27455-1-AP

antibody from Proteintech Group

Targeting: GDF15 MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB

Provider product page for 27455-1-AP

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Immunohistochemistry

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Antibody Data
Antigen structure
References [27]
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Product number: 27455-1-AP - Provider product page
Provider: Proteintech Group
Product name: GDF15 antibody
Antibody type: Polyclonal
Description: KD/KO validated GDF15 antibody (Cat. #27455-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

GDF15 protein structure - 27455-1-AP shown in red.

Submitted references Engineered Basic Fibroblast Growth Factor Specifically Bonded with Injectable Extracellular Matrix Hydrogel for the Functional Restoration of Cerebral Ischemia in Rats.

Shi C, Liu Q, Sun F, Zhang G, Deng M, Xu B, Yuan H
Biomaterials research 2024;28:0020

Exosomes Derived from Meningitic Escherichia coli-Infected Brain Microvascular Endothelial Cells Facilitate Astrocyte Activation.

Yang R, Qu X, Zhi S, Wang J, Fu J, Tan C, Chen H, Wang X
Molecular neurobiology 2024 Sep;61(9):7195-7210

Potential crosstalk between SPP1 + TAMs and CD8 + exhausted T cells promotes an immunosuppressive environment in gastric metastatic cancer.

Du Y, Lin Y, Gan L, Wang S, Chen S, Li C, Hou S, Hu B, Wang B, Ye Y, Shen Z
Journal of translational medicine 2024 Feb 16;22(1):158

1,4-dihydroxy quininib activates ferroptosis pathways in metastatic uveal melanoma and reveals a novel prognostic biomarker signature.

Tonelotto V, Costa-Garcia M, O'Reilly E, Smith KF, Slater K, Dillon ET, Pendino M, Higgins C, Sist P, Bosch R, Passamonti S, Piulats JM, Villanueva A, Tramer F, Vanella L, Carey M, Kennedy BN
Cell death discovery 2024 Feb 10;10(1):70

Ergolide mediates anti-cancer effects on metastatic uveal melanoma cells and modulates their cellular and extracellular vesicle proteomes.

Sundaramurthi H, Tonelotto V, Wynne K, O'Connell F, O'Reilly E, Costa-Garcia M, Kovácsházi C, Kittel A, Marcone S, Blanco A, Pallinger E, Hambalkó S, Piulats Rodriguez JM, Ferdinandy P, O'Sullivan J, Matallanas D, Jensen LD, Giricz Z, Kennedy BN
Open research Europe 2023;3:88

Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells.

Joshi PR, Sadre S, Guo XA, McCoy JG, Mootha VK
The Journal of biological chemistry 2023 Sep;299(9):105075

Shexiang Baoxin Pill treats acute myocardial infarction by promoting angiogenesis via GDF15-TRPV4 signaling.

Wei BY, Hou JN, Yan CP, Wen SY, Shang XS, Guo YC, Feng T, Liu TF, Chen ZY, Chen XP
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115186

BET inhibitors synergize with sunitinib in melanoma through GDF15 suppression.

Zeng F, Li Y, Meng Y, Sun H, He Y, Yin M, Chen X, Deng G
Experimental & molecular medicine 2023 Feb;55(2):364-376

Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.

Chen J, Cui Z, Wang Y, Lyu L, Feng C, Feng D, Cheng Y, Li Z, Sun S
Oxidative medicine and cellular longevity 2022;2022:3182368

GDF15 negatively regulates RGS16 to impair hepatic lipid metabolism in male mice offspring conceived by in vitro fertilization.

Liu J, Zhu Y, Zhu D, Shi Y, Lu L, Li W, Li L, Zhou X, Zhang P, Yang H, Li M, Wang B, Sun M
American journal of translational research 2022;14(10):7535-7551

GDF15 Contributes to Radioresistance by Mediating the EMT and Stemness of Breast Cancer Cells.

Zhao X, Liu X, Hu S, Pan Y, Zhang J, Tai G, Shao C
International journal of molecular sciences 2022 Sep 18;23(18)

GDF15 Is an Eribulin Response Biomarker also Required for Survival of DTP Breast Cancer Cells.

Bellio C, Emperador M, Castellano P, Gris-Oliver A, Canals F, Sánchez-Pla A, Zamora E, Arribas J, Saura C, Serra V, Tabernero J, Littlefield BA, Villanueva J
Cancers 2022 May 23;14(10)

N-glycosylation of GDF15 abolishes its inhibitory effect on EGFR in AR inhibitor-resistant prostate cancer cells.

Wang R, Wen P, Yang G, Feng Y, Mi Y, Wang X, Zhu S, Chen YQ
Cell death & disease 2022 Jul 19;13(7):626

SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer.

He R, Shi J, Xu D, Yang J, Shen Y, Jiang YS, Tao L, Yang M, Fu X, Yang JY, Liu D, Huo Y, Shen X, Lu P, Niu N, Sun YW, Xue J, Liu W
Cancer letters 2022 Jul 10;538:215693

Local anesthetic lidocaine-inducible gene, growth differentiation factor-15 suppresses the growth of cancer cell lines.

Haraguchi-Suzuki K, Kawabata-Iwakawa R, Suzuki T, Suto T, Takazawa T, Saito S
Scientific reports 2022 Aug 25;12(1):14520

Uraemic Cardiomyopathy in Different Mouse Models.

Chen C, Xie C, Wu H, Wu L, Zhu J, Mao H, Xing C
Frontiers in medicine 2021;8:690517

Long noncoding RNA SH3PXD2A-AS1 promotes colorectal cancer progression by regulating p53-mediated gene transcription.

Hou P, Lin T, Meng S, Shi M, Chen F, Jiang T, Li Z, Li M, Chu S, Zheng J, Bai J
International journal of biological sciences 2021;17(8):1979-1994

Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer.

Bernasocchi T, El Tekle G, Bolis M, Mutti A, Vallerga A, Brandt LP, Spriano F, Svinkina T, Zoma M, Ceserani V, Rinaldi A, Janouskova H, Bossi D, Cavalli M, Mosole S, Geiger R, Dong Z, Yang CG, Albino D, Rinaldi A, Schraml P, Linder S, Carbone GM, Alimonti A, Bertoni F, Moch H, Carr SA, Zwart W, Kruithof-de Julio M, Rubin MA, Udeshi ND, Theurillat JP
Nature communications 2021 Feb 2;12(1):734

Bottom up proteomics identifies neuronal differentiation pathway networks activated by cathepsin inhibition treatment in neuroblastoma cells that are enhanced by concurrent 13-cis retinoic acid treatment.

Halakos EG, Connell AJ, Glazewski L, Wei S, Mason RW
Journal of proteomics 2021 Feb 10;232:104068

Hepatic Stellate Cells in Hepatocellular Carcinoma Promote Tumor Growth Via Growth Differentiation Factor 15 Production.

Myojin Y, Hikita H, Sugiyama M, Sasaki Y, Fukumoto K, Sakane S, Makino Y, Takemura N, Yamada R, Shigekawa M, Kodama T, Sakamori R, Kobayashi S, Tatsumi T, Suemizu H, Eguchi H, Kokudo N, Mizokami M, Takehara T
Gastroenterology 2021 Apr;160(5):1741-1754.e16

NR5A2 transcriptional activation by BRD4 promotes pancreatic cancer progression by upregulating GDF15.

Guo F, Zhou Y, Guo H, Ren D, Jin X, Wu H
Cell death discovery 2021 Apr 13;7(1):78

Grape Seed Proanthocyanidins Induce Apoptosis and Cell Cycle Arrest of HepG2 Cells Accompanied by Induction of the MAPK Pathway and NAG-1.

Wang L, Zhan J, Huang W
Antioxidants (Basel, Switzerland) 2020 Nov 28;9(12)

GDF15 knockdown promotes erastin-induced ferroptosis by decreasing SLC7A11 expression.

Chen L, Qiao L, Bian Y, Sun X
Biochemical and biophysical research communications 2020 May 28;526(2):293-299

GDF15 induced by compressive force contributes to osteoclast differentiation in human periodontal ligament cells.

Li S, Li Q, Zhu Y, Hu W
Experimental cell research 2020 Feb 1;387(1):111745

Normoxia is not favorable for maintaining stemness of human endothelial progenitor cells.

Lin Y, Liu B, Deng T, Zhong J, Feng Z, Zeng Q, Huang G, Chen Z
Stem cell research 2019 Jul;38:101464

GDF15 promotes epithelial-to-mesenchymal transition in colorectal [corrected].

Zhang Y, Wang X, Zhang M, Zhang Z, Jiang L, Li L
Artificial cells, nanomedicine, and biotechnology 2018;46(sup2):652-658

Growth differentiation factor 15 promotes cell viability, invasion, migration, and angiogenesis in human liver carcinoma cell line HepG2.

Wang L, Liu Y, Li W, Song Z
Clinics and research in hepatology and gastroenterology 2017 Sep;41(4):408-414

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