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antibody from antibodies-online
Targeting: CHEK2
bA444G7, CDS1, CHK2, HuCds1, PP1425, RAD53
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [7]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [2]
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- Product number
- ABIN408359 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Checkpoint Kinase 2 (CHEK2) (pThr68) antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- pThr68
- Vial size
- 0.1 mL
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress.
Centrosome aberrations in human mammary epithelial cells driven by cooperative interactions between p16INK4a deficiency and telomere-dependent genotoxic stress.
A dual role for autophagy in a murine model of lung cancer.
DNA damage response in renal ischemia-reperfusion and ATP-depletion injury of renal tubular cells.
The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis.
Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer.
The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression.
Ercilla A, Llopis A, Feu S, Aranda S, Ernfors P, Freire R, Agell N
Nucleic acids research 2016 Jun 2;44(10):4745-62
Nucleic acids research 2016 Jun 2;44(10):4745-62
Centrosome aberrations in human mammary epithelial cells driven by cooperative interactions between p16INK4a deficiency and telomere-dependent genotoxic stress.
Domínguez D, Feijoo P, Bernal A, Ercilla A, Agell N, Genescà A, Tusell L
Oncotarget 2015 Sep 29;6(29):28238-56
Oncotarget 2015 Sep 29;6(29):28238-56
A dual role for autophagy in a murine model of lung cancer.
Rao S, Tortola L, Perlot T, Wirnsberger G, Novatchkova M, Nitsch R, Sykacek P, Frank L, Schramek D, Komnenovic V, Sigl V, Aumayr K, Schmauss G, Fellner N, Handschuh S, Glösmann M, Pasierbek P, Schlederer M, Resch GP, Ma Y, Yang H, Popper H, Kenner L, Kroemer G, Penninger JM
Nature communications 2014;5:3056
Nature communications 2014;5:3056
DNA damage response in renal ischemia-reperfusion and ATP-depletion injury of renal tubular cells.
Ma Z, Wei Q, Dong G, Huo Y, Dong Z
Biochimica et biophysica acta 2014 Jul;1842(7):1088-96
Biochimica et biophysica acta 2014 Jul;1842(7):1088-96
The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis.
Evangelou K, Bartkova J, Kotsinas A, Pateras IS, Liontos M, Velimezi G, Kosar M, Liloglou T, Trougakos IP, Dyrskjot L, Andersen CL, Papaioannou M, Drosos Y, Papafotiou G, Hodny Z, Sosa-Pineda B, Wu XR, Klinakis A, Ørntoft T, Lukas J, Bartek J, Gorgoulis VG
Cell death and differentiation 2013 Nov;20(11):1485-97
Cell death and differentiation 2013 Nov;20(11):1485-97
Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer.
Velimezi G, Liontos M, Vougas K, Roumeliotis T, Bartkova J, Sideridou M, Dereli-Oz A, Kocylowski M, Pateras IS, Evangelou K, Kotsinas A, Orsolic I, Bursac S, Cokaric-Brdovcak M, Zoumpourlis V, Kletsas D, Papafotiou G, Klinakis A, Volarevic S, Gu W, Bartek J, Halazonetis TD, Gorgoulis VG
Nature cell biology 2013 Aug;15(8):967-77
Nature cell biology 2013 Aug;15(8):967-77
The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression.
Schramek D, Kotsinas A, Meixner A, Wada T, Elling U, Pospisilik JA, Neely GG, Zwick RH, Sigl V, Forni G, Serrano M, Gorgoulis VG, Penninger JM
Nature genetics 2011 Mar;43(3):212-9
Nature genetics 2011 Mar;43(3):212-9
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Supportive validation
- Submitted by
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- IHC
- Submitted by
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