard PM, Elia AJ, Wakeham A, Okada H, Sarkissian T, Wong JA, Sakai T, De Stanchina E, Bristow RG, Suda T, Lowe SW, Jeggo PA, Elledge SJ, Mak TW
Molecular and cellular biology 2002 Sep;22(18):6521-32
Molecular and cellular biology 2002 Sep;22(18):6521-32
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Supportive validation
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- Western blot analysis of extracts from Jurkat cells, using CHEK2 polyclonal antibody (Cat # PAB18147).Peptide "+" means "peptide blocking".
Supportive validation
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CHEK2 polyclonal antibody (Cat # PAB18147).Peptide "+" means "peptide blocking".
- Validation comment
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
