22378-1-AP

antibody from Proteintech Group

Targeting: PPARGC1B PERC, PGC1B

Provider product page for 22378-1-AP

Western blot

ELISA

Antibody data

Antibody Data
Antigen structure
References [22]
Comments [0]
Validations
Western blot [1]

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Product number: 22378-1-AP - Provider product page
Provider: Proteintech Group
Product name: PPARGC1B antibody
Antibody type: Polyclonal
Description: KD/KO validated PPARGC1B antibody (Cat. #22378-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: WB, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PPARGC1B protein structure - 22378-1-AP shown in red.

Submitted references Mechanistic insights into the PAI-1 inhibitor PAItrap3: enhancing lipid metabolism in adipose tissue of diabetic db/db mice.

Wang L, Zhang Z, Lin M, Qi L, Liu L, Chen Z, Tang S, Wang L
Frontiers in pharmacology 2025;16:1596655

Ferulic acid inhibits lipogenesis and ameliorates MASLD via targeting PGC-1β.

Cui K, Ren L, Zhang L, An Y, Ji P, Yang Y, Li F, Li Z
Frontiers in nutrition 2025;12:1730916

High-Fat Diet-Induced Diabetic Cardiomyopathy in Female Zebrafish: Cardiac Pathology and Functional Decline Mediated by Type 2 Diabetes.

Huang S, Chen Z, Li H, Zou Y, Wang B, Zhao W, Zheng L, Zhou Z, Peng X, Tang C
Nutrients 2025 Jul 2;17(13)

Moderate-intensity interval exercise exacerbates cardiac lipotoxicity in high-fat, high-calories diet-fed mice.

Geng J, Zhang X, Guo Y, Wen H, Guo D, Liang Q, Pu S, Wang Y, Liu M, Li Z, Hu W, Yang X, Chang P, Hu L, Li Y
Nature communications 2025 Jan 12;16(1):613

CRIP1 inhibits cutaneous melanoma progression through TFAM-mediated mitochondrial biogenesis.

Wu J, Chen L, Wen P
Scientific reports 2025 Feb 4;15(1):4298

MTHFD2 promotes osteoclastogenesis and bone loss in rheumatoid arthritis by enhancing CKMT1-mediated oxidative phosphorylation.

Li Y, Cai M, Qin Y, Dai X, Liang L, Li Z, Wen X, Jin H, Yang C, Chen Z
BMC medicine 2025 Feb 27;23(1):124

A liver-fat crosstalk for iron flux during healthy beiging of adipose tissue.

Yang J, Shi L, Cubito AL, Collins JF, Cheng Z
Autophagy reports 2024;3(1):2396696

Novel Choline-Deficient and 0.1%-Methionine-Added High-Fat Diet Induces Burned-Out Metabolic-Dysfunction-Associated Steatohepatitis with Inflammation by Rapid Immune Cell Infiltration on Male Mice.

Sakaguchi T, Nagahama Y, Hamada N, Singh SK, Mikami H, Maeda K, Akira S
Nutrients 2024 Nov 29;16(23)

miR-484 mediates oxidative stress-induced ovarian dysfunction and promotes granulosa cell apoptosis via SESN2 downregulation.

Wang X, Yang J, Li H, Mu H, Zeng L, Cai S, Su P, Li H, Zhang L, Xiang W
Redox biology 2023 Jun;62:102684

PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma.

Zhao M, Li Y, Lu C, Ding F, Xu M, Ge X, Li M, Wang Z, Yin J, Zhang J, Wang X, Ge Z, Xiao H, Xiao Y, Liu H, Liu W, Cao Y, Wang Q, You Y, Wang X, Yang K, Shi Z, Qian X
Cancer research 2023 Apr 4;83(7):1094-1110

Metabolism-Based Molecular Subtyping Endows Effective Ketogenic Therapy in p53-Mutant Colon Cancer.

Tang M, Xu H, Huang H, Kuang H, Wang C, Li Q, Zhang X, Ge Y, Song M, Zhang X, Wang Z, Ma C, Kang J, Zhang W, Wang Y, Zhang B, Zhang X, Chen Y, Cong M, Melino G, Wang X, Zhou F, Sun Q, Shi H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Oct;9(29):e2201992

Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine.

Han L, Wang G, Zhou S, Situ C, He Z, Li Y, Qiu Y, Huang Y, Xu A, Ong MTY, Wang H, Zhang J, Wu Z
Cell reports 2022 May 31;39(9):110884

Interactions between dietary carbohydrate and thiamine: implications on the growth performance and intestinal mitochondrial biogenesis and function of Megalobrama amblycephala.

Xu C, Li YY, Brown PB, Liu WB, Gao LL, Ding ZR, Li XF, Xie DZ
The British journal of nutrition 2022 Feb 14;127(3):321-334

PGC-1β modulates catabolism and fiber atrophy in the fasting-response of specific skeletal muscle beds.

Schmid S, Heim-Kupr B, Pérez-Schindler J, Mansingh S, Beer M, Mittal N, Ehrenfeuchter N, Handschin C
Molecular metabolism 2022 Dec;66:101643

Andrographolide prevents bone loss via targeting estrogen-related receptor-α-regulated metabolic adaption of osteoclastogenesis.

Huang T, Fu X, Wang N, Yang M, Zhang M, Wang B, Chen T, Majaz S, Wang H, Wong CW, Liu J, Guan M
British journal of pharmacology 2021 Nov;178(21):4352-4367

Mitophagy receptor FUNDC1 is regulated by PGC-1α/NRF1 to fine tune mitochondrial homeostasis.

Liu L, Li Y, Wang J, Zhang D, Wu H, Li W, Wei H, Ta N, Fan Y, Liu Y, Wang X, Wang J, Pan X, Liao X, Zhu Y, Chen Q
EMBO reports 2021 Mar 3;22(3):e50629

Carbonyl cyanide 3-chlorophenylhydrazone induced the imbalance of mitochondrial homeostasis in the liver of Megalobrama amblycephala: A dynamic study.

Zhang L, Zheng XC, Huang YY, Ge YP, Sun M, Chen WL, Liu WB, Li XF
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2021 Jun;244:109003

Mitochondrial metabolism is inhibited by the HIF1α-MYC-PGC-1β axis in BRAF V600E thyroid cancer.

Gao Y, Yang F, Yang XA, Zhang L, Yu H, Cheng X, Xu S, Pan J, Wang K, Li P
The FEBS journal 2019 Apr;286(7):1420-1436

miR-25 modulates triacylglycerol and lipid accumulation in goat mammary epithelial cells by repressing PGC-1beta.

Ma L, Qiu H, Chen Z, Li L, Zeng Y, Luo J, Gou D
Journal of animal science and biotechnology 2018;9:48

Benfotiamine, a Lipid-Soluble Analog of Vitamin B(1), Improves the Mitochondrial Biogenesis and Function in Blunt Snout Bream (Megalobrama amblycephala) Fed High-Carbohydrate Diets by Promoting the AMPK/PGC-1β/NRF-1 Axis.

Xu C, Liu WB, Zhang DD, Shi HJ, Zhang L, Li XF
Frontiers in physiology 2018;9:1079

Dietary leucine supplementation alters energy metabolism and induces slow-to-fast transitions in longissimus dorsi muscle of weanling piglets.

Fan Q, Long B, Yan G, Wang Z, Shi M, Bao X, Hu J, Li X, Chen C, Zheng Z, Yan X
The British journal of nutrition 2017 May;117(9):1222-1234

Hypolipidemic effect of oleanolic acid is mediated by the miR-98-5p/PGC-1β axis in high-fat diet-induced hyperlipidemic mice.

Chen S, Wen X, Zhang W, Wang C, Liu J, Liu C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Mar;31(3):1085-1096

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse liver tissue were subjected to SDS PAGE followed by western blot with 22378-1-AP( PPARGC1B Antibody) at dilution of 1:300
Other comments: WB
Appendix: 22378-1-AP.pdf

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