27455-1-AP

antibody from Proteintech Group

Targeting: GDF15 MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB

Provider product page for 27455-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [61]
Comments [0]
Validations [0]

Submit

Product number: 27455-1-AP - Provider product page
Provider: Proteintech Group
Product name: GDF15 antibody
Antibody type: Polyclonal
Description: KD/KO validated GDF15 antibody (Cat. #27455-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

GDF15 protein structure - 27455-1-AP shown in red.

Submitted references Exercise Attenuates Neuroinflammation in Chronic Restraint Stress Induced Depression Model by Downregulating GDF15 Expression.

Chen J, Du C, Lu J, Liang M, Sun M, Lyu Y, Huang M, Sun J, Li Y, Wang Z, Li G, Han G
Journal of immunology research 2026;2026(1):e6816624

Association between elevated expression of GDF15/GFRAL and sarcopenia risk.

Zhang ZS, Fan PD, Zhang WY, Zou HQ, Ni JD, Yang XL, Wu J
iScience 2026 Mar 20;29(3):115023

GDF15 orchestrates mitochondrial-immune crosstalk via SMAD7-HIF-1α-PKM2 cascade to attenuate septic liver injury.

Kuang X, Niu Z, Liu W, Huang Z, Li S, Zhang Y, Wang L, Cai X, Wang F, Zhang P
Frontiers in immunology 2025;16:1712741

GDF15 is associated with thyroid cancer progression and may modulate thyroid cancer cell senescence in a p53-dependent manner.

Ma J, Liu Z, Hua R, Ding C, Yang Z, Liang W, Lv B
Frontiers in endocrinology 2025;16:1675245

Unveiling GDF15 as a promising biomarker for predicting survival in pancreatic ductal carcinoma: a retrospective research.

Xiao J, Lu X, Luo W, Wang Y, Zhang T
BMC cancer 2025 Oct 14;25(1):1569

Cigarette smoke extract promotes metastasis and oxaliplatin resistance in colon adenocarcinoma through GDF15/ERBB2/AKT pathway.

Jiang W, Wang Y, Wang WJ, Zhou BC, Hu XS, Xu AM
European journal of medical research 2025 Oct 10;30(1):958

GDF15 attenuates sepsis-induced acute lung injury by suppressing the HIF-1α/LDHA pathway.

Kuang X, Niu Z, Huang Z, Cai X, Wang L, Zhang Y, Luo J, Zhao X, Shuo L, Zhang P
International immunopharmacology 2025 Oct 10;163:115198

RUNX3 drives HTR-8/SVneo cell ferroptosis and spontaneous abortion: involvement of the suppression of GDF15 transcriptional activity.

Cheng L, Zhang J, Xiang Y, Tan L
Molecular and cellular endocrinology 2025 Oct 1;608:112618

A CEBPB/TYMP/GDF15 signaling axis mediates tumor growth and cisplatin resistance in bladder cancer.

Tian S, Wang C, Zhao X, Xuan Y, Wei W, Dong Y, Tao W, Zhang C, Cai T, Liu C, Huang Y, Zhang X
Translational oncology 2025 Nov;61:102537

The local anesthetic, lidocaine, suppresses the growth of colon cancer SW480 cells by decreasing the voltage-gated sodium channel subunit Na(v)1.5.

Haraguchi-Suzuki K, Suzuki T, Nakasone C, Kawabata-Iwakawa R, Saito S
Scientific reports 2025 Nov 22;15(1):45018

Oligoclonal tumor-specific CD8 T-cell revival and IRE1α/XBP1-GDF15-mediated immunosuppressive niches determine neoadjuvant chemoimmunotherapy efficacy in cervical cancer.

Cao G, Wang Y, Zeng H, Zhi Y, Guo Y, Xu M, Ruan Y, Wang Y, Xiao Y, Lu J, Tse KY, Gao J, Zhang Q, Wang C, Han Z, Li F
Journal for immunotherapy of cancer 2025 Nov 19;13(11)

Dual-responsive nanoparticles targeting ACE-II senescence for therapeutic mitigation of acute lung injury.

Gao L, Zheng F, Fu Z, Wang W
Journal of nanobiotechnology 2025 May 8;23(1):339

Verbascoside attenuates myocardial ischemia/reperfusion-induced ferroptosis following heterotopic heart transplantation via modulating GDF15/GPX4/SLC7A11 pathway.

Zhang Y, Zhan J, Qiu Z, Tian H, Lei S, Huang Q, Xue R, Sun Q, Xia Z
Scientific reports 2025 May 5;15(1):15651

Melatonin affects trophoblast epithelial-to-mesenchymal transition and oxidative damage resistance by modulating GDF15 expression to promote embryo implantation.

Yang G, Yao G, Wang H, Jiang R, Fang J, Hu J, Kong Y, Jin H, Song W, Wu Z, Huang X, Sun Y
Communications biology 2025 Mar 8;8(1):396

Senescent alveolar type II epithelial cells-secreted GDF15 promotes silicosis progression via interfering intercellular communication.

Lian W, Cheng D, Sun W, Wang T, Jia X, Jia Z, Liu Y, Ni C
Ecotoxicology and environmental safety 2025 Mar 1;292:117917

GDF15 suppresses abdominal aortic aneurysm by upregulating AREG expression to adjust macrophage polarization.

Wu W, Tang W, Liang W, Li Q, Qi X, Gao R, Zhou P, Chen G, Xiong J, Gu X, Ding P, Yu M, Yang C, Wen S
International immunopharmacology 2025 Jun 26;159:114899

GDF15 attenuates Parkinson's disease progression via suppressing the activation of cGAS-STING pathway.

Wang J, Geng T, Yao X, Liu Y
Molecular and cellular biochemistry 2025 Jul;480(7):4449-4466

Identification of a ferroptosis related genes signature and GDF15 contributing to a new perspective for the diagnosis of CRPC.

Shao Y, Li X, Liu J, Qiu Z, Zhang T, Li N, Hu J, Lu F, Zhu Z
Scientific reports 2025 Jul 1;15(1):21624

Tumor-Derived GDF15 Induces Tumor Associated Fibroblast Transformation From BMSCs and Fibroblasts in Oral Squamous Cell Carcinoma.

Zhao J, Li Y, Huang Y, Su P, Nie F, Yang P, Yang C
Journal of cellular physiology 2025 Jan;240(1):e31498

GDF15 promotes osteogenic differentiation of human dental pulp stem cells by activating the TGF-β/SMAD signaling pathway.

Deng P, Yang B, Huang C, Li Y, Mei Z, Li Y, Li J
Journal of tissue engineering 2025 Jan-Dec;16:20417314251357752

GDF15-mediated enhancement of the Warburg effect sustains multiple myeloma growth via TGFβ signaling pathway.

Xue W, Li Y, Ma Y, Zhang F
Cancer & metabolism 2025 Jan 27;13(1):3

Therapeutic Effects of GDF6-Overexpressing Mesenchymal Stem Cells through Upregulation of the GDF15/SIRT1 Axis in Age-Related Hearing Loss.

Liu J, Peng H, Liu Y, Li C, Xie W
Frontiers in bioscience (Landmark edition) 2025 Jan 15;30(1):26179

Growth differentiation factor 15 aggravates sepsis-induced cognitive and memory impairments by promoting microglial inflammatory responses and phagocytosis.

Chen L, Luo S, Liu T, Shuai Z, Song Y, Yang Q, Wang Y, Huang H, Luo Y
Journal of neuroinflammation 2025 Feb 21;22(1):44

Growth Differentiation Factor 15 Inhibits Cardiac Fibrosis, Oxidative Stress, Inflammation, and Apoptosis in a Rat Model of Heart Failure with Preserved Ejection Fraction.

Meng X, Li Y, Meng L, Yang C, Xia C, Wang X, Wang F
Frontiers in bioscience (Landmark edition) 2025 Feb 18;30(2):26857

Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis.

Park B, Nicaise AM, Tsitsipatis D, Pirvan L, Zucha D, Munteanu A, Prasad P, De Novales MLL, Bulgaru C, Kollyfas R, Whitten J, Willis CM, Culig L, Llewellyn J, Ionescu RB, Mekdad M, Simões-Abade MBC, Krzak G, Fan J, De S, Ellis MO, Cubero MS, Spathopoulou A, Peruzzotti-Jametti L, Leonardi T, Balmus G, Edenhofer F, Gorospe M, Valihrach L, Mohorianu I, Pluchino S, Beerman I
Neuron 2025 Dec 17;113(24):4158-4177.e10

Engineered Basic Fibroblast Growth Factor Specifically Bonded with Injectable Extracellular Matrix Hydrogel for the Functional Restoration of Cerebral Ischemia in Rats.

Shi C, Liu Q, Sun F, Zhang G, Deng M, Xu B, Yuan H
Biomaterials research 2024;28:0020

Potential Association of Gut Microbial Metabolism and Circulating mRNA Based on Multiomics Sequencing Analysis in Fetal Growth Restriction.

Tang H, Li D, Peng J, Yang W, Zhang X, Li H
Mediators of inflammation 2024;2024:9986187

Exosomes Derived from Meningitic Escherichia coli-Infected Brain Microvascular Endothelial Cells Facilitate Astrocyte Activation.

Yang R, Qu X, Zhi S, Wang J, Fu J, Tan C, Chen H, Wang X
Molecular neurobiology 2024 Sep;61(9):7195-7210

The MondoA-dependent TXNIP/GDF15 axis predicts oxaliplatin response in colorectal adenocarcinomas.

Deng J, Pan T, Wang D, Hong Y, Liu Z, Zhou X, An Z, Li L, Alfano G, Li G, Dolcetti L, Evans R, Vicencio JM, Vlckova P, Chen Y, Monypenny J, Gomes CAC, Weitsman G, Ng K, McCarthy C, Yang X, Hu Z, Porter JC, Tape CJ, Yin M, Wei F, Rodriguez-Justo M, Zhang J, Tejpar S, Beatson R, Ng T
EMBO molecular medicine 2024 Sep;16(9):2080-2108

Transcription factor EGR2 alleviates autoimmune uveitis via activation of GDF15 to modulate the retinal microglial phenotype.

Li W, He S, Tan J, Li N, Zhao C, Wang X, Zhang Z, Liu J, Huang J, Li X, Zhou Q, Hu K, Yang P, Hou S
Proceedings of the National Academy of Sciences of the United States of America 2024 Sep 24;121(39):e2316161121

Cancer-Associated Endocrine Cells Participate in Pancreatic Carcinogenesis.

Chen Y, Yin X, Xu R, Ruze R, Song J, Yin C, Hu C, Wang C, Xu Q, Zhao Y
Gastroenterology 2024 Nov;167(6):1167-1182.e23

GDF15 attenuates sepsis-induced myocardial dysfunction by inhibiting cardiomyocytes ferroptosis via the SOCS1/GPX4 signaling pathway.

Li X, Sun H, Zhang L, Liang H, Zhang B, Yang J, Peng X, Sun J, Zhou Y, Zhai M, Jiang L, Zhu H, Duan W
European journal of pharmacology 2024 Nov 5;982:176894

Multi-ancestry GWAS of severe pregnancy nausea and vomiting identifies risk loci associated with appetite, insulin signaling, and brain plasticity.

Fejzo M, Wang X, Zöllner J, Pujol-Gualdo N, Laisk T, Estonian Biobank Research Team, Finer S, van Heel DA, Genes & Health Research Team, Brumpton B, Bhatta L, Hveem K, Jasper EA, Velez Edwards DR, Hellwege JN, Edwards T, Jarvik GP, Luo Y, Khan A, MacGibbon K, Gao Y, Ge G, Averbukh I, Soon E, Angelo M, Magnus P, Johansson S, Njølstad PR, Vaudel M, Shu C, Mancuso N
medRxiv : the preprint server for health sciences 2024 Nov 20;

Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis.

Guo X, Asthana P, Zhai L, Cheng KW, Gurung S, Huang J, Wu J, Zhang Y, Mahato AK, Saarma M, Ustav M, Kwan HY, Lyu A, Chan KM, Xu P, Bian ZX, Wong HLX
Nature communications 2024 Feb 3;15(1):1034

Potential crosstalk between SPP1 + TAMs and CD8 + exhausted T cells promotes an immunosuppressive environment in gastric metastatic cancer.

Du Y, Lin Y, Gan L, Wang S, Chen S, Li C, Hou S, Hu B, Wang B, Ye Y, Shen Z
Journal of translational medicine 2024 Feb 16;22(1):158

1,4-dihydroxy quininib activates ferroptosis pathways in metastatic uveal melanoma and reveals a novel prognostic biomarker signature.

Tonelotto V, Costa-Garcia M, O'Reilly E, Smith KF, Slater K, Dillon ET, Pendino M, Higgins C, Sist P, Bosch R, Passamonti S, Piulats JM, Villanueva A, Tramer F, Vanella L, Carey M, Kennedy BN
Cell death discovery 2024 Feb 10;10(1):70

GDF15 enhances anoikis resistance and metastasis of gastric cancer through protective autophagy.

Gao X, Zhang Z, Li Q, Tai G, Wang Z
Cellular signalling 2024 Dec;124:111457

Multi-ancestry GWAS of severe pregnancy nausea and vomiting identifies risk loci associated with appetite, insulin signaling, and brain plasticity.

Ergolide mediates anti-cancer effects on metastatic uveal melanoma cells and modulates their cellular and extracellular vesicle proteomes.

Sundaramurthi H, Tonelotto V, Wynne K, O'Connell F, O'Reilly E, Costa-Garcia M, Kovácsházi C, Kittel A, Marcone S, Blanco A, Pallinger E, Hambalkó S, Piulats Rodriguez JM, Ferdinandy P, O'Sullivan J, Matallanas D, Jensen LD, Giricz Z, Kennedy BN
Open research Europe 2023;3:88

Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells.

Joshi PR, Sadre S, Guo XA, McCoy JG, Mootha VK
The Journal of biological chemistry 2023 Sep;299(9):105075

Shexiang Baoxin Pill treats acute myocardial infarction by promoting angiogenesis via GDF15-TRPV4 signaling.

Wei BY, Hou JN, Yan CP, Wen SY, Shang XS, Guo YC, Feng T, Liu TF, Chen ZY, Chen XP
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115186

BET inhibitors synergize with sunitinib in melanoma through GDF15 suppression.

Zeng F, Li Y, Meng Y, Sun H, He Y, Yin M, Chen X, Deng G
Experimental & molecular medicine 2023 Feb;55(2):364-376

Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.

Chen J, Cui Z, Wang Y, Lyu L, Feng C, Feng D, Cheng Y, Li Z, Sun S
Oxidative medicine and cellular longevity 2022;2022:3182368

GDF15 negatively regulates RGS16 to impair hepatic lipid metabolism in male mice offspring conceived by in vitro fertilization.

Liu J, Zhu Y, Zhu D, Shi Y, Lu L, Li W, Li L, Zhou X, Zhang P, Yang H, Li M, Wang B, Sun M
American journal of translational research 2022;14(10):7535-7551

GDF15 Contributes to Radioresistance by Mediating the EMT and Stemness of Breast Cancer Cells.

Zhao X, Liu X, Hu S, Pan Y, Zhang J, Tai G, Shao C
International journal of molecular sciences 2022 Sep 18;23(18)

GDF15 Is an Eribulin Response Biomarker also Required for Survival of DTP Breast Cancer Cells.

Bellio C, Emperador M, Castellano P, Gris-Oliver A, Canals F, Sánchez-Pla A, Zamora E, Arribas J, Saura C, Serra V, Tabernero J, Littlefield BA, Villanueva J
Cancers 2022 May 23;14(10)

N-glycosylation of GDF15 abolishes its inhibitory effect on EGFR in AR inhibitor-resistant prostate cancer cells.

Wang R, Wen P, Yang G, Feng Y, Mi Y, Wang X, Zhu S, Chen YQ
Cell death & disease 2022 Jul 19;13(7):626

SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer.

He R, Shi J, Xu D, Yang J, Shen Y, Jiang YS, Tao L, Yang M, Fu X, Yang JY, Liu D, Huo Y, Shen X, Lu P, Niu N, Sun YW, Xue J, Liu W
Cancer letters 2022 Jul 10;538:215693

Local anesthetic lidocaine-inducible gene, growth differentiation factor-15 suppresses the growth of cancer cell lines.

Haraguchi-Suzuki K, Kawabata-Iwakawa R, Suzuki T, Suto T, Takazawa T, Saito S
Scientific reports 2022 Aug 25;12(1):14520

Uraemic Cardiomyopathy in Different Mouse Models.

Chen C, Xie C, Wu H, Wu L, Zhu J, Mao H, Xing C
Frontiers in medicine 2021;8:690517

Long noncoding RNA SH3PXD2A-AS1 promotes colorectal cancer progression by regulating p53-mediated gene transcription.

Hou P, Lin T, Meng S, Shi M, Chen F, Jiang T, Li Z, Li M, Chu S, Zheng J, Bai J
International journal of biological sciences 2021;17(8):1979-1994

Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer.

Bernasocchi T, El Tekle G, Bolis M, Mutti A, Vallerga A, Brandt LP, Spriano F, Svinkina T, Zoma M, Ceserani V, Rinaldi A, Janouskova H, Bossi D, Cavalli M, Mosole S, Geiger R, Dong Z, Yang CG, Albino D, Rinaldi A, Schraml P, Linder S, Carbone GM, Alimonti A, Bertoni F, Moch H, Carr SA, Zwart W, Kruithof-de Julio M, Rubin MA, Udeshi ND, Theurillat JP
Nature communications 2021 Feb 2;12(1):734

Bottom up proteomics identifies neuronal differentiation pathway networks activated by cathepsin inhibition treatment in neuroblastoma cells that are enhanced by concurrent 13-cis retinoic acid treatment.

Halakos EG, Connell AJ, Glazewski L, Wei S, Mason RW
Journal of proteomics 2021 Feb 10;232:104068

Hepatic Stellate Cells in Hepatocellular Carcinoma Promote Tumor Growth Via Growth Differentiation Factor 15 Production.

Myojin Y, Hikita H, Sugiyama M, Sasaki Y, Fukumoto K, Sakane S, Makino Y, Takemura N, Yamada R, Shigekawa M, Kodama T, Sakamori R, Kobayashi S, Tatsumi T, Suemizu H, Eguchi H, Kokudo N, Mizokami M, Takehara T
Gastroenterology 2021 Apr;160(5):1741-1754.e16

NR5A2 transcriptional activation by BRD4 promotes pancreatic cancer progression by upregulating GDF15.

Guo F, Zhou Y, Guo H, Ren D, Jin X, Wu H
Cell death discovery 2021 Apr 13;7(1):78

Grape Seed Proanthocyanidins Induce Apoptosis and Cell Cycle Arrest of HepG2 Cells Accompanied by Induction of the MAPK Pathway and NAG-1.

Wang L, Zhan J, Huang W
Antioxidants (Basel, Switzerland) 2020 Nov 28;9(12)

GDF15 knockdown promotes erastin-induced ferroptosis by decreasing SLC7A11 expression.

Chen L, Qiao L, Bian Y, Sun X
Biochemical and biophysical research communications 2020 May 28;526(2):293-299

GDF15 induced by compressive force contributes to osteoclast differentiation in human periodontal ligament cells.

Li S, Li Q, Zhu Y, Hu W
Experimental cell research 2020 Feb 1;387(1):111745

Normoxia is not favorable for maintaining stemness of human endothelial progenitor cells.

Lin Y, Liu B, Deng T, Zhong J, Feng Z, Zeng Q, Huang G, Chen Z
Stem cell research 2019 Jul;38:101464

GDF15 promotes epithelial-to-mesenchymal transition in colorectal [corrected].

Zhang Y, Wang X, Zhang M, Zhang Z, Jiang L, Li L
Artificial cells, nanomedicine, and biotechnology 2018;46(sup2):652-658

Growth differentiation factor 15 promotes cell viability, invasion, migration, and angiogenesis in human liver carcinoma cell line HepG2.

Wang L, Liu Y, Li W, Song Z
Clinics and research in hepatology and gastroenterology 2017 Sep;41(4):408-414

No comments: Submit comment

No validations: Submit validation data