HPA044487

antibody from Atlas Antibodies

Targeting: GSDMD DF5L, FLJ12150, GSDMDC1

Western blot (Data presented on provider website)

Antibody Data

Product number

HPA044487

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA044487, RRID:AB_2678957

Product name

Anti-GSDMD

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human GSDMD, Gene description: gasdermin D, Alternative Gene Names: DF5L, FLJ12150, GSDMDC1, Validated applications: WB, Uniprot ID: P57764, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.2 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

SARS-CoV-2 and oncolytic EV-D68-encoded proteases differentially regulate pyroptosis

Shen S, Guo H, Li Y, Zhang L, Tang Y, Li H, Li X, Wang P, Yu X, Wei W, Liu S
Journal of Virology 2024;98(2)

---

Gasdermin D deficiency aborts myeloid calcium influx to drive granulopoiesis in lupus nephritis

Shen J, Li F, Han X, Fu D, Xu Y, Zhu C, Liang Z, Tang Z, Zheng R, Hu X, Lin R, Pei Q, Nie J, Luo N, Li X, Chen W, Mao H, Zhou Y, Yu X
Cell Communication and Signaling 2024;22(1)

---

Human Coronavirus 229E Infection Inactivates Pyroptosis Executioner Gasdermin D but Ultimately Leads to Lytic Cell Death Partly Mediated by Gasdermin E

Martiáñez-Vendrell X, Bloeme-ter Horst J, Hutchinson R, Guy C, Bowie A, Kikkert M
Viruses 2024;16(6):898

---

Enterovirus D68 Infection Induces TDP-43 Cleavage, Aggregation, and Neurotoxicity

Zhang L, Yang J, Li H, Zhang Z, Ji Z, Zhao L, Wei W, Dutch R
Journal of Virology 2023;97(4)

---

Mutations in the B30.2 and the central helical scaffold domains of pyrin differentially affect inflammasome activation

Chirita D, Bronnec P, Magnotti F, Dalmon S, Martin A, Popoff M, Gerfaud-Valentin M, Sève P, Belot A, Contis A, Duquesne A, Nocturne G, Lemelle I, Georgin-Lavialle S, Boursier G, Touitou I, Jamilloux Y, Henry T
Cell Death & Disease 2023;14(3)

---

Protein engineering reveals that gasdermin A preferentially targets mitochondrial membranes over the plasma membrane during pyroptosis.

Kondolf HC, D'Orlando DA, Dubyak GR, Abbott DW
The Journal of biological chemistry 2023 Feb;299(2):102908

---

Pyroptosis inhibiting nanobodies block Gasdermin D pore formation.

Kopp A, Hagelueken G, Jamitzky I, Moecking J, Schiffelers LDJ, Schmidt FI, Geyer M
Nature communications 2023 Dec 1;14(1):7923

---

Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism

Magnotti F, Chirita D, Dalmon S, Martin A, Bronnec P, Sousa J, Helynck O, Lee W, Kastner D, Chae J, McDermott M, Belot A, Popoff M, Sève P, Georgin-Lavialle S, Munier-Lehmann H, Tran T, De Langhe E, Wouters C, Jamilloux Y, Henry T
Cell Reports 2022;41(2):111472

---

Gasdermins and pannexin-1 mediate pathways of chemotherapy-induced cell lysis in hematopoietic malignancies.

Zhou B, Ryder CB, Dubyak GR, Abbott DW
Science signaling 2022 Dec 20;15(765):eabl6781

---

Gasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages

Theobald S, Gräb J, Fritsch M, Suárez I, Eisfeld H, Winter S, Koch M, Hölscher C, Pasparakis M, Kashkar H, Rybniker J
Cell Death Discovery 2021;7(1)

---

Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases.

Zhou B, Abbott DW
Cell reports 2021 Apr 13;35(2):108998

---

Human polymorphisms in GSDMD alter the inflammatory response

Rathkey J, Xiao T, Abbott D
Journal of Biological Chemistry 2020;295(10):3228-3238