Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- BS3872 - Provider product page
- Provider
- Bioworld Technology, Inc
- Proper citation
- Bioworld Technology Cat#BS3872, RRID:AB_1914251
- Product name
- GDF 15 (L64) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 32-80 of Human GDF-15.
- Description
- Growth differentiation factor 15 (GDF-15), also known as PDF, MIC-1, PLAB, NAG-1 or PTGF-ÉÇ, is a member of the transforming growth factor beta (TGF-beta) superfamily. Synthesized intracellularly, the protein is secreted as a dimer linked by disulfide bonds. Epithelial cells and macrophages are the sites of strongest GDF-15 expression, although it is widely expressed in adult tissue. In the brain, GDF-15 expression occurs in the choroid plexus, from which the protein is secreted into the cerebrospinal fluid. The gene for GDF-15 is responsive to p53 tumor suppressor protein, and in cultured cerebellar granule neurons GDF-15 can prevent cell death by the activation of Akt and inhibition of ERK. GDF-15 acts as a trophic factor for certain classes of neurons, promoting cell survival and differentiation. Overexpression of GDF-15 occurs in prostate cancer, and may be a means of diagnosis.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of GDF-15 (L64) pAb at 1:500 dilutionLane1:MCF-7 whole cell lysateLane2:Raw264.7 whole cell lysateLane3:PC12 whole cell lysate