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- Product number
- 20770-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20770-1-AP, RRID:AB_10696319
- Product name
- GSDMD antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated GSDMD antibody (Cat. #20770-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Identification of Azalamellarin N as a Pyroptosis Inhibitor.
Xinfeng Capsule Inhibits Pyroptosis and Ameliorates Myocardial Injury in Rats with Adjuvant Arthritis via the GAS5/miR-21/TLR4 Axis.
TAK1 inhibition mitigates intracerebral hemorrhage-induced brain injury through reduction of oxidative stress and neuronal pyroptosis via the NRF2 signaling pathway.
Toll-Like Receptor 9 Aggravates Pulmonary Fibrosis by Promoting NLRP3-Mediated Pyroptosis of Alveolar Epithelial Cells.
LncRNA H19/miR-107 regulates endothelial progenitor cell pyroptosis and promotes flow recovery of lower extremity ischemia through targeting FADD.
A palmitoylation-depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis.
Conditioned medium from human dental pulp stem cells treats spinal cord injury by inhibiting microglial pyroptosis.
Platelet-rich plasma-derived extracellular vesicles inhibit NF-κB/NLRP3 pathway-mediated pyroptosis in intervertebral disc degeneration via the MALAT1/microRNA-217/SIRT1 axis.
Transcriptomics confirms IRF1 as a key regulator of pyroptosis in diabetic retinopathy.
MSC-derived exosomal miR-140-3p improves cognitive dysfunction in sepsis-associated encephalopathy by HMGB1 and S-lactoylglutathione metabolism.
Natural compound library screening to identify berberine as a treatment for rheumatoid arthritis.
Human vascular smooth muscle cells utilise chymase for the atypical cleavage and activation of Interleukin-1β.
GSDMD mediated pyroptosis induced inflammation of Graves' orbitopathy via the NF-κB/ AIM2/ Caspase-1 pathway.
PI3K/AKT signaling pathway associates with pyroptosis and inflammation in patients with endometriosis.
BRCC36 Deubiquitinates HMGCR to Regulate the Interplay Between Ferroptosis and Pyroptosis.
Kongensin a attenuates intervertebral disc degeneration by inhibiting TAK1-mediated PANoptosis of nucleus pulposus cells.
Effect of lipopolysaccharide on TAK1-mediated hepatocyte PANoptosis through Toll-like receptor 4 during acute liver failure.
Punicalagin Ameliorates Diabetic Liver Injury by Inhibiting Pyroptosis and Promoting Autophagy via Modulation of the FoxO1/TXNIP Signaling Pathway.
Efficient Delivery of Lomitapide using Hybrid Membrane-Coated Tetrahedral DNA Nanostructures for Glioblastoma Therapy.
A natural hydrogel complex improves intervertebral disc degeneration by correcting fatty acid metabolism and inhibiting nucleus pulposus cell pyroptosis.
Modulating synovial macrophage pyroptosis and mitophagy interactions to mitigate osteoarthritis progression using functionalized nanoparticles.
Elevated NLRP3 Inflammasome Activation Is Associated with Motor Neuron Degeneration in ALS.
Neutrophil extracellular traps induce pyroptosis of pulmonary microvascular endothelial cells by activating the NLRP3 inflammasome.
Bacillus cereus CwpFM induces colonic tissue damage and inflammatory responses through oxidative stress and the NLRP3/NF-κB pathway.
Tangeretin attenuates acute lung injury in septic mice by inhibiting ROS-mediated NLRP3 inflammasome activation via regulating PLK1/AMPK/DRP1 signaling axis.
Pyroptosis-related gene signature elicits immune response in rosacea.
Prognostic, immunity, stemness, and anticancer drug sensitivity characterization of pyroptosis related genes in non-small cell lung cancer.
Preparation and characterization of monoclonal antibodies against porcine gasdermin D protein.
A slow-releasing donor of hydrogen sulfide inhibits neuronal cell death via anti-PANoptosis in rats with spinal cord ischemia‒reperfusion injury.
Neuroprotective effects of Jie-du-huo-xue decoction on microglia pyroptosis after cerebral ischemia and reperfusion--From the perspective of glial-vascular unit.
Modified Simiaowan prevents and treats gouty arthritis via the Nrf2/NLRP3 inflammasome signaling pathway.
Neuronal pyroptosis mediated by STAT3 in early brain injury after subarachnoid hemorrhage.
Deficiency of N6-Methyladenosine Demethylase ALKBH5 Alleviates Ultraviolet B Radiation-Induced Chronic Actinic Dermatitis via Regulating Pyroptosis.
Tangeretin Attenuates Cerebral Ischemia-Reperfusion-Induced Neuronal Pyroptosis by Inhibiting AIM2 Inflammasome Activation via Regulating NRF2.
Serabelisib regulates GSDMD-mediated pyroptosis, apoptosis and migration of hepatoma cells via the PI3K/Akt/E-cadherin signaling pathway.
Ibuprofen inhibits anaplastic thyroid cells in vivo and in vitro by triggering NLRP3-ASC-GSDMD-dependent pyroptosis.
Dihydroxyacetone phosphate accumulation leads to podocyte pyroptosis in diabetic kidney disease.
KLF4 interacts with TXNIP to modulate the pyroptosis in ulcerative colitis via regulating NLRP3 signaling.
Berberine inhibits NLRP3 inflammasome activation by regulating mTOR/mtROS axis to alleviate diabetic cardiomyopathy.
SERTAD1 initiates NLRP3-mediated inflammasome activation through restricting NLRP3 polyubiquitination.
PANoptosis in vascular smooth muscle cells regulated by TNF-α/IL-1β can be a new target for alleviating the progression of abdominal aortic aneurysm.
PANoptosis signaling enables broad immune response in psoriasis: From pathogenesis to new therapeutic strategies.
Dihydroartemisinin-driven TOM70 inhibition leads to mitochondrial destabilization to induce pyroptosis against lung cancer.
Obstructive Sleep Apnea Plasma-Derived Exosomes Mediate Cognitive Impairment Through Hippocampal Neuronal Cell Pyroptosis.
Apoptosis and pyroptosis in the nasal mucosa of Syrian hamster during SARS-CoV-2 infection and reinfection.
Co-exposure of microcystin-LR and nitrite induced kidney injury through TLR4/NLRP3/GSDMD-mediated pyroptosis.
STAT4-Mediated Klotho Up-Regulation Contributes to the Brain Ischemic Tolerance by Cerebral Ischemic Preconditioning via Inhibiting Neuronal Pyroptosis.
Ketamine Improves the Glymphatic Pathway by Reducing the Pyroptosis of Hippocampal Astrocytes in the Chronic Unpredictable Mild Stress Model.
Identification of PKM2 as a pyroptosis-related key gene aggravates senile osteoporosis via the NLRP3/Caspase-1/GSDMD signaling pathway.
Gypenoside XLIX alleviates acute liver injury: Emphasis on NF-κB/PPAR-α/NLRP3 pathways.
Inhibition of spinal BRD4 alleviates pyroptosis and M1 microglia polarization via STING-IRF3 pathway in morphine-tolerant rats.
Preliminary investigation into the impact of BPA on osteoblast activity and bone development: In vitro and in vivo models.
LncRNA GAS5 restrains ISO-induced cardiac fibrosis by modulating mir-217 regulation of SIRT1.
Circular RNA protein tyrosine kinase 2 aggravates pyroptosis and inflammation in septic lung tissue by promoting microRNA-766/eukaryotic initiation factor 5A axis-mediated ATP efflux.
Inhibition of Schwann Cell Pyroptosis Promotes Nerve Regeneration in Peripheral Nerve Injury in Rats.
Transcutaneous Electrical Nerve Stimulation (TENS) Alleviates Brain Ischemic Injury by Regulating Neuronal Oxidative Stress, Pyroptosis, and Mitophagy.
High-dose remifentanil exacerbates myocardial ischemia-reperfusion injury through activation of calcium-sensing receptor-mediated pyroptosis.
Suppression of NLRP3/Caspase-1/GSDMD Mediated Corneal Epithelium Pyroptosis Using Melatonin-Loaded Liposomes to Inhibit Benzalkonium Chloride-Induced Dry Eye Disease.
Network Pharmacology Analysis and Machine-Learning Models Confirmed the Ability of YiShen HuoXue Decoction to Alleviate Renal Fibrosis by Inhibiting Pyroptosis.
Transcutaneous electrical acupoint stimulation alleviates cerebral ischemic injury through the TLR4/MyD88/NF-κ B pathway.
Qinhuo Shanggan oral solution resolves acute lung injury by down-regulating TLR4/NF-κB signaling cascade and inhibiting NLRP3 inflammasome activation.
The non-canonical inflammasome activators Caspase-4 and Caspase-5 are differentially regulated during immunosuppression-associated organ damage.
A novel colchicine-myricetin heterozygous molecule: design, synthesis, and effective evaluations on the pathological models of acute lung injury in vitro and in vivo.
β-sitosterol alleviates dextran sulfate sodium-induced experimental colitis via inhibition of NLRP3/Caspase-1/GSDMD-mediated pyroptosis.
Phenylalanine promotes alveolar macrophage pyroptosis via the activation of CaSR in ARDS.
Silibinin ameliorates deoxycholic acid-induced pyroptosis in steatotic HepG2 cells by inhibiting NLRP3 inflammasome activation.
CD73 mitigates hepatic damage in alcoholic steatohepatitis by regulating PI3K/AKT-mediated hepatocyte pyroptosis.
Bone marrow mesenchymal stem cellsderived exosomes stabilize atherosclerosis through inhibiting pyroptosis.
Oryza sativa L. Indica Seed Coat Ameliorated Concanavalin A-Induced Acute Hepatitis in Mice via MDM2/p53 and PKCα/MAPK1 Signaling Pathways.
Steroidal saponins PPI/CCRIS/PSV induce cell death in pancreatic cancer cell through GSDME-dependent pyroptosis.
Loganin reduces diabetic kidney injury by inhibiting the activation of NLRP3 inflammasome-mediated pyroptosis.
A high-throughput Gaussia luciferase reporter assay for screening potential gasdermin E activators against pancreatic cancer.
Systemic pharmacology reveal the mechanism by which the Qiangjin Zhuanggu Qufeng mixture inhibits LPS-induced pyroptosis of rat nucleus pulposus cells.
GSDMD promotes neutrophil extracellular traps via mtDNA-cGAS-STING pathway during lung ischemia/reperfusion.
Aluminum exposure induces central nervous system impairment via activating NLRP3-medicated pyroptosis pathway.
Oxalate‑induced renal pyroptotic injury and crystal formation mediated by NLRP3‑GSDMD signaling in vitro and in vivo.
Selenium Deficiency via the ROS/NLRP3/IL-1β Signaling Pathway Leads to Pyroptosis Injury in Pig Spleen.
Escherichia coli infection mediates pyroptosis via activating p53-p21 pathway-regulated apoptosis and cell cycle arrest in bovine mammary epithelial cells.
Butyrate alleviates renal fibrosis in CKD by regulating NLRP3-mediated pyroptosis via the STING/NF-κB/p65 pathway.
Irisin suppresses pancreatic β cell pyroptosis in T2DM by inhibiting the NLRP3-GSDMD pathway and activating the Nrf2-TrX/TXNIP signaling axis.
Regulation of megakaryo/thrombopoiesis by endosomal toll-like receptor 7 and 8 activation of CD34(+) cells in a viral infection model.
The involvement of DDX3X in compression-induced nucleus pulposus pyroptosis.
Pyroptosis of Macrophages Induced by Clostridium perfringens Beta-1 Toxin.
Gasdermin D Plays an Oncogenic Role in Glioma and Correlates to an Immunosuppressive Microenvironment.
HuNoV Non-Structural Protein P22 Induces Maturation of IL-1β and IL-18 and N-GSDMD-Dependent Pyroptosis through Activating NLRP3 Inflammasome.
Single-cell sequencing reveals homogeneity and heterogeneity of the cytopathological mechanisms in different etiology-induced AKI.
Elsholtzia bodinieri Vaniot ameliorated acute lung injury in mice by regulating pyroptosis, inflammation, oxidative stress and macrophage polarization.
hASCs-derived exosomal miR-155-5p targeting TGFβR2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration.
Cytoskeletal protein SPTA1 mediating the decrease in erectile function induced by high-fat diet via Hippo signaling pathway.
Hydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes.
Emodin alleviates testicular ischemia-reperfusion injury through the inhibition of NLRP3-mediated pyroptosis.
Sulconazole Induces PANoptosis by Triggering Oxidative Stress and Inhibiting Glycolysis to Increase Radiosensitivity in Esophageal Cancer.
Baicalin inhibited both the Furin/TGFβ1/Smad3/TSP-1 pathway in endothelial cells and the AKT/Ca(2+)/ROS pathway in platelets to ameliorate inflammatory coagulopathy.
Withdrawn: Ticagrelor reduces myocardial cell injury induced by myocardial ischemia/reperfusion in diabetic rats by activating JAK2/STAT3.
Fibrin glue delivery system containing rhein ameliorates intervertebral disc degeneration by anti-inflammatory efficacy.
Exercise-induced irisin improves follicular dysfunction by inhibiting IRE1α-TXNIP/ROS-NLRP3 pathway in PCOS.
circACTA2 inhibits NLRP3 inflammasome-mediated inflammation via interacting with NF-κB in vascular smooth muscle cells.
Neobavaisoflavone induces pyroptosis of liver cancer cells via Tom20 sensing the activated ROS signal.
Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia.
Induced neural stem cells suppressed neuroinflammation by inhibiting the microglial pyroptotic pathway in intracerebral hemorrhage rats.
Dihydromyricetin inhibits African swine fever virus replication by downregulating toll-like receptor 4-dependent pyroptosis in vitro.
Attenuation of experimental osteoarthritis with human adipose-derived mesenchymal stem cell therapy: inhibition of the pyroptosis in chondrocytes.
Trophoblastic mitochondrial DNA induces endothelial dysfunction and NLRP3 inflammasome activation: Implications for preeclampsia.
Protective effects of leonurine hydrochloride on pyroptosis in premature ovarian insufficiency via regulating NLRP3/GSDMD pathway.
TMBIM4 Deficiency Facilitates NLRP3 Inflammasome Activation-Induced Pyroptosis of Trophoblasts: A Potential Pathogenesis of Preeclampsia.
Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis.
Jatrorrhizine Suppresses Murine-Norovirus-Triggered N-GSDMD-Dependent Pyroptosis in RAW264.7 Macrophages.
PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons.
Ginsenoside Rg3 Ameliorates DSS-Induced Colitis by Inhibiting NLRP3 Inflammasome Activation and Regulating Microbial Homeostasis.
Apoptosis or Antiapoptosis? Interrupted Regulated Cell Death of Host Cells by Ascovirus Infection In Vitro.
Alpha-kinase1 promotes tubular injury and interstitial inflammation in diabetic nephropathy by canonical pyroptosis pathway.
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice.
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Inhibition of Caspase-11-Mediated Pyroptosis Alleviates Acute Kidney Injury Associated with Severe Acute Pancreatitis in Rats.
Inhibition of macrophage pyroptosis ameliorates silica-induced pulmonary fibrosis.
Ursodeoxycholic acid alleviates sepsis-induced lung injury by blocking PANoptosis via STING pathway.
ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation.
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression.
CASP1 is a target for combination therapy in pancreatic cancer.
Paeoniflorin recued hepatotoxicity under zinc oxide nanoparticles exposure via regulation on gut-liver axis and reversal of pyroptosis.
Hyperuricemia promotes the progression of atherosclerosis by activating endothelial cell pyroptosis via the ROS/NLRP3 pathway.
MiR-195-5p is involved in testicular ischemia/reperfusion injury by directly targeting PELP1 and regulating spermatogonia pyroptosis.
Exploring the application of sildenafil for high-fat diet-induced erectile dysfunction based on interleukin-18-mediated NLRP3/Caspase-1 signaling pathway.
SMAD2 inhibits pyroptosis of fibroblast-like synoviocytes and secretion of inflammatory factors via the TGF-β pathway in rheumatoid arthritis.
Protective Role of Vitamin K3 on SARS-CoV-2 Structural Protein-Induced Inflammation and Cell Death.
GABA(B) Receptor Activation Attenuates Neuronal Pyroptosis in Post-cardiac Arrest Brain Injury.
A novel mechanism regulating pyroptosis-induced fibrosis in endometriosis via lnc-MALAT1/miR-141-3p/NLRP3 pathway†.
Schisandrin B induces HepG2 cells pyroptosis by activating NK cells mediated anti-tumor immunity.
SARS-CoV-2 E protein-induced THP-1 pyroptosis is reversed by Ruscogenin.
Irisin attenuates acute lung injury by suppressing the pyroptosis of alveolar macrophages.
Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells.
Overexpression of CASP1 triggers acute promyelocytic leukemia cell pyroptosis and differentiation.
Oroxin A ameliorates the oleic acid-induced A549 cell injury through the suppression of pyroptosis and degradation of alveolar surfactant.
Induction of Pyroptosis in Renal Tubular Epithelial Cells Using High Glucose.
Luteolin Induced Hippocampal Neuronal Pyroptosis Inhibition by Regulation of miR-124-3p/TNF-α/TRAF6 Axis in Mice Affected by Breast-Cancer-Related Depression.
Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis.
Lignans from Mosla scabra Ameliorated Influenza A Virus-Induced Pneumonia via Inhibiting Macrophage Activation.
Microtubule affinity regulating kinase 4 promoted activation of the NLRP3 inflammasome-mediated pyroptosis in periodontitis.
NLRP3 downregulation enhances engraftment and functionality of adipose-derived stem cells to alleviate erectile dysfunction in diabetic rats.
Natural Compound Library Screening Identifies Oroxin A for the Treatment of Myocardial Ischemia/Reperfusion Injury.
Protective Effect of Danshen Zexie Decoction Against Non-Alcoholic Fatty Liver Disease Through Inhibition of ROS/NLRP3/IL-1β Pathway by Nrf2 Signaling Activation.
Herpes Simplex Virus 1 Induces Microglia Gasdermin D-Dependent Pyroptosis Through Activating the NLR Family Pyrin Domain Containing 3 Inflammasome.
Cochlear Marginal Cell Pyroptosis Is Induced by Cisplatin via NLRP3 Inflammasome Activation.
Fucoidan Alleviates Renal Fibrosis in Diabetic Kidney Disease via Inhibition of NLRP3 Inflammasome-Mediated Podocyte Pyroptosis.
Pyroptosis relates to tumor microenvironment remodeling and prognosis: A pan-cancer perspective.
Prognostic value and immune infiltration of the gasdermin family in lung adenocarcinoma.
Lactobacillus rhamnosus GR-1 attenuates foodborne Bacillus cereus-induced NLRP3 inflammasome activity in bovine mammary epithelial cells by protecting intercellular tight junctions.
Gasdermin D is involved in switching from apoptosis to pyroptosis in TLR4-mediated renal tubular epithelial cells injury in diabetic kidney disease.
Bisdemethoxycurcumin Alleviates Dextran Sodium Sulfate-Induced Colitis via Inhibiting NLRP3 Inflammasome Activation and Modulating the Gut Microbiota in Mice.
Nuclear translocation of Gasdermin D sensitizes colorectal cancer to chemotherapy in a pyroptosis-independent manner.
S100A8-Mediated NLRP3 Inflammasome-Dependent Pyroptosis in Macrophages Facilitates Liver Fibrosis Progression.
The role of discoid domain receptor 1 on renal tubular epithelial pyroptosis in diabetic nephropathy.
Anti‑β(2)GPI/β(2)GPI induces neutrophil pyroptosis and thereby enhances ICAM‑1 and IL‑8 expression in endothelial cells.
Silica nanoparticles induce pyroptosis and cardiac hypertrophy via ROS/NLRP3/Caspase-1 pathway.
The TLR-chaperone CNPY3 is a critical regulator of NLRP3-inflammasome activation.
3,4,5-O-tricaffeoylquinic acid with anti-radiation activity suppresses LPS-induced NLRP3 inflammasome activation via autophagy in THP-1 macrophages.
Crosstalk Between RPE Cells and Choroidal Endothelial Cells via the ANXA1/FPR2/SHP2/NLRP3 Inflammasome/Pyroptosis Axis Promotes Choroidal Neovascularization.
ATG5-Mediated Autophagy May Inhibit Pyroptosis to Ameliorate Oleic Acid-Induced Hepatocyte Steatosis.
Elsholtzia bodinieri Vaniot Ameliorated Acute Lung Injury by NQO1, BCL2 and PTGS2 In Silico and In Vitro Analyses.
Extracellular traps from activated vascular smooth muscle cells drive the progression of atherosclerosis.
Curcumin activates NLRC4, AIM2, and IFI16 inflammasomes and induces pyroptosis by up-regulated ISG3 transcript factor in acute myeloid leukemia cell lines.
The selective NLRP3 inflammasome inhibitor MCC950 improves isoproterenol-induced cardiac dysfunction by inhibiting cardiomyocyte senescence.
NLRP6 Induces Lung Injury and Inflammation Early in Brucella and Influenza Coinfection.
Anti-depressant effects of acupuncture: The insights from NLRP3 mediated pyroptosis and inflammation.
Alda-1, an Activator of ALDH2, Improves Postresuscitation Cardiac and Neurological Outcomes by Inhibiting Pyroptosis in Swine.
Tubastatin A Improves Post-Resuscitation Myocardial Dysfunction by Inhibiting NLRP3-Mediated Pyroptosis Through Enhancing Transcription Factor EB Signaling.
Baclofen attenuates cognitive deficits in post-cardiac arrest brain injury.
Dietary Tryptophan Supplementation Improves Antioxidant Status and Alleviates Inflammation, Endoplasmic Reticulum Stress, Apoptosis, and Pyroptosis in the Intestine of Piglets after Lipopolysaccharide Challenge.
Escin Sodium Improves the Prognosis of Acute Pancreatitis via Promoting Cell Apoptosis by Suppression of the ERK/STAT3 Signaling Pathway.
Sodium Houttuyfonate Ameliorates β-amyloid(1-42)-Induced Memory Impairment and Neuroinflammation through Inhibiting the NLRP3/GSDMD Pathway in Alzheimer's Disease.
Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo.
Destructive Effects of Pyroptosis on Homeostasis of Neuron Survival Associated with the Dysfunctional BBB-Glymphatic System and Amyloid-Beta Accumulation after Cerebral Ischemia/Reperfusion in Rats.
Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome-Induced Pyroptosis via Inhibiting the TLR4/NF-κB/PFKFB3 Signaling in Trophoblasts: Implication for a Potential Therapy of Preeclampsia.
Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3/caspase-1/GSDMD Pathway in Triple-Negative Breast Cancer.
Ginsenoside Rg1 Inhibits Microglia Pyroptosis Induced by Lipopolysaccharide Through Regulating STAT3 Signaling.
Assessment of Pyroptosis-Related Indicators as Potential Biomarkers and Their Association with Severity in Patients with Liver Cirrhosis.
Mesenchymal Stem Cells Alleviate Post-resuscitation Cardiac and Cerebral Injuries by Inhibiting Cell Pyroptosis and Ferroptosis in a Swine Model of Cardiac Arrest.
Metallothionein 3-Zinc Axis Suppresses Caspase-11 Inflammasome Activation and Impairs Antibacterial Immunity.
CBD Alleviates Liver Injuries in Alcoholics With High-Fat High-Cholesterol Diet Through Regulating NLRP3 Inflammasome-Pyroptosis Pathway.
siRNAs Targeting Mouse-Specific lncRNA AA388235 Induce Human Tumor Cell Pyroptosis/Apoptosis.
Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration.
Engineering Extracellular Vesicles Restore the Impaired Cellular Uptake and Attenuate Intervertebral Disc Degeneration.
Plasma exosomes derived from patients with intestinal Behçet's syndrome induce intestinal epithelial cell pyroptosis.
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
(-)-Epicatechin ameliorates cigarette smoke-induced lung inflammation via inhibiting ROS/NLRP3 inflammasome pathway in rats with COPD.
The relationship between liver pathological inflammation degree and pyroptosis in chronic hepatitis B patients.
Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway.
The balance between AIM2-associated inflammation and autophagy: the role of CHMP2A in brain injury after cardiac arrest.
Gasdermin D Is a Novel Prognostic Biomarker and Relates to TMZ Response in Glioblastoma.
Mesenchymal stromal cells protect hepatocytes from lipotoxicity through alleviation of endoplasmic reticulum stress by restoring SERCA activity.
Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes.
Macrophage membrane-mediated targeted drug delivery for treatment of spinal cord injury regardless of the macrophage polarization states.
Suppressing ROS generation by apocynin inhibited cyclic stretch-induced inflammatory reaction in HPDLCs via a caspase-1 dependent pathway.
Low shear stress induced vascular endothelial cell pyroptosis by TET2/SDHB/ROS pathway.
Histone deacetylase 2 regulates ULK1 mediated pyroptosis during acute liver failure by the K68 acetylation site.
Gasdermin D: in vivo evidence of pyroptosis in spontaneous labor at term.
Macrophages regulates the transition of pericyte to peritoneal fibrosis through the GSDMD/IL-1β axis.
Isoorientin Attenuated the Pyroptotic Hepatocyte Damage Induced by Benzo[a]pyrene via ROS/NF-κB/NLRP3/Caspase-1 Signaling Pathway.
Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP.
CD147 Expression Is Associated with Tumor Proliferation in Bladder Cancer via GSDMD.
Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis.
Overexpression of gasdermin D promotes invasion of adenoid cystic carcinoma.
Detection of proteins associated with the pyroptosis signaling pathway in breast cancer tissues and their significance.
Tangshen Formula Attenuates Diabetic Kidney Injury by Imparting Anti-pyroptotic Effects via the TXNIP-NLRP3-GSDMD Axis.
IFN regulatory Factor-1 induced macrophage pyroptosis by modulating m6A modification of circ_0029589 in patients with acute coronary syndrome.
Trimethylamine N-oxide promotes apoE(-/-) mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway.
Type I Interferon Increases Inflammasomes Associated Pyroptosis in the Salivary Glands of Patients with Primary Sjögren's Syndrome.
MiR-124-3p promotes trophoblast cell HTR-8/SVneo pyroptosis by targeting placental growth factor.
Exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the NLRP3 inflammasome in mice.
HMGB1 mediates homocysteine-induced endothelial cells pyroptosis via cathepsin V-dependent pathway.
NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology.
TNF-α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury.
Discovery of novel TNNI3K inhibitor suppresses pyroptosis and apoptosis in murine myocardial infarction injury.
Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer.
Cyclin-Dependent Kinase 9 Inhibition Suppresses Necroptosis and Pyroptosis in the Progress of Endotoxemia.
Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis.
IFN Regulatory Factor 1 Mediates Macrophage Pyroptosis Induced by Oxidized Low-Density Lipoprotein in Patients with Acute Coronary Syndrome.
HMGB1-induced endothelial cell pyroptosis is involved in systemic inflammatory response syndrome following radiofrequency ablation of hepatic hemangiomas.
Trichomonas vaginalis Induces NLRP3 Inflammasome Activation and Pyroptotic Cell Death in Human Macrophages.
TLR4/NF-κB Signaling Induces GSDMD-Related Pyroptosis in Tubular Cells in Diabetic Kidney Disease.
Neferine inhibits LPS-ATP-induced endothelial cell pyroptosis via regulation of ROS/NLRP3/Caspase-1 signaling pathway.
Gasdermin D: Evidence of pyroptosis in spontaneous preterm labor with sterile intra-amniotic inflammation or intra-amniotic infection.
Endothelial pyroptosis underlies systemic inflammatory response following radiofrequency ablation of hepatic hemangiomas.
Bacteroides fragilis Strain ZY-312 Defense against Cronobacter sakazakii-Induced Necrotizing Enterocolitis In Vitro and in a Neonatal Rat Model.
Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis.
Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts.
Atypical Gasdermin D and Mixed Lineage Kinase Domain-like Protein Leakage Aggravates Tetrachlorobenzoquinone-Induced Nod-like Receptor Protein 3 Inflammasome Activation.
Protein kinase D at the Golgi controls NLRP3 inflammasome activation.
Inflammasome activators induce fibronectin expression and release in macrophages.
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion.
Takouda J, Nakamura M, Murasaki A, Shimosako W, Hidaka A, Honda S, Tanimura S, Ishibashi F, Kawasaki N, Ishihara J, Fukuda T, Takeda K
Biological & pharmaceutical bulletin 2024;47(1):28-36
Biological & pharmaceutical bulletin 2024;47(1):28-36
Xinfeng Capsule Inhibits Pyroptosis and Ameliorates Myocardial Injury in Rats with Adjuvant Arthritis via the GAS5/miR-21/TLR4 Axis.
Fu W, Cao Y, Liu J, Huang C, Shu K, Zhu N
Drug design, development and therapy 2024;18:2421-2433
Drug design, development and therapy 2024;18:2421-2433
TAK1 inhibition mitigates intracerebral hemorrhage-induced brain injury through reduction of oxidative stress and neuronal pyroptosis via the NRF2 signaling pathway.
Zhao J, Chen C, Ge L, Jiang Z, Hu Z, Yin L
Frontiers in immunology 2024;15:1386780
Frontiers in immunology 2024;15:1386780
Toll-Like Receptor 9 Aggravates Pulmonary Fibrosis by Promoting NLRP3-Mediated Pyroptosis of Alveolar Epithelial Cells.
Ren C, Wang Q, Fan S, Mi T, Zhang Z, He D
Inflammation 2024 Oct;47(5):1744-1761
Inflammation 2024 Oct;47(5):1744-1761
LncRNA H19/miR-107 regulates endothelial progenitor cell pyroptosis and promotes flow recovery of lower extremity ischemia through targeting FADD.
Huang L, Ye Y, Sun Y, Zhou Z, Deng T, Liu Y, Wu R, Wang K, Yao C
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167323
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167323
A palmitoylation-depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis.
Zhang N, Zhang J, Yang Y, Shan H, Hou S, Fang H, Ma M, Chen Z, Tan L, Xu D
Nature cell biology 2024 May;26(5):757-769
Nature cell biology 2024 May;26(5):757-769
Conditioned medium from human dental pulp stem cells treats spinal cord injury by inhibiting microglial pyroptosis.
Liu T, Ma Z, Liu L, Pei Y, Wu Q, Xu S, Liu Y, Ding N, Guan Y, Zhang Y, Chen X
Neural regeneration research 2024 May;19(5):1105-1111
Neural regeneration research 2024 May;19(5):1105-1111
Platelet-rich plasma-derived extracellular vesicles inhibit NF-κB/NLRP3 pathway-mediated pyroptosis in intervertebral disc degeneration via the MALAT1/microRNA-217/SIRT1 axis.
Tao X, Xue F, Xu J, Wang W
Cellular signalling 2024 May;117:111106
Cellular signalling 2024 May;117:111106
Transcriptomics confirms IRF1 as a key regulator of pyroptosis in diabetic retinopathy.
Xian Y, Wang X, Yu Y, Chen X
Biochemical and biophysical research communications 2024 May 21;709:149760
Biochemical and biophysical research communications 2024 May 21;709:149760
MSC-derived exosomal miR-140-3p improves cognitive dysfunction in sepsis-associated encephalopathy by HMGB1 and S-lactoylglutathione metabolism.
Ma Y, She X, Liu Y, Qin X
Communications biology 2024 May 11;7(1):562
Communications biology 2024 May 11;7(1):562
Natural compound library screening to identify berberine as a treatment for rheumatoid arthritis.
Zhang L, Tan M, Mao J, Zhang J, Wang XY, Zhang Y, Duo RX, Hao JY, Shen HL
Clinical rheumatology 2024 Mar;43(3):959-969
Clinical rheumatology 2024 Mar;43(3):959-969
Human vascular smooth muscle cells utilise chymase for the atypical cleavage and activation of Interleukin-1β.
Morales-Maldonado A, Humphry M, Figg N, Clarke MC
Atherosclerosis 2024 Mar;390:117308
Atherosclerosis 2024 Mar;390:117308
GSDMD mediated pyroptosis induced inflammation of Graves' orbitopathy via the NF-κB/ AIM2/ Caspase-1 pathway.
Sha X, Ye H, Wang X, Xu Z, Sun A, Xiao W, Zhang T, Yang S, Yang H
Experimental eye research 2024 Mar;240:109812
Experimental eye research 2024 Mar;240:109812
PI3K/AKT signaling pathway associates with pyroptosis and inflammation in patients with endometriosis.
An M, Fu X, Meng X, Liu H, Ma Y, Li Y, Li Q, Chen J
Journal of reproductive immunology 2024 Mar;162:104213
Journal of reproductive immunology 2024 Mar;162:104213
BRCC36 Deubiquitinates HMGCR to Regulate the Interplay Between Ferroptosis and Pyroptosis.
Wang H, Shu L, Lv C, Liu N, Long Y, Peng X, Ling H, Tao T, Tang J, Cheng Y, Liu S, Xiao D, Tao Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(11):e2304263
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(11):e2304263
Kongensin a attenuates intervertebral disc degeneration by inhibiting TAK1-mediated PANoptosis of nucleus pulposus cells.
Chen Y, Hu B, Ni F, Han Y, Shu S, Xiong L, Shao Z, Wei Y
International immunopharmacology 2024 Mar 10;129:111661
International immunopharmacology 2024 Mar 10;129:111661
Effect of lipopolysaccharide on TAK1-mediated hepatocyte PANoptosis through Toll-like receptor 4 during acute liver failure.
Li W, Zhang W, Zhang D, Shi C, Wang Y
International immunopharmacology 2024 Mar 10;129:111612
International immunopharmacology 2024 Mar 10;129:111612
Punicalagin Ameliorates Diabetic Liver Injury by Inhibiting Pyroptosis and Promoting Autophagy via Modulation of the FoxO1/TXNIP Signaling Pathway.
Tan X, Long Y, Zhang R, Zhang Y, You Z, Yang L
Molecular nutrition & food research 2024 Jun;68(12):e2300912
Molecular nutrition & food research 2024 Jun;68(12):e2300912
Efficient Delivery of Lomitapide using Hybrid Membrane-Coated Tetrahedral DNA Nanostructures for Glioblastoma Therapy.
Song M, Tian J, Wang L, Dong S, Fu K, Chen S, Liu C
Advanced materials (Deerfield Beach, Fla.) 2024 Jun;36(24):e2311760
Advanced materials (Deerfield Beach, Fla.) 2024 Jun;36(24):e2311760
A natural hydrogel complex improves intervertebral disc degeneration by correcting fatty acid metabolism and inhibiting nucleus pulposus cell pyroptosis.
Wang D, Zhang L, He D, Zhang Y, Zhao L, Miao Z, Cheng W, Zhu C, Shao Y, Ge G, Zhu H, Jin H, Zhang W, Pan H
Materials today. Bio 2024 Jun;26:101081
Materials today. Bio 2024 Jun;26:101081
Modulating synovial macrophage pyroptosis and mitophagy interactions to mitigate osteoarthritis progression using functionalized nanoparticles.
Qi W, Jin L, Huang S, Aikebaier A, Xue S, Wang Q, Chen Q, Lu Y, Ding C
Acta biomaterialia 2024 Jun;181:425-439
Acta biomaterialia 2024 Jun;181:425-439
Elevated NLRP3 Inflammasome Activation Is Associated with Motor Neuron Degeneration in ALS.
Cihankaya H, Bader V, Winklhofer KF, Vorgerd M, Matschke J, Stahlke S, Theiss C, Matschke V
Cells 2024 Jun 7;13(12)
Cells 2024 Jun 7;13(12)
Neutrophil extracellular traps induce pyroptosis of pulmonary microvascular endothelial cells by activating the NLRP3 inflammasome.
Zhao P, Zhu J, Bai L, Ma W, Li F, Zhang C, Zhao L, Wang L, Zhang S
Clinical and experimental immunology 2024 Jun 20;217(1):89-98
Clinical and experimental immunology 2024 Jun 20;217(1):89-98
Bacillus cereus CwpFM induces colonic tissue damage and inflammatory responses through oxidative stress and the NLRP3/NF-κB pathway.
Shan Q, Wang X, Yang H, Zhu Y, Wang J, Yang G
The Science of the total environment 2024 Jul 10;933:173079
The Science of the total environment 2024 Jul 10;933:173079
Tangeretin attenuates acute lung injury in septic mice by inhibiting ROS-mediated NLRP3 inflammasome activation via regulating PLK1/AMPK/DRP1 signaling axis.
Liu Y, Zhang Y, You G, Zheng D, He Z, Guo W, Antonina K, Shukhrat Z, Ding B, Zan J, Zhang Z
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Jan;73(1):47-63
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Jan;73(1):47-63
Pyroptosis-related gene signature elicits immune response in rosacea.
Hu XM, Zheng SY, Mao R, Zhang Q, Wan XX, Zhang YY, Li J, Yang RH, Xiong K
Experimental dermatology 2024 Jan;33(1):e14812
Experimental dermatology 2024 Jan;33(1):e14812
Prognostic, immunity, stemness, and anticancer drug sensitivity characterization of pyroptosis related genes in non-small cell lung cancer.
Xu C, Ma H, Chen J, Li X, Wang Z, Hu B, Zhang N, Meng F
Thoracic cancer 2024 Jan;15(3):215-226
Thoracic cancer 2024 Jan;15(3):215-226
Preparation and characterization of monoclonal antibodies against porcine gasdermin D protein.
Yang M, Ge X, Zhou L, Guo X, Han J, Zhang Y, Yang H
Applied microbiology and biotechnology 2024 Jan 25;108(1):173
Applied microbiology and biotechnology 2024 Jan 25;108(1):173
A slow-releasing donor of hydrogen sulfide inhibits neuronal cell death via anti-PANoptosis in rats with spinal cord ischemia‒reperfusion injury.
Xie L, Wu H, He Q, Shi W, Zhang J, Xiao X, Yu T
Cell communication and signaling : CCS 2024 Jan 12;22(1):33
Cell communication and signaling : CCS 2024 Jan 12;22(1):33
Neuroprotective effects of Jie-du-huo-xue decoction on microglia pyroptosis after cerebral ischemia and reperfusion--From the perspective of glial-vascular unit.
Zhou C, Li JX, Zheng CX, Zhou XQ, Chen C, Qiu SW, Liu WH, Li H
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):116990
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):116990
Modified Simiaowan prevents and treats gouty arthritis via the Nrf2/NLRP3 inflammasome signaling pathway.
Qin DE, Liang W, Yu Y, Whelan EC, Yuan X, Wang ZL, Wu XW, Cao ZR, Hua SY, Yin L, Shi L, Liang T
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116906
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116906
Neuronal pyroptosis mediated by STAT3 in early brain injury after subarachnoid hemorrhage.
Tang S, Lai N, Xu L
Brain research 2024 Jan 1;1822:148666
Brain research 2024 Jan 1;1822:148666
Deficiency of N6-Methyladenosine Demethylase ALKBH5 Alleviates Ultraviolet B Radiation-Induced Chronic Actinic Dermatitis via Regulating Pyroptosis.
He L, Liu L, Xu D, Tu Y, Yang C, Zhang M, Wang H, Nong X
Inflammation 2024 Feb;47(1):159-172
Inflammation 2024 Feb;47(1):159-172
Tangeretin Attenuates Cerebral Ischemia-Reperfusion-Induced Neuronal Pyroptosis by Inhibiting AIM2 Inflammasome Activation via Regulating NRF2.
You G, Zheng L, Zhang Y, Zhang Y, Wang Y, Guo W, Liu H, Tatiana P, Vladimir K, Zan J
Inflammation 2024 Feb;47(1):145-158
Inflammation 2024 Feb;47(1):145-158
Serabelisib regulates GSDMD-mediated pyroptosis, apoptosis and migration of hepatoma cells via the PI3K/Akt/E-cadherin signaling pathway.
Li M, Huang Z, Zhou Y
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 Feb;33(2):171-181
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 Feb;33(2):171-181
Ibuprofen inhibits anaplastic thyroid cells in vivo and in vitro by triggering NLRP3-ASC-GSDMD-dependent pyroptosis.
Guo H, Ma R, Zhang Y, Yin K, Du G, Yin F, Li H, Wang Z, Yin D
Inflammopharmacology 2024 Feb;32(1):733-745
Inflammopharmacology 2024 Feb;32(1):733-745
Dihydroxyacetone phosphate accumulation leads to podocyte pyroptosis in diabetic kidney disease.
Zhang Z, Hu H, Luo Q, Yang K, Zou Z, Shi M, Liang W
Journal of cellular and molecular medicine 2024 Feb;28(3):e18073
Journal of cellular and molecular medicine 2024 Feb;28(3):e18073
KLF4 interacts with TXNIP to modulate the pyroptosis in ulcerative colitis via regulating NLRP3 signaling.
Chen Y, Sun L, Liu H, Li J, Guo L, Wang Z
Immunity, inflammation and disease 2024 Feb;12(2):e1199
Immunity, inflammation and disease 2024 Feb;12(2):e1199
Berberine inhibits NLRP3 inflammasome activation by regulating mTOR/mtROS axis to alleviate diabetic cardiomyopathy.
Zhong C, Xie Y, Wang H, Chen W, Yang Z, Zhang L, Deng Q, Cheng T, Li M, Ju J, Liu Y, Liang H
European journal of pharmacology 2024 Feb 5;964:176253
European journal of pharmacology 2024 Feb 5;964:176253
SERTAD1 initiates NLRP3-mediated inflammasome activation through restricting NLRP3 polyubiquitination.
Ha J, Kim M, Park JS, Lee Y, Lee JY, Shin JC, Seo D, Park SS, You J, Jung SM, Kim HY, Mizuno S, Takahashi S, Kim SJ, Park SH
Cell reports 2024 Feb 27;43(2):113752
Cell reports 2024 Feb 27;43(2):113752
PANoptosis in vascular smooth muscle cells regulated by TNF-α/IL-1β can be a new target for alleviating the progression of abdominal aortic aneurysm.
Li K, Wei M, Zhang D, Zhai S, Liu H
Physiological genomics 2024 Feb 1;56(2):158-166
Physiological genomics 2024 Feb 1;56(2):158-166
PANoptosis signaling enables broad immune response in psoriasis: From pathogenesis to new therapeutic strategies.
Hu XM, Zheng S, Zhang Q, Wan X, Li J, Mao R, Yang R, Xiong K
Computational and structural biotechnology journal 2024 Dec;23:64-76
Computational and structural biotechnology journal 2024 Dec;23:64-76
Dihydroartemisinin-driven TOM70 inhibition leads to mitochondrial destabilization to induce pyroptosis against lung cancer.
Li LG, Hu J, Han N, Chen NN, Yu TT, Ren T, Xu HZ, Peng XC, Li XY, Ma TQ, Chen H, Zhang L, Chen X, Wang MF, Li TF
Phytotherapy research : PTR 2024 Aug;38(8):3856-3876
Phytotherapy research : PTR 2024 Aug;38(8):3856-3876
Obstructive Sleep Apnea Plasma-Derived Exosomes Mediate Cognitive Impairment Through Hippocampal Neuronal Cell Pyroptosis.
Chen Z, Shang Y, Ou Y, Shen C, Cao Y, Hu H, Yang R, Liu T, Liu Q, Song M, Zong D, Xiang X, Peng Y, Ouyang R
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2024 Aug;32(8):922-939
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2024 Aug;32(8):922-939
Apoptosis and pyroptosis in the nasal mucosa of Syrian hamster during SARS-CoV-2 infection and reinfection.
Li H, Zhao X, Zhang X, Zheng H, Wang Y, Hou J, Li J, Zhao Y, Peng S, Li Y, Zhang X, Zhang Y, Yang J, Zhang Z, Shi H, Liu L
Apoptosis : an international journal on programmed cell death 2024 Aug;29(7-8):1246-1259
Apoptosis : an international journal on programmed cell death 2024 Aug;29(7-8):1246-1259
Co-exposure of microcystin-LR and nitrite induced kidney injury through TLR4/NLRP3/GSDMD-mediated pyroptosis.
Guo Y, Du X, Wang F, Fu Y, Guo X, Meng R, Ge K, Zhang S
Ecotoxicology and environmental safety 2024 Aug;281:116629
Ecotoxicology and environmental safety 2024 Aug;281:116629
STAT4-Mediated Klotho Up-Regulation Contributes to the Brain Ischemic Tolerance by Cerebral Ischemic Preconditioning via Inhibiting Neuronal Pyroptosis.
Liu XY, Zhang LY, Wang XY, Li SC, Hu YY, Zhang JG, Xian XH, Li WB, Zhang M
Molecular neurobiology 2024 Apr;61(4):2336-2356
Molecular neurobiology 2024 Apr;61(4):2336-2356
Ketamine Improves the Glymphatic Pathway by Reducing the Pyroptosis of Hippocampal Astrocytes in the Chronic Unpredictable Mild Stress Model.
Wen G, Zhan X, Xu X, Xia X, Jiang S, Ren X, Ren W, Lou H, Lu L, Hermenean A, Yao J, Gao L, Li B, Lu Y, Wu X
Molecular neurobiology 2024 Apr;61(4):2049-2062
Molecular neurobiology 2024 Apr;61(4):2049-2062
Identification of PKM2 as a pyroptosis-related key gene aggravates senile osteoporosis via the NLRP3/Caspase-1/GSDMD signaling pathway.
Li Z, Wang B, Wang R, Zhang Z, Xiong J, Wang X, Ma Y, Han L
The international journal of biochemistry & cell biology 2024 Apr;169:106537
The international journal of biochemistry & cell biology 2024 Apr;169:106537
Gypenoside XLIX alleviates acute liver injury: Emphasis on NF-κB/PPAR-α/NLRP3 pathways.
Zhou M, Cao Y, Xie S, Xiang Y, Li M, Yang H, Dong Z
International immunopharmacology 2024 Apr 20;131:111872
International immunopharmacology 2024 Apr 20;131:111872
Inhibition of spinal BRD4 alleviates pyroptosis and M1 microglia polarization via STING-IRF3 pathway in morphine-tolerant rats.
Jia X, Ju J, Li Z, Peng X, Wang J, Gao F
European journal of pharmacology 2024 Apr 15;969:176428
European journal of pharmacology 2024 Apr 15;969:176428
Preliminary investigation into the impact of BPA on osteoblast activity and bone development: In vitro and in vivo models.
Shi X, Wu K, Liu C, Cao K, Zhang Q, Wu W, Luo C, Huang W
Environmental pollution (Barking, Essex : 1987) 2024 Apr 15;347:123731
Environmental pollution (Barking, Essex : 1987) 2024 Apr 15;347:123731
LncRNA GAS5 restrains ISO-induced cardiac fibrosis by modulating mir-217 regulation of SIRT1.
Zhang YH, Sun TT, Liu ZH, Li X, Fan XF, Han LP
Scientific reports 2024 Apr 1;14(1):7652
Scientific reports 2024 Apr 1;14(1):7652
Circular RNA protein tyrosine kinase 2 aggravates pyroptosis and inflammation in septic lung tissue by promoting microRNA-766/eukaryotic initiation factor 5A axis-mediated ATP efflux.
Ding F, Zhu J, Hu Y
Acta cirurgica brasileira 2023;38:e380323
Acta cirurgica brasileira 2023;38:e380323
Inhibition of Schwann Cell Pyroptosis Promotes Nerve Regeneration in Peripheral Nerve Injury in Rats.
Wang J, Lu S, Yuan Y, Huang L, Bian M, Yu J, Zou J, Jiang L, Meng D, Zhang J
Mediators of inflammation 2023;2023:9721375
Mediators of inflammation 2023;2023:9721375
Transcutaneous Electrical Nerve Stimulation (TENS) Alleviates Brain Ischemic Injury by Regulating Neuronal Oxidative Stress, Pyroptosis, and Mitophagy.
Tan Z, Dong F, Wu L, Feng Y, Zhang M, Zhang F
Mediators of inflammation 2023;2023:5677865
Mediators of inflammation 2023;2023:5677865
High-dose remifentanil exacerbates myocardial ischemia-reperfusion injury through activation of calcium-sensing receptor-mediated pyroptosis.
Zhu Y, Chi J, Cai S, Liu S, Yuan J, Xu H, Zhou H
International journal of medical sciences 2023;20(12):1570-1583
International journal of medical sciences 2023;20(12):1570-1583
Suppression of NLRP3/Caspase-1/GSDMD Mediated Corneal Epithelium Pyroptosis Using Melatonin-Loaded Liposomes to Inhibit Benzalkonium Chloride-Induced Dry Eye Disease.
Lou Q, Pan L, Xiang S, Li Y, Jin J, Tan J, Huang B, Nan K, Lin S
International journal of nanomedicine 2023;18:2447-2463
International journal of nanomedicine 2023;18:2447-2463
Network Pharmacology Analysis and Machine-Learning Models Confirmed the Ability of YiShen HuoXue Decoction to Alleviate Renal Fibrosis by Inhibiting Pyroptosis.
Feng M, Luo F, Wu H, Chen Y, Zuo J, Weng X, Chen G, Zhong J
Drug design, development and therapy 2023;17:3169-3192
Drug design, development and therapy 2023;17:3169-3192
Transcutaneous electrical acupoint stimulation alleviates cerebral ischemic injury through the TLR4/MyD88/NF-κ B pathway.
Wu L, Tan Z, Su L, Dong F, Xu G, Zhang F
Frontiers in cellular neuroscience 2023;17:1343842
Frontiers in cellular neuroscience 2023;17:1343842
Qinhuo Shanggan oral solution resolves acute lung injury by down-regulating TLR4/NF-κB signaling cascade and inhibiting NLRP3 inflammasome activation.
Tang S, Liang Y, Wang M, Lei J, Peng Y, Tao Q, Ming T, Yang W, Zhang C, Guo J, Xu H
Frontiers in immunology 2023;14:1285550
Frontiers in immunology 2023;14:1285550
The non-canonical inflammasome activators Caspase-4 and Caspase-5 are differentially regulated during immunosuppression-associated organ damage.
Ghait M, Duduskar SN, Rooney M, Häfner N, Reng L, Göhrig B, Reuken PA, Bloos F, Bauer M, Sponholz C, Bruns T, Rubio I
Frontiers in immunology 2023;14:1239474
Frontiers in immunology 2023;14:1239474
A novel colchicine-myricetin heterozygous molecule: design, synthesis, and effective evaluations on the pathological models of acute lung injury in vitro and in vivo.
Li Z, Yan X, Wei J, Pu L, Zhu G, Cao Y, Liu Z, Liu Y, Li Y, Li L, Li X, Wu Z
Frontiers in pharmacology 2023;14:1224906
Frontiers in pharmacology 2023;14:1224906
β-sitosterol alleviates dextran sulfate sodium-induced experimental colitis via inhibition of NLRP3/Caspase-1/GSDMD-mediated pyroptosis.
Zhang D, Ge F, Ji J, Li YJ, Zhang FR, Wang SY, Zhang SJ, Zhang DM, Chen M
Frontiers in pharmacology 2023;14:1218477
Frontiers in pharmacology 2023;14:1218477
Phenylalanine promotes alveolar macrophage pyroptosis via the activation of CaSR in ARDS.
Tang Y, Yu Y, Li R, Tao Z, Zhang L, Wang X, Qi X, Li Y, Meng T, Qu H, Zhou M, Xu J, Liu J
Frontiers in immunology 2023;14:1114129
Frontiers in immunology 2023;14:1114129
Silibinin ameliorates deoxycholic acid-induced pyroptosis in steatotic HepG2 cells by inhibiting NLRP3 inflammasome activation.
Mai M, Wang Y, Luo M, Li Z, Wang D, Ruan Y, Guo H
Biochemistry and biophysics reports 2023 Sep;35:101545
Biochemistry and biophysics reports 2023 Sep;35:101545
CD73 mitigates hepatic damage in alcoholic steatohepatitis by regulating PI3K/AKT-mediated hepatocyte pyroptosis.
Zhu H, Zhang M, Ye Y, Liu Z, Wang J, Wu X, Lv X
Biochemical pharmacology 2023 Sep;215:115753
Biochemical pharmacology 2023 Sep;215:115753
Bone marrow mesenchymal stem cellsderived exosomes stabilize atherosclerosis through inhibiting pyroptosis.
Bai Z, Hu H, Hu F, Ji J, Ji Z
BMC cardiovascular disorders 2023 Sep 7;23(1):441
BMC cardiovascular disorders 2023 Sep 7;23(1):441
Oryza sativa L. Indica Seed Coat Ameliorated Concanavalin A-Induced Acute Hepatitis in Mice via MDM2/p53 and PKCα/MAPK1 Signaling Pathways.
Zhao Z, Li Y, Guo S, Chen Y, Yin H, Li Y, Cheng G, Tian L
International journal of molecular sciences 2023 Sep 25;24(19)
International journal of molecular sciences 2023 Sep 25;24(19)
Steroidal saponins PPI/CCRIS/PSV induce cell death in pancreatic cancer cell through GSDME-dependent pyroptosis.
Liu Y, Zhang W, Zhou H, Chen J
Biochemical and biophysical research communications 2023 Sep 17;673:51-58
Biochemical and biophysical research communications 2023 Sep 17;673:51-58
Loganin reduces diabetic kidney injury by inhibiting the activation of NLRP3 inflammasome-mediated pyroptosis.
Kong X, Zhao Y, Wang X, Yu Y, Meng Y, Yan G, Yu M, Jiang L, Song W, Wang B, Wang X
Chemico-biological interactions 2023 Sep 1;382:110640
Chemico-biological interactions 2023 Sep 1;382:110640
A high-throughput Gaussia luciferase reporter assay for screening potential gasdermin E activators against pancreatic cancer.
Liu Y, Zhang X, Zhang P, He T, Zhang W, Ma D, Li P, Chen J
Acta pharmaceutica Sinica. B 2023 Oct;13(10):4253-4272
Acta pharmaceutica Sinica. B 2023 Oct;13(10):4253-4272
Systemic pharmacology reveal the mechanism by which the Qiangjin Zhuanggu Qufeng mixture inhibits LPS-induced pyroptosis of rat nucleus pulposus cells.
Wang D, Zhang L, He D, Zhang Y, Bao J, Gao W, Cheng W, Zhu C, Jin H, Zhang W, Zhu H, Pan H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:154998
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:154998
GSDMD promotes neutrophil extracellular traps via mtDNA-cGAS-STING pathway during lung ischemia/reperfusion.
Zhao C, Liang F, Ye M, Wu S, Qin Y, Zhao L, Zhang L, He J, Cen L, Lin F
Cell death discovery 2023 Oct 4;9(1):368
Cell death discovery 2023 Oct 4;9(1):368
Aluminum exposure induces central nervous system impairment via activating NLRP3-medicated pyroptosis pathway.
Hao W, Zhu X, Liu Z, Song Y, Wu S, Lu X, Yang J, Jin C
Ecotoxicology and environmental safety 2023 Oct 1;264:115401
Ecotoxicology and environmental safety 2023 Oct 1;264:115401
Oxalate‑induced renal pyroptotic injury and crystal formation mediated by NLRP3‑GSDMD signaling in vitro and in vivo.
Chen Y, Yang S, Kong H, Wang Q, Chen S, Wang X, Chen L, Qi S
Molecular medicine reports 2023 Nov;28(5)
Molecular medicine reports 2023 Nov;28(5)
Selenium Deficiency via the ROS/NLRP3/IL-1β Signaling Pathway Leads to Pyroptosis Injury in Pig Spleen.
Song L, Jiang Z, Zhang X, Song Y, Xing Y, Wang G
Biological trace element research 2023 Nov;201(11):5192-5200
Biological trace element research 2023 Nov;201(11):5192-5200
Escherichia coli infection mediates pyroptosis via activating p53-p21 pathway-regulated apoptosis and cell cycle arrest in bovine mammary epithelial cells.
Zhuang C, Zhao J, Zhang S, Shahid M
Microbial pathogenesis 2023 Nov;184:106338
Microbial pathogenesis 2023 Nov;184:106338
Butyrate alleviates renal fibrosis in CKD by regulating NLRP3-mediated pyroptosis via the STING/NF-κB/p65 pathway.
Tian X, Zeng Y, Tu Q, Jiao Y, Yao S, Chen Y, Sun L, Xia Q, Luo Y, Yuan L, Jiang Q
International immunopharmacology 2023 Nov;124(Pt B):111010
International immunopharmacology 2023 Nov;124(Pt B):111010
Irisin suppresses pancreatic β cell pyroptosis in T2DM by inhibiting the NLRP3-GSDMD pathway and activating the Nrf2-TrX/TXNIP signaling axis.
Li T, Yang J, Tan A, Chen H
Diabetology & metabolic syndrome 2023 Nov 22;15(1):239
Diabetology & metabolic syndrome 2023 Nov 22;15(1):239
Regulation of megakaryo/thrombopoiesis by endosomal toll-like receptor 7 and 8 activation of CD34(+) cells in a viral infection model.
Rodríguez CS, Charó N, Tatti S, Gómez RM, D'Atri LP, Schattner M
Research and practice in thrombosis and haemostasis 2023 May;7(4):100184
Research and practice in thrombosis and haemostasis 2023 May;7(4):100184
The involvement of DDX3X in compression-induced nucleus pulposus pyroptosis.
Chi S, Li S, Xu Z, Yang G, Song Y, Liao Z, Yang C, Wu X
Biochemical and biophysical research communications 2023 May 7;655:1-10
Biochemical and biophysical research communications 2023 May 7;655:1-10
Pyroptosis of Macrophages Induced by Clostridium perfringens Beta-1 Toxin.
Zhang S, Ma L, Song F, Wang D, Shi K, Li Y, Zeng J, Wang Y
Toxins 2023 May 29;15(6)
Toxins 2023 May 29;15(6)
Gasdermin D Plays an Oncogenic Role in Glioma and Correlates to an Immunosuppressive Microenvironment.
Li M, Jiang P, Wei S, Yang Y, Xiong L, Wang J, Li C
Biomolecules 2023 May 29;13(6)
Biomolecules 2023 May 29;13(6)
HuNoV Non-Structural Protein P22 Induces Maturation of IL-1β and IL-18 and N-GSDMD-Dependent Pyroptosis through Activating NLRP3 Inflammasome.
Chen N, Chen P, Zhou Y, Chen S, Gong S, Fu M, Geng L
Vaccines 2023 May 17;11(5)
Vaccines 2023 May 17;11(5)
Single-cell sequencing reveals homogeneity and heterogeneity of the cytopathological mechanisms in different etiology-induced AKI.
Chen Z, Li Y, Yuan Y, Lai K, Ye K, Lin Y, Lan R, Chen H, Xu Y
Cell death & disease 2023 May 11;14(5):318
Cell death & disease 2023 May 11;14(5):318
Elsholtzia bodinieri Vaniot ameliorated acute lung injury in mice by regulating pyroptosis, inflammation, oxidative stress and macrophage polarization.
Jiang X, Sun J, Guo S, Zhao Z, Chen Y, Cao J, Liu Y, Cheng G, Tian L, Li Y
Journal of ethnopharmacology 2023 May 10;307:116232
Journal of ethnopharmacology 2023 May 10;307:116232
hASCs-derived exosomal miR-155-5p targeting TGFβR2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration.
Chen D, Jiang X, Zou H
Journal of orthopaedic translation 2023 Mar;39:163-176
Journal of orthopaedic translation 2023 Mar;39:163-176
Cytoskeletal protein SPTA1 mediating the decrease in erectile function induced by high-fat diet via Hippo signaling pathway.
Chen Y, Wang L, Huang ZS, Feng JX, Li SX, Du ZJ, Zhang ZB, Liu J, Yang J, Hu ZM, Wang ZL, Chen J
Andrology 2023 Mar;11(3):591-610
Andrology 2023 Mar;11(3):591-610
Hydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes.
Yang X, Dong S, Li C, Li M, Xing C, He J, Peng C, Shao H, Jia Q
Toxicology letters 2023 Mar 1;376:39-50
Toxicology letters 2023 Mar 1;376:39-50
Emodin alleviates testicular ischemia-reperfusion injury through the inhibition of NLRP3-mediated pyroptosis.
He KX, Ning JZ, Li W, Cheng F
Tissue & cell 2023 Jun;82:102069
Tissue & cell 2023 Jun;82:102069
Sulconazole Induces PANoptosis by Triggering Oxidative Stress and Inhibiting Glycolysis to Increase Radiosensitivity in Esophageal Cancer.
Liu LX, Heng JH, Deng DX, Zhao H, Zheng ZY, Liao LD, Lin W, Xu XE, Li EM, Xu LY
Molecular & cellular proteomics : MCP 2023 Jun;22(6):100551
Molecular & cellular proteomics : MCP 2023 Jun;22(6):100551
Baicalin inhibited both the Furin/TGFβ1/Smad3/TSP-1 pathway in endothelial cells and the AKT/Ca(2+)/ROS pathway in platelets to ameliorate inflammatory coagulopathy.
Wang P, Wu J, Wang Q, Zhuang S, Zhao J, Yu Y, Zhang W, Zheng Y, Liu X
European journal of pharmacology 2023 Jun 15;949:175674
European journal of pharmacology 2023 Jun 15;949:175674
Withdrawn: Ticagrelor reduces myocardial cell injury induced by myocardial ischemia/reperfusion in diabetic rats by activating JAK2/STAT3.
Xie D, Chen Q, Huang J, Huang C, Li Y, Li S, Zhang S, Fang H, Sang S, Cao Y
Cell biology international 2023 Jul;47(7):1289
Cell biology international 2023 Jul;47(7):1289
Fibrin glue delivery system containing rhein ameliorates intervertebral disc degeneration by anti-inflammatory efficacy.
Bao J, Gao W, Zhang W, Wang D, Pan H
Journal of orthopaedic surgery and research 2023 Jul 6;18(1):485
Journal of orthopaedic surgery and research 2023 Jul 6;18(1):485
Exercise-induced irisin improves follicular dysfunction by inhibiting IRE1α-TXNIP/ROS-NLRP3 pathway in PCOS.
Weng Y, Zhang Y, Wang D, Wang R, Xiang Z, Shen S, Wang H, Wu X, Wen Y, Wang Y
Journal of ovarian research 2023 Jul 31;16(1):151
Journal of ovarian research 2023 Jul 31;16(1):151
circACTA2 inhibits NLRP3 inflammasome-mediated inflammation via interacting with NF-κB in vascular smooth muscle cells.
Bai Y, Zhang L, Zheng B, Zhang X, Zhang H, Zhao A, Yu J, Yang Z, Wen J
Cellular and molecular life sciences : CMLS 2023 Jul 27;80(8):229
Cellular and molecular life sciences : CMLS 2023 Jul 27;80(8):229
Neobavaisoflavone induces pyroptosis of liver cancer cells via Tom20 sensing the activated ROS signal.
Li Y, Zhao R, Xiu Z, Yang X, Zhu Y, Han J, Li S, Li Y, Sun L, Li X, Jin N, Li Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154869
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154869
Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia.
Chen Q, He J, Liu H, Huang Q, Wang S, Yin A, Chen S, Shen X, Xiao Y, Hu H, Jiang J, Chen W, Wang S, Huang Z, Li J, Peng Y, Wang X, Yang X, Wang Z, Zhong M
Journal of translational medicine 2023 Jul 24;21(1):496
Journal of translational medicine 2023 Jul 24;21(1):496
Induced neural stem cells suppressed neuroinflammation by inhibiting the microglial pyroptotic pathway in intracerebral hemorrhage rats.
Liu J, Cao C, Jin Y, Wang Y, Ma X, Li J, Guo S, Yang J, Niu J, Liang X
iScience 2023 Jul 21;26(7):107022
iScience 2023 Jul 21;26(7):107022
Dihydromyricetin inhibits African swine fever virus replication by downregulating toll-like receptor 4-dependent pyroptosis in vitro.
Chen Y, Song Z, Chang H, Guo Y, Wei Z, Sun Y, Gong L, Zheng Z, Zhang G
Veterinary research 2023 Jul 12;54(1):58
Veterinary research 2023 Jul 12;54(1):58
Attenuation of experimental osteoarthritis with human adipose-derived mesenchymal stem cell therapy: inhibition of the pyroptosis in chondrocytes.
Xu L, Zhang F, Cheng G, Yuan X, Wu Y, Wu H, Wang Q, Chen J, Kuai J, Chang Y, Wei W, Yan S
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jan;72(1):89-105
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jan;72(1):89-105
Trophoblastic mitochondrial DNA induces endothelial dysfunction and NLRP3 inflammasome activation: Implications for preeclampsia.
Lv Z, Lv DY, Meng JY, Sha XY, Qian XY, Chen YS, Pan XY, Yu GY, Liu HS
International immunopharmacology 2023 Jan;114:109523
International immunopharmacology 2023 Jan;114:109523
Protective effects of leonurine hydrochloride on pyroptosis in premature ovarian insufficiency via regulating NLRP3/GSDMD pathway.
Chi YN, Hai DM, Ma L, Cui YH, Hu HT, Liu N, Juan-Du, Lan XB, Yu JQ, Yang JM
International immunopharmacology 2023 Jan;114:109520
International immunopharmacology 2023 Jan;114:109520
TMBIM4 Deficiency Facilitates NLRP3 Inflammasome Activation-Induced Pyroptosis of Trophoblasts: A Potential Pathogenesis of Preeclampsia.
Chen Y, Xiao L, Sun G, Li M, Yang H, Ming Z, Zhao K, Shang X, Zhang H, Liu C
Biology 2023 Jan 29;12(2)
Biology 2023 Jan 29;12(2)
Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis.
Tian Y, Feng X, Zhou Z, Qin S, Chen S, Zhao J, Hou J, Liu D
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1499-1509
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1499-1509
Jatrorrhizine Suppresses Murine-Norovirus-Triggered N-GSDMD-Dependent Pyroptosis in RAW264.7 Macrophages.
Fu M, Chen N, Zhou Y, Chen S, Xu W, Gong S, Geng L
Vaccines 2023 Jan 12;11(1)
Vaccines 2023 Jan 12;11(1)
PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons.
Yan WT, Zhao WJ, Hu XM, Ban XX, Ning WY, Wan H, Zhang Q, Xiong K
Neural regeneration research 2023 Feb;18(2):357-363
Neural regeneration research 2023 Feb;18(2):357-363
Ginsenoside Rg3 Ameliorates DSS-Induced Colitis by Inhibiting NLRP3 Inflammasome Activation and Regulating Microbial Homeostasis.
Liu D, Tian Q, Liu K, Ren F, Liu G, Zhou J, Yuan L, Fang Z, Zou B, Wang S
Journal of agricultural and food chemistry 2023 Feb 8;
Journal of agricultural and food chemistry 2023 Feb 8;
Apoptosis or Antiapoptosis? Interrupted Regulated Cell Death of Host Cells by Ascovirus Infection In Vitro.
Yu H, Li JR, Xiao HY, Cao SK, Chen B, Li N, Chen G, Huang GH
mBio 2023 Feb 28;14(1):e0311922
mBio 2023 Feb 28;14(1):e0311922
Alpha-kinase1 promotes tubular injury and interstitial inflammation in diabetic nephropathy by canonical pyroptosis pathway.
Cui X, Li Y, Yuan S, Huang Y, Chen X, Han Y, Liu Z, Li Z, Xiao Y, Wang Y, Sun L, Liu H, Zhu X
Biological research 2023 Feb 2;56(1):5
Biological research 2023 Feb 2;56(1):5
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice.
Chen JW, Shan TK, Wei TW, Jiang QQ, Du C, Gu LF, Yang TT, Zhou LH, Wang SB, Bao YL, Wang H, Ji Y, Xie LP, Gu AH, Sun CQ, Wang QM, Wang LS
Archives of toxicology 2023 Dec;97(12):3209-3226
Archives of toxicology 2023 Dec;97(12):3209-3226
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Wang HG, Wang D, Sarfraz M, Afzal A, Jing MR, Zhang YX, Cai CB, Qi HW, Chen HJ, Li T, Hu SJ, Liu HX, Ji XY, Wu DD
Translational oncology 2023 Dec;38:101770
Translational oncology 2023 Dec;38:101770
Inhibition of Caspase-11-Mediated Pyroptosis Alleviates Acute Kidney Injury Associated with Severe Acute Pancreatitis in Rats.
Shao Y, Li C, Jiang Y, Li H, Tang X, Gao Z, Zhang D
Journal of investigative surgery : the official journal of the Academy of Surgical Research 2023 Dec;36(1):1-7
Journal of investigative surgery : the official journal of the Academy of Surgical Research 2023 Dec;36(1):1-7
Inhibition of macrophage pyroptosis ameliorates silica-induced pulmonary fibrosis.
Jiang F, Jiang Q, Hou L, Zhao J, Zhu Z, Jia Q, Xue W, Wang H, Wang Y, Tian L
Ecotoxicology and environmental safety 2023 Dec;268:115693
Ecotoxicology and environmental safety 2023 Dec;268:115693
Ursodeoxycholic acid alleviates sepsis-induced lung injury by blocking PANoptosis via STING pathway.
He YQ, Deng JL, Zhou CC, Jiang SG, Zhang F, Tao X, Chen WS
International immunopharmacology 2023 Dec;125(Pt B):111161
International immunopharmacology 2023 Dec;125(Pt B):111161
ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation.
Zheng S, Que X, Wang S, Zhou Q, Xing X, Chen L, Hou C, Ma J, An P, Peng Y, Yao Y, Song Q, Li J, Zhang P, Pei H
Molecular cell 2023 Dec 21;83(24):4570-4585.e7
Molecular cell 2023 Dec 21;83(24):4570-4585.e7
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression.
Cong L, Liu X, Bai Y, Qin Q, Zhao L, Shi Y, Bai Y, Guo Z
Biological research 2023 Dec 2;56(1):62
Biological research 2023 Dec 2;56(1):62
CASP1 is a target for combination therapy in pancreatic cancer.
Wang X, Chen Z, Nie D, Zeng X, Zhong M, Liu X, Zhong S, Wang L, Liao Z, Chen C, Li Y, Zeng C
European journal of pharmacology 2023 Dec 15;961:176175
European journal of pharmacology 2023 Dec 15;961:176175
Paeoniflorin recued hepatotoxicity under zinc oxide nanoparticles exposure via regulation on gut-liver axis and reversal of pyroptosis.
Pei X, Tang S, Jiang H, Zhang W, Xu G, Zuo Z, Ren Z, Chen C, Shen Y, Li C, Li D
The Science of the total environment 2023 Dec 15;904:166885
The Science of the total environment 2023 Dec 15;904:166885
Hyperuricemia promotes the progression of atherosclerosis by activating endothelial cell pyroptosis via the ROS/NLRP3 pathway.
He B, Nie Q, Wang F, Wang X, Zhou Y, Wang C, Guo J, Fan X, Ye Z, Liu P, Wen J
Journal of cellular physiology 2023 Aug;238(8):1808-1822
Journal of cellular physiology 2023 Aug;238(8):1808-1822
MiR-195-5p is involved in testicular ischemia/reperfusion injury by directly targeting PELP1 and regulating spermatogonia pyroptosis.
He KX, Xu L, Ning JZ, Cheng F
International immunopharmacology 2023 Aug;121:110427
International immunopharmacology 2023 Aug;121:110427
Exploring the application of sildenafil for high-fat diet-induced erectile dysfunction based on interleukin-18-mediated NLRP3/Caspase-1 signaling pathway.
Zhu B, Niu Y, Niu L, Zhang X, Liu F
Sexual medicine 2023 Aug;11(4):qfad044
Sexual medicine 2023 Aug;11(4):qfad044
SMAD2 inhibits pyroptosis of fibroblast-like synoviocytes and secretion of inflammatory factors via the TGF-β pathway in rheumatoid arthritis.
Mao X, Wu W, Nan Y, Sun W, Wang Y
Arthritis research & therapy 2023 Aug 9;25(1):144
Arthritis research & therapy 2023 Aug 9;25(1):144
Protective Role of Vitamin K3 on SARS-CoV-2 Structural Protein-Induced Inflammation and Cell Death.
Zhan Y, Zha D, Lin H, Mao X, Yang L, Huang H, He Z, Zhou S, Xu F, Qian Y, Liu Y
Pharmaceuticals (Basel, Switzerland) 2023 Aug 3;16(8)
Pharmaceuticals (Basel, Switzerland) 2023 Aug 3;16(8)
GABA(B) Receptor Activation Attenuates Neuronal Pyroptosis in Post-cardiac Arrest Brain Injury.
Sun Y, Li J, Wu H, Zhao Z, Cong T, Li L, Zhang X, Yin S, Xiao Z
Neuroscience 2023 Aug 21;526:97-106
Neuroscience 2023 Aug 21;526:97-106
A novel mechanism regulating pyroptosis-induced fibrosis in endometriosis via lnc-MALAT1/miR-141-3p/NLRP3 pathway†.
Xu Y, Liu H, Xiong W, Peng Y, Li X, Long X, Jin J, Liang J, Weng R, Liu J, Zhang L, Liu Y
Biology of reproduction 2023 Aug 10;109(2):156-171
Biology of reproduction 2023 Aug 10;109(2):156-171
Schisandrin B induces HepG2 cells pyroptosis by activating NK cells mediated anti-tumor immunity.
Song A, Ding T, Wei N, Yang J, Ma M, Zheng S, Jin H
Toxicology and applied pharmacology 2023 Aug 1;472:116574
Toxicology and applied pharmacology 2023 Aug 1;472:116574
SARS-CoV-2 E protein-induced THP-1 pyroptosis is reversed by Ruscogenin.
Huang H, Li X, Zha D, Lin H, Yang L, Wang Y, Xu L, Wang L, Lei T, Zhou Z, Xiao YF, Xin HB, Fu M, Qian Y
Biochemistry and cell biology = Biochimie et biologie cellulaire 2023 Aug 1;101(4):303-312
Biochemistry and cell biology = Biochimie et biologie cellulaire 2023 Aug 1;101(4):303-312
Irisin attenuates acute lung injury by suppressing the pyroptosis of alveolar macrophages.
Han Z, Ma J, Han Y, Yuan G, Jiao R, Meng A
International journal of molecular medicine 2023 Apr;51(4)
International journal of molecular medicine 2023 Apr;51(4)
Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells.
Wu Y, Pi D, Zhou S, Yi Z, Dong Y, Wang W, Ye H, Chen Y, Zuo Q, Ouyang M
Acta biochimica et biophysica Sinica 2023 Apr 19;55(4):587-600
Acta biochimica et biophysica Sinica 2023 Apr 19;55(4):587-600
Overexpression of CASP1 triggers acute promyelocytic leukemia cell pyroptosis and differentiation.
Yu X, Liu X, Liu X, Jin S, Zhong M, Nie D, Zeng X, Wang X, Tan J, Li Y, Zeng C
European journal of pharmacology 2023 Apr 15;945:175614
European journal of pharmacology 2023 Apr 15;945:175614
Oroxin A ameliorates the oleic acid-induced A549 cell injury through the suppression of pyroptosis and degradation of alveolar surfactant.
Huang J, Chen C, Xie J, Zhai K, Wei S, Cheng X, Zhang R
Anais da Academia Brasileira de Ciencias 2022;94(suppl 4):e20211400
Anais da Academia Brasileira de Ciencias 2022;94(suppl 4):e20211400
Induction of Pyroptosis in Renal Tubular Epithelial Cells Using High Glucose.
Liu Y, He M, Xiong H, Yuan F
Frontiers in medicine 2022;9:874916
Frontiers in medicine 2022;9:874916
Luteolin Induced Hippocampal Neuronal Pyroptosis Inhibition by Regulation of miR-124-3p/TNF-α/TRAF6 Axis in Mice Affected by Breast-Cancer-Related Depression.
Zhu Q, Meng P, Han Y, Yang H, Yang Q, Liu Z, Wang Y, Long M
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2715325
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2715325
Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis.
Hong Q, Zhang Y, Lin W, Wang W, Yuan Y, Lin J, Xie Z, Li X, Meng Y
Journal of immunology research 2022;2022:2291877
Journal of immunology research 2022;2022:2291877
Lignans from Mosla scabra Ameliorated Influenza A Virus-Induced Pneumonia via Inhibiting Macrophage Activation.
Cai W, Wu LR, Zhang SL
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1688826
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1688826
Microtubule affinity regulating kinase 4 promoted activation of the NLRP3 inflammasome-mediated pyroptosis in periodontitis.
Wang L, Pu W, Wang C, Lei L, Li H
Journal of oral microbiology 2022;14(1):2015130
Journal of oral microbiology 2022;14(1):2015130
NLRP3 downregulation enhances engraftment and functionality of adipose-derived stem cells to alleviate erectile dysfunction in diabetic rats.
Luo C, Peng Y, Zhou X, Fan J, Chen W, Zhang H, Wei A
Frontiers in endocrinology 2022;13:913296
Frontiers in endocrinology 2022;13:913296
Natural Compound Library Screening Identifies Oroxin A for the Treatment of Myocardial Ischemia/Reperfusion Injury.
Cheng X, Huang T, Wang C, Hao S, Shu L, Wang S, Cheng G, Zhang Q, Huang J, Chen C
Frontiers in pharmacology 2022;13:894899
Frontiers in pharmacology 2022;13:894899
Protective Effect of Danshen Zexie Decoction Against Non-Alcoholic Fatty Liver Disease Through Inhibition of ROS/NLRP3/IL-1β Pathway by Nrf2 Signaling Activation.
Biao Y, Chen J, Liu C, Wang R, Han X, Li L, Zhang Y
Frontiers in pharmacology 2022;13:877924
Frontiers in pharmacology 2022;13:877924
Herpes Simplex Virus 1 Induces Microglia Gasdermin D-Dependent Pyroptosis Through Activating the NLR Family Pyrin Domain Containing 3 Inflammasome.
Hu X, Zeng Q, Xiao J, Qin S, Wang Y, Shan T, Hu D, Zhu Y, Liu K, Zheng K, Wang Y, Ren Z
Frontiers in microbiology 2022;13:838808
Frontiers in microbiology 2022;13:838808
Cochlear Marginal Cell Pyroptosis Is Induced by Cisplatin via NLRP3 Inflammasome Activation.
Yu W, Zong S, Zhou P, Wei J, Wang E, Ming R, Xiao H
Frontiers in immunology 2022;13:823439
Frontiers in immunology 2022;13:823439
Fucoidan Alleviates Renal Fibrosis in Diabetic Kidney Disease via Inhibition of NLRP3 Inflammasome-Mediated Podocyte Pyroptosis.
Wang MZ, Wang J, Cao DW, Tu Y, Liu BH, Yuan CC, Li H, Fang QJ, Chen JX, Fu Y, Wan BY, Wan ZY, Wan YG, Wu GW
Frontiers in pharmacology 2022;13:790937
Frontiers in pharmacology 2022;13:790937
Pyroptosis relates to tumor microenvironment remodeling and prognosis: A pan-cancer perspective.
Khan M, Ai M, Du K, Song J, Wang B, Lin J, Ren A, Chen C, Huang Z, Qiu W, Zhang J, Tian Y, Yuan Y
Frontiers in immunology 2022;13:1062225
Frontiers in immunology 2022;13:1062225
Prognostic value and immune infiltration of the gasdermin family in lung adenocarcinoma.
Peng LS, Duan SL, Li RQ, Wang D, Han YY, Huang T, Yu YP, Ou CL, Wang JP
Frontiers in oncology 2022;12:1043862
Frontiers in oncology 2022;12:1043862
Lactobacillus rhamnosus GR-1 attenuates foodborne Bacillus cereus-induced NLRP3 inflammasome activity in bovine mammary epithelial cells by protecting intercellular tight junctions.
Shan Q, Liu N, Wang X, Zhu Y, Yin J, Wang J
Journal of animal science and biotechnology 2022 Sep 9;13(1):101
Journal of animal science and biotechnology 2022 Sep 9;13(1):101
Gasdermin D is involved in switching from apoptosis to pyroptosis in TLR4-mediated renal tubular epithelial cells injury in diabetic kidney disease.
Yuan S, Wang Y, Li Z, Chen X, Song P, Chen A, Qu Z, Wen S, Liu H, Zhu X
Archives of biochemistry and biophysics 2022 Sep 30;727:109347
Archives of biochemistry and biophysics 2022 Sep 30;727:109347
Bisdemethoxycurcumin Alleviates Dextran Sodium Sulfate-Induced Colitis via Inhibiting NLRP3 Inflammasome Activation and Modulating the Gut Microbiota in Mice.
Zhang J, Li Q, Zhang X, Chen Y, Lu Y, Wang X, Zhang L, Wang T
Antioxidants (Basel, Switzerland) 2022 Oct 7;11(10)
Antioxidants (Basel, Switzerland) 2022 Oct 7;11(10)
Nuclear translocation of Gasdermin D sensitizes colorectal cancer to chemotherapy in a pyroptosis-independent manner.
Peng X, Na R, Zhou W, Meng X, Yang Y, Amini S, Song L
Oncogene 2022 Nov;41(47):5092-5106
Oncogene 2022 Nov;41(47):5092-5106
S100A8-Mediated NLRP3 Inflammasome-Dependent Pyroptosis in Macrophages Facilitates Liver Fibrosis Progression.
Liu Y, Kong X, You Y, Xiang L, Zhang Y, Wu R, Zhou L, Duan L
Cells 2022 Nov 12;11(22)
Cells 2022 Nov 12;11(22)
The role of discoid domain receptor 1 on renal tubular epithelial pyroptosis in diabetic nephropathy.
Zhao W, He C, Jiang J, Zhao Z, Yuan H, Wang F, Shen B
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2022 Nov 1;26(6):427-438
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2022 Nov 1;26(6):427-438
Anti‑β(2)GPI/β(2)GPI induces neutrophil pyroptosis and thereby enhances ICAM‑1 and IL‑8 expression in endothelial cells.
Luo J, Zhang M, Wang Z, Yan L, Liu Y
International journal of molecular medicine 2022 May;49(5)
International journal of molecular medicine 2022 May;49(5)
Silica nanoparticles induce pyroptosis and cardiac hypertrophy via ROS/NLRP3/Caspase-1 pathway.
Wang F, Liang Q, Ma Y, Sun M, Li T, Lin L, Sun Z, Duan J
Free radical biology & medicine 2022 Mar;182:171-181
Free radical biology & medicine 2022 Mar;182:171-181
The TLR-chaperone CNPY3 is a critical regulator of NLRP3-inflammasome activation.
Ghait M, Husain RA, Duduskar SN, Haack TB, Rooney M, Göhrig B, Bauer M, Rubio I, Deshmukh SD
European journal of immunology 2022 Jun;52(6):907-923
European journal of immunology 2022 Jun;52(6):907-923
3,4,5-O-tricaffeoylquinic acid with anti-radiation activity suppresses LPS-induced NLRP3 inflammasome activation via autophagy in THP-1 macrophages.
Liu J, Chen J, Xu B, Lin L, Liu S, Ma X, Liu J
Molecular immunology 2022 Jul;147:187-198
Molecular immunology 2022 Jul;147:187-198
Crosstalk Between RPE Cells and Choroidal Endothelial Cells via the ANXA1/FPR2/SHP2/NLRP3 Inflammasome/Pyroptosis Axis Promotes Choroidal Neovascularization.
Zhu M, Wang Y, Zhu L, Du S, Wang Z, Zhang Y, Guo Y, Tu Y, Song E
Inflammation 2022 Feb;45(1):414-427
Inflammation 2022 Feb;45(1):414-427
ATG5-Mediated Autophagy May Inhibit Pyroptosis to Ameliorate Oleic Acid-Induced Hepatocyte Steatosis.
Tang Q, Liu W, Yang X, Tian Y, Chen J, Hu Y, Fu N
DNA and cell biology 2022 Dec;41(12):1038-1052
DNA and cell biology 2022 Dec;41(12):1038-1052
Elsholtzia bodinieri Vaniot Ameliorated Acute Lung Injury by NQO1, BCL2 and PTGS2 In Silico and In Vitro Analyses.
Sun J, Jiang X, Chen Y, Guo S, Zhao Z, Cao J, Liu Y, Cheng G, Li Y, Tian L
International journal of molecular sciences 2022 Dec 9;23(24)
International journal of molecular sciences 2022 Dec 9;23(24)
Extracellular traps from activated vascular smooth muscle cells drive the progression of atherosclerosis.
Zhai M, Gong S, Luan P, Shi Y, Kou W, Zeng Y, Shi J, Yu G, Hou J, Yu Q, Jian W, Zhuang J, Feinberg MW, Peng W
Nature communications 2022 Dec 6;13(1):7500
Nature communications 2022 Dec 6;13(1):7500
Curcumin activates NLRC4, AIM2, and IFI16 inflammasomes and induces pyroptosis by up-regulated ISG3 transcript factor in acute myeloid leukemia cell lines.
Zhou Y, Kong Y, Jiang M, Kuang L, Wan J, Liu S, Zhang Q, Yu K, Li N, Le A, Zhang Z
Cancer biology & therapy 2022 Dec 31;23(1):328-335
Cancer biology & therapy 2022 Dec 31;23(1):328-335
The selective NLRP3 inflammasome inhibitor MCC950 improves isoproterenol-induced cardiac dysfunction by inhibiting cardiomyocyte senescence.
Shi Y, Zhao L, Wang J, Liu S, Zhang Y, Qin Q
European journal of pharmacology 2022 Dec 15;937:175364
European journal of pharmacology 2022 Dec 15;937:175364
NLRP6 Induces Lung Injury and Inflammation Early in Brucella and Influenza Coinfection.
Shi B, Han H, Li H, Tan L, Li X, Wang K, Li B, He W, Tian C, Yan F, Shi Y, Zheng Y, Zhao Z
Journal of personalized medicine 2022 Dec 14;12(12)
Journal of personalized medicine 2022 Dec 14;12(12)
Anti-depressant effects of acupuncture: The insights from NLRP3 mediated pyroptosis and inflammation.
Chen Y, Hao C, Chen W, Cheng W, Li P, Shen J, Tong T, Yan S, Huang S, He T, Huang Z, Meng X
Neuroscience letters 2022 Aug 10;785:136787
Neuroscience letters 2022 Aug 10;785:136787
Alda-1, an Activator of ALDH2, Improves Postresuscitation Cardiac and Neurological Outcomes by Inhibiting Pyroptosis in Swine.
Diao M, Xu J, Wang J, Zhang M, Wu C, Hu X, Zhu Y, Zhang M, Hu W
Neurochemical research 2022 Apr;47(4):1097-1109
Neurochemical research 2022 Apr;47(4):1097-1109
Tubastatin A Improves Post-Resuscitation Myocardial Dysfunction by Inhibiting NLRP3-Mediated Pyroptosis Through Enhancing Transcription Factor EB Signaling.
Xu J, Zhao X, Jiang X, He L, Wu X, Wang J, Chen Q, Li Y, Zhang M
Journal of the American Heart Association 2022 Apr 5;11(7):e024205
Journal of the American Heart Association 2022 Apr 5;11(7):e024205
Baclofen attenuates cognitive deficits in post-cardiac arrest brain injury.
Sun Y, Cong T, Li L, Li J, Wu H, Chen X, Zhou Y, Xiao Z
Biochemical and biophysical research communications 2022 Apr 30;602:135-141
Biochemical and biophysical research communications 2022 Apr 30;602:135-141
Dietary Tryptophan Supplementation Improves Antioxidant Status and Alleviates Inflammation, Endoplasmic Reticulum Stress, Apoptosis, and Pyroptosis in the Intestine of Piglets after Lipopolysaccharide Challenge.
Liu G, Tao J, Lu J, Jia G, Zhao H, Chen X, Tian G, Cai J, Zhang R, Wang J
Antioxidants (Basel, Switzerland) 2022 Apr 28;11(5)
Antioxidants (Basel, Switzerland) 2022 Apr 28;11(5)
Escin Sodium Improves the Prognosis of Acute Pancreatitis via Promoting Cell Apoptosis by Suppression of the ERK/STAT3 Signaling Pathway.
Zhang Q, Zhao C, Zhang L, Sun K, Yu L, Wang X, Ren L, Zhang N, Chen C, Liu J, Wang H, Tian H
Oxidative medicine and cellular longevity 2021;2021:9921839
Oxidative medicine and cellular longevity 2021;2021:9921839
Sodium Houttuyfonate Ameliorates β-amyloid(1-42)-Induced Memory Impairment and Neuroinflammation through Inhibiting the NLRP3/GSDMD Pathway in Alzheimer's Disease.
Zhao Y, Tian Y, Feng T
Mediators of inflammation 2021;2021:8817698
Mediators of inflammation 2021;2021:8817698
Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo.
Liao Z, Li S, Liu R, Feng X, Shi Y, Wang K, Li S, Zhang Y, Wu X, Yang C
Oxidative medicine and cellular longevity 2021;2021:5584447
Oxidative medicine and cellular longevity 2021;2021:5584447
Destructive Effects of Pyroptosis on Homeostasis of Neuron Survival Associated with the Dysfunctional BBB-Glymphatic System and Amyloid-Beta Accumulation after Cerebral Ischemia/Reperfusion in Rats.
Lyu Z, Chan Y, Li Q, Zhang Q, Liu K, Xiang J, Li X, Cai D, Li Y, Wang B, Yu Z
Neural plasticity 2021;2021:4504363
Neural plasticity 2021;2021:4504363
Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome-Induced Pyroptosis via Inhibiting the TLR4/NF-κB/PFKFB3 Signaling in Trophoblasts: Implication for a Potential Therapy of Preeclampsia.
Zhang Y, Liu W, Zhong Y, Li Q, Wu M, Yang L, Liu X, Zou L
Oxidative medicine and cellular longevity 2021;2021:1806344
Oxidative medicine and cellular longevity 2021;2021:1806344
Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3/caspase-1/GSDMD Pathway in Triple-Negative Breast Cancer.
Yan H, Luo B, Wu X, Guan F, Yu X, Zhao L, Ke X, Wu J, Yuan J
International journal of biological sciences 2021;17(10):2606-2621
International journal of biological sciences 2021;17(10):2606-2621
Ginsenoside Rg1 Inhibits Microglia Pyroptosis Induced by Lipopolysaccharide Through Regulating STAT3 Signaling.
Yao Y, Li C, Qian F, Zhao Y, Shi X, Hong D, Ai Q, Zhong L
Journal of inflammation research 2021;14:6619-6632
Journal of inflammation research 2021;14:6619-6632
Assessment of Pyroptosis-Related Indicators as Potential Biomarkers and Their Association with Severity in Patients with Liver Cirrhosis.
Wang D, Zhan X, Wu R, You Y, Chen W, Duan L
Journal of inflammation research 2021;14:3185-3196
Journal of inflammation research 2021;14:3185-3196
Mesenchymal Stem Cells Alleviate Post-resuscitation Cardiac and Cerebral Injuries by Inhibiting Cell Pyroptosis and Ferroptosis in a Swine Model of Cardiac Arrest.
Xu J, Zhang M, Liu F, Shi L, Jiang X, Chen C, Wang J, Diao M, Khan ZU, Zhang M
Frontiers in pharmacology 2021;12:793829
Frontiers in pharmacology 2021;12:793829
Metallothionein 3-Zinc Axis Suppresses Caspase-11 Inflammasome Activation and Impairs Antibacterial Immunity.
Chowdhury D, Gardner JC, Satpati A, Nookala S, Mukundan S, Porollo A, Landero Figueroa JA, Subramanian Vignesh K
Frontiers in immunology 2021;12:755961
Frontiers in immunology 2021;12:755961
CBD Alleviates Liver Injuries in Alcoholics With High-Fat High-Cholesterol Diet Through Regulating NLRP3 Inflammasome-Pyroptosis Pathway.
Jiang X, Gu Y, Huang Y, Zhou Y, Pang N, Luo J, Tang Z, Zhang Z, Yang L
Frontiers in pharmacology 2021;12:724747
Frontiers in pharmacology 2021;12:724747
siRNAs Targeting Mouse-Specific lncRNA AA388235 Induce Human Tumor Cell Pyroptosis/Apoptosis.
Chen YR, Feng WY, Cheng YX, Zhu H, Liu HJ, Gao Y, Zhou WJ
Frontiers in oncology 2021;11:662444
Frontiers in oncology 2021;11:662444
Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration.
Xing H, Zhang Z, Mao Q, Wang C, Zhou Y, Zhou X, Ying L, Xu H, Hu S, Zhang N
Journal of nanobiotechnology 2021 Sep 6;19(1):264
Journal of nanobiotechnology 2021 Sep 6;19(1):264
Engineering Extracellular Vesicles Restore the Impaired Cellular Uptake and Attenuate Intervertebral Disc Degeneration.
Liao Z, Liu H, Ma L, Lei J, Tong B, Li G, Ke W, Wang K, Feng X, Hua W, Li S, Yang C
ACS nano 2021 Sep 28;15(9):14709-14724
ACS nano 2021 Sep 28;15(9):14709-14724
Plasma exosomes derived from patients with intestinal Behçet's syndrome induce intestinal epithelial cell pyroptosis.
Hou CC, Ma HF, Ye JF, Luo D, Bao HF, Guan JL
Clinical rheumatology 2021 Oct;40(10):4143-4155
Clinical rheumatology 2021 Oct;40(10):4143-4155
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Zhao Y, Liu X, Zheng Y, Liu W, Ding C
Scientific reports 2021 Oct 18;11(1):20558
Scientific reports 2021 Oct 18;11(1):20558
(-)-Epicatechin ameliorates cigarette smoke-induced lung inflammation via inhibiting ROS/NLRP3 inflammasome pathway in rats with COPD.
Tian X, Xue Y, Xie G, Zhou Y, Xiao H, Ding F, Zhang M
Toxicology and applied pharmacology 2021 Oct 15;429:115674
Toxicology and applied pharmacology 2021 Oct 15;429:115674
The relationship between liver pathological inflammation degree and pyroptosis in chronic hepatitis B patients.
Wang Y, Li X, Chen Q, Jiao F, Shi C, Pei M, Wang L, Gong Z
Journal of medical virology 2021 Nov;93(11):6229-6235
Journal of medical virology 2021 Nov;93(11):6229-6235
Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway.
Hao W, Hao C, Wu C, Xu Y, Wu S, Lu X, Yang J, Jin C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112591
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112591
The balance between AIM2-associated inflammation and autophagy: the role of CHMP2A in brain injury after cardiac arrest.
Shao R, Wang X, Xu T, Xia Y, Cui D
Journal of neuroinflammation 2021 Nov 5;18(1):257
Journal of neuroinflammation 2021 Nov 5;18(1):257
Gasdermin D Is a Novel Prognostic Biomarker and Relates to TMZ Response in Glioblastoma.
Liu J, Gao L, Zhu X, Geng R, Tao X, Xu H, Chen Z
Cancers 2021 Nov 10;13(22)
Cancers 2021 Nov 10;13(22)
Mesenchymal stromal cells protect hepatocytes from lipotoxicity through alleviation of endoplasmic reticulum stress by restoring SERCA activity.
Li L, Zeng X, Liu Z, Chen X, Li L, Luo R, Liu X, Zhang J, Liu J, Lu Y, Cheng J, Chen Y
Journal of cellular and molecular medicine 2021 Mar;25(6):2976-2993
Journal of cellular and molecular medicine 2021 Mar;25(6):2976-2993
Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes.
Tsuchiya K, Hosojima S, Hara H, Kushiyama H, Mahib MR, Kinoshita T, Suda T
Cell reports 2021 Mar 23;34(12):108887
Cell reports 2021 Mar 23;34(12):108887
Macrophage membrane-mediated targeted drug delivery for treatment of spinal cord injury regardless of the macrophage polarization states.
Tang W, Yang Y, Yang L, Tang M, Chen Y, Li C
Asian journal of pharmaceutical sciences 2021 Jul;16(4):459-470
Asian journal of pharmaceutical sciences 2021 Jul;16(4):459-470
Suppressing ROS generation by apocynin inhibited cyclic stretch-induced inflammatory reaction in HPDLCs via a caspase-1 dependent pathway.
Wang Y, Song Y, Zhong Q, Wu Y, Zhuang J, Qu F, Xu C
International immunopharmacology 2021 Jan;90:107129
International immunopharmacology 2021 Jan;90:107129
Low shear stress induced vascular endothelial cell pyroptosis by TET2/SDHB/ROS pathway.
Chen J, Zhang J, Wu J, Zhang S, Liang Y, Zhou B, Wu P, Wei D
Free radical biology & medicine 2021 Jan;162:582-591
Free radical biology & medicine 2021 Jan;162:582-591
Histone deacetylase 2 regulates ULK1 mediated pyroptosis during acute liver failure by the K68 acetylation site.
Wang Y, Chen Q, Jiao F, Shi C, Pei M, Wang L, Gong Z
Cell death & disease 2021 Jan 11;12(1):55
Cell death & disease 2021 Jan 11;12(1):55
Gasdermin D: in vivo evidence of pyroptosis in spontaneous labor at term.
Gomez-Lopez N, Romero R, Panaitescu B, Miller D, Zou C, Gudicha DW, Tarca AL, Para R, Pacora P, Hassan SS, Hsu CD
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2021 Feb;34(4):569-579
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2021 Feb;34(4):569-579
Macrophages regulates the transition of pericyte to peritoneal fibrosis through the GSDMD/IL-1β axis.
Shao Q, Sun C, Zhang Q, Liu J, Xia Y, Jin B, Qian X
International immunopharmacology 2021 Dec;101(Pt A):108323
International immunopharmacology 2021 Dec;101(Pt A):108323
Isoorientin Attenuated the Pyroptotic Hepatocyte Damage Induced by Benzo[a]pyrene via ROS/NF-κB/NLRP3/Caspase-1 Signaling Pathway.
Li H, Yuan L, Li X, Luo Y, Zhang Z, Li J
Antioxidants (Basel, Switzerland) 2021 Aug 11;10(8)
Antioxidants (Basel, Switzerland) 2021 Aug 11;10(8)
Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP.
Ji Q, Wang L, Liu J, Wu Y, Lv H, Wen Y, Shi L, Qu B, Szentmáry N
Inflammation 2021 Apr;44(2):682-692
Inflammation 2021 Apr;44(2):682-692
CD147 Expression Is Associated with Tumor Proliferation in Bladder Cancer via GSDMD.
Peng J, Jiang H, Guo J, Huang J, Yuan Q, Xie J, Xiao K
BioMed research international 2020;2020:7638975
BioMed research international 2020;2020:7638975
Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis.
Zeng X, Zhu M, Liu X, Chen X, Yuan Y, Li L, Liu J, Lu Y, Cheng J, Chen Y
Nutrition & metabolism 2020;17:11
Nutrition & metabolism 2020;17:11
Overexpression of gasdermin D promotes invasion of adenoid cystic carcinoma.
Shen X, Zhang Q, He Z, Xiao S, Li H, Huang Z
International journal of clinical and experimental pathology 2020;13(7):1802-1811
International journal of clinical and experimental pathology 2020;13(7):1802-1811
Detection of proteins associated with the pyroptosis signaling pathway in breast cancer tissues and their significance.
Wu X, Mao X, Huang Y, Zhu Q, Guan J, Wu L
International journal of clinical and experimental pathology 2020;13(6):1408-1414
International journal of clinical and experimental pathology 2020;13(6):1408-1414
Tangshen Formula Attenuates Diabetic Kidney Injury by Imparting Anti-pyroptotic Effects via the TXNIP-NLRP3-GSDMD Axis.
Li N, Zhao T, Cao Y, Zhang H, Peng L, Wang Y, Zhou X, Wang Q, Li J, Yan M, Dong X, Zhao H, Li P
Frontiers in pharmacology 2020;11:623489
Frontiers in pharmacology 2020;11:623489
IFN regulatory Factor-1 induced macrophage pyroptosis by modulating m6A modification of circ_0029589 in patients with acute coronary syndrome.
Guo M, Yan R, Ji Q, Yao H, Sun M, Duan L, Xue Z, Jia Y
International immunopharmacology 2020 Sep;86:106800
International immunopharmacology 2020 Sep;86:106800
Trimethylamine N-oxide promotes apoE(-/-) mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway.
Wu P, Chen J, Chen J, Tao J, Wu S, Xu G, Wang Z, Wei D, Yin W
Journal of cellular physiology 2020 Oct;235(10):6582-6591
Journal of cellular physiology 2020 Oct;235(10):6582-6591
Type I Interferon Increases Inflammasomes Associated Pyroptosis in the Salivary Glands of Patients with Primary Sjögren's Syndrome.
Hong SM, Lee J, Jang SG, Lee J, Cho ML, Kwok SK, Park SH
Immune network 2020 Oct;20(5):e39
Immune network 2020 Oct;20(5):e39
MiR-124-3p promotes trophoblast cell HTR-8/SVneo pyroptosis by targeting placental growth factor.
Tao J, Xia LZ, Liang L, Chen Y, Wei D, Meng J, Wu S, Wang Z
Placenta 2020 Nov;101:176-184
Placenta 2020 Nov;101:176-184
Exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the NLRP3 inflammasome in mice.
Wang D, Weng Y, Zhang Y, Wang R, Wang T, Zhou J, Shen S, Wang H, Wang Y
The Science of the total environment 2020 Nov 25;745:141049
The Science of the total environment 2020 Nov 25;745:141049
HMGB1 mediates homocysteine-induced endothelial cells pyroptosis via cathepsin V-dependent pathway.
Leng Y, Chen R, Chen R, He S, Shi X, Zhou X, Zhang Z, Chen AF
Biochemical and biophysical research communications 2020 Nov 19;532(4):640-646
Biochemical and biophysical research communications 2020 Nov 19;532(4):640-646
NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology.
He X, Yang W, Zeng Z, Wei Y, Gao J, Zhang B, Li L, Liu L, Wan Y, Zeng Q, Gong Z, Liu L, Zhang H, Li Y, Yang S, Hu T, Wu L, Masliah E, Huang S, Cao H
Cellular & molecular immunology 2020 Mar;17(3):283-299
Cellular & molecular immunology 2020 Mar;17(3):283-299
TNF-α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury.
Wang Y, Zhang H, Chen Q, Jiao F, Shi C, Pei M, Lv J, Zhang H, Wang L, Gong Z
Cell proliferation 2020 Jun;53(6):e12829
Cell proliferation 2020 Jun;53(6):e12829
Discovery of novel TNNI3K inhibitor suppresses pyroptosis and apoptosis in murine myocardial infarction injury.
Pang H, Wang N, Chai J, Wang X, Zhang Y, Bi Z, Wu W, He G
European journal of medicinal chemistry 2020 Jul 1;197:112314
European journal of medicinal chemistry 2020 Jul 1;197:112314
Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer.
Teng JF, Mei QB, Zhou XG, Tang Y, Xiong R, Qiu WQ, Pan R, Law BY, Wong VK, Yu CL, Long HA, Xiao XL, Zhang F, Wu JM, Qin DL, Wu AG
Cancers 2020 Jan 13;12(1)
Cancers 2020 Jan 13;12(1)
Cyclin-Dependent Kinase 9 Inhibition Suppresses Necroptosis and Pyroptosis in the Progress of Endotoxemia.
Li J, Mao H, Pan Y, Li H, Lei L
Inflammation 2020 Dec;43(6):2061-2074
Inflammation 2020 Dec;43(6):2061-2074
Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis.
Zhang X, Zhang P, An L, Sun N, Peng L, Tang W, Ma D, Chen J
Acta pharmaceutica Sinica. B 2020 Aug;10(8):1397-1413
Acta pharmaceutica Sinica. B 2020 Aug;10(8):1397-1413
IFN Regulatory Factor 1 Mediates Macrophage Pyroptosis Induced by Oxidized Low-Density Lipoprotein in Patients with Acute Coronary Syndrome.
Guo M, Yan R, Yao H, Duan L, Sun M, Xue Z, Jia Y
Mediators of inflammation 2019;2019:2917128
Mediators of inflammation 2019;2019:2917128
HMGB1-induced endothelial cell pyroptosis is involved in systemic inflammatory response syndrome following radiofrequency ablation of hepatic hemangiomas.
Yang M, Yang X, Wang S, Xu L, Ke S, Ding X, Sun W, Gao J
American journal of translational research 2019;11(12):7555-7567
American journal of translational research 2019;11(12):7555-7567
Trichomonas vaginalis Induces NLRP3 Inflammasome Activation and Pyroptotic Cell Death in Human Macrophages.
Riestra AM, Valderrama JA, Patras KA, Booth SD, Quek XY, Tsai CM, Nizet V
Journal of innate immunity 2019;11(1):86-98
Journal of innate immunity 2019;11(1):86-98
TLR4/NF-κB Signaling Induces GSDMD-Related Pyroptosis in Tubular Cells in Diabetic Kidney Disease.
Wang Y, Zhu X, Yuan S, Wen S, Liu X, Wang C, Qu Z, Li J, Liu H, Sun L, Liu F
Frontiers in endocrinology 2019;10:603
Frontiers in endocrinology 2019;10:603
Neferine inhibits LPS-ATP-induced endothelial cell pyroptosis via regulation of ROS/NLRP3/Caspase-1 signaling pathway.
Tang YS, Zhao YH, Zhong Y, Li XZ, Pu JX, Luo YC, Zhou QL
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2019 Sep;68(9):727-738
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2019 Sep;68(9):727-738
Gasdermin D: Evidence of pyroptosis in spontaneous preterm labor with sterile intra-amniotic inflammation or intra-amniotic infection.
Gomez-Lopez N, Romero R, Tarca AL, Miller D, Panaitescu B, Schwenkel G, Gudicha DW, Hassan SS, Pacora P, Jung E, Hsu CD
American journal of reproductive immunology (New York, N.Y. : 1989) 2019 Dec;82(6):e13184
American journal of reproductive immunology (New York, N.Y. : 1989) 2019 Dec;82(6):e13184
Endothelial pyroptosis underlies systemic inflammatory response following radiofrequency ablation of hepatic hemangiomas.
Wang S, Yang M, Yang X, Xu L, Ke S, Ding X, Sun W, Gao J
Scandinavian journal of clinical and laboratory investigation 2019 Dec;79(8):619-628
Scandinavian journal of clinical and laboratory investigation 2019 Dec;79(8):619-628
Bacteroides fragilis Strain ZY-312 Defense against Cronobacter sakazakii-Induced Necrotizing Enterocolitis In Vitro and in a Neonatal Rat Model.
Fan H, Chen Z, Lin R, Liu Y, Wu X, Puthiyakunnon S, Wang Y, Zhu B, Zhang Q, Bai Y, Zhi F
mSystems 2019 Aug 6;4(4)
mSystems 2019 Aug 6;4(4)
Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis.
Guo Q, Wu Y, Hou Y, Liu Y, Liu T, Zhang H, Fan C, Guan H, Li Y, Shan Z, Teng W
Frontiers in immunology 2018;9:1197
Frontiers in immunology 2018;9:1197
Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts.
Jun HK, Jung YJ, Ji S, An SJ, Choi BK
Cell death and differentiation 2018 Feb;25(2):380-391
Cell death and differentiation 2018 Feb;25(2):380-391
Atypical Gasdermin D and Mixed Lineage Kinase Domain-like Protein Leakage Aggravates Tetrachlorobenzoquinone-Induced Nod-like Receptor Protein 3 Inflammasome Activation.
Xia X, Lu B, Dong W, Yang B, Wang Y, Qin Q, Liu Z, Song E, Song Y
Chemical research in toxicology 2018 Dec 17;31(12):1418-1425
Chemical research in toxicology 2018 Dec 17;31(12):1418-1425
Protein kinase D at the Golgi controls NLRP3 inflammasome activation.
Zhang Z, Meszaros G, He WT, Xu Y, de Fatima Magliarelli H, Mailly L, Mihlan M, Liu Y, Puig Gámez M, Goginashvili A, Pasquier A, Bielska O, Neven B, Quartier P, Aebersold R, Baumert TF, Georgel P, Han J, Ricci R
The Journal of experimental medicine 2017 Sep 4;214(9):2671-2693
The Journal of experimental medicine 2017 Sep 4;214(9):2671-2693
Inflammasome activators induce fibronectin expression and release in macrophages.
Jun HK, Jung YJ, Choi BK
Cellular microbiology 2017 May;19(5)
Cellular microbiology 2017 May;19(5)
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.
Liu X, Zhang Z, Ruan J, Pan Y, Magupalli VG, Wu H, Lieberman J
Nature 2016 Jul 7;535(7610):153-8
Nature 2016 Jul 7;535(7610):153-8
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion.
He WT, Wan H, Hu L, Chen P, Wang X, Huang Z, Yang ZH, Zhong CQ, Han J
Cell research 2015 Dec;25(12):1285-98
Cell research 2015 Dec;25(12):1285-98
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 20770-1-AP(GSDMD antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using GSDMD antibody 20770-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human skin using 20770-1-AP(GSDMD antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human skin using 20770-1-AP(GSDMD antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
