CABT-BL1392

antibody from Creative Diagnostics

Targeting: ERCC6L FLJ20105, PICH, RAD26L

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Antibody Data

Product number

CABT-BL1392

Provider

Creative Diagnostics

Product name

Anti-ERCC6L monoclonal antibody, clone 4G23-3C21

Antibody type

Monoclonal

Description

Plk1-interacting checkpoint helicase (PICH ) is an essential component of the spindle assembly checkpoint (Baumann, C., et al. (2007). Cell 128:101ÿ114). This protein is an ATPase family SNF2 member, and serves as a binding partner and substrate for Plk1. When PICH is phosphorylated, it retrieves Plk1 which serves to mediate the localization of PICH. As a DNA helicase, PICH gathers at kinetochores and centromeres during prometaphase, acting as a necessary part of the spindle assembly checkpoint by recruiting MAD2 and mediating chromatin centromeric tension. Depleted PICH results in the cancellation of the spindle checkpoint causing large scale missegregation of the chromosome.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

4G23-3C21

Storage

Store at -2°C or lower. Aliquot to avoid repeated freezing and thawing.