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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [14]
- Comments [0]
- Validations
- Immunohistochemistry [1]
- Other assay [1]
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- Product number
- V3268 - Provider product page
- Provider
- NSJ Bioreagents
- Product name
- Desmocollin 2/3 Antibody
- Antibody type
- Monoclonal
- Description
- Purified
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Antibody clone number
- 7G6
- Vial size
- 20 µg, 100 µg (with BSA, sodium azide), 100 µg (without BSA, sodium azide), 7 ml (prediluted for IHC)
- Concentration
- 0.2 mg/ml
- Storage
- Store the Desmocollin 2/3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Submitted references Inflammation-induced desmoglein-2 ectodomain shedding compromises the mucosal barrier.
The cancer stem cell marker CD133 interacts with plakoglobin and controls desmoglein-2 protein levels.
Estrogens promote cell-cell adhesion of normal and malignant mammary cells through increased desmosome formation.
Upregulation of plakophilin-2 and its acquisition to adherens junctions identifies a novel molecular ensemble of cell-cell-attachment characteristic for transformed mesenchymal cells.
Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly.
Characterization of a novel type of adherens junction in meningiomas and the derived cell line HBL-52.
The area composita of adhering junctions connecting heart muscle cells of vertebrates - IV: coalescence and amalgamation of desmosomal and adhaerens junction components - late processes in mammalian heart development.
Proteomic analysis of exfoliation deposits.
Mispolarization of desmosomal proteins and altered intercellular adhesion in autosomal dominant polycystic kidney disease.
Remodeling of myocyte gap junctions in arrhythmogenic right ventricular cardiomyopathy due to a deletion in plakoglobin (Naxos disease).
Structural and molecular pathology of the heart in Carvajal syndrome.
Molecular characterization of desmosomes in meningiomas and arachnoidal tissue.
Assembly of desmosomal cadherins into desmosomes is isoform dependent.
Contributions of extracellular and intracellular domains of full length and chimeric cadherin molecules to junction assembly in epithelial cells.
Kamekura R, Nava P, Feng M, Quiros M, Nishio H, Weber DA, Parkos CA, Nusrat A
Molecular biology of the cell 2015 Sep 15;26(18):3165-77
Molecular biology of the cell 2015 Sep 15;26(18):3165-77
The cancer stem cell marker CD133 interacts with plakoglobin and controls desmoglein-2 protein levels.
Koyama-Nasu R, Takahashi R, Yanagida S, Nasu-Nishimura Y, Oyama M, Kozuka-Hata H, Haruta R, Manabe E, Hoshino-Okubo A, Omi H, Yanaihara N, Okamoto A, Tanaka T, Akiyama T
PloS one 2013;8(1):e53710
PloS one 2013;8(1):e53710
Estrogens promote cell-cell adhesion of normal and malignant mammary cells through increased desmosome formation.
Maynadier M, Chambon M, Basile I, Gleizes M, Nirde P, Gary-Bobo M, Garcia M
Molecular and cellular endocrinology 2012 Nov 25;364(1-2):126-33
Molecular and cellular endocrinology 2012 Nov 25;364(1-2):126-33
Upregulation of plakophilin-2 and its acquisition to adherens junctions identifies a novel molecular ensemble of cell-cell-attachment characteristic for transformed mesenchymal cells.
Rickelt S, Winter-Simanowski S, Noffz E, Kuhn C, Franke WW
International journal of cancer 2009 Nov 1;125(9):2036-48
International journal of cancer 2009 Nov 1;125(9):2036-48
Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly.
Bass-Zubek AE, Hobbs RP, Amargo EV, Garcia NJ, Hsieh SN, Chen X, Wahl JK 3rd, Denning MF, Green KJ
The Journal of cell biology 2008 May 19;181(4):605-13
The Journal of cell biology 2008 May 19;181(4):605-13
Characterization of a novel type of adherens junction in meningiomas and the derived cell line HBL-52.
Akat K, Bleck CK, Lee YM, Haselmann-Weiss U, Kartenbeck J
Cell and tissue research 2008 Feb;331(2):401-12
Cell and tissue research 2008 Feb;331(2):401-12
The area composita of adhering junctions connecting heart muscle cells of vertebrates - IV: coalescence and amalgamation of desmosomal and adhaerens junction components - late processes in mammalian heart development.
Pieperhoff S, Franke WW
European journal of cell biology 2007 Jul;86(7):377-91
European journal of cell biology 2007 Jul;86(7):377-91
Proteomic analysis of exfoliation deposits.
Ovodenko B, Rostagno A, Neubert TA, Shetty V, Thomas S, Yang A, Liebmann J, Ghiso J, Ritch R
Investigative ophthalmology & visual science 2007 Apr;48(4):1447-57
Investigative ophthalmology & visual science 2007 Apr;48(4):1447-57
Mispolarization of desmosomal proteins and altered intercellular adhesion in autosomal dominant polycystic kidney disease.
Silberberg M, Charron AJ, Bacallao R, Wandinger-Ness A
American journal of physiology. Renal physiology 2005 Jun;288(6):F1153-63
American journal of physiology. Renal physiology 2005 Jun;288(6):F1153-63
Remodeling of myocyte gap junctions in arrhythmogenic right ventricular cardiomyopathy due to a deletion in plakoglobin (Naxos disease).
Kaplan SR, Gard JJ, Protonotarios N, Tsatsopoulou A, Spiliopoulou C, Anastasakis A, Squarcioni CP, McKenna WJ, Thiene G, Basso C, Brousse N, Fontaine G, Saffitz JE
Heart rhythm 2004 May;1(1):3-11
Heart rhythm 2004 May;1(1):3-11
Structural and molecular pathology of the heart in Carvajal syndrome.
Kaplan SR, Gard JJ, Carvajal-Huerta L, Ruiz-Cabezas JC, Thiene G, Saffitz JE
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2004 Jan-Feb;13(1):26-32
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2004 Jan-Feb;13(1):26-32
Molecular characterization of desmosomes in meningiomas and arachnoidal tissue.
Akat K, Mennel HD, Kremer P, Gassler N, Bleck CK, Kartenbeck J
Acta neuropathologica 2003 Oct;106(4):337-47
Acta neuropathologica 2003 Oct;106(4):337-47
Assembly of desmosomal cadherins into desmosomes is isoform dependent.
Ishii K, Norvell SM, Bannon LJ, Amargo EV, Pascoe LT, Green KJ
The Journal of investigative dermatology 2001 Jul;117(1):26-35
The Journal of investigative dermatology 2001 Jul;117(1):26-35
Contributions of extracellular and intracellular domains of full length and chimeric cadherin molecules to junction assembly in epithelial cells.
Norvell SM, Green KJ
Journal of cell science 1998 May;111 ( Pt 9):1305-18
Journal of cell science 1998 May;111 ( Pt 9):1305-18
No comments: Submit comment
Supportive validation
- Submitted by
- NSJ Bioreagents (provider)
- Main image
- Experimental details
- IHC testing of FFPE human skin with Desmocollin 2/3 antibody (clone 7G6). Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9, for 10-20 min.
Supportive validation
- Submitted by
- NSJ Bioreagents (provider)
- Main image
- Experimental details
- SDS-PAGE Analysis of Purified, BSA-Free Desmocollin 2/3 Antibody (clone 7G6). Confirmation of Integrity and Purity of the Antibody.
