RA0271

antibody from Oursmab

Targeting: GDF15 MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB

Western blot (Supportive data in Antibodypedia)

ELISA (Supportive data in Antibodypedia)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0271

Provider

Oursmab

Product name

Ponsegromab (Biosimilar Reference Antibody) (GDF15)

Antibody type

Monoclonal

Description

Ponsegromab (PF-06946860) is a humanized IgG1 monoclonal antibody designed to selectively neutralize Growth Differentiation Factor 15 (GDF15), a key signaling protein associated with cachexia and metabolic dysfunction. By binding to GDF15, it blocks its interaction with the GFRAL receptor, thereby inhibiting pathways that lead to appetite suppression and weight loss. It is primarily investigated for treating conditions like cancer-associated cachexia.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.

Western blot

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

Ponsegromab (Biosimilar Reference Antibody) (GDF15)-RA0271-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.

ELISA

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

ELISA plate pre-coated Antigen protein, can bind Ponsegromab (Biosimilar Reference Antibody) (GDF15)-RA0271 in a linear range of 15.63¨C125 ng/mL.