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- Antigen structure
- References [19]
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- Western blot [1]
- Immunohistochemistry [3]
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- Product number
- NBP2-33422 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP2-33422, RRID:AB_2687913
- Product name
- Rabbit Polyclonal GSDMDC1 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Specificity of human GSDMDC1 antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Caspase-3 Promotes Diabetic Kidney Disease Through Gasdermin E-Mediated Progression to Secondary Necrosis During Apoptosis.
Caspase-1 interdomain linker cleavage is required for pyroptosis.
Minocycline alleviates NLRP3 inflammasome-dependent pyroptosis in monosodium glutamate-induced depressive rats.
Inactivation of the Cytoprotective Major Vault Protein by Caspase-1 and -9 in Epithelial Cells during Apoptosis.
Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer.
Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation.
Human Lung Cell Pyroptosis Following Traumatic Brain Injury.
Intracellular C3 Protects Human Airway Epithelial Cells from Stress-associated Cell Death.
Toxoplasma gondii activates a Syk-CARD9-NF-κB signaling axis and gasdermin D-independent release of IL-1β during infection of primary human monocytes.
Contribution of the inflammasome to inflammaging.
Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury.
Progressive waves of IL-1β release by primary human monocytes via sequential activation of vesicular and gasdermin D-mediated secretory pathways.
The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages.
Supporting those who work and learn: A phenomenological research study.
DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia.
DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis.
Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages.
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.
Wen S, Wang ZH, Zhang CX, Yang Y, Fan QL
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:313-323
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:313-323
Caspase-1 interdomain linker cleavage is required for pyroptosis.
Ball DP, Taabazuing CY, Griswold AR, Orth EL, Rao SD, Kotliar IB, Vostal LE, Johnson DC, Bachovchin DA
Life science alliance 2020 Mar;3(3)
Life science alliance 2020 Mar;3(3)
Minocycline alleviates NLRP3 inflammasome-dependent pyroptosis in monosodium glutamate-induced depressive rats.
Yang F, Zhu W, Cai X, Zhang W, Yu Z, Li X, Zhang J, Cai M, Xiang J, Cai D
Biochemical and biophysical research communications 2020 Jun 4;526(3):553-559
Biochemical and biophysical research communications 2020 Jun 4;526(3):553-559
Inactivation of the Cytoprotective Major Vault Protein by Caspase-1 and -9 in Epithelial Cells during Apoptosis.
Grossi S, Fenini G, Kockmann T, Hennig P, Di Filippo M, Beer HD
The Journal of investigative dermatology 2020 Jul;140(7):1335-1345.e10
The Journal of investigative dermatology 2020 Jul;140(7):1335-1345.e10
Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer.
Ma J, Ramachandran M, Jin C, Quijano-Rubio C, Martikainen M, Yu D, Essand M
Cell death & disease 2020 Jan 22;11(1):48
Cell death & disease 2020 Jan 22;11(1):48
Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation.
Burgener SS, Leborgne NGF, Snipas SJ, Salvesen GS, Bird PI, Benarafa C
Cell reports 2019 Jun 18;27(12):3646-3656.e5
Cell reports 2019 Jun 18;27(12):3646-3656.e5
Human Lung Cell Pyroptosis Following Traumatic Brain Injury.
Kerr NA, de Rivero Vaccari JP, Umland O, Bullock MR, Conner GE, Dietrich WD, Keane RW
Cells 2019 Jan 18;8(1)
Cells 2019 Jan 18;8(1)
Intracellular C3 Protects Human Airway Epithelial Cells from Stress-associated Cell Death.
Kulkarni HS, Elvington ML, Perng YC, Liszewski MK, Byers DE, Farkouh C, Yusen RD, Lenschow DJ, Brody SL, Atkinson JP
American journal of respiratory cell and molecular biology 2019 Feb;60(2):144-157
American journal of respiratory cell and molecular biology 2019 Feb;60(2):144-157
Toxoplasma gondii activates a Syk-CARD9-NF-κB signaling axis and gasdermin D-independent release of IL-1β during infection of primary human monocytes.
Pandori WJ, Lima TS, Mallya S, Kao TH, Gov L, Lodoen MB
PLoS pathogens 2019 Aug;15(8):e1007923
PLoS pathogens 2019 Aug;15(8):e1007923
Contribution of the inflammasome to inflammaging.
Mejias NH, Martinez CC, Stephens ME, de Rivero Vaccari JP
Journal of inflammation (London, England) 2018;15:23
Journal of inflammation (London, England) 2018;15:23
Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury.
Zhang Z, Shao X, Jiang N, Mou S, Gu L, Li S, Lin Q, He Y, Zhang M, Zhou W, Ni Z
Cell death & disease 2018 Sep 24;9(10):983
Cell death & disease 2018 Sep 24;9(10):983
Progressive waves of IL-1β release by primary human monocytes via sequential activation of vesicular and gasdermin D-mediated secretory pathways.
Semino C, Carta S, Gattorno M, Sitia R, Rubartelli A
Cell death & disease 2018 Oct 23;9(11):1088
Cell death & disease 2018 Oct 23;9(11):1088
The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages.
Evavold CL, Ruan J, Tan Y, Xia S, Wu H, Kagan JC
Immunity 2018 Jan 16;48(1):35-44.e6
Immunity 2018 Jan 16;48(1):35-44.e6
Supporting those who work and learn: A phenomenological research study.
Thurgate C
Nurse education today 2018 Feb;61:83-88
Nurse education today 2018 Feb;61:83-88
DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia.
Johnson DC, Taabazuing CY, Okondo MC, Chui AJ, Rao SD, Brown FC, Reed C, Peguero E, de Stanchina E, Kentsis A, Bachovchin DA
Nature medicine 2018 Aug;24(8):1151-1156
Nature medicine 2018 Aug;24(8):1151-1156
DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis.
Okondo MC, Johnson DC, Sridharan R, Go EB, Chui AJ, Wang MS, Poplawski SE, Wu W, Liu Y, Lai JH, Sanford DG, Arciprete MO, Golub TR, Bachovchin WW, Bachovchin DA
Nature chemical biology 2017 Jan;13(1):46-53
Nature chemical biology 2017 Jan;13(1):46-53
Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages.
Taabazuing CY, Okondo MC, Bachovchin DA
Cell chemical biology 2017 Apr 20;24(4):507-514.e4
Cell chemical biology 2017 Apr 20;24(4):507-514.e4
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.
Liu X, Zhang Z, Ruan J, Pan Y, Magupalli VG, Wu H, Lieberman J
Nature 2016 Jul 7;535(7610):153-8
Nature 2016 Jul 7;535(7610):153-8
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.
Shi J, Zhao Y, Wang K, Shi X, Wang Y, Huang H, Zhuang Y, Cai T, Wang F, Shao F
Nature 2015 Oct 29;526(7575):660-5
Nature 2015 Oct 29;526(7575):660-5
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: GSDMDC1 Antibody [NBP2-33422] - Analysis in human cell lines U2OS and HEK293 using anti-GSDMD antibody. Corresponding GSDMD RNA-seq data are presented for the same cell lines. Loading control: anti-HSP90B1.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: GSDMDC1 Antibody [NBP2-33422] - Staining of human fallopian tube shows moderate to strong cytoplasmic and membranous positivity in glandular cells.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: GSDMDC1 Antibody [NBP2-33422] - Staining of human small intestine shows moderate cytoplasmic and membranous positivity in glandular cells.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: GSDMDC1 Antibody [NBP2-33422] - Staining of human stomach shows moderate cytoplasmic and membranous positivity in glandular cells.
