Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS5929 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- SLC5A2 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 151-196 of Human SLC5A2.
- Description
- Glucose is the main source of energy for mammalian cells and its entry is mediated by various transporters. This process involves seven facilitative (GLUT-1 to -7) and 2 concentrative glucose transporters (SGLT-1, SGLT-2) and a sensor (SGLT-3). The SGLT family members use the electrochemical gradient of two sodium ions to transport one glucose molecule. The mRNA of SGLTs increase steadily from the fetal period to maturity along with an increase in their functional activity. SGLT-1 is responsible for the uptake of the dietary sugars glucose and galactose from the intestinal lumen, while SGLT-3 is involved in the detection of luminal glucose only. Both the sodium glucose co-transporters SGLT-1 and SGLT-2 are expressed in kidneys. Mutations in the gene encoding SGLT-2 result in familial renal glucosuria (FRG), an isolated disorder of proximal tubular glucose transport, characterized by abnormal urinary glucose excretion in the presence of normal blood glucose levels.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
- Submitted by
- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of SLC5A2 pAb at 1:500 dilutionLane1:Hela cell lysateLane2:sp2/0 cell lysateLane3:H9C2 cell lysate