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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [44]
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- Product number
- ABIN361708 - Provider product page
- Provider
- antibodies-online
- Proper citation
- Antibodies-Online Cat#ABIN361708, RRID:AB_10772214
- Product name
- anti-Heat Shock Protein 70 (HSP70) antibody
- Antibody type
- Monoclonal
- Description
- Protein G Purified
- Reactivity
- Human, Mouse, Rat, Bovine, Canine, Chicken/Avian, Guinea Pig, Hamster, Porcine, Rabbit, Sheep, Simian
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- C92F3A-5
- Vial size
- 200 μg
- Storage
- -20°C
Submitted references Heat shock protein 70 regulates degradation of the mumps virus phosphoprotein via the ubiquitin-proteasome pathway.
Prostaglandin E synthase interacts with inducible heat shock protein 70 after heat stress in bovine primary dermal fibroblast cells.
Heat-induced expression of the immediate-early gene IER5 and its involvement in the proliferation of heat-shocked cells.
Masseter muscle myofibrillar protein synthesis and degradation in an experimental critical illness myopathy model.
Fasting enhances TRAIL-mediated liver natural killer cell activity via HSP70 upregulation.
Direct binding of the Alu binding protein dimer SRP9/14 to 40S ribosomal subunits promotes stress granule formation and is regulated by Alu RNA.
A cardiopulmonary bypass with deep hypothermic circulatory arrest rat model for the investigation of the systemic inflammation response and induced organ damage.
Therapeutic inducers of the HSP70/HSP110 protect mice against traumatic brain injury.
Macrophage inflammatory protein derivative ECI301 enhances the alarmin-associated abscopal benefits of tumor radiotherapy.
Overexpression of heat shock protein 72 attenuates NF-κB activation using a combination of regulatory mechanisms in microglia.
Inhibition of autophagy, lysosome and VCP function impairs stress granule assembly.
Moderate alcohol induces stress proteins HSF1 and hsp70 and inhibits proinflammatory cytokines resulting in endotoxin tolerance.
Structure-activity relationships for withanolides as inducers of the cellular heat-shock response.
Iron modulates cell survival in a Ras- and MAPK-dependent manner in ovarian cells.
Effects of corticosteroids in the development of limb muscle weakness in a porcine intensive care unit model.
Influences of temperature, oxidative stress, and phosphorylation on binding of heat shock proteins in skeletal muscle fibers.
Hsp70 promotes epithelial sodium channel functional expression by increasing its association with coat complex II and its exit from endoplasmic reticulum.
Absolute amounts and diffusibility of HSP72, HSP25, and αB-crystallin in fast- and slow-twitch skeletal muscle fibers of rat.
Using the heat-shock response to discover anticancer compounds that target protein homeostasis.
DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau.
Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport.
Associations of HSP90 client proteins in human breast cancer.
Deciphering human heat shock transcription factor 1 regulation via post-translational modification in yeast.
Effects of HSP70 on the compression force-induced TNF-α and RANKL expression in human periodontal ligament cells.
Mechanisms underlying the sparing of masticatory versus limb muscle function in an experimental critical illness model.
Co-overexpression of Bag-1 and heat shock protein 70 in human epidermal squamous cell carcinoma: Bag-1-mediated resistance to 5-fluorouracil-induced apoptosis.
Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: underlying mechanisms.
Tamm-Horsfall protein and urinary exosome isolation.
Gene expression and muscle fiber function in a porcine ICU model.
Identification of phosphorylation-dependent binding partners of aquaporin-2 using protein mass spectrometry.
2,3-Dihydrowithaferin A-3beta-O-sulfate, a new potential prodrug of withaferin A from aeroponically grown Withania somnifera.
Persistent sub-lethal chlorine exposure augments temperature induced immunosuppression in Cyprinus carpio advanced fingerlings.
Presence of both constitutive and inducible forms of heat shock protein 70 in the cerebral cortex and hippocampal synapses.
Suppression of heat shock protein-70 by ceramide in heat shock-induced HL-60 cell apoptosis.
Heat shock protein 70 is able to prevent heat shock-induced resistance of target cells to CTL.
Stimulation of p38 mitogen-activated protein kinase is an early regulatory event for the cadmium-induced apoptosis in human promonocytic cells.
Chaperone-mediated protein folding.
Detection of heat shock protein 70 (Hsp70) and anti-Hsp70 antibodies in the serum of normal individuals.
Induction in vitro of 72-kD heat shock protein in a continuous culture of rat thyroid cells, FRTL5.
Molecular evolution of the HSP70 multigene family.
An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins.
Uncoating protein (hsc70) binds a conformationally labile domain of clathrin light chain LCa to stimulate ATP hydrolysis.
Polypeptide chain binding proteins: catalysts of protein folding and related processes in cells.
Cellular and biochemical events in mammalian cells during and after recovery from physiological stress.
Katoh H, Kubota T, Kita S, Nakatsu Y, Aoki N, Mori Y, Maenaka K, Takeda M, Kidokoro M
Journal of virology 2015 Mar;89(6):3188-99
Journal of virology 2015 Mar;89(6):3188-99
Prostaglandin E synthase interacts with inducible heat shock protein 70 after heat stress in bovine primary dermal fibroblast cells.
Richter C, Viergutz T, Schwerin M, Weitzel JM
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2015 Jan;87(1):61-7
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2015 Jan;87(1):61-7
Heat-induced expression of the immediate-early gene IER5 and its involvement in the proliferation of heat-shocked cells.
Ishikawa Y, Sakurai H
The FEBS journal 2015 Jan;282(2):332-40
The FEBS journal 2015 Jan;282(2):332-40
Masseter muscle myofibrillar protein synthesis and degradation in an experimental critical illness myopathy model.
Akkad H, Corpeno R, Larsson L
PloS one 2014;9(4):e92622
PloS one 2014;9(4):e92622
Fasting enhances TRAIL-mediated liver natural killer cell activity via HSP70 upregulation.
Dang VT, Tanabe K, Tanaka Y, Tokumoto N, Misumi T, Saeki Y, Fujikuni N, Ohdan H
PloS one 2014;9(10):e110748
PloS one 2014;9(10):e110748
Direct binding of the Alu binding protein dimer SRP9/14 to 40S ribosomal subunits promotes stress granule formation and is regulated by Alu RNA.
Berger A, Ivanova E, Gareau C, Scherrer A, Mazroui R, Strub K
Nucleic acids research 2014;42(17):11203-17
Nucleic acids research 2014;42(17):11203-17
A cardiopulmonary bypass with deep hypothermic circulatory arrest rat model for the investigation of the systemic inflammation response and induced organ damage.
Engels M, Bilgic E, Pinto A, Vasquez E, Wollschläger L, Steinbrenner H, Kellermann K, Akhyari P, Lichtenberg A, Boeken U
Journal of inflammation (London, England) 2014;11:26
Journal of inflammation (London, England) 2014;11:26
Therapeutic inducers of the HSP70/HSP110 protect mice against traumatic brain injury.
Eroglu B, Kimbler DE, Pang J, Choi J, Moskophidis D, Yanasak N, Dhandapani KM, Mivechi NF
Journal of neurochemistry 2014 Sep;130(5):626-41
Journal of neurochemistry 2014 Sep;130(5):626-41
Macrophage inflammatory protein derivative ECI301 enhances the alarmin-associated abscopal benefits of tumor radiotherapy.
Kanegasaki S, Matsushima K, Shiraishi K, Nakagawa K, Tsuchiya T
Cancer research 2014 Sep 15;74(18):5070-8
Cancer research 2014 Sep 15;74(18):5070-8
Overexpression of heat shock protein 72 attenuates NF-κB activation using a combination of regulatory mechanisms in microglia.
Sheppard PW, Sun X, Khammash M, Giffard RG
PLoS computational biology 2014 Feb;10(2):e1003471
PLoS computational biology 2014 Feb;10(2):e1003471
Inhibition of autophagy, lysosome and VCP function impairs stress granule assembly.
Seguin SJ, Morelli FF, Vinet J, Amore D, De Biasi S, Poletti A, Rubinsztein DC, Carra S
Cell death and differentiation 2014 Dec;21(12):1838-51
Cell death and differentiation 2014 Dec;21(12):1838-51
Moderate alcohol induces stress proteins HSF1 and hsp70 and inhibits proinflammatory cytokines resulting in endotoxin tolerance.
Muralidharan S, Ambade A, Fulham MA, Deshpande J, Catalano D, Mandrekar P
Journal of immunology (Baltimore, Md. : 1950) 2014 Aug 15;193(4):1975-87
Journal of immunology (Baltimore, Md. : 1950) 2014 Aug 15;193(4):1975-87
Structure-activity relationships for withanolides as inducers of the cellular heat-shock response.
Wijeratne EM, Xu YM, Scherz-Shouval R, Marron MT, Rocha DD, Liu MX, Costa-Lotufo LV, Santagata S, Lindquist S, Whitesell L, Gunatilaka AA
Journal of medicinal chemistry 2014 Apr 10;57(7):2851-63
Journal of medicinal chemistry 2014 Apr 10;57(7):2851-63
Iron modulates cell survival in a Ras- and MAPK-dependent manner in ovarian cells.
Bauckman KA, Haller E, Flores I, Nanjundan M
Cell death & disease 2013 Apr 18;4:e592
Cell death & disease 2013 Apr 18;4:e592
Effects of corticosteroids in the development of limb muscle weakness in a porcine intensive care unit model.
Aare S, Radell P, Eriksson LI, Akkad H, Chen YW, Hoffman EP, Larsson L
Physiological genomics 2013 Apr 16;45(8):312-20
Physiological genomics 2013 Apr 16;45(8):312-20
Influences of temperature, oxidative stress, and phosphorylation on binding of heat shock proteins in skeletal muscle fibers.
Larkins NT, Murphy RM, Lamb GD
American journal of physiology. Cell physiology 2012 Sep 15;303(6):C654-65
American journal of physiology. Cell physiology 2012 Sep 15;303(6):C654-65
Hsp70 promotes epithelial sodium channel functional expression by increasing its association with coat complex II and its exit from endoplasmic reticulum.
Chanoux RA, Robay A, Shubin CB, Kebler C, Suaud L, Rubenstein RC
The Journal of biological chemistry 2012 Jun 1;287(23):19255-65
The Journal of biological chemistry 2012 Jun 1;287(23):19255-65
Absolute amounts and diffusibility of HSP72, HSP25, and αB-crystallin in fast- and slow-twitch skeletal muscle fibers of rat.
Larkins NT, Murphy RM, Lamb GD
American journal of physiology. Cell physiology 2012 Jan 1;302(1):C228-39
American journal of physiology. Cell physiology 2012 Jan 1;302(1):C228-39
Using the heat-shock response to discover anticancer compounds that target protein homeostasis.
Santagata S, Xu YM, Wijeratne EM, Kontnik R, Rooney C, Perley CC, Kwon H, Clardy J, Kesari S, Whitesell L, Lindquist S, Gunatilaka AA
ACS chemical biology 2012 Feb 17;7(2):340-9
ACS chemical biology 2012 Feb 17;7(2):340-9
DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau.
Abisambra JF, Jinwal UK, Suntharalingam A, Arulselvam K, Brady S, Cockman M, Jin Y, Zhang B, Dickey CA
Journal of molecular biology 2012 Aug 24;421(4-5):653-61
Journal of molecular biology 2012 Aug 24;421(4-5):653-61
Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport.
Patterson KR, Ward SM, Combs B, Voss K, Kanaan NM, Morfini G, Brady ST, Gamblin TC, Binder LI
Biochemistry 2011 Nov 29;50(47):10300-10
Biochemistry 2011 Nov 29;50(47):10300-10
Associations of HSP90 client proteins in human breast cancer.
Shipp C, Watson K, Jones GL
Anticancer research 2011 Jun;31(6):2095-101
Anticancer research 2011 Jun;31(6):2095-101
Deciphering human heat shock transcription factor 1 regulation via post-translational modification in yeast.
Batista-Nascimento L, Neef DW, Liu PC, Rodrigues-Pousada C, Thiele DJ
PloS one 2011 Jan 6;6(1):e15976
PloS one 2011 Jan 6;6(1):e15976
Effects of HSP70 on the compression force-induced TNF-α and RANKL expression in human periodontal ligament cells.
Mitsuhashi M, Yamaguchi M, Kojima T, Nakajima R, Kasai K
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2011 Feb;60(2):187-94
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2011 Feb;60(2):187-94
Mechanisms underlying the sparing of masticatory versus limb muscle function in an experimental critical illness model.
Aare S, Ochala J, Norman HS, Radell P, Eriksson LI, Göransson H, Chen YW, Hoffman EP, Larsson L
Physiological genomics 2011 Dec 16;43(24):1334-50
Physiological genomics 2011 Dec 16;43(24):1334-50
Co-overexpression of Bag-1 and heat shock protein 70 in human epidermal squamous cell carcinoma: Bag-1-mediated resistance to 5-fluorouracil-induced apoptosis.
Wood J, Pring M, Eveson JW, Price N, Proby CM, Hague A
British journal of cancer 2011 Apr 26;104(9):1459-71
British journal of cancer 2011 Apr 26;104(9):1459-71
Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: underlying mechanisms.
Ochala J, Gustafson AM, Diez ML, Renaud G, Li M, Aare S, Qaisar R, Banduseela VC, Hedström Y, Tang X, Dworkin B, Ford GC, Nair KS, Perera S, Gautel M, Larsson L
The Journal of physiology 2011 Apr 15;589(Pt 8):2007-26
The Journal of physiology 2011 Apr 15;589(Pt 8):2007-26
Tamm-Horsfall protein and urinary exosome isolation.
Fernández-Llama P, Khositseth S, Gonzales PA, Star RA, Pisitkun T, Knepper MA
Kidney international 2010 Apr;77(8):736-42
Kidney international 2010 Apr;77(8):736-42
Gene expression and muscle fiber function in a porcine ICU model.
Banduseela VC, Ochala J, Chen YW, Göransson H, Norman H, Radell P, Eriksson LI, Hoffman EP, Larsson L
Physiological genomics 2009 Nov 6;39(3):141-59
Physiological genomics 2009 Nov 6;39(3):141-59
Identification of phosphorylation-dependent binding partners of aquaporin-2 using protein mass spectrometry.
Zwang NA, Hoffert JD, Pisitkun T, Moeller HB, Fenton RA, Knepper MA
Journal of proteome research 2009 Mar;8(3):1540-54
Journal of proteome research 2009 Mar;8(3):1540-54
2,3-Dihydrowithaferin A-3beta-O-sulfate, a new potential prodrug of withaferin A from aeroponically grown Withania somnifera.
Xu YM, Marron MT, Seddon E, McLaughlin SP, Ray DT, Whitesell L, Gunatilaka AA
Bioorganic & medicinal chemistry 2009 Mar 15;17(6):2210-4
Bioorganic & medicinal chemistry 2009 Mar 15;17(6):2210-4
Persistent sub-lethal chlorine exposure augments temperature induced immunosuppression in Cyprinus carpio advanced fingerlings.
Verma AK, Pal AK, Manush SM, Das T, Dalvi RS, Chandrachoodan PP, Ravi PM, Apte SK
Fish & shellfish immunology 2007 May;22(5):547-55
Fish & shellfish immunology 2007 May;22(5):547-55
Presence of both constitutive and inducible forms of heat shock protein 70 in the cerebral cortex and hippocampal synapses.
Moon IS, Park IS, Schenker LT, Kennedy MB, Moon JI, Jin I
Cerebral cortex (New York, N.Y. : 1991) 2001 Mar;11(3):238-48
Cerebral cortex (New York, N.Y. : 1991) 2001 Mar;11(3):238-48
Suppression of heat shock protein-70 by ceramide in heat shock-induced HL-60 cell apoptosis.
Kondo T, Matsuda T, Tashima M, Umehara H, Domae N, Yokoyama K, Uchiyama T, Okazaki T
The Journal of biological chemistry 2000 Mar 24;275(12):8872-9
The Journal of biological chemistry 2000 Mar 24;275(12):8872-9
Heat shock protein 70 is able to prevent heat shock-induced resistance of target cells to CTL.
Dressel R, Elsner L, Quentin T, Walter L, Günther E
Journal of immunology (Baltimore, Md. : 1950) 2000 Mar 1;164(5):2362-71
Journal of immunology (Baltimore, Md. : 1950) 2000 Mar 1;164(5):2362-71
Stimulation of p38 mitogen-activated protein kinase is an early regulatory event for the cadmium-induced apoptosis in human promonocytic cells.
Galán A, García-Bermejo ML, Troyano A, Vilaboa NE, de Blas E, Kazanietz MG, Aller P
The Journal of biological chemistry 2000 Apr 14;275(15):11418-24
The Journal of biological chemistry 2000 Apr 14;275(15):11418-24
Chaperone-mediated protein folding.
Fink AL
Physiological reviews 1999 Apr;79(2):425-49
Physiological reviews 1999 Apr;79(2):425-49
Detection of heat shock protein 70 (Hsp70) and anti-Hsp70 antibodies in the serum of normal individuals.
Pockley AG, Shepherd J, Corton JM
Immunological investigations 1998 Dec;27(6):367-77
Immunological investigations 1998 Dec;27(6):367-77
Induction in vitro of 72-kD heat shock protein in a continuous culture of rat thyroid cells, FRTL5.
Misaki T, Takeuchi R, Miyamoto S, Hirano A, Kasagi K, Konishi J
Clinical and experimental immunology 1994 Nov;98(2):234-9
Clinical and experimental immunology 1994 Nov;98(2):234-9
Molecular evolution of the HSP70 multigene family.
Boorstein WR, Ziegelhoffer T, Craig EA
Journal of molecular evolution 1994 Jan;38(1):1-17
Journal of molecular evolution 1994 Jan;38(1):1-17
An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins.
Bork P, Sander C, Valencia A
Proceedings of the National Academy of Sciences of the United States of America 1992 Aug 15;89(16):7290-4
Proceedings of the National Academy of Sciences of the United States of America 1992 Aug 15;89(16):7290-4
Uncoating protein (hsc70) binds a conformationally labile domain of clathrin light chain LCa to stimulate ATP hydrolysis.
DeLuca-Flaherty C, McKay DB, Parham P, Hill BL
Cell 1990 Sep 7;62(5):875-87
Cell 1990 Sep 7;62(5):875-87
Polypeptide chain binding proteins: catalysts of protein folding and related processes in cells.
Rothman JE
Cell 1989 Nov 17;59(4):591-601
Cell 1989 Nov 17;59(4):591-601
Cellular and biochemical events in mammalian cells during and after recovery from physiological stress.
Welch WJ, Suhan JP
The Journal of cell biology 1986 Nov;103(5):2035-52
The Journal of cell biology 1986 Nov;103(5):2035-52
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