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- Product number
- 20770-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20770-1-AP, RRID:AB_10696319
- Product name
- GSDMD antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated GSDMD antibody (Cat. #20770-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references GBP2 promotes podocyte pyroptosis and contributes to the pathogenesis of pediatric lupus nephritis.
A Topical Chinese Herbal Alleviates Psoriasis by Regulating Keratinocytes Pyroptosis Through Inhibition of NLRP3 Inflammasome Activation.
Prim-O-glucosylcimifugin ameliorates DSS-induced ulcerative colitis via suppressing NLRP3 inflammasome activation.
Identifying pyroptosis-related lncRNAs to predict prognosis and immune regulation in hepatocellular carcinoma.
Statins targeting mevalonate-geranylgeranyl diphosphate pathway inhibit proliferation in NK/T lymphoma by promoting pyroptosis.
Maresin 1 activates autophagy through SIRT1/PPAR-γ signaling to mitigate high glucose-induced pyroptosis in human retinal pigment epithelial cells.
d-amino acids restrain macrophage IL-1β release through gasdermin D acetylation.
The "Tianyu" Formulation Alleviates Rheumatoid Arthritis by Modulating the NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis Pathway.
The sphingolipid metabolite sphingosine protects against hypertension by targeting metabolic-inflammatory crosstalk via the NLRP3 inflammasome.
Chromatin remodeling factor CHRAC1 regulates doxorubicin-induced cardiotoxicity via IRF9/GSDMD/CASP-1.
SELENOF Mitigates Bovine Mastitis by Preserving Mitochondrial Homeostasis and Suppressing NLRP3-Mediated Pyroptosis.
Didymin alleviates neuropathic pain by targeting RKIP-mediated NF-κB/NLRP3 crosstalk to inhibit pyroptosis and neuroinflammation.
Hydrogen sulfide ameliorates oxalate crystal-related renal injury via inhibiting the activation of NOD-like receptor thermal protein domain associated protein 3 inflammasome in mice.
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression.
Qualitative analysis of chemical components in Berberis kaschgarica Rupr. and study on the in vitro anti-inflammatory effects of its alkaloids.
Fibroblast-derived exosomes induce macrophage pyroptosis to mediate orthodontic bone remodeling through the mtDNA/NLRP3 axis.
S100A11 regulates microglial inflammatory response in neuropathic pain via H3K27ac-TFEB-mitochondrial autophagy axis.
Lnc-USP28-6/ZBTB16 axis orchestrates NLRP3 inflammasome activation and α-synuclein SUMOylation to drive Parkinson's disease pathogenesis.
Chemerin Promotes Oral Squamous Cell Carcinoma Progression via NLRP3-Mediated Pyroptosis and the GSDMD-N Pathway.
Dual-targeting nuclear and mitochondrial DNA damage drives immunogenic activation via PANoptosis for synergistic magneto-thermodynamic-chemotherapy.
The role of apolipoprotein C1 in mediating pyroptosis in Hashimoto's thyroiditis via TLR10/MyD88/NF-κB pathway.
Neutrophil aconitate decarboxylase 1/itaconate axis suppresses extracellular traps via alkylating GSDMD and alleviates murine liver injury.
Molecular hydrogen suppresses gut inflammation and pyroptosis in ulcerative colitis through promoting PKM2 lactylation to block NLRP3 inflammasome activation.
CSB6B attenuates renal inflammation and fibrosis by inhibiting the activation of NLRP3 inflammasome through the NLRP3/Caspase-1/GSDMD/IL-1β signaling pathway.
Elucidating the mechanism of traditional Chinese medicine formula (Yifei-sanjie Pill) in alleviating the chemobrain based on network pharmacology and experimental verification.
Qingqi Liangying formula inhibits brain endothelial cell pyroptosis via NLRP3/caspase-1/GSDMD in sepsis-associated encephalopathy.
Free Fatty Acids and Endotoxins Synergically Induce Pyroptosis in Bovine Hepatocytes.
Polyphyllin II Triggers Pyroptosis in Hepatocellular Carcinoma via Modulation of the ROS/NLRP3/Caspase-1/GSDMD Axis.
Acupuncture as a modulator of microglial polarization and pyroptosis in depression: evidence from a chronic unpredictable mild stress rat model.
Thonningianin A derived from Penthorum chinense Pursh alleviates cerebral ischemia/reperfusion-mediated apoptosis and pyroptosis through the activation of PINK1/Parkin-dependent mitophagy.
IGF2BP3/m6A-mediated intron retention isoform of DUSP6 promotes cisplatin resistance in nasopharyngeal carcinoma by inhibiting pyroptosis.
Dual NLRC4 and non-canonical inflammasome signaling drives human GSDMD-mediated killing of Shigella flexneri independently of bacterial cardiolipin.
CACNB1 alleviates mepivacaine‑induced myocardial ischemia/reperfusion injury by promoting Nrf2 nuclear translocation.
CUEDC2 improves pyroptosis and kidney damage in diabetic kidney disease by inhibiting NLRP3 inflammasome activation.
Cathepsin B overexpression and lysosomal leakage in inflammatory microglia promote neuroinflammation in olfactory dysfunction by triggering mitochondrial dysfunction and pyroptosis.
Macrophage pyroptosis inhibition alleviates postinjury neointimal formation and vascular restenosis.
Sleep deprivation impairs follicular development attributable to granulosa cell pyroptosis mediated by S100A8/A9-driven macrophage M1 polarization.
ADSC-Conditioned Medium Mitigates LPS-Induced Acute Lung Injury by Inhibiting Alveolar Macrophage Pyroptosis.
FGF4 activates FGFR1 - PI3K/AKT signaling to enhance Clec10a-mediated intracellular myelin debris processing and promote spinal cord repair.
HIFU postoperative hypoxia-activated metal-organic frameworks modulate the tumor microenvironment to augment immunotherapy.
Sirtuin 5-mediated desuccinylation of PRDX6 inhibits ferroptosis and alleviates sepsis-associated acute kidney injury.
Hypothermic machine perfusion protects DCD graft liver from ischemia‑reperfusion injury by enhancing macrophage efferocytosis via KLF2‑NLRP3 signaling.
Zinc-doped carbon dots from natural Isatis Indigotica folium and calamine: SOD/CAT-mimetic activity targets ROS-Ca²⁺-NLRP3 axis for psoriatic dermatitis therapy.
Geum japonicum Thunb. var. Chinese-P.decorata H.Andres herbal pair ameliorates CIRI-induced neuronal injury by facilitating mitochondrial transfer via the CD38/Miro1 signaling pathway.
Huangqi Chifeng decoction alleviates cerebral ischemia and reperfusion injury by targeting NFKBIA, NF-κB1 p105 and PIAS1 to multi-dimensionally inhibit NF-κB/NLRP3 signaling: A multi-omics analysis.
Inducible Nitric Oxide Deficiency Attenuates Necroptosis in Psoriasis-Like Dermatitis in Mice by Reducing Oxidative Stress.
MiR-93-5p Loaded Lipid Nanoparticles Break the Dry Eye Vicious Cycle via Targeting MAP3K8.
ADAMTS7 selective inhibitor BAY-9835 alleviates acute myocardial infarction by suppressing the NF-κB-mediated pyroptosis.
FOXE1 promotes the progression of pulp inflammation by activating PANoptosis in dental pulp cells.
Macrophage-Targeted Nanocarriers Based on Tetrahedral DNA Nanostructure Alleviate Sepsis-Induced Acute Lung Injury by Triple-Pathway Suppression of Pyroptosis.
USP53 Drives Ethanol-Induced Myocardial Injury by Promoting K63 Deubiquitination-Dependent RIPK1 Activation at K377.
Neonatal-Inspired Reprogramming of Microglial Pan-Programmed Cell Death Enhances Regeneration in Adult Spinal Cord Injury.
Biosynthesis of Lysosomally Escaped Apoptotic Bodies Inhibits Inflammasome Synthesis in Macrophages.
Breaking the Chains of Therapeutic Blockade: Pyroptosis-Induced Photothermal-Chemotherapy with Targeted Nanoprobes in Triple-Negative Breast Cancer.
Lipin3 deficiency aggravates cisplatin induced acute kidney injury via activating Sirt1-p21-Caspase 3-GSDME pyroptosis pathway.
MIF-Mediated NLRP3 Inflammasome-Dependent Pyroptosis in Spinal Neurons and Microglial Polarization Facilitate Neuropathic Pain Progression.
TMAO Induces Vascular Endothelial Cells Pyroptosis Through TET2-CYTB-ROS Pathway.
Influence of Pyroptosis Induced by NOD-Like Receptor Pyrin Domain-Containing 3 Inflammasomes on Viral Myocarditis in Children.
Effect of Acupotomy Modulation of NLRP3/Caspase-1/GSDMD Pathway on Chondrocyte Pyroptosis in Knee Osteoarthritis.
Glycochenodeoxycholic acid induces the release of IL-1beta from L02 cells via the NLRP3/caspase-1/GSDMD pathway to activate LX2 cells.
MALAT1's m(6)A Modification by METTL3 Promotes Pyroptosis and Inflammation in Sepsis-Induced Acute Kidney Injury in Mice.
Electroacupuncture Regulates Oxidative Stress-Mediated NLRP3/ASC/Caspase-1 Pathway to Inhibit Microglial Activation: Alleviating Neuroinflammation and Depression in IBD.
ALDH2 Ameliorates Acute Gouty Arthritis Through Inhibiting NLRP3 Inflammasome and Pyroptosis by Nrf2/ROS Pathway.
Electroacupuncture alleviates Parkinson's disease by inhibiting the NLRP3 inflammasome pathway.
Verteporfin inhibits the cGAS-STING pathway and improves the tumor microenvironment during cisplatin treatment in hepatocellular carcinoma.
Analysis of GSDMD-N abnormality promoting neutrophil NETs mediated RA disease through NLRP3-dependent pathway.
Integrated proteomics analysis and network pharmacology to elucidate the mechanism of Zhilong Huoxue Tongyu Capsule alleviate hypertensive retinopathy in Ang II infusion mice model.
Osteopontin regulates right ventricular failure through integrin ανβ3/PERK/CHOP-dependent inflammatory and apoptotic pathways.
Thymoquinone alleviates the accumulation of ROS and pyroptosis and promotes perforator skin flap survival through SIRT1/NF-κB pathway.
Hydrogen sulfide as a therapeutic agent for diabetic wounds: effects on inflammation and fibroblast pyroptosis.
Suppression of NLRP3 inflammasome by a small molecule targeting CK1α-β-catenin-NF-κB and CK1α-NRF2-mitochondrial OXPHOS pathways during mycobacterial infection.
Evaluation of pyroptosis-associated genes in endometrial cancer utilizing a 101-combination machine learning framework and multi-omics data.
Combined effects of quinic acid and isochlorogenic acid B on LPS-induced inflammation and pyroptosis in MAC-T cells and mouse mammary glands.
Lithocarpus polystachyus Rehd. leaves aqueous extract inhibits learning and memory impairment in Alzheimer's disease rats: Involvement of the SIRT6/NLRP3 signaling pathway.
Inhibition of tRF- 02514 in Extracellular Vesicles Preserves Microglia Pyroptosis and Protects Against Parkinson's Disease.
Oridonin Ameliorates Metabolic-Dysfunction-Associated Fatty Liver Disease by Inhibiting PANoptosis via Modulating SIRT2/NLRP3 Pathway.
The viral BCL2 protein BHRF1 of Epstein-Barr virus promotes AIM2 inflammasome activation to facilitate lytic replication.
β-elemene promotes ferroptosis to improve the sensitivity of imatinib in gastrointestinal stromal tumours by targeting N6AMT1.
Bacteroides Fragilis-Derived Outer Membrane Vesicles Deliver MiR-5119 and Alleviate Colitis by Targeting PD-L1 to Inhibit GSDMD-Mediated Neutrophil Extracellular Trap Formation.
DCAAA mitigates neuroinflammation and microglial pyroptosis in spinal cord injury by inhibiting PI3K/AKT/NF-κB and NLRP3/caspase-1/GSDMD signaling.
Tianlong kechuanling ameliorated COPD-PH through DNMT3A-GSDMD axis-dependent regulation of endothelial cell pyroptosis.
Astragaloside IV alleviates LPS-induced acute lung injury by regulating receptor C5aR1 and macrophage pyroptosis.
Melatonin attenuates ischemia-reperfusion-induced acute kidney injury by regulating abnormal autophagy and pyroptosis through SIRT1-mediated p53 deacetylation.
Rufy3 Knockdown Induces PANoptosis Through MAP4/CDK1 Axis to Inhibit Colorectal Cancer Growth: Evidence From In Vitro and In Vivo Models.
SVF Cell Sheets as a New Multicellular Material-Based Strategy for Promoting Angiogenesis and Regeneration in Diced Cartilage Grafts.
Gestational zearalenone causes fetal intrauterine growth restriction partially through deriving ROS-Drp1 mediated placental PANoptosis.
Canagliflozin Attenuates Podocyte Inflammatory Injury through Suppressing the TXNIP/NLRP3 Signaling Pathway in Diabetic Kidney Disease Mice.
Baicalein Reduces Pyroptosis of Acinar Cells in Hyperlipidemic Acute Pancreatitis by Inhibiting M1 Polarization of Macrophages via the HMGB1/TLR4/NLRP3 Pathway.
Astragaloside IV-PESV facilitates pyroptosis by enhancing palmitoylation of GSDMD protein mediated by ZDHHC1.
Endothelial HMGB1-AIM2 axis worsens myocardial ischemia-reperfusion injury by regulating endothelial pyroptosis.
AIM2-PANoptosome-driven PANoptosis in hepatic lipid dysregulation induced by β-HCH and nanoplastics co-exposure.
Scorpion venom heat-resistant synthetic peptide regulates Nrf-2 to alleviate neuronal pyroptosis in an AD model induced by endoplasmic reticulum stress under PM(2.5) exposure.
Mesenchymal Stem Cells Derived from Different Adipose Tissue Depots Ameliorate Severe Acute Pancreatitis by Inhibiting NF-κB/NLRP3/Caspase-1 Pathways.
Inhibition of PINK1 senses ROS signaling to facilitate neuroblastoma cell pyroptosis.
1,8-Cineole alleviates spinal cord injury by inhibiting microglial pyroptosis via the P38 MAPK and PI3K/AKT/NLRP3 signaling pathways to protects neurons.
cGAS-STING-NF-κB Axis Mediates Rotenone-Induced NLRP3 Inflammasome Activation Through Mitochondrial DNA Release.
Bisphenol S as an emerging osteotoxicant: Mechanistic insights from osteoblasts and zebrafish models.
PACAP inhibits high fat-induced NLRP3 inflammasome-mediated pyroptosis in vascular endothelial cells by regulating the SIRT1/ROS pathway.
Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury.
Mechanism of Berberine Ameliorating Severe Pneumonia by Targeting PTGS2 Inhibition to Regulate C-Type Lectin Receptor Pathway, Mitochondrial Function and Cellular Focalization.
Activation of IRF2 signaling networks facilitates podocyte pyroptosis in lupus nephritis.
Dnmt1 Alleviates S1PR1-Mediated Pyroptosis after Spinal Cord Injury through Regulating Pon3 Expression.
LPS-Induced Mitochondrial Damage via SLC41A1-Mediated Magnesium Ion Efflux Leads to the Pyroptosis of Dental Stem Cells.
Hydrogen Sulfide Attenuates Cisplatin-Induced Acute Kidney Injury via Dual Inhibition of Apoptosis and Pyroptosis.
Acetylation reader BRD4-driven TXNIP transcription enhances NLRP3 inflammasome activation in PCOS.
Shen Yuan Yi Qi Huo Xue capsules inhibit neutrophil NETosis by regulating the PAD4/NLRP3 signaling pathway to prevent heart failure after myocardial infarction.
Bushen Huatan formula alleviates polycystic ovary syndrome in rats by activating the PI3K/Akt pathway to inhibit GSDMD-mediated pyroptosis and mitochondrial damage.
Targeting ICAM1 through LIF-mediated NF-κB/JAK2-STAT3 crosstalk protects nucleus pulposus from IL-1β-driven pyroptosis to ameliorate intervertebral disc degeneration.
Fusobacterium nucleatum-derived extracellular vesicles carrying virulence factor DNA trigger AIM2 inflammasome activation to facilitate UC progression.
Protective effects of taurochenodeoxycholic acid on aflatoxin B1-induced hepatic pyroptosis and gut-liver dysfunction.
Non-anticoagulant heparin alleviates myocardial ischemia-reperfusion injury through inhibiting GSDMD-mediated cardiomyocyte pyroptosis via the HMGB1/RAGE pathway.
Punicalin ameliorates vascular endothelial cell pyroptosis and dysfunction induced by hyperlipidemia and hyperglycemia through activation of PPARγ.
MiR-193b-3p Regulates Gasdermin-D/NLRP3 by Targeting the Signaling Axis Inhibition of Pyroptosis Attenuates Myocardial Ischemia-Reperfusion Injury.
Macelignan Improves Functional Recovery After Spinal Cord Injury by Augmenting Autophagy via the AKT-mTOR-TFEB Signaling Pathway.
Decoding ozone's impact on the cornea: disruption of barrier integrity and its molecular drivers.
Grafting of syringic acid onto fucoidan: Enhanced functional properties and therapeutic potential in histamine-induced liver injury.
Co-exposure to ozone and polystyrene nanoplastic exacerbates cognitive impairment and anxiety-like behavior by regulating neuronal pyroptosis in mice.
Unusual chaetoglobosins and a new type of ferroptosis inducer from an endophytic fungus Chaetomium sp. UJN-EF006.
Piperlongumine alleviates viral myocarditis by inhibiting pyroptosis through NF-κB pathway.
Lycium barbarum glycopeptide attenuates intracerebral hemorrhage-induced inflammation and oxidative stress via activation of the Sirt3 signaling pathway.
Aryl Hydrocarbon Receptor-Dependent miRNA-382-5p Mediates the Classical Pyroptosis Induced by Foodborne Benzo(a)pyrene through Targeting IκB in Liver.
ZC3H13 Promotes NSUN4-Mediated Chondrocyte Mitochondrial Dysfunction and Pyroptosis in Temporomandibular Joint Osteoarthritis.
IFI204 in microglia mediates traumatic brain injury-induced mitochondrial dysfunction and pyroptosis via SENP7 interaction.
Microcystin-LR induces lung injury in mice through the NF-κB/NLRP3 pathway.
Impaired Mitophagy Contributes to Pyroptosis in Sarcopenic Obesity Zebrafish Skeletal Muscle.
Inhibition of hsa_circ_0003314 contributes to trophoblast cell migration and invasion and inhibits pyroptosis in preeclampsia.
Clemastine fumarate accelerates accumulation of disability in progressive multiple sclerosis by enhancing pyroptosis.
Comprehensive single-cell transcriptomic reveals different destinies of melanocytes and dynamic changes of immune microenvironment in a psychological stress-induced leukoderma and leukotrichia mouse model.
Panax ginseng exerts cardioprotective effect post myocardial infarction by attenuating myocardial fibrosis and inflammation through SIRT1 signaling pathways.
GABARAPL1 Exerts Regulatory Effects on Hypoxia-Induced Pyroptosis in the Pathogenesis of Myocardial Infarction.
Neutrophil extracellular traps-induced pyroptosis of liver sinusoidal endothelial cells exacerbates intrahepatic coagulation in cholestatic mice.
WISP1 promotes the progression of rheumatoid arthritis through NLRP3 inflammasome activation.
ALKBH5 promotes cardiac fibroblasts pyroptosis after myocardial infarction through Notch1/NLRP3 pathway.
ALPK1 signaling pathway activation by HMGB1 drives microglial pyroptosis and ferroptosis and brain injury after acute ischemic stroke.
Erianin alleviates autoimmune myocarditis by suppressing the M1 polarization of macrophages via the NF-κB/NLRP3 signaling pathway.
Olfactory bulb microglia activation mediates neuronal pyroptosis in ozone-exposed mice with olfactory and cognitive dysfunction.
Sinomenine alleviates neuroinflammation in chronic cerebral hypoperfusion by promoting M2 microglial polarization and inhibiting neuronal pyroptosis via exosomal miRNA-223-3p.
Photothermal therapy combined with a STING agonist induces pyroptosis, and gasdermin D could be a new biomarker for guiding the treatment of pancreatic cancer.
Phenethyl isothiocyanate ameliorates liver injuries secondary to inflammatory bowel disease.
Exosome-mediated effects of BRCA1 on cardiovascular artery disease.
Why do microplastics aggravate cholestatic liver disease? The NLRP3-mediated intestinal barrier integrity damage matter.
Knockdown TNF family prognosis index crucial gene PDE4B promoted PANoptosis of ovarian carcinoma cell:Based in vitro and in vivo experiments.
Polystyrene nanoplastics trigger pyroptosis in dopaminergic neurons through TSC2/TFEB-mediated disruption of autophagosome-lysosome fusion in Parkinson's disease.
STING-mediated mitochondrial DNA release exacerbates PANoptosis in liver ischemia reperfusion injury.
Effects of electroacupuncture on neural function and the expression of inflammation-related proteins NLRP3/caspase-1 in rats with ischemic stroke.
Emodin influences pyroptosis-related Caspase 1-GSDMD axis alleviated cerebral ischemia-reperfusion injury in rats.
Endoplasmic reticulum stress induces trophoblast pyroptosis via regulating CYLD during labor initiation.
CEBPD is a pivotal factor for the activation of NLRP3 inflammasome in traumatic brain injury.
miR-29a nanoparticles improve chronic insomnia by regulating microglia activation and hippocampal neuronal cell pyroptosis through PER2/NF-κB axis.
Investigating the Mechanism of Emodin in Rheumatoid Arthritis Through the HIF-1α/NLRP3 Pathway and Mitochondrial Autophagy.
Carbon monoxide gas molecules: Therapeutic mechanisms in radiation-induced lung injury.
Coptis chinensis-derived extracellular vesicle-like nanoparticles delivered miRNA-5106 suppresses NETs by restoring zinc homeostasis to alleviate colitis.
Hydroxysafflor Yellow A Ameliorates Ischemic Stroke by Inhibiting NLRP3, AIM2, and Pyrin Inflammasome-Mediated Pyroptosis.
Coptisine inhibits esophageal carcinoma growth by modulating pyroptosis via inhibition of HGF/c-Met signaling.
Propofol alleviates traumatic brain injury through regulating Th17/Treg balance by activation of the AMPK/SIRT1 pathway.
Shengjiang powder ameliorates cell pyroptosis and inflammation induced by MCAO in rats through the NLRP3/Caspase-1 pathway.
Circular RNA-OGDH promotes PANoptosis in diabetic cardiomyopathy: A novel mechanistic insight.
Scutellarein ameliorates pulmonary arterial hypertension via sirtuin 1 mediated deacetylation of nicotinamide nucleotide transhydrogenase.
FTO triggers NLRP3/GSDMD-dependent pyroptosis to enhance cisplatin-sensitivity in ovarian cancer.
Neoadjuvant Chemotherapy With Cisplatin Up-Regulates GSDMD to Enhance Oral Squamous Cell Carcinoma Metastasis Through MMP14-Mediated EMT Activation.
JC124 confers multimodal neuroprotection in epilepsy by suppressing NLRP3 inflammasome activation: evidence from animal and human neuronal models.
Hyperandrogenism-mediated YAP activation drives ovarian inflammation and pyroptosis in PCOS: implications for follicular dysfunction.
Dahuang Huanglian Decoction alleviates dysbiosis by inhibiting GBP5/NLRP3 signaling pathway-mediated pyroptosis of colonic epithelial cells.
Ameliorating Myocardial Infarction by Concurrent Pyroptosis Suppression and On-Demand Oxygen Production via Functionalized Nanocarrier.
HOXC8 impacts lung tumorigenesis by preventing pyroptotic cell death through the suppression of caspase-1 expression.
Time- and dose-dependent activation of the NLRP3 and MyD88/NF-κB pathways by Trueperella pyogenes membrane vesicles in bovine endometrial epithelial cells.
Rosmarinic Acid Ameliorates Type 2 Diabetic Osteoporosis by Reducing NLRP3 Expression and Alleviating Osteoblast Pyroptosis via the FOXO1/TXNIP Signaling Pathway.
Long-term exposure to silica nanoparticles induces cardiac hypertrophy through the pyroptosis pathway.
The N-terminal domain of gasdermin D induces liver fibrosis by reprogrammed lipid metabolism.
Pyroptosis inhibition alleviates acute lung injury via E-twenty-six variant gene 5-mediated downregulation of gasdermin D.
Paris saponin VII induces Caspase-3/GSDME-dependent pyroptosis in pancreatic ductal adenocarcinoma cells by activating ROS/Bax signaling.
CASP5 associated with PANoptosis promotes tumorigenesis and progression of clear cell renal cell carcinoma.
FuKe QianJin capsule alleviates endometritis via inhibiting inflammation and pyroptosis through modulating TLR4/ NF-κB /NLRP3 pathway.
The regulatory role of the Netrin-1/UNC5H3 pathway in neuronal pyroptosis after stroke.
Therapeutic effects of tripterygium glycosides on periodontitis: Exploring the role of ursolic acid and the RIPK3/NLRP3 signaling pathway.
The injury effect of osteopontin in sepsis-associated lung injury.
Inhibition of tumor necrosis factor receptor-associated factor 6 alleviates secondary brain injury by reducing neuronal pyroptosis after intracerebral hemorrhage.
Trimethylamine N-oxide induces pyroptosis in HTR8-S/Vneo cells through the ten-eleven translocation 2-cytochrome b-reactive oxygen species pathway.
TAT-N24 enhances retinal ganglion cell survival by suppressing ZBP1-PANoptosome-mediated PANoptosis in an acute glaucoma mouse model.
TRIM44 alleviates renal ischemia-reperfusion injury by inhibiting pyroptosis through the NLRP3 pathway.
Targeting pyroptosis reverses KIAA1199-mediated immunotherapy resistance in colorectal cancer.
Mechanistic studies of Ca(2+)-induced classical pyroptosis pathway promoting renal adhesion on calcium oxalate kidney stone formation.
Echinococcus granulosus-Induced Liver Damage Through Ferroptosis in Rat Model.
Anticancer effects of OSW-1 on colorectal cancer cells via the ROS/NLRP3/Caspase-1 pyroptosis signaling pathway.
Ferroptosis and PANoptosis under hypoxia pivoting on the crosstalk between DHODH and GPX4 in corneal epithelium.
New idea of Fuke Qianjin capsule in treating sequelae of pelvic inflammatory disease: Anti-inflammatory in the early stage and reparative in the later stage.
By inhibiting pyroptosis to reduce neuroinflammation, PEG-bHb may prevent the development of secondary injury after traumatic brain injury.
Geniposide alleviates rheumatoid arthritis by inhibiting pyroptosis by regulating the miR-223-3p/NLRP3 Axis.
Activated oligoadenylate synthetase-ribonuclease L pathway promotes endothelial pyroptosis and impairs diabetic wound healing via thioredoxin-interacting protein m(6)A methylation.
Palmatine Attenuates Lipopolysaccharide-Induced Acute Lung Injury Via Suppression of NLRP3 Inflammasome Activation, Pyroptosis, and Metabolic Remodeling.
Honokiol attenuates diabetic nephropathy by targeting SIRT3 to suppress mitochondrial ROS-induced pyroptosis.
Artesunate attenuates cerebral injury after cardiac arrest via inhibiting caspase-11-mediated pyroptosis through NEDD4.
Inhibition of BRD4 alleviates pyroptosis induced by testicular ischemia/reperfusion injury through the NLRP3 pathway.
Colchicine Alleviates Interstitial Lung Disease in an Experimental Autoimmune Myositis Murine Model by Inhibiting the Formation of Neutrophil Extracellular Traps.
Nicotinamide N-oxide Inhibits Microglial Pyroptosis by Upregulating Mitophagy and Alleviates Neural Damage in Rats after TBI.
Activation of pyroptosis impairs basal cell differentiation in the nasal epithelium in chronic rhinosinusitis with nasal polyps.
FCV activates NLRP3 inflammasome through ion-dependent pathway to promote IL-1β secretion.
Glycosides of Buyang Huanwu decoction alleviate cerebral infarction injury by inhibiting neuronal pyroptosis via astrocyte-derived exosomal miR-378b_L+1.
Targeting Wnt/beta-catenin signaling to attenuate short-chain chlorinated paraffins-triggered hepatocyte mitochondrial fission and subsequent pyroptosis.
Caspase-8-driven NLRP3 inflammasome activation exacerbates bronchopulmonary dysplasia by increasing the apoptosis and pyroptosis crosstalk of alveolar epithelial cells.
β-Hydroxybutyric Acid-Induced Bovine Endometrial Epithelial Cell Pyroptosis via Activating P2X7R.
HIIT and MICT mitigate endothelial dysfunction in early atherosclerotic mice via PCSK9 inhibition.
GSDMD deficiency mitigates intestinal damage via macrophage pyroptosis control in experimental NEC.
SENP3 protects hepatocyte from pyroptosis during acute liver injury through deSUMOylation of HNRNPL.
MiR-153 is Involved in Testicular Ischemia/Reperfusion Injury by Directly Targeting FOXO3 and Regulating Spermatogonia Pyroptosis.
Chlorogenic acid mitigates heat stress-induced oxidative damage in bovine mammary epithelial cells by inhibiting NF-κB-mediated NLRP3 inflammasome activation via upregulating the Nrf2 signaling pathway.
Design, Synthesis, and Biological Evaluation of Naphthalimide-Polyamine Conjugate as a Potential Anti-Colorectal Cancer Agent.
WTAP Promotes Atherosclerosis by Inducing Macrophage Pyroptosis and M1 Polarization through Upregulating NLRP3.
Microglial pyroptosis drives neuropathic pain and targeting NLRP3 alleviates pain and neuroinflammation.
Targeting ceramide-induced microglial pyroptosis: Icariin is a promising therapy for Alzheimer's disease.
ErTao decoction alleviates liver fibrosis by suppressing STING-mediated macrophages and NLRP3 inflammasome activation.
Chrysophanol Attenuates Cardiac Fibrosis and Arrhythmia by Suppressing the Endoplasmic Reticulum Stress/Pyroptosis Axis and Inflammation.
Targeting UAF1 Alleviate Neurotoxicity by Inhibiting APP/NLRP3 Axis-Mediated Pyroptosis and Apoptosis.
Integrated bioinformatics analysis of biomarkers and pathways to explore the mechanisms and molecular targets related to allergic rhinitis and pyroptosis.
Farrerol alleviates cognitive impairments in chronic cerebral hypoperfusion via suppressing NLRP3 inflammasome-mediated pyroptosis.
PRDM16 suppresses pyroptosis to attenuate the progression of AKI caused by rhabdomyolysis via upregulation of USP10.
Knockdown of PAK1IP1 can Induce Pyroptosis to Inhibit the Progression of Hepatocellular Carcinoma.
TLR4-mediated endoplasmic reticulum stress regulates pyroptosis in macrophages infected with the Bacillus Calmette-Guérin mycobacterial.
VEGF secreted by human dental pulp stem cell promotes spinal cord injury repair by inhibiting microglial pyroptosis through the PI3K/AKT pathway.
Identification of Azalamellarin N as a Pyroptosis Inhibitor.
Electroacupuncture Protects Against Cerebral Ischemia-Reperfusion Injury: Reducing Inflammatory Response and Cell Pyroptosis by Inhibiting P2X7/NLRP3/GSDMD Pathway.
TAK-242 alleviates diabetic cardiomyopathy via inhibiting pyroptosis and TLR4/CaMKII/NLRP3 pathway.
Xinfeng Capsule Inhibits Pyroptosis and Ameliorates Myocardial Injury in Rats with Adjuvant Arthritis via the GAS5/miR-21/TLR4 Axis.
Arctiin Alleviates Atopic Dermatitis Against Inflammation and Pyroptosis Through Suppressing TLR4/MyD88/NF-κB and NLRP3/Caspase-1/GSDMD Signaling Pathways.
Pretreatment with Indole-3-Propionic Acid Attenuates Lipopolysaccharide-Induced Cardiac Dysfunction and Inflammation Through the AhR/NF-κB/NLRP3 Pathway.
The METTL3/m6A Reader Protein YTHDF1 Regulates Endothelial Cell Pyroptosis by Enhancing NLRP3 Expression to Affect Soft Tissue Injury.
Novel insights into sevoflurane-induced developmental neurotoxicity mechanisms.
Exosomes from IH- Induced bEnd3 Cells Promote OSA Cognitive Impairment via miR-20a-5p/MFN2 Mediated Pyroptosis of HT22 Cells.
Astrocyte-derived exosomal miR-378a-5p mitigates cerebral ischemic neuroinflammation by modulating NLRP3-mediated pyroptosis.
Gasdermin D could be lost in the brain parenchyma infarct core and a pyroptosis-autophagy inhibition effect of Jie-Du-Huo-Xue decoction after stroke.
GSDMD is associated with survival in human breast cancer but does not impact anti-tumor immunity in a mouse breast cancer model.
Targeting the PANoptosis signaling pathway for myocardial protection: therapeutic potential of Xian Ling Gu Bao capsule.
TAK1 inhibition mitigates intracerebral hemorrhage-induced brain injury through reduction of oxidative stress and neuronal pyroptosis via the NRF2 signaling pathway.
E3 ubiquitin ligase MARCH1 reduces inflammation and pyroptosis in cerebral ischemia-reperfusion injury via PCSK9 downregulation.
Inhibition of GBP1 alleviates pyroptosis of human pulmonary microvascular endothelial cells through STAT1/NLRP3/GSDMD pathway.
Role of caspase-11 non-canonical inflammasomes in retinal ischemia/reperfusion injury.
Pyroptotic macrophages induce disruption of glutamate metabolism in periodontal ligament stem cells contributing to their compromised osteogenic potential.
Immune Rejection of Cartilage in a Swine Vascularized Composite Allotransplantation Model.
Placental growth factor alleviates hyperglycemia-induced trophoblast pyroptosis by regulating mitophagy.
Toll-Like Receptor 9 Aggravates Pulmonary Fibrosis by Promoting NLRP3-Mediated Pyroptosis of Alveolar Epithelial Cells.
Anisodamine hydrobromide ameliorates acute lung injury via inhibiting pyroptosis in murine sepsis model.
LncRNA H19/miR-107 regulates endothelial progenitor cell pyroptosis and promotes flow recovery of lower extremity ischemia through targeting FADD.
Gasdermin D promotes development of intestinal tumors through regulating IL-1β release and gut microbiota composition.
Glutamine metabolism modulates microglial NLRP3 inflammasome activity through mitophagy in Alzheimer's disease.
Pre-electroacupuncture Ameliorates Cerebral Ischemia-reperfusion Injury by Inhibiting Microglial RhoA/pyrin/GSDMD Signaling Pathway.
Polystyrene Microplastics Induce Injury to the Vascular Endothelial Through NLRP3-Mediated Pyroptosis.
Ginkgo Flavone Aglycone Ameliorates Atherosclerosis via Inhibiting Endothelial Pyroptosis by Activating the Nrf2 Pathway.
Angiopoietin 1 Relieves Osteolysis by Promoting Macrophage Mitophagy Through the TBK1-SQSTM1 Pathway to Inhibit AIM2 Inflammasome-Mediated Pyroptosis.
Paeoniflorin inhibited GSDMD to alleviate ANIT-induced cholestasis via pyroptosis signaling pathway.
GEFT inhibits the GSDM-mediated proptosis signalling pathway, promoting the progression and drug resistance of rhabdomyosarcoma.
SS31 alleviates LPS-induced acute lung injury by inhibiting inflammatory responses through the S100A8/NLRP3/GSDMD signaling pathway.
Salidroside promotes liver regeneration after partial hepatectomy in mice by modulating NLRP3 inflammasome-mediated pyroptosis pathway.
Neutrophil extracellular traps facilitate liver inflammation/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis.
Bay-117082 treats sepsis by inhibiting neutrophil extracellular traps (NETs) formation through down-regulating NLRP3/N-GSDMD.
Integrative Gut Microbiota and Metabolomic Analyses Reveal the PANoptosis- and Ferroptosis-Related Mechanisms of Chrysoeriol in Inhibiting Melanoma.
Hydrogen regulated pyroptosis through NLRP3-GSDMD pathway to improve airway mucosal oxidative stress injury induced by endotracheal tube cuff compression.
A palmitoylation-depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis.
Conditioned medium from human dental pulp stem cells treats spinal cord injury by inhibiting microglial pyroptosis.
Platelet-rich plasma-derived extracellular vesicles inhibit NF-κB/NLRP3 pathway-mediated pyroptosis in intervertebral disc degeneration via the MALAT1/microRNA-217/SIRT1 axis.
Transcriptomics confirms IRF1 as a key regulator of pyroptosis in diabetic retinopathy.
Mitochondrial ROS participates in Porphyromonas gingivalis-induced pyroptosis in cementoblasts.
Therapeutic Potential of Fucoidan in Alleviating Histamine-Induced Liver Injury: Insights from Mice Studies.
MSC-derived exosomal miR-140-3p improves cognitive dysfunction in sepsis-associated encephalopathy by HMGB1 and S-lactoylglutathione metabolism.
Natural compound library screening to identify berberine as a treatment for rheumatoid arthritis.
Human vascular smooth muscle cells utilise chymase for the atypical cleavage and activation of Interleukin-1β.
GSDMD mediated pyroptosis induced inflammation of Graves' orbitopathy via the NF-κB/ AIM2/ Caspase-1 pathway.
Lipocalin 2 (LCN2) confers acquired resistance to almonertinib in NSCLC through LCN2-MMP-9 signaling pathway.
PI3K/AKT signaling pathway associates with pyroptosis and inflammation in patients with endometriosis.
BRCC36 Deubiquitinates HMGCR to Regulate the Interplay Between Ferroptosis and Pyroptosis.
Kongensin a attenuates intervertebral disc degeneration by inhibiting TAK1-mediated PANoptosis of nucleus pulposus cells.
Effect of lipopolysaccharide on TAK1-mediated hepatocyte PANoptosis through Toll-like receptor 4 during acute liver failure.
Punicalagin Ameliorates Diabetic Liver Injury by Inhibiting Pyroptosis and Promoting Autophagy via Modulation of the FoxO1/TXNIP Signaling Pathway.
Efficient Delivery of Lomitapide using Hybrid Membrane-Coated Tetrahedral DNA Nanostructures for Glioblastoma Therapy.
SNORD99 promotes endometrial cancer development by inhibiting GSDMD-mediated pyroptosis through 2'-O-methylation modification.
A natural hydrogel complex improves intervertebral disc degeneration by correcting fatty acid metabolism and inhibiting nucleus pulposus cell pyroptosis.
Modulating synovial macrophage pyroptosis and mitophagy interactions to mitigate osteoarthritis progression using functionalized nanoparticles.
Deacetylated MDH1 and IDH1 aggravates PANoptosis in acute liver failure through endoplasmic reticulum stress signaling.
Elevated NLRP3 Inflammasome Activation Is Associated with Motor Neuron Degeneration in ALS.
Caspase-1 deletion reveals pyroptosis participates in neural damage induced by cerebral ischemia/reperfusion in tMCAO model mice.
Apolipoprotein O modulates cholesterol metabolism via NRF2/CYB5R3 independent of LDL receptor.
Interferon-γ induces combined pyroptotic angiopathy and APOL1 expression in human kidney disease.
Neutrophil extracellular traps induce pyroptosis of pulmonary microvascular endothelial cells by activating the NLRP3 inflammasome.
Mechanism of Vaginal Epithelial Cell Pyroptosis Induced by the NLRP3 Inflammasome in Vulvovaginal Candidiasis.
Glaesserella parasuis serotype 5 induces pyroptosis via the RIG-I/MAVS/NLRP3 pathway in swine tracheal epithelial cells.
Esaxerenone Attenuates Aldosterone-Induced Mitochondrial Damage-Mediated Pyroptosis in Mouse Aorta and Rat Vascular Smooth Muscle Cells.
Urolithin A Protects against Hypoxia-Induced Pulmonary Hypertension by Inhibiting Pulmonary Arterial Smooth Muscle Cell Pyroptosis via AMPK/NF-κB/NLRP3 Signaling.
Mesenchymal stem cells ameliorate inflammation and pyroptosis in diabetic cardiomyopathy via the miRNA-223-3p/NLRP3 pathway.
Acceleration of bone repairation by BMSCs overexpressing NGF combined with NSA and allograft bone scaffolds.
Dental pulp mesenchymal stem cell-derived exosomes inhibit neuroinflammation and microglial pyroptosis in subarachnoid hemorrhage via the miRNA-197-3p/FOXO3 axis.
Ultrasound-responsive Bi(2)MoO(6)-MXene heterojunction as ferroptosis inducers for stimulating immunogenic cell death against ovarian cancer.
Bacillus cereus CwpFM induces colonic tissue damage and inflammatory responses through oxidative stress and the NLRP3/NF-κB pathway.
Tangeretin attenuates acute lung injury in septic mice by inhibiting ROS-mediated NLRP3 inflammasome activation via regulating PLK1/AMPK/DRP1 signaling axis.
Pyroptosis-related gene signature elicits immune response in rosacea.
Prognostic, immunity, stemness, and anticancer drug sensitivity characterization of pyroptosis related genes in non-small cell lung cancer.
Preparation and characterization of monoclonal antibodies against porcine gasdermin D protein.
A slow-releasing donor of hydrogen sulfide inhibits neuronal cell death via anti-PANoptosis in rats with spinal cord ischemia‒reperfusion injury.
Neuroprotective effects of Jie-du-huo-xue decoction on microglia pyroptosis after cerebral ischemia and reperfusion--From the perspective of glial-vascular unit.
Modified Simiaowan prevents and treats gouty arthritis via the Nrf2/NLRP3 inflammasome signaling pathway.
Neuronal pyroptosis mediated by STAT3 in early brain injury after subarachnoid hemorrhage.
4-octyl itaconate ameliorates ventilator-induced lung injury.
Betaine alleviates cognitive impairment induced by homocysteine through attenuating NLRP3-mediated microglial pyroptosis in an m(6)A-YTHDF2-dependent manner.
Deficiency of N6-Methyladenosine Demethylase ALKBH5 Alleviates Ultraviolet B Radiation-Induced Chronic Actinic Dermatitis via Regulating Pyroptosis.
Tangeretin Attenuates Cerebral Ischemia-Reperfusion-Induced Neuronal Pyroptosis by Inhibiting AIM2 Inflammasome Activation via Regulating NRF2.
Serabelisib regulates GSDMD-mediated pyroptosis, apoptosis and migration of hepatoma cells via the PI3K/Akt/E-cadherin signaling pathway.
Ibuprofen inhibits anaplastic thyroid cells in vivo and in vitro by triggering NLRP3-ASC-GSDMD-dependent pyroptosis.
Dihydroxyacetone phosphate accumulation leads to podocyte pyroptosis in diabetic kidney disease.
KLF4 interacts with TXNIP to modulate the pyroptosis in ulcerative colitis via regulating NLRP3 signaling.
Berberine inhibits NLRP3 inflammasome activation by regulating mTOR/mtROS axis to alleviate diabetic cardiomyopathy.
SERTAD1 initiates NLRP3-mediated inflammasome activation through restricting NLRP3 polyubiquitination.
PANoptosis in vascular smooth muscle cells regulated by TNF-α/IL-1β can be a new target for alleviating the progression of abdominal aortic aneurysm.
Eclipta prostrata improves alveolar development of bronchopulmonary dysplasia via suppressing the NLRP3 inflammasome in a DLD-dependent manner.
Shikonin from lithospermum erythrorhizon induces pyroptosis in trophoblast cells by activating the CTSB-NLRP3 inflammasome.
Bleomycin induces endothelial cell pyroptosis and regulates fibrosis by activating the NLRP3/caspase-1/GSDMD pathway: a possible mechanism contributing to the sclerotherapy of venous malformations.
PANoptosis signaling enables broad immune response in psoriasis: From pathogenesis to new therapeutic strategies.
TMAO induces pyroptosis of vascular endothelial cells and atherosclerosis in ApoE(-/-) mice via MBOAT2-mediated endoplasmic reticulum stress.
Fucoidan from Laminaria japonica protects renal tubular epithelial cells from uric acid induced NLRP3-mediated pyroptosis through inhibition of NF-κB pathway.
Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair.
Macrophage-derived exosomal miR-2137 regulates pyroptosis in LPS-induced acute lung injury.
Butyrate attenuates intestinal inflammation in Crohn's disease by suppressing pyroptosis of intestinal epithelial cells via the cGSA-STING-NLRP3 axis.
Astragaloside IV attenuates podocyte apoptosis via regulating TXNIP/NLRP3/GSDMD signaling pathway in diabetic nephropathy.
Molecular profiling unveils pyroptosis markers in preterm birth.
Exosomes derived from diabetic microenvironment-preconditioned mesenchymal stem cells ameliorate nonalcoholic fatty liver disease and inhibit pyroptosis of hepatocytes.
Disturbance of mitochondrial dynamics led to spermatogenesis disorder in mice exposed to polystyrene micro- and nanoplastics.
Exosomes from human bone marrow MSCs alleviate PD-1/PD-L1 inhibitor-induced myocardial injury in melanoma mice by regulating macrophage polarization and pyroptosis.
Autocatalytic, Brain Tumor-Targeting Delivery of Bardoxolone Methyl Self-Assembled Nanoparticles for Glioblastoma Treatment.
Dihydroartemisinin-driven TOM70 inhibition leads to mitochondrial destabilization to induce pyroptosis against lung cancer.
Obstructive Sleep Apnea Plasma-Derived Exosomes Mediate Cognitive Impairment Through Hippocampal Neuronal Cell Pyroptosis.
Apoptosis and pyroptosis in the nasal mucosa of Syrian hamster during SARS-CoV-2 infection and reinfection.
Co-exposure of microcystin-LR and nitrite induced kidney injury through TLR4/NLRP3/GSDMD-mediated pyroptosis.
Activation of the inflammasome and pyroptosis cascade in podocytes of patients with minimal change disease.
Miltirone induces GSDME-dependent pyroptosis in colorectal cancer by activating caspase 3.
Potential mechanisms of aortic medial degeneration promoted by co-exposure to microplastics and lead.
STAT4-Mediated Klotho Up-Regulation Contributes to the Brain Ischemic Tolerance by Cerebral Ischemic Preconditioning via Inhibiting Neuronal Pyroptosis.
Ketamine Improves the Glymphatic Pathway by Reducing the Pyroptosis of Hippocampal Astrocytes in the Chronic Unpredictable Mild Stress Model.
Identification of PKM2 as a pyroptosis-related key gene aggravates senile osteoporosis via the NLRP3/Caspase-1/GSDMD signaling pathway.
Gypenoside XLIX alleviates acute liver injury: Emphasis on NF-κB/PPAR-α/NLRP3 pathways.
Inhibition of spinal BRD4 alleviates pyroptosis and M1 microglia polarization via STING-IRF3 pathway in morphine-tolerant rats.
Preliminary investigation into the impact of BPA on osteoblast activity and bone development: In vitro and in vivo models.
LncRNA GAS5 restrains ISO-induced cardiac fibrosis by modulating mir-217 regulation of SIRT1.
Circular RNA protein tyrosine kinase 2 aggravates pyroptosis and inflammation in septic lung tissue by promoting microRNA-766/eukaryotic initiation factor 5A axis-mediated ATP efflux.
Inhibition of Schwann Cell Pyroptosis Promotes Nerve Regeneration in Peripheral Nerve Injury in Rats.
Transcutaneous Electrical Nerve Stimulation (TENS) Alleviates Brain Ischemic Injury by Regulating Neuronal Oxidative Stress, Pyroptosis, and Mitophagy.
High-dose remifentanil exacerbates myocardial ischemia-reperfusion injury through activation of calcium-sensing receptor-mediated pyroptosis.
Suppression of NLRP3/Caspase-1/GSDMD Mediated Corneal Epithelium Pyroptosis Using Melatonin-Loaded Liposomes to Inhibit Benzalkonium Chloride-Induced Dry Eye Disease.
Network Pharmacology Analysis and Machine-Learning Models Confirmed the Ability of YiShen HuoXue Decoction to Alleviate Renal Fibrosis by Inhibiting Pyroptosis.
Transcutaneous electrical acupoint stimulation alleviates cerebral ischemic injury through the TLR4/MyD88/NF-κ B pathway.
Qinhuo Shanggan oral solution resolves acute lung injury by down-regulating TLR4/NF-κB signaling cascade and inhibiting NLRP3 inflammasome activation.
The non-canonical inflammasome activators Caspase-4 and Caspase-5 are differentially regulated during immunosuppression-associated organ damage.
A novel colchicine-myricetin heterozygous molecule: design, synthesis, and effective evaluations on the pathological models of acute lung injury in vitro and in vivo.
β-sitosterol alleviates dextran sulfate sodium-induced experimental colitis via inhibition of NLRP3/Caspase-1/GSDMD-mediated pyroptosis.
Phenylalanine promotes alveolar macrophage pyroptosis via the activation of CaSR in ARDS.
Silibinin ameliorates deoxycholic acid-induced pyroptosis in steatotic HepG2 cells by inhibiting NLRP3 inflammasome activation.
CD73 mitigates hepatic damage in alcoholic steatohepatitis by regulating PI3K/AKT-mediated hepatocyte pyroptosis.
Bone marrow mesenchymal stem cellsderived exosomes stabilize atherosclerosis through inhibiting pyroptosis.
Oryza sativa L. Indica Seed Coat Ameliorated Concanavalin A-Induced Acute Hepatitis in Mice via MDM2/p53 and PKCα/MAPK1 Signaling Pathways.
Steroidal saponins PPI/CCRIS/PSV induce cell death in pancreatic cancer cell through GSDME-dependent pyroptosis.
Loganin reduces diabetic kidney injury by inhibiting the activation of NLRP3 inflammasome-mediated pyroptosis.
Astragaloside IV Inhibited Podocyte Pyroptosis in Diabetic Kidney Disease by Regulating SIRT6/HIF-1α Axis.
A high-throughput Gaussia luciferase reporter assay for screening potential gasdermin E activators against pancreatic cancer.
Systemic pharmacology reveal the mechanism by which the Qiangjin Zhuanggu Qufeng mixture inhibits LPS-induced pyroptosis of rat nucleus pulposus cells.
GSDMD promotes neutrophil extracellular traps via mtDNA-cGAS-STING pathway during lung ischemia/reperfusion.
Aluminum exposure induces central nervous system impairment via activating NLRP3-medicated pyroptosis pathway.
Oxalate‑induced renal pyroptotic injury and crystal formation mediated by NLRP3‑GSDMD signaling in vitro and in vivo.
Selenium Deficiency via the ROS/NLRP3/IL-1β Signaling Pathway Leads to Pyroptosis Injury in Pig Spleen.
Escherichia coli infection mediates pyroptosis via activating p53-p21 pathway-regulated apoptosis and cell cycle arrest in bovine mammary epithelial cells.
Butyrate alleviates renal fibrosis in CKD by regulating NLRP3-mediated pyroptosis via the STING/NF-κB/p65 pathway.
Competitive binding of circCCDC6 to microRNA-128-3p activates TXNIP/NLRP3 pathway and promotes cerebral ischemia-reperfusion defects.
Irisin suppresses pancreatic β cell pyroptosis in T2DM by inhibiting the NLRP3-GSDMD pathway and activating the Nrf2-TrX/TXNIP signaling axis.
Regulation of megakaryo/thrombopoiesis by endosomal toll-like receptor 7 and 8 activation of CD34(+) cells in a viral infection model.
The involvement of DDX3X in compression-induced nucleus pulposus pyroptosis.
Pyroptosis of Macrophages Induced by Clostridium perfringens Beta-1 Toxin.
Gasdermin D Plays an Oncogenic Role in Glioma and Correlates to an Immunosuppressive Microenvironment.
HuNoV Non-Structural Protein P22 Induces Maturation of IL-1β and IL-18 and N-GSDMD-Dependent Pyroptosis through Activating NLRP3 Inflammasome.
Single-cell sequencing reveals homogeneity and heterogeneity of the cytopathological mechanisms in different etiology-induced AKI.
Elsholtzia bodinieri Vaniot ameliorated acute lung injury in mice by regulating pyroptosis, inflammation, oxidative stress and macrophage polarization.
hASCs-derived exosomal miR-155-5p targeting TGFβR2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration.
Exosomal miR-23b from bone marrow mesenchymal stem cells alleviates oxidative stress and pyroptosis after intracerebral hemorrhage.
Cytoskeletal protein SPTA1 mediating the decrease in erectile function induced by high-fat diet via Hippo signaling pathway.
Hydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes.
Emodin alleviates testicular ischemia-reperfusion injury through the inhibition of NLRP3-mediated pyroptosis.
Sulconazole Induces PANoptosis by Triggering Oxidative Stress and Inhibiting Glycolysis to Increase Radiosensitivity in Esophageal Cancer.
Baicalin inhibited both the Furin/TGFβ1/Smad3/TSP-1 pathway in endothelial cells and the AKT/Ca(2+)/ROS pathway in platelets to ameliorate inflammatory coagulopathy.
Withdrawn: Ticagrelor reduces myocardial cell injury induced by myocardial ischemia/reperfusion in diabetic rats by activating JAK2/STAT3.
Fibrin glue delivery system containing rhein ameliorates intervertebral disc degeneration by anti-inflammatory efficacy.
Exercise-induced irisin improves follicular dysfunction by inhibiting IRE1α-TXNIP/ROS-NLRP3 pathway in PCOS.
circACTA2 inhibits NLRP3 inflammasome-mediated inflammation via interacting with NF-κB in vascular smooth muscle cells.
Neobavaisoflavone induces pyroptosis of liver cancer cells via Tom20 sensing the activated ROS signal.
Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia.
Induced neural stem cells suppressed neuroinflammation by inhibiting the microglial pyroptotic pathway in intracerebral hemorrhage rats.
Dihydromyricetin inhibits African swine fever virus replication by downregulating toll-like receptor 4-dependent pyroptosis in vitro.
Attenuation of experimental osteoarthritis with human adipose-derived mesenchymal stem cell therapy: inhibition of the pyroptosis in chondrocytes.
Trophoblastic mitochondrial DNA induces endothelial dysfunction and NLRP3 inflammasome activation: Implications for preeclampsia.
Protective effects of leonurine hydrochloride on pyroptosis in premature ovarian insufficiency via regulating NLRP3/GSDMD pathway.
TMBIM4 Deficiency Facilitates NLRP3 Inflammasome Activation-Induced Pyroptosis of Trophoblasts: A Potential Pathogenesis of Preeclampsia.
Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis.
Jatrorrhizine Suppresses Murine-Norovirus-Triggered N-GSDMD-Dependent Pyroptosis in RAW264.7 Macrophages.
PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons.
Ginsenoside Rg3 Ameliorates DSS-Induced Colitis by Inhibiting NLRP3 Inflammasome Activation and Regulating Microbial Homeostasis.
Apoptosis or Antiapoptosis? Interrupted Regulated Cell Death of Host Cells by Ascovirus Infection In Vitro.
Alpha-kinase1 promotes tubular injury and interstitial inflammation in diabetic nephropathy by canonical pyroptosis pathway.
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice.
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Inhibition of Caspase-11-Mediated Pyroptosis Alleviates Acute Kidney Injury Associated with Severe Acute Pancreatitis in Rats.
Inhibition of macrophage pyroptosis ameliorates silica-induced pulmonary fibrosis.
Ursodeoxycholic acid alleviates sepsis-induced lung injury by blocking PANoptosis via STING pathway.
ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation.
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression.
CASP1 is a target for combination therapy in pancreatic cancer.
Paeoniflorin recued hepatotoxicity under zinc oxide nanoparticles exposure via regulation on gut-liver axis and reversal of pyroptosis.
Hyperuricemia promotes the progression of atherosclerosis by activating endothelial cell pyroptosis via the ROS/NLRP3 pathway.
MiR-195-5p is involved in testicular ischemia/reperfusion injury by directly targeting PELP1 and regulating spermatogonia pyroptosis.
Exploring the application of sildenafil for high-fat diet-induced erectile dysfunction based on interleukin-18-mediated NLRP3/Caspase-1 signaling pathway.
SMAD2 inhibits pyroptosis of fibroblast-like synoviocytes and secretion of inflammatory factors via the TGF-β pathway in rheumatoid arthritis.
Protective Role of Vitamin K3 on SARS-CoV-2 Structural Protein-Induced Inflammation and Cell Death.
GABA(B) Receptor Activation Attenuates Neuronal Pyroptosis in Post-cardiac Arrest Brain Injury.
A novel mechanism regulating pyroptosis-induced fibrosis in endometriosis via lnc-MALAT1/miR-141-3p/NLRP3 pathway†.
Schisandrin B induces HepG2 cells pyroptosis by activating NK cells mediated anti-tumor immunity.
SARS-CoV-2 E protein-induced THP-1 pyroptosis is reversed by Ruscogenin.
Irisin attenuates acute lung injury by suppressing the pyroptosis of alveolar macrophages.
Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells.
Overexpression of CASP1 triggers acute promyelocytic leukemia cell pyroptosis and differentiation.
Oroxin A ameliorates the oleic acid-induced A549 cell injury through the suppression of pyroptosis and degradation of alveolar surfactant.
Induction of Pyroptosis in Renal Tubular Epithelial Cells Using High Glucose.
Luteolin Induced Hippocampal Neuronal Pyroptosis Inhibition by Regulation of miR-124-3p/TNF-α/TRAF6 Axis in Mice Affected by Breast-Cancer-Related Depression.
Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis.
Lignans from Mosla scabra Ameliorated Influenza A Virus-Induced Pneumonia via Inhibiting Macrophage Activation.
Microtubule affinity regulating kinase 4 promoted activation of the NLRP3 inflammasome-mediated pyroptosis in periodontitis.
NLRP3 downregulation enhances engraftment and functionality of adipose-derived stem cells to alleviate erectile dysfunction in diabetic rats.
Natural Compound Library Screening Identifies Oroxin A for the Treatment of Myocardial Ischemia/Reperfusion Injury.
Protective Effect of Danshen Zexie Decoction Against Non-Alcoholic Fatty Liver Disease Through Inhibition of ROS/NLRP3/IL-1β Pathway by Nrf2 Signaling Activation.
Herpes Simplex Virus 1 Induces Microglia Gasdermin D-Dependent Pyroptosis Through Activating the NLR Family Pyrin Domain Containing 3 Inflammasome.
Cochlear Marginal Cell Pyroptosis Is Induced by Cisplatin via NLRP3 Inflammasome Activation.
Fucoidan Alleviates Renal Fibrosis in Diabetic Kidney Disease via Inhibition of NLRP3 Inflammasome-Mediated Podocyte Pyroptosis.
Pyroptosis relates to tumor microenvironment remodeling and prognosis: A pan-cancer perspective.
Prognostic value and immune infiltration of the gasdermin family in lung adenocarcinoma.
Lactobacillus rhamnosus GR-1 attenuates foodborne Bacillus cereus-induced NLRP3 inflammasome activity in bovine mammary epithelial cells by protecting intercellular tight junctions.
Gasdermin D is involved in switching from apoptosis to pyroptosis in TLR4-mediated renal tubular epithelial cells injury in diabetic kidney disease.
Bisdemethoxycurcumin Alleviates Dextran Sodium Sulfate-Induced Colitis via Inhibiting NLRP3 Inflammasome Activation and Modulating the Gut Microbiota in Mice.
Nuclear translocation of Gasdermin D sensitizes colorectal cancer to chemotherapy in a pyroptosis-independent manner.
S100A8-Mediated NLRP3 Inflammasome-Dependent Pyroptosis in Macrophages Facilitates Liver Fibrosis Progression.
The role of discoid domain receptor 1 on renal tubular epithelial pyroptosis in diabetic nephropathy.
Anti‑β(2)GPI/β(2)GPI induces neutrophil pyroptosis and thereby enhances ICAM‑1 and IL‑8 expression in endothelial cells.
Silica nanoparticles induce pyroptosis and cardiac hypertrophy via ROS/NLRP3/Caspase-1 pathway.
The TLR-chaperone CNPY3 is a critical regulator of NLRP3-inflammasome activation.
3,4,5-O-tricaffeoylquinic acid with anti-radiation activity suppresses LPS-induced NLRP3 inflammasome activation via autophagy in THP-1 macrophages.
Crosstalk Between RPE Cells and Choroidal Endothelial Cells via the ANXA1/FPR2/SHP2/NLRP3 Inflammasome/Pyroptosis Axis Promotes Choroidal Neovascularization.
ATG5-Mediated Autophagy May Inhibit Pyroptosis to Ameliorate Oleic Acid-Induced Hepatocyte Steatosis.
Elsholtzia bodinieri Vaniot Ameliorated Acute Lung Injury by NQO1, BCL2 and PTGS2 In Silico and In Vitro Analyses.
Extracellular traps from activated vascular smooth muscle cells drive the progression of atherosclerosis.
Curcumin activates NLRC4, AIM2, and IFI16 inflammasomes and induces pyroptosis by up-regulated ISG3 transcript factor in acute myeloid leukemia cell lines.
The selective NLRP3 inflammasome inhibitor MCC950 improves isoproterenol-induced cardiac dysfunction by inhibiting cardiomyocyte senescence.
NLRP6 Induces Lung Injury and Inflammation Early in Brucella and Influenza Coinfection.
Anti-depressant effects of acupuncture: The insights from NLRP3 mediated pyroptosis and inflammation.
Alda-1, an Activator of ALDH2, Improves Postresuscitation Cardiac and Neurological Outcomes by Inhibiting Pyroptosis in Swine.
Tubastatin A Improves Post-Resuscitation Myocardial Dysfunction by Inhibiting NLRP3-Mediated Pyroptosis Through Enhancing Transcription Factor EB Signaling.
Baclofen attenuates cognitive deficits in post-cardiac arrest brain injury.
Dietary Tryptophan Supplementation Improves Antioxidant Status and Alleviates Inflammation, Endoplasmic Reticulum Stress, Apoptosis, and Pyroptosis in the Intestine of Piglets after Lipopolysaccharide Challenge.
Escin Sodium Improves the Prognosis of Acute Pancreatitis via Promoting Cell Apoptosis by Suppression of the ERK/STAT3 Signaling Pathway.
Sodium Houttuyfonate Ameliorates β-amyloid(1-42)-Induced Memory Impairment and Neuroinflammation through Inhibiting the NLRP3/GSDMD Pathway in Alzheimer's Disease.
Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo.
Destructive Effects of Pyroptosis on Homeostasis of Neuron Survival Associated with the Dysfunctional BBB-Glymphatic System and Amyloid-Beta Accumulation after Cerebral Ischemia/Reperfusion in Rats.
Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome-Induced Pyroptosis via Inhibiting the TLR4/NF-κB/PFKFB3 Signaling in Trophoblasts: Implication for a Potential Therapy of Preeclampsia.
Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3/caspase-1/GSDMD Pathway in Triple-Negative Breast Cancer.
Ginsenoside Rg1 Inhibits Microglia Pyroptosis Induced by Lipopolysaccharide Through Regulating STAT3 Signaling.
Assessment of Pyroptosis-Related Indicators as Potential Biomarkers and Their Association with Severity in Patients with Liver Cirrhosis.
Mesenchymal Stem Cells Alleviate Post-resuscitation Cardiac and Cerebral Injuries by Inhibiting Cell Pyroptosis and Ferroptosis in a Swine Model of Cardiac Arrest.
Metallothionein 3-Zinc Axis Suppresses Caspase-11 Inflammasome Activation and Impairs Antibacterial Immunity.
CBD Alleviates Liver Injuries in Alcoholics With High-Fat High-Cholesterol Diet Through Regulating NLRP3 Inflammasome-Pyroptosis Pathway.
siRNAs Targeting Mouse-Specific lncRNA AA388235 Induce Human Tumor Cell Pyroptosis/Apoptosis.
Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration.
Engineering Extracellular Vesicles Restore the Impaired Cellular Uptake and Attenuate Intervertebral Disc Degeneration.
Plasma exosomes derived from patients with intestinal Behçet's syndrome induce intestinal epithelial cell pyroptosis.
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
(-)-Epicatechin ameliorates cigarette smoke-induced lung inflammation via inhibiting ROS/NLRP3 inflammasome pathway in rats with COPD.
The relationship between liver pathological inflammation degree and pyroptosis in chronic hepatitis B patients.
Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway.
The balance between AIM2-associated inflammation and autophagy: the role of CHMP2A in brain injury after cardiac arrest.
Gasdermin D Is a Novel Prognostic Biomarker and Relates to TMZ Response in Glioblastoma.
Mesenchymal stromal cells protect hepatocytes from lipotoxicity through alleviation of endoplasmic reticulum stress by restoring SERCA activity.
Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes.
Macrophage membrane-mediated targeted drug delivery for treatment of spinal cord injury regardless of the macrophage polarization states.
Suppressing ROS generation by apocynin inhibited cyclic stretch-induced inflammatory reaction in HPDLCs via a caspase-1 dependent pathway.
Low shear stress induced vascular endothelial cell pyroptosis by TET2/SDHB/ROS pathway.
Histone deacetylase 2 regulates ULK1 mediated pyroptosis during acute liver failure by the K68 acetylation site.
Gasdermin D: in vivo evidence of pyroptosis in spontaneous labor at term.
Macrophages regulates the transition of pericyte to peritoneal fibrosis through the GSDMD/IL-1β axis.
Isoorientin Attenuated the Pyroptotic Hepatocyte Damage Induced by Benzo[a]pyrene via ROS/NF-κB/NLRP3/Caspase-1 Signaling Pathway.
Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP.
CD147 Expression Is Associated with Tumor Proliferation in Bladder Cancer via GSDMD.
Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis.
Overexpression of gasdermin D promotes invasion of adenoid cystic carcinoma.
Detection of proteins associated with the pyroptosis signaling pathway in breast cancer tissues and their significance.
Tangshen Formula Attenuates Diabetic Kidney Injury by Imparting Anti-pyroptotic Effects via the TXNIP-NLRP3-GSDMD Axis.
IFN regulatory Factor-1 induced macrophage pyroptosis by modulating m6A modification of circ_0029589 in patients with acute coronary syndrome.
Trimethylamine N-oxide promotes apoE(-/-) mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway.
Type I Interferon Increases Inflammasomes Associated Pyroptosis in the Salivary Glands of Patients with Primary Sjögren's Syndrome.
MiR-124-3p promotes trophoblast cell HTR-8/SVneo pyroptosis by targeting placental growth factor.
Exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the NLRP3 inflammasome in mice.
HMGB1 mediates homocysteine-induced endothelial cells pyroptosis via cathepsin V-dependent pathway.
NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology.
TNF-α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury.
Discovery of novel TNNI3K inhibitor suppresses pyroptosis and apoptosis in murine myocardial infarction injury.
Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer.
Cyclin-Dependent Kinase 9 Inhibition Suppresses Necroptosis and Pyroptosis in the Progress of Endotoxemia.
Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis.
IFN Regulatory Factor 1 Mediates Macrophage Pyroptosis Induced by Oxidized Low-Density Lipoprotein in Patients with Acute Coronary Syndrome.
HMGB1-induced endothelial cell pyroptosis is involved in systemic inflammatory response syndrome following radiofrequency ablation of hepatic hemangiomas.
Trichomonas vaginalis Induces NLRP3 Inflammasome Activation and Pyroptotic Cell Death in Human Macrophages.
TLR4/NF-κB Signaling Induces GSDMD-Related Pyroptosis in Tubular Cells in Diabetic Kidney Disease.
Neferine inhibits LPS-ATP-induced endothelial cell pyroptosis via regulation of ROS/NLRP3/Caspase-1 signaling pathway.
Gasdermin D: Evidence of pyroptosis in spontaneous preterm labor with sterile intra-amniotic inflammation or intra-amniotic infection.
Endothelial pyroptosis underlies systemic inflammatory response following radiofrequency ablation of hepatic hemangiomas.
Bacteroides fragilis Strain ZY-312 Defense against Cronobacter sakazakii-Induced Necrotizing Enterocolitis In Vitro and in a Neonatal Rat Model.
Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis.
Biological functions and clinical significance of the newly identified long non‑coding RNA RP1‑85F18.6 in colorectal cancer.
Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts.
Atypical Gasdermin D and Mixed Lineage Kinase Domain-like Protein Leakage Aggravates Tetrachlorobenzoquinone-Induced Nod-like Receptor Protein 3 Inflammasome Activation.
Protein kinase D at the Golgi controls NLRP3 inflammasome activation.
Inflammasome activators induce fibronectin expression and release in macrophages.
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion.
Sun Y, Wei J, Zhao Y, Jiang X, He C, Huang X, Lei F, Qin Y
PloS one 2026;21(3):e0344601
PloS one 2026;21(3):e0344601
A Topical Chinese Herbal Alleviates Psoriasis by Regulating Keratinocytes Pyroptosis Through Inhibition of NLRP3 Inflammasome Activation.
Wang X, Deng Y, Ren X, Li Y, Liu T, Hu B, Li Y
Clinical, cosmetic and investigational dermatology 2026;19:559712
Clinical, cosmetic and investigational dermatology 2026;19:559712
Prim-O-glucosylcimifugin ameliorates DSS-induced ulcerative colitis via suppressing NLRP3 inflammasome activation.
Wang F, Xiong X, Ruan Q, Zhang D, Huang C, Xie T, Cheng L
Frontiers in pharmacology 2026;17:1750305
Frontiers in pharmacology 2026;17:1750305
Identifying pyroptosis-related lncRNAs to predict prognosis and immune regulation in hepatocellular carcinoma.
Zhang W, Wang Y, Meng Q, Liu Z, Qu S, Zhou J
Frontiers in molecular biosciences 2026;13:1714966
Frontiers in molecular biosciences 2026;13:1714966
Statins targeting mevalonate-geranylgeranyl diphosphate pathway inhibit proliferation in NK/T lymphoma by promoting pyroptosis.
Wang Y, Mei M, Wang J, Wei L, Zhang M, Zhang M
Translational oncology 2026 May;67:102747
Translational oncology 2026 May;67:102747
Maresin 1 activates autophagy through SIRT1/PPAR-γ signaling to mitigate high glucose-induced pyroptosis in human retinal pigment epithelial cells.
Zhang J, Zhao D, Zhang Y, Sun H, Yan Z, Sun H
Experimental and therapeutic medicine 2026 May;31(5):141
Experimental and therapeutic medicine 2026 May;31(5):141
d-amino acids restrain macrophage IL-1β release through gasdermin D acetylation.
Wu Z, Hu Q, Shen Y, Fu J, Liu B, Zhang M, Hung I, Liu C, Ren W
Science advances 2026 May;12(18):eaed1676
Science advances 2026 May;12(18):eaed1676
The "Tianyu" Formulation Alleviates Rheumatoid Arthritis by Modulating the NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis Pathway.
Zhu Y, Cai X, Zheng Q, Fang C, Pan Z, Wang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 May 15;40(9):e71824
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 May 15;40(9):e71824
The sphingolipid metabolite sphingosine protects against hypertension by targeting metabolic-inflammatory crosstalk via the NLRP3 inflammasome.
Li W, Zhou D, Ji Y, Yang M, Yang Y, Dao M, He X, Jin X
International journal of cardiology. Cardiovascular risk and prevention 2026 Mar;28:200562
International journal of cardiology. Cardiovascular risk and prevention 2026 Mar;28:200562
Chromatin remodeling factor CHRAC1 regulates doxorubicin-induced cardiotoxicity via IRF9/GSDMD/CASP-1.
Zang T, Zhou C, Yu Y, Lin W, Xu Q, Shen L
Cellular signalling 2026 Mar;139:112290
Cellular signalling 2026 Mar;139:112290
SELENOF Mitigates Bovine Mastitis by Preserving Mitochondrial Homeostasis and Suppressing NLRP3-Mediated Pyroptosis.
Qi X, Shi L, Shi X, Hu C
Animals : an open access journal from MDPI 2026 Mar 4;16(5)
Animals : an open access journal from MDPI 2026 Mar 4;16(5)
Didymin alleviates neuropathic pain by targeting RKIP-mediated NF-κB/NLRP3 crosstalk to inhibit pyroptosis and neuroinflammation.
Wang K, Guo A, Chen Y, Xia C, Liang J, Zhang X, Huang L, Zhang Z, Wu L, Yan H
Journal of ethnopharmacology 2026 Mar 25;359:121046
Journal of ethnopharmacology 2026 Mar 25;359:121046
Hydrogen sulfide ameliorates oxalate crystal-related renal injury via inhibiting the activation of NOD-like receptor thermal protein domain associated protein 3 inflammasome in mice.
Shi Y, Chen L, Li M, Wang J, Yin P, Zhou X, Cong Q, Song K
Urolithiasis 2026 Mar 24;54(1)
Urolithiasis 2026 Mar 24;54(1)
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression.
Yan K, Jiang Y, Yong Y, Zhang T, Zhang N, Zeng Q, Gong X, Meng L, Bi F, Liu Y
Annals of clinical and translational neurology 2026 Mar 24;
Annals of clinical and translational neurology 2026 Mar 24;
Qualitative analysis of chemical components in Berberis kaschgarica Rupr. and study on the in vitro anti-inflammatory effects of its alkaloids.
Ainiwaer S, Dilimulati D, Wumaier A, Zhou W
Scientific reports 2026 Mar 2;16(1)
Scientific reports 2026 Mar 2;16(1)
Fibroblast-derived exosomes induce macrophage pyroptosis to mediate orthodontic bone remodeling through the mtDNA/NLRP3 axis.
Yu Q, Guo K, Yang Y, Liu H, Han Y, Yu X, Wang J, Zhao Y, Su X, Zhu K, Zheng S, Wang S, Li W, Huang Y
Journal of nanobiotechnology 2026 Mar 14;24(1)
Journal of nanobiotechnology 2026 Mar 14;24(1)
S100A11 regulates microglial inflammatory response in neuropathic pain via H3K27ac-TFEB-mitochondrial autophagy axis.
Zheng H, Tian S, Wu L, Jia G, Xiao Y, Yu X, Zuo Q, Zhou R, Min J, Wu Q, Xie H, Luo Q, Wu W
The journal of headache and pain 2026 Mar 11;27(1)
The journal of headache and pain 2026 Mar 11;27(1)
Lnc-USP28-6/ZBTB16 axis orchestrates NLRP3 inflammasome activation and α-synuclein SUMOylation to drive Parkinson's disease pathogenesis.
Wang N, Wang M, You Y, An J, Jia R, Zhao B, Cao Z, Wang X, Ge R, Li C, Wang H
Brain, behavior, and immunity 2026 Mar 1;135:106510
Brain, behavior, and immunity 2026 Mar 1;135:106510
Chemerin Promotes Oral Squamous Cell Carcinoma Progression via NLRP3-Mediated Pyroptosis and the GSDMD-N Pathway.
Zhang X, Guo Y, Gao F, Ni X, Li T, Wang C, Lin M, Tan X, Wang N, Feng Y
International dental journal 2026 Jun;76(3):109541
International dental journal 2026 Jun;76(3):109541
Dual-targeting nuclear and mitochondrial DNA damage drives immunogenic activation via PANoptosis for synergistic magneto-thermodynamic-chemotherapy.
Wu L, Su J, Cao Y, Yuan H, Li Z, Ren J, Xiao M, Yu K, Liang B
Biomaterials 2026 Jun;329:123924
Biomaterials 2026 Jun;329:123924
The role of apolipoprotein C1 in mediating pyroptosis in Hashimoto's thyroiditis via TLR10/MyD88/NF-κB pathway.
Sun B, Tan J, Yu S, Ge J, Wei Z, Lei S, Li G
Molecular immunology 2026 Jun;194:52-62
Molecular immunology 2026 Jun;194:52-62
Neutrophil aconitate decarboxylase 1/itaconate axis suppresses extracellular traps via alkylating GSDMD and alleviates murine liver injury.
Zhang K, Li T, Yang L, Li W, Liu W, Yang L, Chang N, Li L
International immunopharmacology 2026 Jun 1;178:116578
International immunopharmacology 2026 Jun 1;178:116578
Molecular hydrogen suppresses gut inflammation and pyroptosis in ulcerative colitis through promoting PKM2 lactylation to block NLRP3 inflammasome activation.
Yang T, Lu F, Kang Y, Wang L, Li M, Xu W, Bai S, Yu Y, Shi Y, Qin H
International immunopharmacology 2026 Jul 1;180:116726
International immunopharmacology 2026 Jul 1;180:116726
CSB6B attenuates renal inflammation and fibrosis by inhibiting the activation of NLRP3 inflammasome through the NLRP3/Caspase-1/GSDMD/IL-1β signaling pathway.
Chen S, Zhu Y, Chen T, Xu Y, Fan Q
Pathology, research and practice 2026 Jan;277:156286
Pathology, research and practice 2026 Jan;277:156286
Elucidating the mechanism of traditional Chinese medicine formula (Yifei-sanjie Pill) in alleviating the chemobrain based on network pharmacology and experimental verification.
Wu Y, Wang H, Liang Z, Cui J, Liu S, Chen Y, Pi D, Ouyang M
Journal of traditional and complementary medicine 2026 Jan;16(1):17-30
Journal of traditional and complementary medicine 2026 Jan;16(1):17-30
Qingqi Liangying formula inhibits brain endothelial cell pyroptosis via NLRP3/caspase-1/GSDMD in sepsis-associated encephalopathy.
Song S, Ding L, Huang Q, Zhang Z, Cao L, Yin K, Wang Z, Zhao D, Wang Z, Zhao L, Tong X, Li X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157391
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157391
Free Fatty Acids and Endotoxins Synergically Induce Pyroptosis in Bovine Hepatocytes.
Li D, Tian Y, Tian L, Yu H, Zhang L, Wang S, Lei C, Long P, Peng T, Liu L, Zhou Y
Metabolites 2026 Jan 8;16(1)
Metabolites 2026 Jan 8;16(1)
Polyphyllin II Triggers Pyroptosis in Hepatocellular Carcinoma via Modulation of the ROS/NLRP3/Caspase-1/GSDMD Axis.
Huang H, Ni B, Chen Q, Wang W, Guo Z, Wang N, Chen R, Yin X, Qu C, Ni J, Dong X
Antioxidants (Basel, Switzerland) 2026 Jan 6;15(1)
Antioxidants (Basel, Switzerland) 2026 Jan 6;15(1)
Acupuncture as a modulator of microglial polarization and pyroptosis in depression: evidence from a chronic unpredictable mild stress rat model.
Wu X, You Z, Zhang T, Zeng J, Li M, Yan S, Li J, Li P, Shen J, Liu S, Aslam MS, Li J, Ning L, Fang H, Li Y, Yao D, Hao C, Meng X
Metabolic brain disease 2026 Jan 16;41(1):20
Metabolic brain disease 2026 Jan 16;41(1):20
Thonningianin A derived from Penthorum chinense Pursh alleviates cerebral ischemia/reperfusion-mediated apoptosis and pyroptosis through the activation of PINK1/Parkin-dependent mitophagy.
Yao Q, Hu G, Yin C, Wu A, Hu G, Qin D, Zhou X, Law BY, Du X, Chen L, Li J, Lin H, Long X, Wu J, Yu L
Chinese medicine 2026 Jan 16;21(1):40
Chinese medicine 2026 Jan 16;21(1):40
IGF2BP3/m6A-mediated intron retention isoform of DUSP6 promotes cisplatin resistance in nasopharyngeal carcinoma by inhibiting pyroptosis.
Li X, Sun X, Gu Q, Long Z, Liu J
BMC cancer 2026 Jan 12;26(1):214
BMC cancer 2026 Jan 12;26(1):214
Dual NLRC4 and non-canonical inflammasome signaling drives human GSDMD-mediated killing of Shigella flexneri independently of bacterial cardiolipin.
Szczerba M, Goldberg MB
bioRxiv : the preprint server for biology 2026 Jan 11;
bioRxiv : the preprint server for biology 2026 Jan 11;
CACNB1 alleviates mepivacaine‑induced myocardial ischemia/reperfusion injury by promoting Nrf2 nuclear translocation.
Shao Q, Zhang J, Wang H
Molecular medicine reports 2026 Feb;33(2)
Molecular medicine reports 2026 Feb;33(2)
CUEDC2 improves pyroptosis and kidney damage in diabetic kidney disease by inhibiting NLRP3 inflammasome activation.
Yang P, Fan L, Yuan D, Xie J, Luo Y, Zeng Q, Lin W, Li Z, Huang Z, Jiang W, Wang M, Huang Y
Cellular signalling 2026 Feb;138:112239
Cellular signalling 2026 Feb;138:112239
Cathepsin B overexpression and lysosomal leakage in inflammatory microglia promote neuroinflammation in olfactory dysfunction by triggering mitochondrial dysfunction and pyroptosis.
Zhou H, Wang L, Yang Y, Ye F, Zhao X, Zhu K, Huang Z, Lv W, Yu H
Brain, behavior, and immunity 2026 Feb;132:106188
Brain, behavior, and immunity 2026 Feb;132:106188
Macrophage pyroptosis inhibition alleviates postinjury neointimal formation and vascular restenosis.
Ji Z, He M, Wu H, Chen S, Wang S, Yin X, Wang H
Journal of translational medicine 2026 Feb 3;24(1)
Journal of translational medicine 2026 Feb 3;24(1)
Sleep deprivation impairs follicular development attributable to granulosa cell pyroptosis mediated by S100A8/A9-driven macrophage M1 polarization.
Fang Q, Luo L, Jin R, Wang Y, Wang J, Jin Q, Meng Y, Shi B, Qiao Z, Li F, Chen M, Chen S, Xu B, Bao J, Han H, Wu L
Science advances 2026 Feb 27;12(9):eady4767
Science advances 2026 Feb 27;12(9):eady4767
ADSC-Conditioned Medium Mitigates LPS-Induced Acute Lung Injury by Inhibiting Alveolar Macrophage Pyroptosis.
Yang F, Li J, Ren Z, Zhang C, Xing M, Jiao Z
Current issues in molecular biology 2026 Feb 26;48(3)
Current issues in molecular biology 2026 Feb 26;48(3)
FGF4 activates FGFR1 - PI3K/AKT signaling to enhance Clec10a-mediated intracellular myelin debris processing and promote spinal cord repair.
Lu W, Jiang M, Zhuang J, Song J, Zhou C, Zhou Y, Zhu Z, Wu A, Sheng S, Zhu S, Wang Z
Journal of neuroinflammation 2026 Feb 23;23(1)
Journal of neuroinflammation 2026 Feb 23;23(1)
HIFU postoperative hypoxia-activated metal-organic frameworks modulate the tumor microenvironment to augment immunotherapy.
Luo C, Wu D, Peng S, Xu S, Zhang D, Huang X, Qin W, Li H, Li H
Journal of nanobiotechnology 2026 Feb 1;24(1)
Journal of nanobiotechnology 2026 Feb 1;24(1)
Sirtuin 5-mediated desuccinylation of PRDX6 inhibits ferroptosis and alleviates sepsis-associated acute kidney injury.
Lin W, Dong C, Jiang Q, Lou Y, Wang L, He Z
Redox report : communications in free radical research 2026 Dec 31;31(1):2657075
Redox report : communications in free radical research 2026 Dec 31;31(1):2657075
Hypothermic machine perfusion protects DCD graft liver from ischemia‑reperfusion injury by enhancing macrophage efferocytosis via KLF2‑NLRP3 signaling.
Deng Q, Liu Z, Ye Q, Liu J, Fu Z, Zhang X, Luo J, Lu Z, Yue P, Xiao J, Xiao Q
International journal of molecular medicine 2026 Apr;57(4)
International journal of molecular medicine 2026 Apr;57(4)
Zinc-doped carbon dots from natural Isatis Indigotica folium and calamine: SOD/CAT-mimetic activity targets ROS-Ca²⁺-NLRP3 axis for psoriatic dermatitis therapy.
Tian X, Huang Y, He C, Dai E, Zhang X, Zou P, Liu R, Xia M, Lu Z, Jin B, Wang S, Zhang Y, Kong H, Qu H, Zhao Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:158013
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:158013
Geum japonicum Thunb. var. Chinese-P.decorata H.Andres herbal pair ameliorates CIRI-induced neuronal injury by facilitating mitochondrial transfer via the CD38/Miro1 signaling pathway.
Sun F, She R, Yang T, Chen B, Liao Z, Liao J, Mei Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157928
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157928
Huangqi Chifeng decoction alleviates cerebral ischemia and reperfusion injury by targeting NFKBIA, NF-κB1 p105 and PIAS1 to multi-dimensionally inhibit NF-κB/NLRP3 signaling: A multi-omics analysis.
Chen X, Ma X, Tang X, Lin W, Zheng Y, Zan J, Ding Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157801
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157801
Inducible Nitric Oxide Deficiency Attenuates Necroptosis in Psoriasis-Like Dermatitis in Mice by Reducing Oxidative Stress.
Sun M, Guo P, Guo Q, Li H, Huang J, Luo J, Zhu Q, Zhu Y, Yuan Q, Song S, He J, Su L, Xing W, Hu L
The Journal of investigative dermatology 2026 Apr;146(4):986-997.e12
The Journal of investigative dermatology 2026 Apr;146(4):986-997.e12
MiR-93-5p Loaded Lipid Nanoparticles Break the Dry Eye Vicious Cycle via Targeting MAP3K8.
Xu B, Ji X, Li L, Zhu L, Wang L, Kang J, Yang S, Fan T
ACS applied materials & interfaces 2026 Apr 8;18(13):18740-18754
ACS applied materials & interfaces 2026 Apr 8;18(13):18740-18754
ADAMTS7 selective inhibitor BAY-9835 alleviates acute myocardial infarction by suppressing the NF-κB-mediated pyroptosis.
Ling Y, Lyu Y, Chen H, Lin B, Zhou G, Chen S, Weng T, Ruan Z, Zhu Y, Zhu Z, Guo Y, Lin K
Toxicology and applied pharmacology 2026 Apr 28;:117836
Toxicology and applied pharmacology 2026 Apr 28;:117836
FOXE1 promotes the progression of pulp inflammation by activating PANoptosis in dental pulp cells.
Gu F, Li R, Huang D, Peng L, Huan T, Ye K, Bian Z, Yin W
iScience 2026 Apr 17;29(4):115204
iScience 2026 Apr 17;29(4):115204
Macrophage-Targeted Nanocarriers Based on Tetrahedral DNA Nanostructure Alleviate Sepsis-Induced Acute Lung Injury by Triple-Pathway Suppression of Pyroptosis.
Zhang Y, Pan M, Ma F, He C, Gu Q, Wang Y, Pan Z, Wang H, Yan Y, Fu X, Jia Y, Duan H, Wu Y, Wei Z, Wang J, Li B, Liao Y, Zhan L
ACS applied materials & interfaces 2026 Apr 15;18(14):20128-20145
ACS applied materials & interfaces 2026 Apr 15;18(14):20128-20145
USP53 Drives Ethanol-Induced Myocardial Injury by Promoting K63 Deubiquitination-Dependent RIPK1 Activation at K377.
Pan J, Liu X, Li X, Wang S, Zhao Y, Yuan C, Liu D, Wang L, Zhang M, Liu F, Zhang M, Dai S
Research (Washington, D.C.) 2025;8:0823
Research (Washington, D.C.) 2025;8:0823
Neonatal-Inspired Reprogramming of Microglial Pan-Programmed Cell Death Enhances Regeneration in Adult Spinal Cord Injury.
Yu B, Zhang Y, Yang Y, Yang S, Wu H, Gao X, Hao Y, Li S, Xia B, Liu J, Guo L, Xue B, Qin M, Chen H, Li J, Gong S, Ma T, Huang J
Research (Washington, D.C.) 2025;8:0759
Research (Washington, D.C.) 2025;8:0759
Biosynthesis of Lysosomally Escaped Apoptotic Bodies Inhibits Inflammasome Synthesis in Macrophages.
Mao J, Xia W, Wu Y, Li M, Zhao Y, Zhai P, Zhang Y, Zan T, Cui W, Sun X
Research (Washington, D.C.) 2025;8:0581
Research (Washington, D.C.) 2025;8:0581
Breaking the Chains of Therapeutic Blockade: Pyroptosis-Induced Photothermal-Chemotherapy with Targeted Nanoprobes in Triple-Negative Breast Cancer.
Li Z, Yu K, Cao Y, Yuan H, Wu L, Xiong L, Tang Y, Liang B
Biomaterials research 2025;29:0200
Biomaterials research 2025;29:0200
Lipin3 deficiency aggravates cisplatin induced acute kidney injury via activating Sirt1-p21-Caspase 3-GSDME pyroptosis pathway.
Liu YX, Huang H, Wang F, Zhao MF, Jin JY, Dong Y, Wang Q, Fan LL, Xiang R
International journal of biological sciences 2025;21(12):5185-5205
International journal of biological sciences 2025;21(12):5185-5205
MIF-Mediated NLRP3 Inflammasome-Dependent Pyroptosis in Spinal Neurons and Microglial Polarization Facilitate Neuropathic Pain Progression.
Zhou F, Tian Y, Liao W, Ma Q, Bao H, Meng F, Jiang J
Anesthesiology research and practice 2025;2025:6624776
Anesthesiology research and practice 2025;2025:6624776
TMAO Induces Vascular Endothelial Cells Pyroptosis Through TET2-CYTB-ROS Pathway.
Xia L, Wang Z, Chen X
Journal of inflammation research 2025;18:8719-8733
Journal of inflammation research 2025;18:8719-8733
Influence of Pyroptosis Induced by NOD-Like Receptor Pyrin Domain-Containing 3 Inflammasomes on Viral Myocarditis in Children.
Huang H, Lou J, Chen W, Cheng X, Xing X, Huang S
International journal of general medicine 2025;18:7003-7011
International journal of general medicine 2025;18:7003-7011
Effect of Acupotomy Modulation of NLRP3/Caspase-1/GSDMD Pathway on Chondrocyte Pyroptosis in Knee Osteoarthritis.
Wang Y, Chen Y, Yang Y, Zhou Y, Yang Y, Zhu J
Journal of pain research 2025;18:4935-4945
Journal of pain research 2025;18:4935-4945
Glycochenodeoxycholic acid induces the release of IL-1beta from L02 cells via the NLRP3/caspase-1/GSDMD pathway to activate LX2 cells.
Li J, Han L, Feng S, Lin G, Zou G, Huang T, Ran T, Zhao X
Journal of inflammation research 2025;18:15429-15440
Journal of inflammation research 2025;18:15429-15440
MALAT1's m(6)A Modification by METTL3 Promotes Pyroptosis and Inflammation in Sepsis-Induced Acute Kidney Injury in Mice.
Guo P, Deng G, Li L, Wei H, Gong Y, Tan Y, Ma Y
Journal of inflammation research 2025;18:14663-14678
Journal of inflammation research 2025;18:14663-14678
Electroacupuncture Regulates Oxidative Stress-Mediated NLRP3/ASC/Caspase-1 Pathway to Inhibit Microglial Activation: Alleviating Neuroinflammation and Depression in IBD.
Li Z, Cao S, Yang J, Chen L, Jia L, Lu P, Liu J, Liu M, Liu Q
Journal of inflammation research 2025;18:11935-11950
Journal of inflammation research 2025;18:11935-11950
ALDH2 Ameliorates Acute Gouty Arthritis Through Inhibiting NLRP3 Inflammasome and Pyroptosis by Nrf2/ROS Pathway.
Tong S, Li X, Wang F, Cheng Q, Zhang P, Chen M, Xie Y, Lu X, Wu H
Journal of inflammation research 2025;18:11095-11108
Journal of inflammation research 2025;18:11095-11108
Electroacupuncture alleviates Parkinson's disease by inhibiting the NLRP3 inflammasome pathway.
Kang M, Cai J, Yi W, Zhang B, Ai L, Ning B, Dong J, Chen L, Fu W
American journal of translational research 2025;17(5):3619-3629
American journal of translational research 2025;17(5):3619-3629
Verteporfin inhibits the cGAS-STING pathway and improves the tumor microenvironment during cisplatin treatment in hepatocellular carcinoma.
Gong Y, Xiong Y, Gao Y, Song X, Gong Y, Wang D, Liu Z, Yang Y, Lu J, Zou IX, Shi X
Frontiers in immunology 2025;16:1658042
Frontiers in immunology 2025;16:1658042
Analysis of GSDMD-N abnormality promoting neutrophil NETs mediated RA disease through NLRP3-dependent pathway.
Sang Y, Liu H, Li B, Zhu L, Wang Y, Bai L
Frontiers in immunology 2025;16:1652608
Frontiers in immunology 2025;16:1652608
Integrated proteomics analysis and network pharmacology to elucidate the mechanism of Zhilong Huoxue Tongyu Capsule alleviate hypertensive retinopathy in Ang II infusion mice model.
Wu J, Xie W, Xie Y, Mazhar M, Duan J
Frontiers in pharmacology 2025;16:1573693
Frontiers in pharmacology 2025;16:1573693
Osteopontin regulates right ventricular failure through integrin ανβ3/PERK/CHOP-dependent inflammatory and apoptotic pathways.
Yang X, Wang X, Li K, Deng Q, Hou Y, Xi G, Lu K, Liu Z, Bai Y, Wu J, Yu J, Zhang P
Frontiers in immunology 2025;16:1569210
Frontiers in immunology 2025;16:1569210
Thymoquinone alleviates the accumulation of ROS and pyroptosis and promotes perforator skin flap survival through SIRT1/NF-κB pathway.
Yang J, Zhang H, Ni L, He J
Frontiers in pharmacology 2025;16:1567762
Frontiers in pharmacology 2025;16:1567762
Hydrogen sulfide as a therapeutic agent for diabetic wounds: effects on inflammation and fibroblast pyroptosis.
Zhao F, Li Y, Hu Q, Xu J, Zhang N, Chen Y, Jiang X, Gu C, Zhang K, Wu G
Frontiers in immunology 2025;16:1558443
Frontiers in immunology 2025;16:1558443
Suppression of NLRP3 inflammasome by a small molecule targeting CK1α-β-catenin-NF-κB and CK1α-NRF2-mitochondrial OXPHOS pathways during mycobacterial infection.
Guan Q, Xiong H, Song X, Liu S, Guang Y, Nie Q, Xie Y, Zhang XL
Frontiers in immunology 2025;16:1553093
Frontiers in immunology 2025;16:1553093
Evaluation of pyroptosis-associated genes in endometrial cancer utilizing a 101-combination machine learning framework and multi-omics data.
Huang LJ, Liu C, Chen L, Tang M, Zhan ST, Chen F, Teng AY, Zhou LN, Sang WL, Yang Y
Frontiers in medicine 2025;12:1590405
Frontiers in medicine 2025;12:1590405
Combined effects of quinic acid and isochlorogenic acid B on LPS-induced inflammation and pyroptosis in MAC-T cells and mouse mammary glands.
Lv X, Long Q, Kang Y, Lin T, Jiang C
Frontiers in veterinary science 2025;12:1476302
Frontiers in veterinary science 2025;12:1476302
Lithocarpus polystachyus Rehd. leaves aqueous extract inhibits learning and memory impairment in Alzheimer's disease rats: Involvement of the SIRT6/NLRP3 signaling pathway.
Wu W, Yan Y, Yi T, Wei Y, Gao J, Gong Q
Ibrain 2025 Summer;11(2):228-244
Ibrain 2025 Summer;11(2):228-244
Inhibition of tRF- 02514 in Extracellular Vesicles Preserves Microglia Pyroptosis and Protects Against Parkinson's Disease.
Dong X, Li Q, Li R, Li Y, Jin F, Li H, Tu K, Wu G
Molecular neurobiology 2025 Sep;62(9):11047-11063
Molecular neurobiology 2025 Sep;62(9):11047-11063
Oridonin Ameliorates Metabolic-Dysfunction-Associated Fatty Liver Disease by Inhibiting PANoptosis via Modulating SIRT2/NLRP3 Pathway.
Wang Z, Sun Y, Wang C, Yao J, Hao R, Wang Y, Sun H
Phytotherapy research : PTR 2025 Sep;39(9):4181-4198
Phytotherapy research : PTR 2025 Sep;39(9):4181-4198
The viral BCL2 protein BHRF1 of Epstein-Barr virus promotes AIM2 inflammasome activation to facilitate lytic replication.
Lan Q, Zhang X, Sun Y, Yang J, Li X, Kuang E
PLoS pathogens 2025 Sep;21(9):e1013509
PLoS pathogens 2025 Sep;21(9):e1013509
β-elemene promotes ferroptosis to improve the sensitivity of imatinib in gastrointestinal stromal tumours by targeting N6AMT1.
Lan J, Zhang W, Zeng K, Li C, He J, Li X, Yang R, Chi J, Hong Z, Wang W, Zhou C, Xiao B, Fan W, Lin J, Ou Q, Fang Y, Pan Z, Peng J, Li W, Wu X
Clinical and translational medicine 2025 Sep;15(9):e70438
Clinical and translational medicine 2025 Sep;15(9):e70438
Bacteroides Fragilis-Derived Outer Membrane Vesicles Deliver MiR-5119 and Alleviate Colitis by Targeting PD-L1 to Inhibit GSDMD-Mediated Neutrophil Extracellular Trap Formation.
Yang Y, Yang L, Yang Y, Deng H, Su S, Xia Y, Su J, Liu Y, Wu J, Zhang J, Liao Y, Wang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e00781
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e00781
DCAAA mitigates neuroinflammation and microglial pyroptosis in spinal cord injury by inhibiting PI3K/AKT/NF-κB and NLRP3/caspase-1/GSDMD signaling.
Gao J, Liu Y, Li R, Liu Y, Qi Z, Zhang Z
European journal of pharmacology 2025 Sep 5;1002:177816
European journal of pharmacology 2025 Sep 5;1002:177816
Tianlong kechuanling ameliorated COPD-PH through DNMT3A-GSDMD axis-dependent regulation of endothelial cell pyroptosis.
Li H, Li Z, Gong J, Yan Y, Cui X, Yu Q, Shi Y, Tian X, Jiang Q, Tan Z, Yang Y, Zhou W, Ding Q, Wang P
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120332
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120332
Astragaloside IV alleviates LPS-induced acute lung injury by regulating receptor C5aR1 and macrophage pyroptosis.
Xu ZH, Li M, Liu L, Wu SJ, Wei RA, Inobubele Sitholumusa MU, Zhao XP, Liu JQ, Kai GY
International immunopharmacology 2025 Sep 23;162:115176
International immunopharmacology 2025 Sep 23;162:115176
Melatonin attenuates ischemia-reperfusion-induced acute kidney injury by regulating abnormal autophagy and pyroptosis through SIRT1-mediated p53 deacetylation.
Sun C, Liu J, Li H, Yan Y
International immunopharmacology 2025 Sep 23;162:115092
International immunopharmacology 2025 Sep 23;162:115092
Rufy3 Knockdown Induces PANoptosis Through MAP4/CDK1 Axis to Inhibit Colorectal Cancer Growth: Evidence From In Vitro and In Vivo Models.
Xie R, Yuan W, Chen X, Hao A, Wu Y, Zhang B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Sep 15;39(17):e70988
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Sep 15;39(17):e70988
SVF Cell Sheets as a New Multicellular Material-Based Strategy for Promoting Angiogenesis and Regeneration in Diced Cartilage Grafts.
Wei Y, Xie C, Wei Y, Li Z, Li L, Chen Y, Jia C, Xie H, Liao J
The Journal of craniofacial surgery 2025 Sep 1;36(6):1889-1898
The Journal of craniofacial surgery 2025 Sep 1;36(6):1889-1898
Gestational zearalenone causes fetal intrauterine growth restriction partially through deriving ROS-Drp1 mediated placental PANoptosis.
Liu JR, Wu FN, Lin S, Chen C, Liu Y, Fan JW, Hong Q, Chen YH
Ecotoxicology and environmental safety 2025 Sep 1;302:118636
Ecotoxicology and environmental safety 2025 Sep 1;302:118636
Canagliflozin Attenuates Podocyte Inflammatory Injury through Suppressing the TXNIP/NLRP3 Signaling Pathway in Diabetic Kidney Disease Mice.
Li S, Wang J, Chen Y, Cheng Y, Wang Y, Xu N, Wang H, Wang L, Chi Y, Ye X, Shi Y, Fang J, Yao X, Huang J, Xia Q, Bai T, Zhu B
Inflammation 2025 Oct;48(5):3180-3193
Inflammation 2025 Oct;48(5):3180-3193
Baicalein Reduces Pyroptosis of Acinar Cells in Hyperlipidemic Acute Pancreatitis by Inhibiting M1 Polarization of Macrophages via the HMGB1/TLR4/NLRP3 Pathway.
Wang X, Zhou Y, Liu Y, Mo T, Chen Z, Zhang Y, Yang L, Liu P
Inflammation 2025 Oct;48(5):3130-3145
Inflammation 2025 Oct;48(5):3130-3145
Astragaloside IV-PESV facilitates pyroptosis by enhancing palmitoylation of GSDMD protein mediated by ZDHHC1.
You X, Li H, Li Q, Zhang Q, Cao Y, Fu W, Wang B
Naunyn-Schmiedeberg's archives of pharmacology 2025 Oct;398(10):13925-13939
Naunyn-Schmiedeberg's archives of pharmacology 2025 Oct;398(10):13925-13939
Endothelial HMGB1-AIM2 axis worsens myocardial ischemia-reperfusion injury by regulating endothelial pyroptosis.
Chen R, Duan J, Zhou Y, Cao M, Su Y, Jiang D, Tao A, Yuan W, Dai Z
Apoptosis : an international journal on programmed cell death 2025 Oct;30(9-10):2466-2479
Apoptosis : an international journal on programmed cell death 2025 Oct;30(9-10):2466-2479
AIM2-PANoptosome-driven PANoptosis in hepatic lipid dysregulation induced by β-HCH and nanoplastics co-exposure.
Lin Q, Cai H, Yu F, Gong C, Wu Y, Wu Q, Xie F, Xu W, Chen S, Yao X, Jin L, Peng R
Apoptosis : an international journal on programmed cell death 2025 Oct;30(9-10):2340-2357
Apoptosis : an international journal on programmed cell death 2025 Oct;30(9-10):2340-2357
Scorpion venom heat-resistant synthetic peptide regulates Nrf-2 to alleviate neuronal pyroptosis in an AD model induced by endoplasmic reticulum stress under PM(2.5) exposure.
Duan K, Qin C, Zhang Y, Li D, Zhang J, Li F
Toxicon : official journal of the International Society on Toxinology 2025 Oct;265:108504
Toxicon : official journal of the International Society on Toxinology 2025 Oct;265:108504
Mesenchymal Stem Cells Derived from Different Adipose Tissue Depots Ameliorate Severe Acute Pancreatitis by Inhibiting NF-κB/NLRP3/Caspase-1 Pathways.
Wang A, An Y, Wang X, Gou W, Xu F, Li Y, Wang C, Tu Z, Hou W, Cui Y
Stem cell reviews and reports 2025 Oct;21(7):2200-2217
Stem cell reviews and reports 2025 Oct;21(7):2200-2217
Inhibition of PINK1 senses ROS signaling to facilitate neuroblastoma cell pyroptosis.
Zhu Y, Cao M, Tang Y, Liu Y, Wang H, Qi J, Huang C, Yan C, Liu X, Jiang S, Luo Y, Wang S, Zhou B, Xu H, Lu YY, Wang L
Autophagy 2025 Oct;21(10):2091-2110
Autophagy 2025 Oct;21(10):2091-2110
1,8-Cineole alleviates spinal cord injury by inhibiting microglial pyroptosis via the P38 MAPK and PI3K/AKT/NLRP3 signaling pathways to protects neurons.
Zhou W, Liu Z, Qiu X, Tian M, He B, Tang C, Tang Q, Ye R, Zhong D, Liao Y
International immunopharmacology 2025 Oct 30;164:115400
International immunopharmacology 2025 Oct 30;164:115400
cGAS-STING-NF-κB Axis Mediates Rotenone-Induced NLRP3 Inflammasome Activation Through Mitochondrial DNA Release.
Mun Y, Kim J, Choi YJ, Lee BH
Antioxidants (Basel, Switzerland) 2025 Oct 24;14(11)
Antioxidants (Basel, Switzerland) 2025 Oct 24;14(11)
Bisphenol S as an emerging osteotoxicant: Mechanistic insights from osteoblasts and zebrafish models.
Shi X, Xie H, Liu C, Wu K, Huang W
Ecotoxicology and environmental safety 2025 Oct 15;305:119240
Ecotoxicology and environmental safety 2025 Oct 15;305:119240
PACAP inhibits high fat-induced NLRP3 inflammasome-mediated pyroptosis in vascular endothelial cells by regulating the SIRT1/ROS pathway.
Dong J, Ma T, Qu Y, Ye R, Feng J, Bai G, Hong A, Ma Y
Molecular and cellular endocrinology 2025 Oct 1;608:112633
Molecular and cellular endocrinology 2025 Oct 1;608:112633
Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury.
Zhang W, Lu Y, Shen R, Wu Y, Liu C, Fang X, Zhang L, Liu B, Rong L
Neural regeneration research 2025 Oct 1;20(10):2955-2968
Neural regeneration research 2025 Oct 1;20(10):2955-2968
Mechanism of Berberine Ameliorating Severe Pneumonia by Targeting PTGS2 Inhibition to Regulate C-Type Lectin Receptor Pathway, Mitochondrial Function and Cellular Focalization.
Wang K, Zhao W, Yin XH, Jiang YP, Tu F, Yang JL, Cheng L, Liu J
Drug development research 2025 Nov;86(7):e70178
Drug development research 2025 Nov;86(7):e70178
Activation of IRF2 signaling networks facilitates podocyte pyroptosis in lupus nephritis.
Zhang F, Xie Y, Dang RN, Yu J, Tian XX, Li LJ, Zhou QM, An XM, Chen PL, Luo YQ, Wu YS, Liu J, Zou HM
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):167990
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):167990
Dnmt1 Alleviates S1PR1-Mediated Pyroptosis after Spinal Cord Injury through Regulating Pon3 Expression.
Peng B, Lin H, Zhang M, Kuang W, Zhang J, Wang S, Sun Y, Xu W, Zhu L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(42):e07330
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(42):e07330
LPS-Induced Mitochondrial Damage via SLC41A1-Mediated Magnesium Ion Efflux Leads to the Pyroptosis of Dental Stem Cells.
Liu Y, Song C, Zhang L, Han X, Li C, Yan Y, Xing L, Si M, Yang B, Cheng L, Muramatsu A, Jiang B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(42):e05666
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(42):e05666
Hydrogen Sulfide Attenuates Cisplatin-Induced Acute Kidney Injury via Dual Inhibition of Apoptosis and Pyroptosis.
Han Z, Jia Y, Yan D, Xue Y, Deng T, Wang P, Xiao L, Wang X
Biomedicines 2025 Nov 3;13(11)
Biomedicines 2025 Nov 3;13(11)
Acetylation reader BRD4-driven TXNIP transcription enhances NLRP3 inflammasome activation in PCOS.
Weng Y, Zhang Y, Dong W, Zhu Z, Xiang Z, Yan G, Wang H, Wen Y, Liu M, Wang D, Wang Y
Cellular and molecular life sciences : CMLS 2025 Nov 26;82(1):427
Cellular and molecular life sciences : CMLS 2025 Nov 26;82(1):427
Shen Yuan Yi Qi Huo Xue capsules inhibit neutrophil NETosis by regulating the PAD4/NLRP3 signaling pathway to prevent heart failure after myocardial infarction.
Lian YJ, Zhang HY, Liu HX, Shang JJ, Lai XL, Xing WL, Li SN
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157462
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157462
Bushen Huatan formula alleviates polycystic ovary syndrome in rats by activating the PI3K/Akt pathway to inhibit GSDMD-mediated pyroptosis and mitochondrial damage.
Xiong Q, Yang J, Liu Q, Yu P, Shen M, Liang J
Journal of ovarian research 2025 Nov 24;18(1):309
Journal of ovarian research 2025 Nov 24;18(1):309
Targeting ICAM1 through LIF-mediated NF-κB/JAK2-STAT3 crosstalk protects nucleus pulposus from IL-1β-driven pyroptosis to ameliorate intervertebral disc degeneration.
Wang Z, Liu J, Xu H, Sun Y, Xu S, He X
Journal of orthopaedic surgery and research 2025 Nov 22;20(1):1096
Journal of orthopaedic surgery and research 2025 Nov 22;20(1):1096
Fusobacterium nucleatum-derived extracellular vesicles carrying virulence factor DNA trigger AIM2 inflammasome activation to facilitate UC progression.
Zhao Y, Wu R, Duan Y, Kong X, Zhang Y, You Y, Zhang J, Wang Y, Zhou L, Duan L
Cellular & molecular biology letters 2025 Nov 17;30(1):138
Cellular & molecular biology letters 2025 Nov 17;30(1):138
Protective effects of taurochenodeoxycholic acid on aflatoxin B1-induced hepatic pyroptosis and gut-liver dysfunction.
Xu C, Wang X, Zhang X, Yao J, Lu Y, Wu G, Li W, Yang J
Ecotoxicology and environmental safety 2025 Nov 15;307:119432
Ecotoxicology and environmental safety 2025 Nov 15;307:119432
Non-anticoagulant heparin alleviates myocardial ischemia-reperfusion injury through inhibiting GSDMD-mediated cardiomyocyte pyroptosis via the HMGB1/RAGE pathway.
Wang X, Liang Z, Liu M, Ouyang J, Gao P, Pan G
International immunopharmacology 2025 Nov 14;165:115412
International immunopharmacology 2025 Nov 14;165:115412
Punicalin ameliorates vascular endothelial cell pyroptosis and dysfunction induced by hyperlipidemia and hyperglycemia through activation of PPARγ.
Chen X, Wei X, Yuan W, Liao Z, Feng C, Xiong S, Wang K, Yan G, Kong Y
International immunopharmacology 2025 Nov 14;165:115389
International immunopharmacology 2025 Nov 14;165:115389
MiR-193b-3p Regulates Gasdermin-D/NLRP3 by Targeting the Signaling Axis Inhibition of Pyroptosis Attenuates Myocardial Ischemia-Reperfusion Injury.
Yu C, Zhu QP, Xie W, Xu WS, Liu JL, Wang W, Zhang YF, Zhang T, Shao G
Journal of physiological investigation 2025 Nov 1;68(6):349-357
Journal of physiological investigation 2025 Nov 1;68(6):349-357
Macelignan Improves Functional Recovery After Spinal Cord Injury by Augmenting Autophagy via the AKT-mTOR-TFEB Signaling Pathway.
Zhu Y, Yang S, Su S, Huang Y, Chen Y, Liang H, Miao J, Wu Z, Li X, Xiao J, Wang X
Phytotherapy research : PTR 2025 May;39(5):2091-2109
Phytotherapy research : PTR 2025 May;39(5):2091-2109
Decoding ozone's impact on the cornea: disruption of barrier integrity and its molecular drivers.
Tian Y, Li L, Sun Z, Liu J, Qiu C, Zhou J, Sun X, Lei Y
Ecotoxicology and environmental safety 2025 May;296:118213
Ecotoxicology and environmental safety 2025 May;296:118213
Grafting of syringic acid onto fucoidan: Enhanced functional properties and therapeutic potential in histamine-induced liver injury.
Zhang M, Tang J, Wang J, Qi C, Chen G, Chen W, Wang C
Food research international (Ottawa, Ont.) 2025 May;208:116161
Food research international (Ottawa, Ont.) 2025 May;208:116161
Co-exposure to ozone and polystyrene nanoplastic exacerbates cognitive impairment and anxiety-like behavior by regulating neuronal pyroptosis in mice.
Dai A, Liu X, Chen Y, Wang Y, Qi H, Zeng Y, Li J
Environment international 2025 May;199:109501
Environment international 2025 May;199:109501
Unusual chaetoglobosins and a new type of ferroptosis inducer from an endophytic fungus Chaetomium sp. UJN-EF006.
Wang YY, Wang YS, Li JJ, Wan ZY, Zhang H
Bioorganic chemistry 2025 May;158:108342
Bioorganic chemistry 2025 May;158:108342
Piperlongumine alleviates viral myocarditis by inhibiting pyroptosis through NF-κB pathway.
Li H, Wang M, Hua Z, Guo H, Qiu Y, Zhang Z, Zou Y, Lu L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156606
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156606
Lycium barbarum glycopeptide attenuates intracerebral hemorrhage-induced inflammation and oxidative stress via activation of the Sirt3 signaling pathway.
Ma CS, Han B, Meng SC, Bai M, Yi WJ, Zhang LY, Duan MY, Wang YJ, He MT
International immunopharmacology 2025 May 8;154:114518
International immunopharmacology 2025 May 8;154:114518
Aryl Hydrocarbon Receptor-Dependent miRNA-382-5p Mediates the Classical Pyroptosis Induced by Foodborne Benzo(a)pyrene through Targeting IκB in Liver.
Meng Y, Jia Y, He Z, Li J, Yuan L
Journal of agricultural and food chemistry 2025 May 28;73(21):12978-12992
Journal of agricultural and food chemistry 2025 May 28;73(21):12978-12992
ZC3H13 Promotes NSUN4-Mediated Chondrocyte Mitochondrial Dysfunction and Pyroptosis in Temporomandibular Joint Osteoarthritis.
Chen Y, Ren H
Cartilage 2025 May 28;:19476035251339410
Cartilage 2025 May 28;:19476035251339410
IFI204 in microglia mediates traumatic brain injury-induced mitochondrial dysfunction and pyroptosis via SENP7 interaction.
Guo T, Lai Y, Wu S, Lin C, Zhou X, Lin P, Zheng M, Chen J, Lin F
Cell biology and toxicology 2025 May 23;41(1):89
Cell biology and toxicology 2025 May 23;41(1):89
Microcystin-LR induces lung injury in mice through the NF-κB/NLRP3 pathway.
Zhang Y, Guan Y, Dai M, Yang Y, Yang F
Journal of toxicology and environmental health. Part A 2025 May 19;88(10):385-394
Journal of toxicology and environmental health. Part A 2025 May 19;88(10):385-394
Impaired Mitophagy Contributes to Pyroptosis in Sarcopenic Obesity Zebrafish Skeletal Muscle.
Tang X, Zou Y, Yang S, Chen Z, Zhou Z, Peng X, Tang C
Nutrients 2025 May 18;17(10)
Nutrients 2025 May 18;17(10)
Inhibition of hsa_circ_0003314 contributes to trophoblast cell migration and invasion and inhibits pyroptosis in preeclampsia.
Zhou Y, Chen Y, Li L, Lin L
Histochemistry and cell biology 2025 May 16;163(1):52
Histochemistry and cell biology 2025 May 16;163(1):52
Clemastine fumarate accelerates accumulation of disability in progressive multiple sclerosis by enhancing pyroptosis.
Kocot J, Kosa P, Ashida S, Pirjanian NA, Goldbach-Mansky R, Peterson K, Fossati V, Holland SM, Bielekova B
The Journal of clinical investigation 2025 May 15;135(10)
The Journal of clinical investigation 2025 May 15;135(10)
Comprehensive single-cell transcriptomic reveals different destinies of melanocytes and dynamic changes of immune microenvironment in a psychological stress-induced leukoderma and leukotrichia mouse model.
Cao X, Yu Y, Yao H, Zheng Y, Lu J, Feng Y, Pei T, Li Z, Lu M, Lu Y
Molecular medicine (Cambridge, Mass.) 2025 May 14;31(1):186
Molecular medicine (Cambridge, Mass.) 2025 May 14;31(1):186
Panax ginseng exerts cardioprotective effect post myocardial infarction by attenuating myocardial fibrosis and inflammation through SIRT1 signaling pathways.
Xu H, Pang M, Hu C, Xu T, Chen G, Zhang G, Han X, Hua Y, Wu Y, Zhang J, Bi Y, Liu B, Zhou Y
Journal of ginseng research 2025 Mar;49(2):197-207
Journal of ginseng research 2025 Mar;49(2):197-207
GABARAPL1 Exerts Regulatory Effects on Hypoxia-Induced Pyroptosis in the Pathogenesis of Myocardial Infarction.
Liu C, Yan C, Liu D, Song H, Han Y
Journal of cellular and molecular medicine 2025 Mar;29(6):e70469
Journal of cellular and molecular medicine 2025 Mar;29(6):e70469
Neutrophil extracellular traps-induced pyroptosis of liver sinusoidal endothelial cells exacerbates intrahepatic coagulation in cholestatic mice.
Yu M, Zheng C, Li X, Ji X, Hu X, Wang X, Zhang J
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167700
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167700
WISP1 promotes the progression of rheumatoid arthritis through NLRP3 inflammasome activation.
Hao T, Niu J, Tang Z, Xie K, Chen H, Wang H
Molecular immunology 2025 Mar;179:106-115
Molecular immunology 2025 Mar;179:106-115
ALKBH5 promotes cardiac fibroblasts pyroptosis after myocardial infarction through Notch1/NLRP3 pathway.
Cui LG, Wang SH, Komal S, Yin JJ, Zhai MM, Zhou YJ, Yu QW, Wang C, Wang P, Wang ZM, Zafar AM, Shakeel M, Zhang LR, Han SN
Cellular signalling 2025 Mar;127:111574
Cellular signalling 2025 Mar;127:111574
ALPK1 signaling pathway activation by HMGB1 drives microglial pyroptosis and ferroptosis and brain injury after acute ischemic stroke.
Du O, Yan YL, Yang HY, Yang YX, Wu AG, Guo YK, Li K, Qiao G, Du JR, Long FY
International immunopharmacology 2025 Mar 6;149:114229
International immunopharmacology 2025 Mar 6;149:114229
Erianin alleviates autoimmune myocarditis by suppressing the M1 polarization of macrophages via the NF-κB/NLRP3 signaling pathway.
Liu W, Mao Y, Li H, Hu J, Gan T, Wang Y, Wang Y, Wang Z
European journal of pharmacology 2025 Mar 5;990:177292
European journal of pharmacology 2025 Mar 5;990:177292
Olfactory bulb microglia activation mediates neuronal pyroptosis in ozone-exposed mice with olfactory and cognitive dysfunction.
Xu R, Chen H, Wang Y, Qi H, Chen Y, Dai A, Yang S, Wang Y, Zeng Y, Li J
Journal of hazardous materials 2025 Mar 5;485:136901
Journal of hazardous materials 2025 Mar 5;485:136901
Sinomenine alleviates neuroinflammation in chronic cerebral hypoperfusion by promoting M2 microglial polarization and inhibiting neuronal pyroptosis via exosomal miRNA-223-3p.
Yang Q, Chen Q, Zhang KB, Liu Y, Zheng JC, Hu DX, Luo J
Acta neuropathologica communications 2025 Mar 5;13(1):48
Acta neuropathologica communications 2025 Mar 5;13(1):48
Photothermal therapy combined with a STING agonist induces pyroptosis, and gasdermin D could be a new biomarker for guiding the treatment of pancreatic cancer.
Hu Y, Qi E, Yun C, Li X, Liu F, Cheng Z, Guan N, Wang Q, Zhao H, Xiao W, Peng L, Yang J, Yu X
Journal of translational medicine 2025 Mar 4;23(1):271
Journal of translational medicine 2025 Mar 4;23(1):271
Phenethyl isothiocyanate ameliorates liver injuries secondary to inflammatory bowel disease.
Ma C, Zhang L, Huang Q, Deng Q, Huang F, Xu J
Food & function 2025 Mar 17;16(6):2589-2597
Food & function 2025 Mar 17;16(6):2589-2597
Exosome-mediated effects of BRCA1 on cardiovascular artery disease.
Yu H, Wei D, Liao W, Shang X, Li D, Liu C, Deng Q, Huangfu H
Cell biology and toxicology 2025 Mar 13;41(1):59
Cell biology and toxicology 2025 Mar 13;41(1):59
Why do microplastics aggravate cholestatic liver disease? The NLRP3-mediated intestinal barrier integrity damage matter.
Li S, Yuan Y, Zeng Y, Fang P, Wang J, Liu Y, Xiao F
Environmental pollution (Barking, Essex : 1987) 2025 Mar 1;368:125753
Environmental pollution (Barking, Essex : 1987) 2025 Mar 1;368:125753
Knockdown TNF family prognosis index crucial gene PDE4B promoted PANoptosis of ovarian carcinoma cell:Based in vitro and in vivo experiments.
Yu Q, Wang Y, Fu T, Han D, Wang L, Zhao L, Xu Y
Translational oncology 2025 Jun;56:102333
Translational oncology 2025 Jun;56:102333
Polystyrene nanoplastics trigger pyroptosis in dopaminergic neurons through TSC2/TFEB-mediated disruption of autophagosome-lysosome fusion in Parkinson's disease.
Liang X, Zeng Y, Zhang P, Zhu B, Feng J, Deng T, Fu Z, Liu C, Chen C, Zhang Y
Journal of translational medicine 2025 Jun 5;23(1):631
Journal of translational medicine 2025 Jun 5;23(1):631
STING-mediated mitochondrial DNA release exacerbates PANoptosis in liver ischemia reperfusion injury.
Wu C, Miao H, Yi Z, Jia H, Huang A, Zhang H, Liu Z, Sun X, Zheng Y, Gao L, Ma S
International immunopharmacology 2025 Jun 5;157:114778
International immunopharmacology 2025 Jun 5;157:114778
Effects of electroacupuncture on neural function and the expression of inflammation-related proteins NLRP3/caspase-1 in rats with ischemic stroke.
Wang Z, Xi Y, Lan J, Yang J, Shi T, Xu S, Xing L, Pan P, Wang J
Neuroreport 2025 Jun 4;36(9):456-466
Neuroreport 2025 Jun 4;36(9):456-466
Emodin influences pyroptosis-related Caspase 1-GSDMD axis alleviated cerebral ischemia-reperfusion injury in rats.
Zhang G, Hu X, Qian J, Shi Y, Ling Z, Xu P, Xu Z, Zhang J, Liang T
Scientific reports 2025 Jun 3;15(1):19397
Scientific reports 2025 Jun 3;15(1):19397
Endoplasmic reticulum stress induces trophoblast pyroptosis via regulating CYLD during labor initiation.
Zhang X, Yang M, Lv D, Zhang Y, Xie Y, He M, Fan Y, Li X, Jallow F, Li F, Deng D
Placenta 2025 Jun 26;167:204-215
Placenta 2025 Jun 26;167:204-215
CEBPD is a pivotal factor for the activation of NLRP3 inflammasome in traumatic brain injury.
Lang J, Li M, Sun B, Feng S, Zhao J, Zhao G, Sun G
International immunopharmacology 2025 Jun 26;159:114930
International immunopharmacology 2025 Jun 26;159:114930
miR-29a nanoparticles improve chronic insomnia by regulating microglia activation and hippocampal neuronal cell pyroptosis through PER2/NF-κB axis.
Hou D, Hu Y, Li H, Yang G
International immunopharmacology 2025 Jun 26;159:114882
International immunopharmacology 2025 Jun 26;159:114882
Investigating the Mechanism of Emodin in Rheumatoid Arthritis Through the HIF-1α/NLRP3 Pathway and Mitochondrial Autophagy.
Du D, Zhou L, Tian J, Cheng L, Zhang H, Tang Y, Qiu Z, Zhang T, Rong X
Current issues in molecular biology 2025 Jun 25;47(7)
Current issues in molecular biology 2025 Jun 25;47(7)
Carbon monoxide gas molecules: Therapeutic mechanisms in radiation-induced lung injury.
Li Y, Zhou B, Liu D, Nie G, Yang F, Chen J, Cheng S, Kang Y, Liu B, Dong B, Liu M
Journal of colloid and interface science 2025 Jun 15;688:250-263
Journal of colloid and interface science 2025 Jun 15;688:250-263
Coptis chinensis-derived extracellular vesicle-like nanoparticles delivered miRNA-5106 suppresses NETs by restoring zinc homeostasis to alleviate colitis.
Yang Y, Yang L, Deng H, Liu Y, Wu J, Yang Y, Su J, Su S, Xu J, Wei J, Deng X, Wu Y, Liao Y, Wang L
Journal of nanobiotechnology 2025 Jun 14;23(1):444
Journal of nanobiotechnology 2025 Jun 14;23(1):444
Hydroxysafflor Yellow A Ameliorates Ischemic Stroke by Inhibiting NLRP3, AIM2, and Pyrin Inflammasome-Mediated Pyroptosis.
Ding YL, Qiao LJ, Fang H, Fan LL, Wu D, Xu JP, Lv QH, Deng MZ, Qiu YH, Zhou ZY, Huang Y, Zheng JY, Zhang SJ, Cai YF
Neurochemical research 2025 Jun 13;50(3):201
Neurochemical research 2025 Jun 13;50(3):201
Coptisine inhibits esophageal carcinoma growth by modulating pyroptosis via inhibition of HGF/c-Met signaling.
Qian C, Zhang X, Tian YS, Yuan L, Wei Q, Yang Y, Xu M, Wang X, Sun M
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jul;398(7):8375-8389
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jul;398(7):8375-8389
Propofol alleviates traumatic brain injury through regulating Th17/Treg balance by activation of the AMPK/SIRT1 pathway.
Wang D, Sun H, Hai K, Li N, Gu Y, Ma Z
Toxicology mechanisms and methods 2025 Jul;35(6):644-654
Toxicology mechanisms and methods 2025 Jul;35(6):644-654
Shengjiang powder ameliorates cell pyroptosis and inflammation induced by MCAO in rats through the NLRP3/Caspase-1 pathway.
Qin L, Peng L, Sun Y, Chen G, Du C, Xie R, Ling Y, Xu H, Zhao M, Zhao Y, Zheng Z
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025 Jul;34(7):108314
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025 Jul;34(7):108314
Circular RNA-OGDH promotes PANoptosis in diabetic cardiomyopathy: A novel mechanistic insight.
Guan J, Shi X, Ma J, Yin Y, Song G, Li Y, Chen X, Yan Y, Wang D, Liu S, Liu G, Zheng M, Ma F
The Journal of biological chemistry 2025 Jul;301(7):110280
The Journal of biological chemistry 2025 Jul;301(7):110280
Scutellarein ameliorates pulmonary arterial hypertension via sirtuin 1 mediated deacetylation of nicotinamide nucleotide transhydrogenase.
Tang H, Ning K, Wu B, Wang X, He J, Li P, Pan L, Zhang J, He Y, Bian S, Ma X, Zhang J, Liu C, Qin Z, Hu H
Biochemical pharmacology 2025 Jul;237:116932
Biochemical pharmacology 2025 Jul;237:116932
FTO triggers NLRP3/GSDMD-dependent pyroptosis to enhance cisplatin-sensitivity in ovarian cancer.
Zhang F, Zhu T, Gan L, Du Y, Liu L, Ding H, Chen X, Guan Y
Cellular signalling 2025 Jul;131:111698
Cellular signalling 2025 Jul;131:111698
Neoadjuvant Chemotherapy With Cisplatin Up-Regulates GSDMD to Enhance Oral Squamous Cell Carcinoma Metastasis Through MMP14-Mediated EMT Activation.
Huang Z, Jiang Q, Zhang Q, Lu N, Rui X, Chen R, Wang Y, Wang Y, Xu X, Huang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(25):e2501149
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(25):e2501149
JC124 confers multimodal neuroprotection in epilepsy by suppressing NLRP3 inflammasome activation: evidence from animal and human neuronal models.
Zhang P, Li Z, Liang M, Yuan J, Zhou J, Zhang J, Deng J, Chen Y, Tang H, Xu C, Shi C, Ma L, Liu Q, Liu Y, Chen Y, Zhang H
Cell communication and signaling : CCS 2025 Jul 8;23(1):327
Cell communication and signaling : CCS 2025 Jul 8;23(1):327
Hyperandrogenism-mediated YAP activation drives ovarian inflammation and pyroptosis in PCOS: implications for follicular dysfunction.
Xu T, Xiang Y, Huang Z, Zhu Q, Wu H, Cai J, Weng L, Ge H
Journal of ovarian research 2025 Jul 30;18(1):170
Journal of ovarian research 2025 Jul 30;18(1):170
Dahuang Huanglian Decoction alleviates dysbiosis by inhibiting GBP5/NLRP3 signaling pathway-mediated pyroptosis of colonic epithelial cells.
Ren T, Yin Y, Zhou X, Chen L, Shen Y, Feng H, Zhou C, Xu Y, Ling Y
Journal of ethnopharmacology 2025 Jul 24;351:120143
Journal of ethnopharmacology 2025 Jul 24;351:120143
Ameliorating Myocardial Infarction by Concurrent Pyroptosis Suppression and On-Demand Oxygen Production via Functionalized Nanocarrier.
Zhu W, Lu Y, Zong B, Chen Z, Ma Y, Wang H, Cao P, Han B
ACS applied materials & interfaces 2025 Jul 23;17(29):41626-41636
ACS applied materials & interfaces 2025 Jul 23;17(29):41626-41636
HOXC8 impacts lung tumorigenesis by preventing pyroptotic cell death through the suppression of caspase-1 expression.
Padia R, Sun L, Liao YF, Calbay O, Chi C, Akter M, Wu L, Fu Z, Zhang DD, Huang S
Cell death & disease 2025 Jul 23;16(1):552
Cell death & disease 2025 Jul 23;16(1):552
Time- and dose-dependent activation of the NLRP3 and MyD88/NF-κB pathways by Trueperella pyogenes membrane vesicles in bovine endometrial epithelial cells.
Li D, Li H, Wang Z, Huang Y, Zhao C, Zhang H, Zhao Y, Zhu N, Tang X, Jin Y, Zhou D
Veterinary research 2025 Jul 21;56(1):155
Veterinary research 2025 Jul 21;56(1):155
Rosmarinic Acid Ameliorates Type 2 Diabetic Osteoporosis by Reducing NLRP3 Expression and Alleviating Osteoblast Pyroptosis via the FOXO1/TXNIP Signaling Pathway.
Feng S, Ma R, Huang Y, Pan L, Guo Y, Wang Y, Chen Z, Li E, Bu Y, Luo J, Tang J, Yang L
Journal of agricultural and food chemistry 2025 Jul 2;73(26):16557-16572
Journal of agricultural and food chemistry 2025 Jul 2;73(26):16557-16572
Long-term exposure to silica nanoparticles induces cardiac hypertrophy through the pyroptosis pathway.
Wang F, Li Y, Liu R, Li T, Liu L, Wu Y, Su X, Wang X
Toxicological sciences : an official journal of the Society of Toxicology 2025 Jul 1;206(1):158-168
Toxicological sciences : an official journal of the Society of Toxicology 2025 Jul 1;206(1):158-168
The N-terminal domain of gasdermin D induces liver fibrosis by reprogrammed lipid metabolism.
Wang X, Ning C, Cheng X, Wu Z, Wu D, Ding X, Ju C, Zhou Z, Wan L, Zhao W, Shi P
Animal models and experimental medicine 2025 Jan;8(1):114-125
Animal models and experimental medicine 2025 Jan;8(1):114-125
Pyroptosis inhibition alleviates acute lung injury via E-twenty-six variant gene 5-mediated downregulation of gasdermin D.
Zhang W, Wang X, Ma C, Liang B, Ma L, Wang Y, Lin Y, Han S
Respiratory physiology & neurobiology 2025 Jan;331:104346
Respiratory physiology & neurobiology 2025 Jan;331:104346
Paris saponin VII induces Caspase-3/GSDME-dependent pyroptosis in pancreatic ductal adenocarcinoma cells by activating ROS/Bax signaling.
Qian X, Liu Y, Chen W, Zheng S, Lu Y, Qiu P, Ke X, Tang H, Zhang X
Chinese herbal medicines 2025 Jan;17(1):94-107
Chinese herbal medicines 2025 Jan;17(1):94-107
CASP5 associated with PANoptosis promotes tumorigenesis and progression of clear cell renal cell carcinoma.
Yang K, Wang Y, Jian Y, Wang B, Du H, Xia Y, Bi J, Guo M, Li Z, Wang N
Cancer cell international 2025 Jan 8;25(1):8
Cancer cell international 2025 Jan 8;25(1):8
FuKe QianJin capsule alleviates endometritis via inhibiting inflammation and pyroptosis through modulating TLR4/ NF-κB /NLRP3 pathway.
Xiong S, Xu C, Yang C, Luo H, Xie J, Xia B, Zhang Z, Liao Y, Li C, Li Y, Lin L
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118962
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118962
The regulatory role of the Netrin-1/UNC5H3 pathway in neuronal pyroptosis after stroke.
Zhai Z, Huang Z, Huang K, Zhong Y, You H, Tao E, Yang Y
International immunopharmacology 2025 Jan 27;146:113939
International immunopharmacology 2025 Jan 27;146:113939
Therapeutic effects of tripterygium glycosides on periodontitis: Exploring the role of ursolic acid and the RIPK3/NLRP3 signaling pathway.
Ren L, Gao Y, Chen L, Yang L
International immunopharmacology 2025 Jan 27;146:113903
International immunopharmacology 2025 Jan 27;146:113903
The injury effect of osteopontin in sepsis-associated lung injury.
Wang Q, Yu Z, Song Z, Lu X, Li Z, Pi D, Li J, Xu F
Journal of inflammation (London, England) 2025 Jan 24;22(1):4
Journal of inflammation (London, England) 2025 Jan 24;22(1):4
Inhibition of tumor necrosis factor receptor-associated factor 6 alleviates secondary brain injury by reducing neuronal pyroptosis after intracerebral hemorrhage.
Hu Q, Zeng H, Feng C, Tian W, He Y, Li B
Experimental animals 2025 Jan 10;74(1):39-48
Experimental animals 2025 Jan 10;74(1):39-48
Trimethylamine N-oxide induces pyroptosis in HTR8-S/Vneo cells through the ten-eleven translocation 2-cytochrome b-reactive oxygen species pathway.
Liang L, Rao Y, Wang J, Zhao J, He L, Meng J, Wu P, Wang Z
The journal of obstetrics and gynaecology research 2025 Feb;51(2):e16237
The journal of obstetrics and gynaecology research 2025 Feb;51(2):e16237
TAT-N24 enhances retinal ganglion cell survival by suppressing ZBP1-PANoptosome-mediated PANoptosis in an acute glaucoma mouse model.
Li F, Zhang Q, Rong Y, Xiang S, Wang J
Experimental eye research 2025 Feb;251:110244
Experimental eye research 2025 Feb;251:110244
TRIM44 alleviates renal ischemia-reperfusion injury by inhibiting pyroptosis through the NLRP3 pathway.
Ning J, Wang J, Sun X, Li H, Cheng F
Molecular immunology 2025 Feb;178:20-31
Molecular immunology 2025 Feb;178:20-31
Targeting pyroptosis reverses KIAA1199-mediated immunotherapy resistance in colorectal cancer.
Li L, Zhao L, Zhou D, Yu Y, Zhang P, Zheng J, Lin Z, Yu D, Ren J, Zhang J, Zhou P, Zhang D, Zhang T
Journal for immunotherapy of cancer 2025 Feb 25;13(2)
Journal for immunotherapy of cancer 2025 Feb 25;13(2)
Mechanistic studies of Ca(2+)-induced classical pyroptosis pathway promoting renal adhesion on calcium oxalate kidney stone formation.
Xiang J, Lv M, Luo Y, Ke K, Zhang B, Wang M, Zhang K, Li H
Scientific reports 2025 Feb 24;15(1):6669
Scientific reports 2025 Feb 24;15(1):6669
Echinococcus granulosus-Induced Liver Damage Through Ferroptosis in Rat Model.
Zhai S, Yang Y, Zhou Y, Lai Q, Li K, Liu S, Li W, Gao F, Guan J
Cells 2025 Feb 22;14(5)
Cells 2025 Feb 22;14(5)
Anticancer effects of OSW-1 on colorectal cancer cells via the ROS/NLRP3/Caspase-1 pyroptosis signaling pathway.
Yao Y, Chen Y, Yao T, Li C, Li S, Wang N
International immunopharmacology 2025 Feb 20;148:114054
International immunopharmacology 2025 Feb 20;148:114054
Ferroptosis and PANoptosis under hypoxia pivoting on the crosstalk between DHODH and GPX4 in corneal epithelium.
Wu MF, Peng X, Zhang MC, Guo H, Xie HT
Free radical biology & medicine 2025 Feb 16;228:173-182
Free radical biology & medicine 2025 Feb 16;228:173-182
New idea of Fuke Qianjin capsule in treating sequelae of pelvic inflammatory disease: Anti-inflammatory in the early stage and reparative in the later stage.
Xu C, Yi M, Xiao Z, Xiang F, Wu M, Zhang Z, Zheng Y, Gong Y, Li Y, Su L, Liao Y, Zhang P, Xia B, Liao D, Lin L
Journal of ethnopharmacology 2025 Feb 10;338(Pt 2):119066
Journal of ethnopharmacology 2025 Feb 10;338(Pt 2):119066
By inhibiting pyroptosis to reduce neuroinflammation, PEG-bHb may prevent the development of secondary injury after traumatic brain injury.
Zeng Q, You G, Li W, An J, Huang Z, Zhang X, Zhou H, Xiao Y, Wang Y, Zhao L
Experimental neurology 2025 Dec;394:115447
Experimental neurology 2025 Dec;394:115447
Geniposide alleviates rheumatoid arthritis by inhibiting pyroptosis by regulating the miR-223-3p/NLRP3 Axis.
Fan XT, Li C, Dong P, Hao H, Lian H, Wu H, Ao LM, Ma CJ
International immunopharmacology 2025 Dec 3;166:115598
International immunopharmacology 2025 Dec 3;166:115598
Activated oligoadenylate synthetase-ribonuclease L pathway promotes endothelial pyroptosis and impairs diabetic wound healing via thioredoxin-interacting protein m(6)A methylation.
Zhou P, Huang Y, Wang Z, Chen D, Long B, Qin P, Li Y, Yang C, Li Q
Molecular biomedicine 2025 Dec 29;6(1):150
Molecular biomedicine 2025 Dec 29;6(1):150
Palmatine Attenuates Lipopolysaccharide-Induced Acute Lung Injury Via Suppression of NLRP3 Inflammasome Activation, Pyroptosis, and Metabolic Remodeling.
Ning P, Wu J, Long Q, Zheng Y, Gan J, Hu X, Song S, Li X, Jiang M, Ye H, Yu W, He Y, Zheng Y, Gao Z
Inflammation 2025 Dec 20;49(1):11
Inflammation 2025 Dec 20;49(1):11
Honokiol attenuates diabetic nephropathy by targeting SIRT3 to suppress mitochondrial ROS-induced pyroptosis.
Yu K, Liu M, Zhang T, Guo C, Du L, Li M, Wang Q, Han N, Chi Y, Li Y
Diabetology & metabolic syndrome 2025 Dec 2;18(1):7
Diabetology & metabolic syndrome 2025 Dec 2;18(1):7
Artesunate attenuates cerebral injury after cardiac arrest via inhibiting caspase-11-mediated pyroptosis through NEDD4.
He L, Zhang W, Hu Y, Zhu J, Liang L, Yang H, Chen Q, Xu J, Zhang M
Life sciences 2025 Dec 1;382:124019
Life sciences 2025 Dec 1;382:124019
Inhibition of BRD4 alleviates pyroptosis induced by testicular ischemia/reperfusion injury through the NLRP3 pathway.
Wang J, Ning J, Zhou Z, Li H
Tissue & cell 2025 Aug;95:102919
Tissue & cell 2025 Aug;95:102919
Colchicine Alleviates Interstitial Lung Disease in an Experimental Autoimmune Myositis Murine Model by Inhibiting the Formation of Neutrophil Extracellular Traps.
Li F, Zhao P, Zhao L, Bai L, Su Q, Feng Y, Ma W, Zhu J, Yang J, Zhang S
Inflammation 2025 Aug;48(4):2692-2703
Inflammation 2025 Aug;48(4):2692-2703
Nicotinamide N-oxide Inhibits Microglial Pyroptosis by Upregulating Mitophagy and Alleviates Neural Damage in Rats after TBI.
Li X, Luo L, Duan P, Bi Y, Meng Y, Zhang X, Feng W, Jin Z, Zuo K, Zhao X, Zhang B
Inflammation 2025 Aug;48(4):2009-2021
Inflammation 2025 Aug;48(4):2009-2021
Activation of pyroptosis impairs basal cell differentiation in the nasal epithelium in chronic rhinosinusitis with nasal polyps.
Zhang G, Jin S, Liu J, Du Y, Li Z, Liu L, Xu X, Wang Z, Yan S
Molecular medicine reports 2025 Aug;32(2)
Molecular medicine reports 2025 Aug;32(2)
FCV activates NLRP3 inflammasome through ion-dependent pathway to promote IL-1β secretion.
Chen H, Zhao S, Liu S, Wei Y, Guo Y, Gao K, Shao H, Zhao H, Bao D, Zhang S, Yi S, Wang K, Hu G
Veterinary microbiology 2025 Aug;307:110628
Veterinary microbiology 2025 Aug;307:110628
Glycosides of Buyang Huanwu decoction alleviate cerebral infarction injury by inhibiting neuronal pyroptosis via astrocyte-derived exosomal miR-378b_L+1.
Lang T, Qin K, Shao L, Fan B, Chen H, Yu B, Li S, Xie Y, Liao Y, Hu J, Sun R, Zhong Z, Deng C, She Y
Journal of ethnopharmacology 2025 Aug 29;352:120234
Journal of ethnopharmacology 2025 Aug 29;352:120234
Targeting Wnt/beta-catenin signaling to attenuate short-chain chlorinated paraffins-triggered hepatocyte mitochondrial fission and subsequent pyroptosis.
Xiao J, Huang D, Wang F, Gan L, Zhang W, Zhang F, Tang J, Shen Z, Jiang M, Egbobe JO, Shao J, Wang X, Zhang Y, Ju L, Zhao X
International immunopharmacology 2025 Aug 28;161:115102
International immunopharmacology 2025 Aug 28;161:115102
Caspase-8-driven NLRP3 inflammasome activation exacerbates bronchopulmonary dysplasia by increasing the apoptosis and pyroptosis crosstalk of alveolar epithelial cells.
Huang D, Xu D, You C, Li B, Li L, Yang Q, Zhou W, Meng Q, Liang Z
International immunopharmacology 2025 Aug 28;161:115025
International immunopharmacology 2025 Aug 28;161:115025
β-Hydroxybutyric Acid-Induced Bovine Endometrial Epithelial Cell Pyroptosis via Activating P2X7R.
Mu J, Sun Q, Lin N, Yue C, Zhu J, Zou H, Zhao H, Song R, Liu Z, Ma Y
Journal of agricultural and food chemistry 2025 Aug 27;73(34):21296-21308
Journal of agricultural and food chemistry 2025 Aug 27;73(34):21296-21308
HIIT and MICT mitigate endothelial dysfunction in early atherosclerotic mice via PCSK9 inhibition.
Liu G, Zhao B, Chen Q, Li X, Zhu X, Duan M, Zhang M, Liu Z, Wen X, Guo J, Zheng M, Wang R, Luo M
Scientific reports 2025 Aug 19;15(1):30411
Scientific reports 2025 Aug 19;15(1):30411
GSDMD deficiency mitigates intestinal damage via macrophage pyroptosis control in experimental NEC.
Yang Y, Yang X, Ma Y, Liu X, Mo D, Ye C, Deng Q, Han W, Ding X, Guo C
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Aug 18;74(1):110
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Aug 18;74(1):110
SENP3 protects hepatocyte from pyroptosis during acute liver injury through deSUMOylation of HNRNPL.
Xiong X, Zhi Y, Yang N, Zhao W, Wang S, Zhu H, Tang J, Yi J, Sun X, Yang J
iScience 2025 Aug 15;28(8):113067
iScience 2025 Aug 15;28(8):113067
MiR-153 is Involved in Testicular Ischemia/Reperfusion Injury by Directly Targeting FOXO3 and Regulating Spermatogonia Pyroptosis.
Ning J, Wang J, Xu L, Li H
Molecular biotechnology 2025 Apr;67(4):1707-1719
Molecular biotechnology 2025 Apr;67(4):1707-1719
Chlorogenic acid mitigates heat stress-induced oxidative damage in bovine mammary epithelial cells by inhibiting NF-κB-mediated NLRP3 inflammasome activation via upregulating the Nrf2 signaling pathway.
Huang Q, Shan Q, Ma F, Li S, Sun P
International journal of biological macromolecules 2025 Apr;301:140133
International journal of biological macromolecules 2025 Apr;301:140133
Design, Synthesis, and Biological Evaluation of Naphthalimide-Polyamine Conjugate as a Potential Anti-Colorectal Cancer Agent.
Dai F, Cao Y, Zhu C, Li Y, Ma X, Wang S, Liu H, Xie X, Gao L, Wang Y, Wang C
Chemistry & biodiversity 2025 Apr;22(4):e202401873
Chemistry & biodiversity 2025 Apr;22(4):e202401873
WTAP Promotes Atherosclerosis by Inducing Macrophage Pyroptosis and M1 Polarization through Upregulating NLRP3.
Luo X, He C, Yang B, Yin S, Li K
Applied biochemistry and biotechnology 2025 Apr;197(4):2397-2416
Applied biochemistry and biotechnology 2025 Apr;197(4):2397-2416
Microglial pyroptosis drives neuropathic pain and targeting NLRP3 alleviates pain and neuroinflammation.
Shin J, Wu J, Park H, Kim SI, Shin N, Shin HJ, Ren G, Kim JA, Hwang PTJ, Jun HW, Lee SY, Lee S, Kim HG, Kim DW
Biochimica et biophysica acta. Molecular basis of disease 2025 Apr;1871(4):167737
Biochimica et biophysica acta. Molecular basis of disease 2025 Apr;1871(4):167737
Targeting ceramide-induced microglial pyroptosis: Icariin is a promising therapy for Alzheimer's disease.
Li H, Xiao Q, Zhu L, Kang J, Zhan Q, Peng W
Journal of pharmaceutical analysis 2025 Apr;15(4):101106
Journal of pharmaceutical analysis 2025 Apr;15(4):101106
ErTao decoction alleviates liver fibrosis by suppressing STING-mediated macrophages and NLRP3 inflammasome activation.
Jia H, Li J, Chen X, Liu Z, Wu C, Liu C, Zhang J, Luo M, Huang M, Huang S, Cai M, Gao L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156489
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156489
Chrysophanol Attenuates Cardiac Fibrosis and Arrhythmia by Suppressing the Endoplasmic Reticulum Stress/Pyroptosis Axis and Inflammation.
Liu C, Qiu S, Liu X, Huang R, Fang Z
Phytotherapy research : PTR 2025 Apr 5;
Phytotherapy research : PTR 2025 Apr 5;
Targeting UAF1 Alleviate Neurotoxicity by Inhibiting APP/NLRP3 Axis-Mediated Pyroptosis and Apoptosis.
Cheng L, Meng X, Tian D, Zheng B, Xiao Y, Zhao X, Xu Y, Yang H, Bi J, Li F, Xie Z
Neurochemical research 2025 Apr 4;50(2):135
Neurochemical research 2025 Apr 4;50(2):135
Integrated bioinformatics analysis of biomarkers and pathways to explore the mechanisms and molecular targets related to allergic rhinitis and pyroptosis.
You M, Liu F, Cai Y, Yu G
Scientific reports 2025 Apr 30;15(1):15241
Scientific reports 2025 Apr 30;15(1):15241
Farrerol alleviates cognitive impairments in chronic cerebral hypoperfusion via suppressing NLRP3 inflammasome-mediated pyroptosis.
Zhang J, Zhang Y, Zhang Y, Lu K, Zhang X, Wang X, Fu J
International immunopharmacology 2025 Apr 24;153:114442
International immunopharmacology 2025 Apr 24;153:114442
PRDM16 suppresses pyroptosis to attenuate the progression of AKI caused by rhabdomyolysis via upregulation of USP10.
Han B, Zheng Q, Li H, Wang Y, Zhang D
Cellular and molecular life sciences : CMLS 2025 Apr 2;82(1):138
Cellular and molecular life sciences : CMLS 2025 Apr 2;82(1):138
Knockdown of PAK1IP1 can Induce Pyroptosis to Inhibit the Progression of Hepatocellular Carcinoma.
Lu X, Chen J, Lu Z, Zang H
Frontiers in bioscience (Landmark edition) 2025 Apr 2;30(4):26654
Frontiers in bioscience (Landmark edition) 2025 Apr 2;30(4):26654
TLR4-mediated endoplasmic reticulum stress regulates pyroptosis in macrophages infected with the Bacillus Calmette-Guérin mycobacterial.
Nie X, Miao S, Hou Y, Ma Y, Li M, Liu Y, Yang Y, Xu J, Wang Y
International immunopharmacology 2025 Apr 16;152:114346
International immunopharmacology 2025 Apr 16;152:114346
VEGF secreted by human dental pulp stem cell promotes spinal cord injury repair by inhibiting microglial pyroptosis through the PI3K/AKT pathway.
Zhang X, Liu T, Ma Z, Li G, Ding N, Wang Z, Guan Y, Zhang Y, Liu L, Chen X
Journal of translational medicine 2025 Apr 12;23(1):437
Journal of translational medicine 2025 Apr 12;23(1):437
Identification of Azalamellarin N as a Pyroptosis Inhibitor.
Takouda J, Nakamura M, Murasaki A, Shimosako W, Hidaka A, Honda S, Tanimura S, Ishibashi F, Kawasaki N, Ishihara J, Fukuda T, Takeda K
Biological & pharmaceutical bulletin 2024;47(1):28-36
Biological & pharmaceutical bulletin 2024;47(1):28-36
Electroacupuncture Protects Against Cerebral Ischemia-Reperfusion Injury: Reducing Inflammatory Response and Cell Pyroptosis by Inhibiting P2X7/NLRP3/GSDMD Pathway.
Chen S, Hao P, Liang Y, Cao Y, Han W, Sun S
Neuropsychiatric disease and treatment 2024;20:2335-2346
Neuropsychiatric disease and treatment 2024;20:2335-2346
TAK-242 alleviates diabetic cardiomyopathy via inhibiting pyroptosis and TLR4/CaMKII/NLRP3 pathway.
Zhao X, Zhang J, Xu F, Shang L, Liu Q, Shen C
Open life sciences 2024;19(1):20220957
Open life sciences 2024;19(1):20220957
Xinfeng Capsule Inhibits Pyroptosis and Ameliorates Myocardial Injury in Rats with Adjuvant Arthritis via the GAS5/miR-21/TLR4 Axis.
Fu W, Cao Y, Liu J, Huang C, Shu K, Zhu N
Drug design, development and therapy 2024;18:2421-2433
Drug design, development and therapy 2024;18:2421-2433
Arctiin Alleviates Atopic Dermatitis Against Inflammation and Pyroptosis Through Suppressing TLR4/MyD88/NF-κB and NLRP3/Caspase-1/GSDMD Signaling Pathways.
Li J, Du X, Mu Z, Han X
Journal of inflammation research 2024;17:8009-8026
Journal of inflammation research 2024;17:8009-8026
Pretreatment with Indole-3-Propionic Acid Attenuates Lipopolysaccharide-Induced Cardiac Dysfunction and Inflammation Through the AhR/NF-κB/NLRP3 Pathway.
Zhang Y, Li S, Fan X, Wu Y
Journal of inflammation research 2024;17:5293-5309
Journal of inflammation research 2024;17:5293-5309
The METTL3/m6A Reader Protein YTHDF1 Regulates Endothelial Cell Pyroptosis by Enhancing NLRP3 Expression to Affect Soft Tissue Injury.
Xie X, Fang F
Journal of inflammation research 2024;17:11331-11346
Journal of inflammation research 2024;17:11331-11346
Novel insights into sevoflurane-induced developmental neurotoxicity mechanisms.
Gao T, Huang Z
Epigenomics 2024;16(18):1231-1252
Epigenomics 2024;16(18):1231-1252
Exosomes from IH- Induced bEnd3 Cells Promote OSA Cognitive Impairment via miR-20a-5p/MFN2 Mediated Pyroptosis of HT22 Cells.
Chen Z, Shang Y, Ou Y, Zhou L, Liu T, Gong S, Xiang X, Peng Y, Ouyang R
Nature and science of sleep 2024;16:2063-2082
Nature and science of sleep 2024;16:2063-2082
Astrocyte-derived exosomal miR-378a-5p mitigates cerebral ischemic neuroinflammation by modulating NLRP3-mediated pyroptosis.
Sun R, Liao W, Lang T, Qin K, Jiao K, Shao L, Deng C, She Y
Frontiers in immunology 2024;15:1454116
Frontiers in immunology 2024;15:1454116
Gasdermin D could be lost in the brain parenchyma infarct core and a pyroptosis-autophagy inhibition effect of Jie-Du-Huo-Xue decoction after stroke.
Zhou C, Qiu SW, Wang FM, Liu YC, Hu W, Yang ML, Liu WH, Li H
Frontiers in pharmacology 2024;15:1449452
Frontiers in pharmacology 2024;15:1449452
GSDMD is associated with survival in human breast cancer but does not impact anti-tumor immunity in a mouse breast cancer model.
Boersma B, Puddinu V, Huard A, Fauteux-Daniel S, Wirapati P, Guedri S, Tille JC, McKee T, Pittet M, Palmer G, Bourquin C
Frontiers in immunology 2024;15:1396777
Frontiers in immunology 2024;15:1396777
Targeting the PANoptosis signaling pathway for myocardial protection: therapeutic potential of Xian Ling Gu Bao capsule.
Wu X, Wei J, Zhang W, Yi Y, Wang T, Gong Q, Liu X, Li H, Gao J
Frontiers in pharmacology 2024;15:1391511
Frontiers in pharmacology 2024;15:1391511
TAK1 inhibition mitigates intracerebral hemorrhage-induced brain injury through reduction of oxidative stress and neuronal pyroptosis via the NRF2 signaling pathway.
Zhao J, Chen C, Ge L, Jiang Z, Hu Z, Yin L
Frontiers in immunology 2024;15:1386780
Frontiers in immunology 2024;15:1386780
E3 ubiquitin ligase MARCH1 reduces inflammation and pyroptosis in cerebral ischemia-reperfusion injury via PCSK9 downregulation.
Guo H, Li W, Yang Z, Xing X
Mammalian genome : official journal of the International Mammalian Genome Society 2024 Sep;35(3):346-361
Mammalian genome : official journal of the International Mammalian Genome Society 2024 Sep;35(3):346-361
Inhibition of GBP1 alleviates pyroptosis of human pulmonary microvascular endothelial cells through STAT1/NLRP3/GSDMD pathway.
Hao Y, Fu H, Li K, Zou X, Zhou X, Tang X, Liu C, Zhou F
Molecular immunology 2024 Sep;173:1-9
Molecular immunology 2024 Sep;173:1-9
Role of caspase-11 non-canonical inflammasomes in retinal ischemia/reperfusion injury.
Wan Y, Li J, Pu J, Yang J, Pei C, Qi Y
Molecular medicine (Cambridge, Mass.) 2024 Sep 27;30(1):159
Molecular medicine (Cambridge, Mass.) 2024 Sep 27;30(1):159
Pyroptotic macrophages induce disruption of glutamate metabolism in periodontal ligament stem cells contributing to their compromised osteogenic potential.
Sun LJ, Qu HL, He XT, Tian BM, Wu RX, Yin Y, Zou JK, Sun HH, Li X, Chen FM
Cell proliferation 2024 Oct;57(10):e13663
Cell proliferation 2024 Oct;57(10):e13663
Immune Rejection of Cartilage in a Swine Vascularized Composite Allotransplantation Model.
Zhang L, Arenas Hoyos I, Helmer A, Banz Y, Haenni B, Lese I, Constantinescu M, Rieben R, Olariu R
Transplantation proceedings 2024 Oct;56(8):1896-1903
Transplantation proceedings 2024 Oct;56(8):1896-1903
Placental growth factor alleviates hyperglycemia-induced trophoblast pyroptosis by regulating mitophagy.
Tao J, Rao Y, Wang J, Tan S, Zhao J, Cao Z, He L, Meng J, Wu P, Wang Z
The journal of obstetrics and gynaecology research 2024 Oct;50(10):1813-1829
The journal of obstetrics and gynaecology research 2024 Oct;50(10):1813-1829
Toll-Like Receptor 9 Aggravates Pulmonary Fibrosis by Promoting NLRP3-Mediated Pyroptosis of Alveolar Epithelial Cells.
Ren C, Wang Q, Fan S, Mi T, Zhang Z, He D
Inflammation 2024 Oct;47(5):1744-1761
Inflammation 2024 Oct;47(5):1744-1761
Anisodamine hydrobromide ameliorates acute lung injury via inhibiting pyroptosis in murine sepsis model.
Zhang B, Luo L, Xiong S, Xiao Y, Zhang T, Xiang T
Immunopharmacology and immunotoxicology 2024 Oct;46(5):662-671
Immunopharmacology and immunotoxicology 2024 Oct;46(5):662-671
LncRNA H19/miR-107 regulates endothelial progenitor cell pyroptosis and promotes flow recovery of lower extremity ischemia through targeting FADD.
Huang L, Ye Y, Sun Y, Zhou Z, Deng T, Liu Y, Wu R, Wang K, Yao C
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167323
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167323
Gasdermin D promotes development of intestinal tumors through regulating IL-1β release and gut microbiota composition.
Gao H, Li W, Xu S, Xu Z, Hu W, Pan L, Luo K, Xie T, Yu Y, Sun H, Huang L, Chen P, Wu J, Yang D, Li L, Luan S, Cao M, Chen P
Cell communication and signaling : CCS 2024 Oct 21;22(1):511
Cell communication and signaling : CCS 2024 Oct 21;22(1):511
Glutamine metabolism modulates microglial NLRP3 inflammasome activity through mitophagy in Alzheimer's disease.
Zhang Z, Li M, Li X, Feng Z, Luo G, Wang Y, Gao X
Journal of neuroinflammation 2024 Oct 15;21(1):261
Journal of neuroinflammation 2024 Oct 15;21(1):261
Pre-electroacupuncture Ameliorates Cerebral Ischemia-reperfusion Injury by Inhibiting Microglial RhoA/pyrin/GSDMD Signaling Pathway.
Fang H, Fan LL, Ding YL, Wu D, Zheng JY, Cai YF, Huang Y, Qiao LJ, Zhang SJ, Zhan J
Neurochemical research 2024 Nov;49(11):3105-3117
Neurochemical research 2024 Nov;49(11):3105-3117
Polystyrene Microplastics Induce Injury to the Vascular Endothelial Through NLRP3-Mediated Pyroptosis.
Huo C, Zhu Y, Fang X, Cui J, Ye H, Zhao H, Ye L, Zhou L
Environmental toxicology 2024 Nov;39(11):5086-5098
Environmental toxicology 2024 Nov;39(11):5086-5098
Ginkgo Flavone Aglycone Ameliorates Atherosclerosis via Inhibiting Endothelial Pyroptosis by Activating the Nrf2 Pathway.
Chen X, Yang Z, Liao M, Zhao Q, Lu Y, Li Q, Liu S, Li S, Chen J, He Y
Phytotherapy research : PTR 2024 Nov;38(11):5458-5473
Phytotherapy research : PTR 2024 Nov;38(11):5458-5473
Angiopoietin 1 Relieves Osteolysis by Promoting Macrophage Mitophagy Through the TBK1-SQSTM1 Pathway to Inhibit AIM2 Inflammasome-Mediated Pyroptosis.
Yin J, Lai P, Zhu L, Ma J
Applied biochemistry and biotechnology 2024 Nov;196(11):7908-7927
Applied biochemistry and biotechnology 2024 Nov;196(11):7908-7927
Paeoniflorin inhibited GSDMD to alleviate ANIT-induced cholestasis via pyroptosis signaling pathway.
Ma X, Zhang W, Chen Y, Hu Q, Wang Z, Jiang T, Zeng Y, Efferth T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:156021
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:156021
GEFT inhibits the GSDM-mediated proptosis signalling pathway, promoting the progression and drug resistance of rhabdomyosarcoma.
Yang F, Xia T, Zhao Z, Lin J, Zhong L, Tang T, Liao D, Lai M, Ceng J, Meng L, Li F, Liu C
Cell death & disease 2024 Nov 30;15(11):867
Cell death & disease 2024 Nov 30;15(11):867
SS31 alleviates LPS-induced acute lung injury by inhibiting inflammatory responses through the S100A8/NLRP3/GSDMD signaling pathway.
Luo P, Gu Q, Wang J, Li X, Li N, Yang W, Meng X, Zhao M
European journal of medical research 2024 Nov 29;29(1):567
European journal of medical research 2024 Nov 29;29(1):567
Salidroside promotes liver regeneration after partial hepatectomy in mice by modulating NLRP3 inflammasome-mediated pyroptosis pathway.
Zhang S, Yu M, Wang F, Li S, Li X, Hu H, Zhang Z, Zhu X, Tian W
Biochemical and biophysical research communications 2024 Nov 26;735:150678
Biochemical and biophysical research communications 2024 Nov 26;735:150678
Neutrophil extracellular traps facilitate liver inflammation/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis.
Zhang Y, Wu R, Zhan X, Wang XY, Xiang LW, Duan YQ, You Y, Zhang JB, Wu R, Zhang YY, Duan L
Cell communication and signaling : CCS 2024 Nov 20;22(1):556
Cell communication and signaling : CCS 2024 Nov 20;22(1):556
Bay-117082 treats sepsis by inhibiting neutrophil extracellular traps (NETs) formation through down-regulating NLRP3/N-GSDMD.
Zou S, Han X, Luo S, Tan Q, Huang H, Yao Z, Hou W, Jie H, Wang J
International immunopharmacology 2024 Nov 15;141:112805
International immunopharmacology 2024 Nov 15;141:112805
Integrative Gut Microbiota and Metabolomic Analyses Reveal the PANoptosis- and Ferroptosis-Related Mechanisms of Chrysoeriol in Inhibiting Melanoma.
Liu Y, Wang L, Huang T, Li Y, Zhang H
Journal of agricultural and food chemistry 2024 Nov 13;72(45):25173-25185
Journal of agricultural and food chemistry 2024 Nov 13;72(45):25173-25185
Hydrogen regulated pyroptosis through NLRP3-GSDMD pathway to improve airway mucosal oxidative stress injury induced by endotracheal tube cuff compression.
Mu G, Chen S, Chen X, Li Q, Lu B, Yu X
Free radical biology & medicine 2024 Nov 1;224:287-300
Free radical biology & medicine 2024 Nov 1;224:287-300
A palmitoylation-depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis.
Zhang N, Zhang J, Yang Y, Shan H, Hou S, Fang H, Ma M, Chen Z, Tan L, Xu D
Nature cell biology 2024 May;26(5):757-769
Nature cell biology 2024 May;26(5):757-769
Conditioned medium from human dental pulp stem cells treats spinal cord injury by inhibiting microglial pyroptosis.
Liu T, Ma Z, Liu L, Pei Y, Wu Q, Xu S, Liu Y, Ding N, Guan Y, Zhang Y, Chen X
Neural regeneration research 2024 May;19(5):1105-1111
Neural regeneration research 2024 May;19(5):1105-1111
Platelet-rich plasma-derived extracellular vesicles inhibit NF-κB/NLRP3 pathway-mediated pyroptosis in intervertebral disc degeneration via the MALAT1/microRNA-217/SIRT1 axis.
Tao X, Xue F, Xu J, Wang W
Cellular signalling 2024 May;117:111106
Cellular signalling 2024 May;117:111106
Transcriptomics confirms IRF1 as a key regulator of pyroptosis in diabetic retinopathy.
Xian Y, Wang X, Yu Y, Chen X
Biochemical and biophysical research communications 2024 May 21;709:149760
Biochemical and biophysical research communications 2024 May 21;709:149760
Mitochondrial ROS participates in Porphyromonas gingivalis-induced pyroptosis in cementoblasts.
Sun W, Yang T, Wang C, Li H, Lei L
Heliyon 2024 May 15;10(9):e30814
Heliyon 2024 May 15;10(9):e30814
Therapeutic Potential of Fucoidan in Alleviating Histamine-Induced Liver Injury: Insights from Mice Studies.
Zhang M, Liu H, Xu L, Zhang X, Chen W, Wang C
Foods (Basel, Switzerland) 2024 May 14;13(10)
Foods (Basel, Switzerland) 2024 May 14;13(10)
MSC-derived exosomal miR-140-3p improves cognitive dysfunction in sepsis-associated encephalopathy by HMGB1 and S-lactoylglutathione metabolism.
Ma Y, She X, Liu Y, Qin X
Communications biology 2024 May 11;7(1):562
Communications biology 2024 May 11;7(1):562
Natural compound library screening to identify berberine as a treatment for rheumatoid arthritis.
Zhang L, Tan M, Mao J, Zhang J, Wang XY, Zhang Y, Duo RX, Hao JY, Shen HL
Clinical rheumatology 2024 Mar;43(3):959-969
Clinical rheumatology 2024 Mar;43(3):959-969
Human vascular smooth muscle cells utilise chymase for the atypical cleavage and activation of Interleukin-1β.
Morales-Maldonado A, Humphry M, Figg N, Clarke MC
Atherosclerosis 2024 Mar;390:117308
Atherosclerosis 2024 Mar;390:117308
GSDMD mediated pyroptosis induced inflammation of Graves' orbitopathy via the NF-κB/ AIM2/ Caspase-1 pathway.
Sha X, Ye H, Wang X, Xu Z, Sun A, Xiao W, Zhang T, Yang S, Yang H
Experimental eye research 2024 Mar;240:109812
Experimental eye research 2024 Mar;240:109812
Lipocalin 2 (LCN2) confers acquired resistance to almonertinib in NSCLC through LCN2-MMP-9 signaling pathway.
Shi C, Wang C, Fu Z, Liu J, Zhou Y, Cheng B, Zhang C, Li S, Zhang Y
Pharmacological research 2024 Mar;201:107088
Pharmacological research 2024 Mar;201:107088
PI3K/AKT signaling pathway associates with pyroptosis and inflammation in patients with endometriosis.
An M, Fu X, Meng X, Liu H, Ma Y, Li Y, Li Q, Chen J
Journal of reproductive immunology 2024 Mar;162:104213
Journal of reproductive immunology 2024 Mar;162:104213
BRCC36 Deubiquitinates HMGCR to Regulate the Interplay Between Ferroptosis and Pyroptosis.
Wang H, Shu L, Lv C, Liu N, Long Y, Peng X, Ling H, Tao T, Tang J, Cheng Y, Liu S, Xiao D, Tao Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(11):e2304263
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(11):e2304263
Kongensin a attenuates intervertebral disc degeneration by inhibiting TAK1-mediated PANoptosis of nucleus pulposus cells.
Chen Y, Hu B, Ni F, Han Y, Shu S, Xiong L, Shao Z, Wei Y
International immunopharmacology 2024 Mar 10;129:111661
International immunopharmacology 2024 Mar 10;129:111661
Effect of lipopolysaccharide on TAK1-mediated hepatocyte PANoptosis through Toll-like receptor 4 during acute liver failure.
Li W, Zhang W, Zhang D, Shi C, Wang Y
International immunopharmacology 2024 Mar 10;129:111612
International immunopharmacology 2024 Mar 10;129:111612
Punicalagin Ameliorates Diabetic Liver Injury by Inhibiting Pyroptosis and Promoting Autophagy via Modulation of the FoxO1/TXNIP Signaling Pathway.
Tan X, Long Y, Zhang R, Zhang Y, You Z, Yang L
Molecular nutrition & food research 2024 Jun;68(12):e2300912
Molecular nutrition & food research 2024 Jun;68(12):e2300912
Efficient Delivery of Lomitapide using Hybrid Membrane-Coated Tetrahedral DNA Nanostructures for Glioblastoma Therapy.
Song M, Tian J, Wang L, Dong S, Fu K, Chen S, Liu C
Advanced materials (Deerfield Beach, Fla.) 2024 Jun;36(24):e2311760
Advanced materials (Deerfield Beach, Fla.) 2024 Jun;36(24):e2311760
SNORD99 promotes endometrial cancer development by inhibiting GSDMD-mediated pyroptosis through 2'-O-methylation modification.
Xian JY, Wu W, Chen X, Bao HJ, Zhang S, Sheng XJ, Chen S
Journal of cellular and molecular medicine 2024 Jun;28(12):e18500
Journal of cellular and molecular medicine 2024 Jun;28(12):e18500
A natural hydrogel complex improves intervertebral disc degeneration by correcting fatty acid metabolism and inhibiting nucleus pulposus cell pyroptosis.
Wang D, Zhang L, He D, Zhang Y, Zhao L, Miao Z, Cheng W, Zhu C, Shao Y, Ge G, Zhu H, Jin H, Zhang W, Pan H
Materials today. Bio 2024 Jun;26:101081
Materials today. Bio 2024 Jun;26:101081
Modulating synovial macrophage pyroptosis and mitophagy interactions to mitigate osteoarthritis progression using functionalized nanoparticles.
Qi W, Jin L, Huang S, Aikebaier A, Xue S, Wang Q, Chen Q, Lu Y, Ding C
Acta biomaterialia 2024 Jun;181:425-439
Acta biomaterialia 2024 Jun;181:425-439
Deacetylated MDH1 and IDH1 aggravates PANoptosis in acute liver failure through endoplasmic reticulum stress signaling.
Shi C, Wang Y, Guo J, Zhang D, Zhang Y, Gong Z
Cell death discovery 2024 Jun 8;10(1):275
Cell death discovery 2024 Jun 8;10(1):275
Elevated NLRP3 Inflammasome Activation Is Associated with Motor Neuron Degeneration in ALS.
Cihankaya H, Bader V, Winklhofer KF, Vorgerd M, Matschke J, Stahlke S, Theiss C, Matschke V
Cells 2024 Jun 7;13(12)
Cells 2024 Jun 7;13(12)
Caspase-1 deletion reveals pyroptosis participates in neural damage induced by cerebral ischemia/reperfusion in tMCAO model mice.
Hao QN, Xue XB, Zhou H, Hu ZL
Neuroreport 2024 Jun 5;35(9):577-583
Neuroreport 2024 Jun 5;35(9):577-583
Apolipoprotein O modulates cholesterol metabolism via NRF2/CYB5R3 independent of LDL receptor.
Chen J, Hu J, Guo X, Yang Y, Qin D, Tang X, Huang Z, Wang F, Hu D, Peng D, Yu B
Cell death & disease 2024 Jun 3;15(6):389
Cell death & disease 2024 Jun 3;15(6):389
Interferon-γ induces combined pyroptotic angiopathy and APOL1 expression in human kidney disease.
Juliar BA, Stanaway IB, Sano F, Fu H, Smith KD, Akilesh S, Scales SJ, El Saghir J, Bhatraju PK, Liu E, Yang J, Lin J, Eddy S, Kretzler M, Zheng Y, Himmelfarb J, Harder JL, Freedman BS
Cell reports 2024 Jun 25;43(6):114310
Cell reports 2024 Jun 25;43(6):114310
Neutrophil extracellular traps induce pyroptosis of pulmonary microvascular endothelial cells by activating the NLRP3 inflammasome.
Zhao P, Zhu J, Bai L, Ma W, Li F, Zhang C, Zhao L, Wang L, Zhang S
Clinical and experimental immunology 2024 Jun 20;217(1):89-98
Clinical and experimental immunology 2024 Jun 20;217(1):89-98
Mechanism of Vaginal Epithelial Cell Pyroptosis Induced by the NLRP3 Inflammasome in Vulvovaginal Candidiasis.
Peng Y, Xu Y, Li S, Shao M, Shen Z, Qi W
American journal of reproductive immunology (New York, N.Y. : 1989) 2024 Jul;92(1):e13893
American journal of reproductive immunology (New York, N.Y. : 1989) 2024 Jul;92(1):e13893
Glaesserella parasuis serotype 5 induces pyroptosis via the RIG-I/MAVS/NLRP3 pathway in swine tracheal epithelial cells.
Li Y, Guo M, Wang Q, Zhou H, Wu W, Lin H, Fan H
Veterinary microbiology 2024 Jul;294:110127
Veterinary microbiology 2024 Jul;294:110127
Esaxerenone Attenuates Aldosterone-Induced Mitochondrial Damage-Mediated Pyroptosis in Mouse Aorta and Rat Vascular Smooth Muscle Cells.
Xian Y, Wang X, Chang Y, Qiang P, Han Y, Hao J, Gao X, Shimosawa T, Xu Q, Yang F
Life (Basel, Switzerland) 2024 Jul 31;14(8)
Life (Basel, Switzerland) 2024 Jul 31;14(8)
Urolithin A Protects against Hypoxia-Induced Pulmonary Hypertension by Inhibiting Pulmonary Arterial Smooth Muscle Cell Pyroptosis via AMPK/NF-κB/NLRP3 Signaling.
He X, Wu Z, Jiang J, Xu W, Yuan A, Liao F, Ding S, Pu J
International journal of molecular sciences 2024 Jul 28;25(15)
International journal of molecular sciences 2024 Jul 28;25(15)
Mesenchymal stem cells ameliorate inflammation and pyroptosis in diabetic cardiomyopathy via the miRNA-223-3p/NLRP3 pathway.
Yang Q, Chen Q, Li S, Luo J
Diabetology & metabolic syndrome 2024 Jul 2;16(1):146
Diabetology & metabolic syndrome 2024 Jul 2;16(1):146
Acceleration of bone repairation by BMSCs overexpressing NGF combined with NSA and allograft bone scaffolds.
Ji Y, Mao Y, Lin H, Wang Y, Zhao P, Guo Y, Gu L, Fu C, Chen X, Lv Z, Wang N, Li Q, Bei C
Stem cell research & therapy 2024 Jul 2;15(1):194
Stem cell research & therapy 2024 Jul 2;15(1):194
Dental pulp mesenchymal stem cell-derived exosomes inhibit neuroinflammation and microglial pyroptosis in subarachnoid hemorrhage via the miRNA-197-3p/FOXO3 axis.
Liang X, Miao Y, Tong X, Chen J, Liu H, He Z, Liu A, Hu Z
Journal of nanobiotechnology 2024 Jul 19;22(1):426
Journal of nanobiotechnology 2024 Jul 19;22(1):426
Ultrasound-responsive Bi(2)MoO(6)-MXene heterojunction as ferroptosis inducers for stimulating immunogenic cell death against ovarian cancer.
Cheng S, Zhou T, Luo Y, Zhang J, Dong K, Zhang Q, Shu W, Zhang T, Zhang Q, Shi R, Yao Y, Wang H
Journal of nanobiotechnology 2024 Jul 11;22(1):408
Journal of nanobiotechnology 2024 Jul 11;22(1):408
Bacillus cereus CwpFM induces colonic tissue damage and inflammatory responses through oxidative stress and the NLRP3/NF-κB pathway.
Shan Q, Wang X, Yang H, Zhu Y, Wang J, Yang G
The Science of the total environment 2024 Jul 10;933:173079
The Science of the total environment 2024 Jul 10;933:173079
Tangeretin attenuates acute lung injury in septic mice by inhibiting ROS-mediated NLRP3 inflammasome activation via regulating PLK1/AMPK/DRP1 signaling axis.
Liu Y, Zhang Y, You G, Zheng D, He Z, Guo W, Antonina K, Shukhrat Z, Ding B, Zan J, Zhang Z
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Jan;73(1):47-63
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Jan;73(1):47-63
Pyroptosis-related gene signature elicits immune response in rosacea.
Hu XM, Zheng SY, Mao R, Zhang Q, Wan XX, Zhang YY, Li J, Yang RH, Xiong K
Experimental dermatology 2024 Jan;33(1):e14812
Experimental dermatology 2024 Jan;33(1):e14812
Prognostic, immunity, stemness, and anticancer drug sensitivity characterization of pyroptosis related genes in non-small cell lung cancer.
Xu C, Ma H, Chen J, Li X, Wang Z, Hu B, Zhang N, Meng F
Thoracic cancer 2024 Jan;15(3):215-226
Thoracic cancer 2024 Jan;15(3):215-226
Preparation and characterization of monoclonal antibodies against porcine gasdermin D protein.
Yang M, Ge X, Zhou L, Guo X, Han J, Zhang Y, Yang H
Applied microbiology and biotechnology 2024 Jan 25;108(1):173
Applied microbiology and biotechnology 2024 Jan 25;108(1):173
A slow-releasing donor of hydrogen sulfide inhibits neuronal cell death via anti-PANoptosis in rats with spinal cord ischemia‒reperfusion injury.
Xie L, Wu H, He Q, Shi W, Zhang J, Xiao X, Yu T
Cell communication and signaling : CCS 2024 Jan 12;22(1):33
Cell communication and signaling : CCS 2024 Jan 12;22(1):33
Neuroprotective effects of Jie-du-huo-xue decoction on microglia pyroptosis after cerebral ischemia and reperfusion--From the perspective of glial-vascular unit.
Zhou C, Li JX, Zheng CX, Zhou XQ, Chen C, Qiu SW, Liu WH, Li H
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):116990
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):116990
Modified Simiaowan prevents and treats gouty arthritis via the Nrf2/NLRP3 inflammasome signaling pathway.
Qin DE, Liang W, Yu Y, Whelan EC, Yuan X, Wang ZL, Wu XW, Cao ZR, Hua SY, Yin L, Shi L, Liang T
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116906
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116906
Neuronal pyroptosis mediated by STAT3 in early brain injury after subarachnoid hemorrhage.
Tang S, Lai N, Xu L
Brain research 2024 Jan 1;1822:148666
Brain research 2024 Jan 1;1822:148666
4-octyl itaconate ameliorates ventilator-induced lung injury.
Wang X, Kong W, Yang R, Yang C
Archives of biochemistry and biophysics 2024 Feb;752:109853
Archives of biochemistry and biophysics 2024 Feb;752:109853
Betaine alleviates cognitive impairment induced by homocysteine through attenuating NLRP3-mediated microglial pyroptosis in an m(6)A-YTHDF2-dependent manner.
Yang ZJ, Huang SY, Zhong KY, Huang WG, Huang ZH, He TT, Yang MT, Wusiman M, Zhou DD, Chen S, Huang BX, Luo XL, Li HB, Zhu HL
Redox biology 2024 Feb;69:103026
Redox biology 2024 Feb;69:103026
Deficiency of N6-Methyladenosine Demethylase ALKBH5 Alleviates Ultraviolet B Radiation-Induced Chronic Actinic Dermatitis via Regulating Pyroptosis.
He L, Liu L, Xu D, Tu Y, Yang C, Zhang M, Wang H, Nong X
Inflammation 2024 Feb;47(1):159-172
Inflammation 2024 Feb;47(1):159-172
Tangeretin Attenuates Cerebral Ischemia-Reperfusion-Induced Neuronal Pyroptosis by Inhibiting AIM2 Inflammasome Activation via Regulating NRF2.
You G, Zheng L, Zhang Y, Zhang Y, Wang Y, Guo W, Liu H, Tatiana P, Vladimir K, Zan J
Inflammation 2024 Feb;47(1):145-158
Inflammation 2024 Feb;47(1):145-158
Serabelisib regulates GSDMD-mediated pyroptosis, apoptosis and migration of hepatoma cells via the PI3K/Akt/E-cadherin signaling pathway.
Li M, Huang Z, Zhou Y
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 Feb;33(2):171-181
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 Feb;33(2):171-181
Ibuprofen inhibits anaplastic thyroid cells in vivo and in vitro by triggering NLRP3-ASC-GSDMD-dependent pyroptosis.
Guo H, Ma R, Zhang Y, Yin K, Du G, Yin F, Li H, Wang Z, Yin D
Inflammopharmacology 2024 Feb;32(1):733-745
Inflammopharmacology 2024 Feb;32(1):733-745
Dihydroxyacetone phosphate accumulation leads to podocyte pyroptosis in diabetic kidney disease.
Zhang Z, Hu H, Luo Q, Yang K, Zou Z, Shi M, Liang W
Journal of cellular and molecular medicine 2024 Feb;28(3):e18073
Journal of cellular and molecular medicine 2024 Feb;28(3):e18073
KLF4 interacts with TXNIP to modulate the pyroptosis in ulcerative colitis via regulating NLRP3 signaling.
Chen Y, Sun L, Liu H, Li J, Guo L, Wang Z
Immunity, inflammation and disease 2024 Feb;12(2):e1199
Immunity, inflammation and disease 2024 Feb;12(2):e1199
Berberine inhibits NLRP3 inflammasome activation by regulating mTOR/mtROS axis to alleviate diabetic cardiomyopathy.
Zhong C, Xie Y, Wang H, Chen W, Yang Z, Zhang L, Deng Q, Cheng T, Li M, Ju J, Liu Y, Liang H
European journal of pharmacology 2024 Feb 5;964:176253
European journal of pharmacology 2024 Feb 5;964:176253
SERTAD1 initiates NLRP3-mediated inflammasome activation through restricting NLRP3 polyubiquitination.
Ha J, Kim M, Park JS, Lee Y, Lee JY, Shin JC, Seo D, Park SS, You J, Jung SM, Kim HY, Mizuno S, Takahashi S, Kim SJ, Park SH
Cell reports 2024 Feb 27;43(2):113752
Cell reports 2024 Feb 27;43(2):113752
PANoptosis in vascular smooth muscle cells regulated by TNF-α/IL-1β can be a new target for alleviating the progression of abdominal aortic aneurysm.
Li K, Wei M, Zhang D, Zhai S, Liu H
Physiological genomics 2024 Feb 1;56(2):158-166
Physiological genomics 2024 Feb 1;56(2):158-166
Eclipta prostrata improves alveolar development of bronchopulmonary dysplasia via suppressing the NLRP3 inflammasome in a DLD-dependent manner.
Zheng X, Tan Z, Zhu D, Zhao D, Liu C, Wang S, Wang X, Zhang Y
Pediatric pulmonology 2024 Dec;59(12):3371-3382
Pediatric pulmonology 2024 Dec;59(12):3371-3382
Shikonin from lithospermum erythrorhizon induces pyroptosis in trophoblast cells by activating the CTSB-NLRP3 inflammasome.
Zeng F, Lai Y, Huang Y, Zhu F, Gao J, Chen Z, Zeng L, Feng M, Qiu P, Yuan S, Deng G
Annals of medicine 2024 Dec;56(1):2394584
Annals of medicine 2024 Dec;56(1):2394584
Bleomycin induces endothelial cell pyroptosis and regulates fibrosis by activating the NLRP3/caspase-1/GSDMD pathway: a possible mechanism contributing to the sclerotherapy of venous malformations.
Chen S, Wang Y, Gao Q, Cui J, Shen W
Journal of molecular histology 2024 Dec;55(6):1239-1250
Journal of molecular histology 2024 Dec;55(6):1239-1250
PANoptosis signaling enables broad immune response in psoriasis: From pathogenesis to new therapeutic strategies.
Hu XM, Zheng S, Zhang Q, Wan X, Li J, Mao R, Yang R, Xiong K
Computational and structural biotechnology journal 2024 Dec;23:64-76
Computational and structural biotechnology journal 2024 Dec;23:64-76
TMAO induces pyroptosis of vascular endothelial cells and atherosclerosis in ApoE(-/-) mice via MBOAT2-mediated endoplasmic reticulum stress.
Yu B, Yuan C, Chen J, Zhou Z, Zhang Y, Su M, Wei D, Wu P
Biochimica et biophysica acta. Molecular and cell biology of lipids 2024 Dec;1869(8):159559
Biochimica et biophysica acta. Molecular and cell biology of lipids 2024 Dec;1869(8):159559
Fucoidan from Laminaria japonica protects renal tubular epithelial cells from uric acid induced NLRP3-mediated pyroptosis through inhibition of NF-κB pathway.
Tan X, Zhang Y, Luo P, Lin Z, Li F, Liu H
Journal of ethnopharmacology 2024 Dec 5;335:118614
Journal of ethnopharmacology 2024 Dec 5;335:118614
Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair.
Jena KK, Mambu J, Boehmer D, Sposito B, Millet V, de Sousa Casal J, Muendlein HI, Spreafico R, Fenouil R, Spinelli L, Wurbel S, Riquier C, Galland F, Naquet P, Chasson L, Elkins M, Mitsialis V, Ketelut-Carneiro N, Bugda Gwilt K, Thiagarajah JR, Ruan HB, Lin Z, Lien E, Shao F, Chou J, Poltorak A, Ordovas-Montanes J, Fitzgerald KA, Snapper SB, Broggi A, Zanoni I
Cell 2024 Dec 26;187(26):7533-7550.e23
Cell 2024 Dec 26;187(26):7533-7550.e23
Macrophage-derived exosomal miR-2137 regulates pyroptosis in LPS-induced acute lung injury.
Ye C, Yang X, Zhu L, Chang G, Hu Y, Wang W
International immunopharmacology 2024 Dec 25;143(Pt 3):113549
International immunopharmacology 2024 Dec 25;143(Pt 3):113549
Butyrate attenuates intestinal inflammation in Crohn's disease by suppressing pyroptosis of intestinal epithelial cells via the cGSA-STING-NLRP3 axis.
Xu X, Huang Z, Huang Z, Lv X, Jiang D, Huang Z, Han B, Lin G, Liu G, Li S, Fan J, Lv X
International immunopharmacology 2024 Dec 25;143(Pt 2):113305
International immunopharmacology 2024 Dec 25;143(Pt 2):113305
Astragaloside IV attenuates podocyte apoptosis via regulating TXNIP/NLRP3/GSDMD signaling pathway in diabetic nephropathy.
Hu Z, Zhou Y, Gao C, Liu J, Pan C, Guo J
Diabetology & metabolic syndrome 2024 Dec 18;16(1):296
Diabetology & metabolic syndrome 2024 Dec 18;16(1):296
Molecular profiling unveils pyroptosis markers in preterm birth.
Li X, Huang Z, Bai J, Che A, Zhou J, Yang H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Dec 13;38(24):e70112
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Dec 13;38(24):e70112
Exosomes derived from diabetic microenvironment-preconditioned mesenchymal stem cells ameliorate nonalcoholic fatty liver disease and inhibit pyroptosis of hepatocytes.
Wang A, Li B, Su W, Zhang H, Hu R, Zhang Y, Zhao J, Ren R, Mu Y, Cheng Y, Lyu Z
Experimental cell research 2024 Dec 1;443(2):114325
Experimental cell research 2024 Dec 1;443(2):114325
Disturbance of mitochondrial dynamics led to spermatogenesis disorder in mice exposed to polystyrene micro- and nanoplastics.
Zhao M, Xie J, Zhang J, Zhao B, Zhang Y, Xue J, Zhang R, Zhang R, Wang H, Li Y, Ge W, Zhou X
Environmental pollution (Barking, Essex : 1987) 2024 Dec 1;362:124935
Environmental pollution (Barking, Essex : 1987) 2024 Dec 1;362:124935
Exosomes from human bone marrow MSCs alleviate PD-1/PD-L1 inhibitor-induced myocardial injury in melanoma mice by regulating macrophage polarization and pyroptosis.
Zhou B, Qin Q, Fang Y, Liu X, Zhang M, Wang S, Zhong L, Guo R
Life sciences 2024 Dec 1;358:123108
Life sciences 2024 Dec 1;358:123108
Autocatalytic, Brain Tumor-Targeting Delivery of Bardoxolone Methyl Self-Assembled Nanoparticles for Glioblastoma Treatment.
Ye Z, Sheu WC, Qu H, Peng B, Liu J, Zhang L, Yuan F, Wei Y, Zhou J, Chen Q, Xiao X, Zhang S
Small science 2024 Aug;4(8):2400081
Small science 2024 Aug;4(8):2400081
Dihydroartemisinin-driven TOM70 inhibition leads to mitochondrial destabilization to induce pyroptosis against lung cancer.
Li LG, Hu J, Han N, Chen NN, Yu TT, Ren T, Xu HZ, Peng XC, Li XY, Ma TQ, Chen H, Zhang L, Chen X, Wang MF, Li TF
Phytotherapy research : PTR 2024 Aug;38(8):3856-3876
Phytotherapy research : PTR 2024 Aug;38(8):3856-3876
Obstructive Sleep Apnea Plasma-Derived Exosomes Mediate Cognitive Impairment Through Hippocampal Neuronal Cell Pyroptosis.
Chen Z, Shang Y, Ou Y, Shen C, Cao Y, Hu H, Yang R, Liu T, Liu Q, Song M, Zong D, Xiang X, Peng Y, Ouyang R
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2024 Aug;32(8):922-939
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2024 Aug;32(8):922-939
Apoptosis and pyroptosis in the nasal mucosa of Syrian hamster during SARS-CoV-2 infection and reinfection.
Li H, Zhao X, Zhang X, Zheng H, Wang Y, Hou J, Li J, Zhao Y, Peng S, Li Y, Zhang X, Zhang Y, Yang J, Zhang Z, Shi H, Liu L
Apoptosis : an international journal on programmed cell death 2024 Aug;29(7-8):1246-1259
Apoptosis : an international journal on programmed cell death 2024 Aug;29(7-8):1246-1259
Co-exposure of microcystin-LR and nitrite induced kidney injury through TLR4/NLRP3/GSDMD-mediated pyroptosis.
Guo Y, Du X, Wang F, Fu Y, Guo X, Meng R, Ge K, Zhang S
Ecotoxicology and environmental safety 2024 Aug;281:116629
Ecotoxicology and environmental safety 2024 Aug;281:116629
Activation of the inflammasome and pyroptosis cascade in podocytes of patients with minimal change disease.
Kajio Y, Suzuki T, Kobayashi K, Kanazawa N, Iyoda M, Honda H, Honda K
Clinical kidney journal 2024 Aug;17(8):sfae216
Clinical kidney journal 2024 Aug;17(8):sfae216
Miltirone induces GSDME-dependent pyroptosis in colorectal cancer by activating caspase 3.
Zheng G, Fang Z, Lin Z, Guan G
Heliyon 2024 Aug 30;10(16):e36603
Heliyon 2024 Aug 30;10(16):e36603
Potential mechanisms of aortic medial degeneration promoted by co-exposure to microplastics and lead.
Xie X, Wang K, Shen X, Li X, Wang S, Yuan S, Li B, Wang Z
Journal of hazardous materials 2024 Aug 15;475:134854
Journal of hazardous materials 2024 Aug 15;475:134854
STAT4-Mediated Klotho Up-Regulation Contributes to the Brain Ischemic Tolerance by Cerebral Ischemic Preconditioning via Inhibiting Neuronal Pyroptosis.
Liu XY, Zhang LY, Wang XY, Li SC, Hu YY, Zhang JG, Xian XH, Li WB, Zhang M
Molecular neurobiology 2024 Apr;61(4):2336-2356
Molecular neurobiology 2024 Apr;61(4):2336-2356
Ketamine Improves the Glymphatic Pathway by Reducing the Pyroptosis of Hippocampal Astrocytes in the Chronic Unpredictable Mild Stress Model.
Wen G, Zhan X, Xu X, Xia X, Jiang S, Ren X, Ren W, Lou H, Lu L, Hermenean A, Yao J, Gao L, Li B, Lu Y, Wu X
Molecular neurobiology 2024 Apr;61(4):2049-2062
Molecular neurobiology 2024 Apr;61(4):2049-2062
Identification of PKM2 as a pyroptosis-related key gene aggravates senile osteoporosis via the NLRP3/Caspase-1/GSDMD signaling pathway.
Li Z, Wang B, Wang R, Zhang Z, Xiong J, Wang X, Ma Y, Han L
The international journal of biochemistry & cell biology 2024 Apr;169:106537
The international journal of biochemistry & cell biology 2024 Apr;169:106537
Gypenoside XLIX alleviates acute liver injury: Emphasis on NF-κB/PPAR-α/NLRP3 pathways.
Zhou M, Cao Y, Xie S, Xiang Y, Li M, Yang H, Dong Z
International immunopharmacology 2024 Apr 20;131:111872
International immunopharmacology 2024 Apr 20;131:111872
Inhibition of spinal BRD4 alleviates pyroptosis and M1 microglia polarization via STING-IRF3 pathway in morphine-tolerant rats.
Jia X, Ju J, Li Z, Peng X, Wang J, Gao F
European journal of pharmacology 2024 Apr 15;969:176428
European journal of pharmacology 2024 Apr 15;969:176428
Preliminary investigation into the impact of BPA on osteoblast activity and bone development: In vitro and in vivo models.
Shi X, Wu K, Liu C, Cao K, Zhang Q, Wu W, Luo C, Huang W
Environmental pollution (Barking, Essex : 1987) 2024 Apr 15;347:123731
Environmental pollution (Barking, Essex : 1987) 2024 Apr 15;347:123731
LncRNA GAS5 restrains ISO-induced cardiac fibrosis by modulating mir-217 regulation of SIRT1.
Zhang YH, Sun TT, Liu ZH, Li X, Fan XF, Han LP
Scientific reports 2024 Apr 1;14(1):7652
Scientific reports 2024 Apr 1;14(1):7652
Circular RNA protein tyrosine kinase 2 aggravates pyroptosis and inflammation in septic lung tissue by promoting microRNA-766/eukaryotic initiation factor 5A axis-mediated ATP efflux.
Ding F, Zhu J, Hu Y
Acta cirurgica brasileira 2023;38:e380323
Acta cirurgica brasileira 2023;38:e380323
Inhibition of Schwann Cell Pyroptosis Promotes Nerve Regeneration in Peripheral Nerve Injury in Rats.
Wang J, Lu S, Yuan Y, Huang L, Bian M, Yu J, Zou J, Jiang L, Meng D, Zhang J
Mediators of inflammation 2023;2023:9721375
Mediators of inflammation 2023;2023:9721375
Transcutaneous Electrical Nerve Stimulation (TENS) Alleviates Brain Ischemic Injury by Regulating Neuronal Oxidative Stress, Pyroptosis, and Mitophagy.
Tan Z, Dong F, Wu L, Feng Y, Zhang M, Zhang F
Mediators of inflammation 2023;2023:5677865
Mediators of inflammation 2023;2023:5677865
High-dose remifentanil exacerbates myocardial ischemia-reperfusion injury through activation of calcium-sensing receptor-mediated pyroptosis.
Zhu Y, Chi J, Cai S, Liu S, Yuan J, Xu H, Zhou H
International journal of medical sciences 2023;20(12):1570-1583
International journal of medical sciences 2023;20(12):1570-1583
Suppression of NLRP3/Caspase-1/GSDMD Mediated Corneal Epithelium Pyroptosis Using Melatonin-Loaded Liposomes to Inhibit Benzalkonium Chloride-Induced Dry Eye Disease.
Lou Q, Pan L, Xiang S, Li Y, Jin J, Tan J, Huang B, Nan K, Lin S
International journal of nanomedicine 2023;18:2447-2463
International journal of nanomedicine 2023;18:2447-2463
Network Pharmacology Analysis and Machine-Learning Models Confirmed the Ability of YiShen HuoXue Decoction to Alleviate Renal Fibrosis by Inhibiting Pyroptosis.
Feng M, Luo F, Wu H, Chen Y, Zuo J, Weng X, Chen G, Zhong J
Drug design, development and therapy 2023;17:3169-3192
Drug design, development and therapy 2023;17:3169-3192
Transcutaneous electrical acupoint stimulation alleviates cerebral ischemic injury through the TLR4/MyD88/NF-κ B pathway.
Wu L, Tan Z, Su L, Dong F, Xu G, Zhang F
Frontiers in cellular neuroscience 2023;17:1343842
Frontiers in cellular neuroscience 2023;17:1343842
Qinhuo Shanggan oral solution resolves acute lung injury by down-regulating TLR4/NF-κB signaling cascade and inhibiting NLRP3 inflammasome activation.
Tang S, Liang Y, Wang M, Lei J, Peng Y, Tao Q, Ming T, Yang W, Zhang C, Guo J, Xu H
Frontiers in immunology 2023;14:1285550
Frontiers in immunology 2023;14:1285550
The non-canonical inflammasome activators Caspase-4 and Caspase-5 are differentially regulated during immunosuppression-associated organ damage.
Ghait M, Duduskar SN, Rooney M, Häfner N, Reng L, Göhrig B, Reuken PA, Bloos F, Bauer M, Sponholz C, Bruns T, Rubio I
Frontiers in immunology 2023;14:1239474
Frontiers in immunology 2023;14:1239474
A novel colchicine-myricetin heterozygous molecule: design, synthesis, and effective evaluations on the pathological models of acute lung injury in vitro and in vivo.
Li Z, Yan X, Wei J, Pu L, Zhu G, Cao Y, Liu Z, Liu Y, Li Y, Li L, Li X, Wu Z
Frontiers in pharmacology 2023;14:1224906
Frontiers in pharmacology 2023;14:1224906
β-sitosterol alleviates dextran sulfate sodium-induced experimental colitis via inhibition of NLRP3/Caspase-1/GSDMD-mediated pyroptosis.
Zhang D, Ge F, Ji J, Li YJ, Zhang FR, Wang SY, Zhang SJ, Zhang DM, Chen M
Frontiers in pharmacology 2023;14:1218477
Frontiers in pharmacology 2023;14:1218477
Phenylalanine promotes alveolar macrophage pyroptosis via the activation of CaSR in ARDS.
Tang Y, Yu Y, Li R, Tao Z, Zhang L, Wang X, Qi X, Li Y, Meng T, Qu H, Zhou M, Xu J, Liu J
Frontiers in immunology 2023;14:1114129
Frontiers in immunology 2023;14:1114129
Silibinin ameliorates deoxycholic acid-induced pyroptosis in steatotic HepG2 cells by inhibiting NLRP3 inflammasome activation.
Mai M, Wang Y, Luo M, Li Z, Wang D, Ruan Y, Guo H
Biochemistry and biophysics reports 2023 Sep;35:101545
Biochemistry and biophysics reports 2023 Sep;35:101545
CD73 mitigates hepatic damage in alcoholic steatohepatitis by regulating PI3K/AKT-mediated hepatocyte pyroptosis.
Zhu H, Zhang M, Ye Y, Liu Z, Wang J, Wu X, Lv X
Biochemical pharmacology 2023 Sep;215:115753
Biochemical pharmacology 2023 Sep;215:115753
Bone marrow mesenchymal stem cellsderived exosomes stabilize atherosclerosis through inhibiting pyroptosis.
Bai Z, Hu H, Hu F, Ji J, Ji Z
BMC cardiovascular disorders 2023 Sep 7;23(1):441
BMC cardiovascular disorders 2023 Sep 7;23(1):441
Oryza sativa L. Indica Seed Coat Ameliorated Concanavalin A-Induced Acute Hepatitis in Mice via MDM2/p53 and PKCα/MAPK1 Signaling Pathways.
Zhao Z, Li Y, Guo S, Chen Y, Yin H, Li Y, Cheng G, Tian L
International journal of molecular sciences 2023 Sep 25;24(19)
International journal of molecular sciences 2023 Sep 25;24(19)
Steroidal saponins PPI/CCRIS/PSV induce cell death in pancreatic cancer cell through GSDME-dependent pyroptosis.
Liu Y, Zhang W, Zhou H, Chen J
Biochemical and biophysical research communications 2023 Sep 17;673:51-58
Biochemical and biophysical research communications 2023 Sep 17;673:51-58
Loganin reduces diabetic kidney injury by inhibiting the activation of NLRP3 inflammasome-mediated pyroptosis.
Kong X, Zhao Y, Wang X, Yu Y, Meng Y, Yan G, Yu M, Jiang L, Song W, Wang B, Wang X
Chemico-biological interactions 2023 Sep 1;382:110640
Chemico-biological interactions 2023 Sep 1;382:110640
Astragaloside IV Inhibited Podocyte Pyroptosis in Diabetic Kidney Disease by Regulating SIRT6/HIF-1α Axis.
Zhang M, Liu W, Liu Y, Zhang Z, Hu Y, Sun D, Li S, Fang J
DNA and cell biology 2023 Oct;42(10):594-607
DNA and cell biology 2023 Oct;42(10):594-607
A high-throughput Gaussia luciferase reporter assay for screening potential gasdermin E activators against pancreatic cancer.
Liu Y, Zhang X, Zhang P, He T, Zhang W, Ma D, Li P, Chen J
Acta pharmaceutica Sinica. B 2023 Oct;13(10):4253-4272
Acta pharmaceutica Sinica. B 2023 Oct;13(10):4253-4272
Systemic pharmacology reveal the mechanism by which the Qiangjin Zhuanggu Qufeng mixture inhibits LPS-induced pyroptosis of rat nucleus pulposus cells.
Wang D, Zhang L, He D, Zhang Y, Bao J, Gao W, Cheng W, Zhu C, Jin H, Zhang W, Zhu H, Pan H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:154998
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:154998
GSDMD promotes neutrophil extracellular traps via mtDNA-cGAS-STING pathway during lung ischemia/reperfusion.
Zhao C, Liang F, Ye M, Wu S, Qin Y, Zhao L, Zhang L, He J, Cen L, Lin F
Cell death discovery 2023 Oct 4;9(1):368
Cell death discovery 2023 Oct 4;9(1):368
Aluminum exposure induces central nervous system impairment via activating NLRP3-medicated pyroptosis pathway.
Hao W, Zhu X, Liu Z, Song Y, Wu S, Lu X, Yang J, Jin C
Ecotoxicology and environmental safety 2023 Oct 1;264:115401
Ecotoxicology and environmental safety 2023 Oct 1;264:115401
Oxalate‑induced renal pyroptotic injury and crystal formation mediated by NLRP3‑GSDMD signaling in vitro and in vivo.
Chen Y, Yang S, Kong H, Wang Q, Chen S, Wang X, Chen L, Qi S
Molecular medicine reports 2023 Nov;28(5)
Molecular medicine reports 2023 Nov;28(5)
Selenium Deficiency via the ROS/NLRP3/IL-1β Signaling Pathway Leads to Pyroptosis Injury in Pig Spleen.
Song L, Jiang Z, Zhang X, Song Y, Xing Y, Wang G
Biological trace element research 2023 Nov;201(11):5192-5200
Biological trace element research 2023 Nov;201(11):5192-5200
Escherichia coli infection mediates pyroptosis via activating p53-p21 pathway-regulated apoptosis and cell cycle arrest in bovine mammary epithelial cells.
Zhuang C, Zhao J, Zhang S, Shahid M
Microbial pathogenesis 2023 Nov;184:106338
Microbial pathogenesis 2023 Nov;184:106338
Butyrate alleviates renal fibrosis in CKD by regulating NLRP3-mediated pyroptosis via the STING/NF-κB/p65 pathway.
Tian X, Zeng Y, Tu Q, Jiao Y, Yao S, Chen Y, Sun L, Xia Q, Luo Y, Yuan L, Jiang Q
International immunopharmacology 2023 Nov;124(Pt B):111010
International immunopharmacology 2023 Nov;124(Pt B):111010
Competitive binding of circCCDC6 to microRNA-128-3p activates TXNIP/NLRP3 pathway and promotes cerebral ischemia-reperfusion defects.
Wang C, Dong M, Zhang X, Wang X, Zhao Y, Cao Y
Acta biochimica Polonica 2023 Nov 7;70(4):807-815
Acta biochimica Polonica 2023 Nov 7;70(4):807-815
Irisin suppresses pancreatic β cell pyroptosis in T2DM by inhibiting the NLRP3-GSDMD pathway and activating the Nrf2-TrX/TXNIP signaling axis.
Li T, Yang J, Tan A, Chen H
Diabetology & metabolic syndrome 2023 Nov 22;15(1):239
Diabetology & metabolic syndrome 2023 Nov 22;15(1):239
Regulation of megakaryo/thrombopoiesis by endosomal toll-like receptor 7 and 8 activation of CD34(+) cells in a viral infection model.
Rodríguez CS, Charó N, Tatti S, Gómez RM, D'Atri LP, Schattner M
Research and practice in thrombosis and haemostasis 2023 May;7(4):100184
Research and practice in thrombosis and haemostasis 2023 May;7(4):100184
The involvement of DDX3X in compression-induced nucleus pulposus pyroptosis.
Chi S, Li S, Xu Z, Yang G, Song Y, Liao Z, Yang C, Wu X
Biochemical and biophysical research communications 2023 May 7;655:1-10
Biochemical and biophysical research communications 2023 May 7;655:1-10
Pyroptosis of Macrophages Induced by Clostridium perfringens Beta-1 Toxin.
Zhang S, Ma L, Song F, Wang D, Shi K, Li Y, Zeng J, Wang Y
Toxins 2023 May 29;15(6)
Toxins 2023 May 29;15(6)
Gasdermin D Plays an Oncogenic Role in Glioma and Correlates to an Immunosuppressive Microenvironment.
Li M, Jiang P, Wei S, Yang Y, Xiong L, Wang J, Li C
Biomolecules 2023 May 29;13(6)
Biomolecules 2023 May 29;13(6)
HuNoV Non-Structural Protein P22 Induces Maturation of IL-1β and IL-18 and N-GSDMD-Dependent Pyroptosis through Activating NLRP3 Inflammasome.
Chen N, Chen P, Zhou Y, Chen S, Gong S, Fu M, Geng L
Vaccines 2023 May 17;11(5)
Vaccines 2023 May 17;11(5)
Single-cell sequencing reveals homogeneity and heterogeneity of the cytopathological mechanisms in different etiology-induced AKI.
Chen Z, Li Y, Yuan Y, Lai K, Ye K, Lin Y, Lan R, Chen H, Xu Y
Cell death & disease 2023 May 11;14(5):318
Cell death & disease 2023 May 11;14(5):318
Elsholtzia bodinieri Vaniot ameliorated acute lung injury in mice by regulating pyroptosis, inflammation, oxidative stress and macrophage polarization.
Jiang X, Sun J, Guo S, Zhao Z, Chen Y, Cao J, Liu Y, Cheng G, Tian L, Li Y
Journal of ethnopharmacology 2023 May 10;307:116232
Journal of ethnopharmacology 2023 May 10;307:116232
hASCs-derived exosomal miR-155-5p targeting TGFβR2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration.
Chen D, Jiang X, Zou H
Journal of orthopaedic translation 2023 Mar;39:163-176
Journal of orthopaedic translation 2023 Mar;39:163-176
Exosomal miR-23b from bone marrow mesenchymal stem cells alleviates oxidative stress and pyroptosis after intracerebral hemorrhage.
Hu LT, Wang BY, Fan YH, He ZY, Zheng WX
Neural regeneration research 2023 Mar;18(3):560-567
Neural regeneration research 2023 Mar;18(3):560-567
Cytoskeletal protein SPTA1 mediating the decrease in erectile function induced by high-fat diet via Hippo signaling pathway.
Chen Y, Wang L, Huang ZS, Feng JX, Li SX, Du ZJ, Zhang ZB, Liu J, Yang J, Hu ZM, Wang ZL, Chen J
Andrology 2023 Mar;11(3):591-610
Andrology 2023 Mar;11(3):591-610
Hydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes.
Yang X, Dong S, Li C, Li M, Xing C, He J, Peng C, Shao H, Jia Q
Toxicology letters 2023 Mar 1;376:39-50
Toxicology letters 2023 Mar 1;376:39-50
Emodin alleviates testicular ischemia-reperfusion injury through the inhibition of NLRP3-mediated pyroptosis.
He KX, Ning JZ, Li W, Cheng F
Tissue & cell 2023 Jun;82:102069
Tissue & cell 2023 Jun;82:102069
Sulconazole Induces PANoptosis by Triggering Oxidative Stress and Inhibiting Glycolysis to Increase Radiosensitivity in Esophageal Cancer.
Liu LX, Heng JH, Deng DX, Zhao H, Zheng ZY, Liao LD, Lin W, Xu XE, Li EM, Xu LY
Molecular & cellular proteomics : MCP 2023 Jun;22(6):100551
Molecular & cellular proteomics : MCP 2023 Jun;22(6):100551
Baicalin inhibited both the Furin/TGFβ1/Smad3/TSP-1 pathway in endothelial cells and the AKT/Ca(2+)/ROS pathway in platelets to ameliorate inflammatory coagulopathy.
Wang P, Wu J, Wang Q, Zhuang S, Zhao J, Yu Y, Zhang W, Zheng Y, Liu X
European journal of pharmacology 2023 Jun 15;949:175674
European journal of pharmacology 2023 Jun 15;949:175674
Withdrawn: Ticagrelor reduces myocardial cell injury induced by myocardial ischemia/reperfusion in diabetic rats by activating JAK2/STAT3.
Xie D, Chen Q, Huang J, Huang C, Li Y, Li S, Zhang S, Fang H, Sang S, Cao Y
Cell biology international 2023 Jul;47(7):1289
Cell biology international 2023 Jul;47(7):1289
Fibrin glue delivery system containing rhein ameliorates intervertebral disc degeneration by anti-inflammatory efficacy.
Bao J, Gao W, Zhang W, Wang D, Pan H
Journal of orthopaedic surgery and research 2023 Jul 6;18(1):485
Journal of orthopaedic surgery and research 2023 Jul 6;18(1):485
Exercise-induced irisin improves follicular dysfunction by inhibiting IRE1α-TXNIP/ROS-NLRP3 pathway in PCOS.
Weng Y, Zhang Y, Wang D, Wang R, Xiang Z, Shen S, Wang H, Wu X, Wen Y, Wang Y
Journal of ovarian research 2023 Jul 31;16(1):151
Journal of ovarian research 2023 Jul 31;16(1):151
circACTA2 inhibits NLRP3 inflammasome-mediated inflammation via interacting with NF-κB in vascular smooth muscle cells.
Bai Y, Zhang L, Zheng B, Zhang X, Zhang H, Zhao A, Yu J, Yang Z, Wen J
Cellular and molecular life sciences : CMLS 2023 Jul 27;80(8):229
Cellular and molecular life sciences : CMLS 2023 Jul 27;80(8):229
Neobavaisoflavone induces pyroptosis of liver cancer cells via Tom20 sensing the activated ROS signal.
Li Y, Zhao R, Xiu Z, Yang X, Zhu Y, Han J, Li S, Li Y, Sun L, Li X, Jin N, Li Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154869
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154869
Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia.
Chen Q, He J, Liu H, Huang Q, Wang S, Yin A, Chen S, Shen X, Xiao Y, Hu H, Jiang J, Chen W, Wang S, Huang Z, Li J, Peng Y, Wang X, Yang X, Wang Z, Zhong M
Journal of translational medicine 2023 Jul 24;21(1):496
Journal of translational medicine 2023 Jul 24;21(1):496
Induced neural stem cells suppressed neuroinflammation by inhibiting the microglial pyroptotic pathway in intracerebral hemorrhage rats.
Liu J, Cao C, Jin Y, Wang Y, Ma X, Li J, Guo S, Yang J, Niu J, Liang X
iScience 2023 Jul 21;26(7):107022
iScience 2023 Jul 21;26(7):107022
Dihydromyricetin inhibits African swine fever virus replication by downregulating toll-like receptor 4-dependent pyroptosis in vitro.
Chen Y, Song Z, Chang H, Guo Y, Wei Z, Sun Y, Gong L, Zheng Z, Zhang G
Veterinary research 2023 Jul 12;54(1):58
Veterinary research 2023 Jul 12;54(1):58
Attenuation of experimental osteoarthritis with human adipose-derived mesenchymal stem cell therapy: inhibition of the pyroptosis in chondrocytes.
Xu L, Zhang F, Cheng G, Yuan X, Wu Y, Wu H, Wang Q, Chen J, Kuai J, Chang Y, Wei W, Yan S
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jan;72(1):89-105
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jan;72(1):89-105
Trophoblastic mitochondrial DNA induces endothelial dysfunction and NLRP3 inflammasome activation: Implications for preeclampsia.
Lv Z, Lv DY, Meng JY, Sha XY, Qian XY, Chen YS, Pan XY, Yu GY, Liu HS
International immunopharmacology 2023 Jan;114:109523
International immunopharmacology 2023 Jan;114:109523
Protective effects of leonurine hydrochloride on pyroptosis in premature ovarian insufficiency via regulating NLRP3/GSDMD pathway.
Chi YN, Hai DM, Ma L, Cui YH, Hu HT, Liu N, Juan-Du, Lan XB, Yu JQ, Yang JM
International immunopharmacology 2023 Jan;114:109520
International immunopharmacology 2023 Jan;114:109520
TMBIM4 Deficiency Facilitates NLRP3 Inflammasome Activation-Induced Pyroptosis of Trophoblasts: A Potential Pathogenesis of Preeclampsia.
Chen Y, Xiao L, Sun G, Li M, Yang H, Ming Z, Zhao K, Shang X, Zhang H, Liu C
Biology 2023 Jan 29;12(2)
Biology 2023 Jan 29;12(2)
Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis.
Tian Y, Feng X, Zhou Z, Qin S, Chen S, Zhao J, Hou J, Liu D
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1499-1509
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1499-1509
Jatrorrhizine Suppresses Murine-Norovirus-Triggered N-GSDMD-Dependent Pyroptosis in RAW264.7 Macrophages.
Fu M, Chen N, Zhou Y, Chen S, Xu W, Gong S, Geng L
Vaccines 2023 Jan 12;11(1)
Vaccines 2023 Jan 12;11(1)
PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons.
Yan WT, Zhao WJ, Hu XM, Ban XX, Ning WY, Wan H, Zhang Q, Xiong K
Neural regeneration research 2023 Feb;18(2):357-363
Neural regeneration research 2023 Feb;18(2):357-363
Ginsenoside Rg3 Ameliorates DSS-Induced Colitis by Inhibiting NLRP3 Inflammasome Activation and Regulating Microbial Homeostasis.
Liu D, Tian Q, Liu K, Ren F, Liu G, Zhou J, Yuan L, Fang Z, Zou B, Wang S
Journal of agricultural and food chemistry 2023 Feb 8;
Journal of agricultural and food chemistry 2023 Feb 8;
Apoptosis or Antiapoptosis? Interrupted Regulated Cell Death of Host Cells by Ascovirus Infection In Vitro.
Yu H, Li JR, Xiao HY, Cao SK, Chen B, Li N, Chen G, Huang GH
mBio 2023 Feb 28;14(1):e0311922
mBio 2023 Feb 28;14(1):e0311922
Alpha-kinase1 promotes tubular injury and interstitial inflammation in diabetic nephropathy by canonical pyroptosis pathway.
Cui X, Li Y, Yuan S, Huang Y, Chen X, Han Y, Liu Z, Li Z, Xiao Y, Wang Y, Sun L, Liu H, Zhu X
Biological research 2023 Feb 2;56(1):5
Biological research 2023 Feb 2;56(1):5
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice.
Chen JW, Shan TK, Wei TW, Jiang QQ, Du C, Gu LF, Yang TT, Zhou LH, Wang SB, Bao YL, Wang H, Ji Y, Xie LP, Gu AH, Sun CQ, Wang QM, Wang LS
Archives of toxicology 2023 Dec;97(12):3209-3226
Archives of toxicology 2023 Dec;97(12):3209-3226
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Wang HG, Wang D, Sarfraz M, Afzal A, Jing MR, Zhang YX, Cai CB, Qi HW, Chen HJ, Li T, Hu SJ, Liu HX, Ji XY, Wu DD
Translational oncology 2023 Dec;38:101770
Translational oncology 2023 Dec;38:101770
Inhibition of Caspase-11-Mediated Pyroptosis Alleviates Acute Kidney Injury Associated with Severe Acute Pancreatitis in Rats.
Shao Y, Li C, Jiang Y, Li H, Tang X, Gao Z, Zhang D
Journal of investigative surgery : the official journal of the Academy of Surgical Research 2023 Dec;36(1):1-7
Journal of investigative surgery : the official journal of the Academy of Surgical Research 2023 Dec;36(1):1-7
Inhibition of macrophage pyroptosis ameliorates silica-induced pulmonary fibrosis.
Jiang F, Jiang Q, Hou L, Zhao J, Zhu Z, Jia Q, Xue W, Wang H, Wang Y, Tian L
Ecotoxicology and environmental safety 2023 Dec;268:115693
Ecotoxicology and environmental safety 2023 Dec;268:115693
Ursodeoxycholic acid alleviates sepsis-induced lung injury by blocking PANoptosis via STING pathway.
He YQ, Deng JL, Zhou CC, Jiang SG, Zhang F, Tao X, Chen WS
International immunopharmacology 2023 Dec;125(Pt B):111161
International immunopharmacology 2023 Dec;125(Pt B):111161
ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation.
Zheng S, Que X, Wang S, Zhou Q, Xing X, Chen L, Hou C, Ma J, An P, Peng Y, Yao Y, Song Q, Li J, Zhang P, Pei H
Molecular cell 2023 Dec 21;83(24):4570-4585.e7
Molecular cell 2023 Dec 21;83(24):4570-4585.e7
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression.
Cong L, Liu X, Bai Y, Qin Q, Zhao L, Shi Y, Bai Y, Guo Z
Biological research 2023 Dec 2;56(1):62
Biological research 2023 Dec 2;56(1):62
CASP1 is a target for combination therapy in pancreatic cancer.
Wang X, Chen Z, Nie D, Zeng X, Zhong M, Liu X, Zhong S, Wang L, Liao Z, Chen C, Li Y, Zeng C
European journal of pharmacology 2023 Dec 15;961:176175
European journal of pharmacology 2023 Dec 15;961:176175
Paeoniflorin recued hepatotoxicity under zinc oxide nanoparticles exposure via regulation on gut-liver axis and reversal of pyroptosis.
Pei X, Tang S, Jiang H, Zhang W, Xu G, Zuo Z, Ren Z, Chen C, Shen Y, Li C, Li D
The Science of the total environment 2023 Dec 15;904:166885
The Science of the total environment 2023 Dec 15;904:166885
Hyperuricemia promotes the progression of atherosclerosis by activating endothelial cell pyroptosis via the ROS/NLRP3 pathway.
He B, Nie Q, Wang F, Wang X, Zhou Y, Wang C, Guo J, Fan X, Ye Z, Liu P, Wen J
Journal of cellular physiology 2023 Aug;238(8):1808-1822
Journal of cellular physiology 2023 Aug;238(8):1808-1822
MiR-195-5p is involved in testicular ischemia/reperfusion injury by directly targeting PELP1 and regulating spermatogonia pyroptosis.
He KX, Xu L, Ning JZ, Cheng F
International immunopharmacology 2023 Aug;121:110427
International immunopharmacology 2023 Aug;121:110427
Exploring the application of sildenafil for high-fat diet-induced erectile dysfunction based on interleukin-18-mediated NLRP3/Caspase-1 signaling pathway.
Zhu B, Niu Y, Niu L, Zhang X, Liu F
Sexual medicine 2023 Aug;11(4):qfad044
Sexual medicine 2023 Aug;11(4):qfad044
SMAD2 inhibits pyroptosis of fibroblast-like synoviocytes and secretion of inflammatory factors via the TGF-β pathway in rheumatoid arthritis.
Mao X, Wu W, Nan Y, Sun W, Wang Y
Arthritis research & therapy 2023 Aug 9;25(1):144
Arthritis research & therapy 2023 Aug 9;25(1):144
Protective Role of Vitamin K3 on SARS-CoV-2 Structural Protein-Induced Inflammation and Cell Death.
Zhan Y, Zha D, Lin H, Mao X, Yang L, Huang H, He Z, Zhou S, Xu F, Qian Y, Liu Y
Pharmaceuticals (Basel, Switzerland) 2023 Aug 3;16(8)
Pharmaceuticals (Basel, Switzerland) 2023 Aug 3;16(8)
GABA(B) Receptor Activation Attenuates Neuronal Pyroptosis in Post-cardiac Arrest Brain Injury.
Sun Y, Li J, Wu H, Zhao Z, Cong T, Li L, Zhang X, Yin S, Xiao Z
Neuroscience 2023 Aug 21;526:97-106
Neuroscience 2023 Aug 21;526:97-106
A novel mechanism regulating pyroptosis-induced fibrosis in endometriosis via lnc-MALAT1/miR-141-3p/NLRP3 pathway†.
Xu Y, Liu H, Xiong W, Peng Y, Li X, Long X, Jin J, Liang J, Weng R, Liu J, Zhang L, Liu Y
Biology of reproduction 2023 Aug 10;109(2):156-171
Biology of reproduction 2023 Aug 10;109(2):156-171
Schisandrin B induces HepG2 cells pyroptosis by activating NK cells mediated anti-tumor immunity.
Song A, Ding T, Wei N, Yang J, Ma M, Zheng S, Jin H
Toxicology and applied pharmacology 2023 Aug 1;472:116574
Toxicology and applied pharmacology 2023 Aug 1;472:116574
SARS-CoV-2 E protein-induced THP-1 pyroptosis is reversed by Ruscogenin.
Huang H, Li X, Zha D, Lin H, Yang L, Wang Y, Xu L, Wang L, Lei T, Zhou Z, Xiao YF, Xin HB, Fu M, Qian Y
Biochemistry and cell biology = Biochimie et biologie cellulaire 2023 Aug 1;101(4):303-312
Biochemistry and cell biology = Biochimie et biologie cellulaire 2023 Aug 1;101(4):303-312
Irisin attenuates acute lung injury by suppressing the pyroptosis of alveolar macrophages.
Han Z, Ma J, Han Y, Yuan G, Jiao R, Meng A
International journal of molecular medicine 2023 Apr;51(4)
International journal of molecular medicine 2023 Apr;51(4)
Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells.
Wu Y, Pi D, Zhou S, Yi Z, Dong Y, Wang W, Ye H, Chen Y, Zuo Q, Ouyang M
Acta biochimica et biophysica Sinica 2023 Apr 19;55(4):587-600
Acta biochimica et biophysica Sinica 2023 Apr 19;55(4):587-600
Overexpression of CASP1 triggers acute promyelocytic leukemia cell pyroptosis and differentiation.
Yu X, Liu X, Liu X, Jin S, Zhong M, Nie D, Zeng X, Wang X, Tan J, Li Y, Zeng C
European journal of pharmacology 2023 Apr 15;945:175614
European journal of pharmacology 2023 Apr 15;945:175614
Oroxin A ameliorates the oleic acid-induced A549 cell injury through the suppression of pyroptosis and degradation of alveolar surfactant.
Huang J, Chen C, Xie J, Zhai K, Wei S, Cheng X, Zhang R
Anais da Academia Brasileira de Ciencias 2022;94(suppl 4):e20211400
Anais da Academia Brasileira de Ciencias 2022;94(suppl 4):e20211400
Induction of Pyroptosis in Renal Tubular Epithelial Cells Using High Glucose.
Liu Y, He M, Xiong H, Yuan F
Frontiers in medicine 2022;9:874916
Frontiers in medicine 2022;9:874916
Luteolin Induced Hippocampal Neuronal Pyroptosis Inhibition by Regulation of miR-124-3p/TNF-α/TRAF6 Axis in Mice Affected by Breast-Cancer-Related Depression.
Zhu Q, Meng P, Han Y, Yang H, Yang Q, Liu Z, Wang Y, Long M
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2715325
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2715325
Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis.
Hong Q, Zhang Y, Lin W, Wang W, Yuan Y, Lin J, Xie Z, Li X, Meng Y
Journal of immunology research 2022;2022:2291877
Journal of immunology research 2022;2022:2291877
Lignans from Mosla scabra Ameliorated Influenza A Virus-Induced Pneumonia via Inhibiting Macrophage Activation.
Cai W, Wu LR, Zhang SL
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1688826
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1688826
Microtubule affinity regulating kinase 4 promoted activation of the NLRP3 inflammasome-mediated pyroptosis in periodontitis.
Wang L, Pu W, Wang C, Lei L, Li H
Journal of oral microbiology 2022;14(1):2015130
Journal of oral microbiology 2022;14(1):2015130
NLRP3 downregulation enhances engraftment and functionality of adipose-derived stem cells to alleviate erectile dysfunction in diabetic rats.
Luo C, Peng Y, Zhou X, Fan J, Chen W, Zhang H, Wei A
Frontiers in endocrinology 2022;13:913296
Frontiers in endocrinology 2022;13:913296
Natural Compound Library Screening Identifies Oroxin A for the Treatment of Myocardial Ischemia/Reperfusion Injury.
Cheng X, Huang T, Wang C, Hao S, Shu L, Wang S, Cheng G, Zhang Q, Huang J, Chen C
Frontiers in pharmacology 2022;13:894899
Frontiers in pharmacology 2022;13:894899
Protective Effect of Danshen Zexie Decoction Against Non-Alcoholic Fatty Liver Disease Through Inhibition of ROS/NLRP3/IL-1β Pathway by Nrf2 Signaling Activation.
Biao Y, Chen J, Liu C, Wang R, Han X, Li L, Zhang Y
Frontiers in pharmacology 2022;13:877924
Frontiers in pharmacology 2022;13:877924
Herpes Simplex Virus 1 Induces Microglia Gasdermin D-Dependent Pyroptosis Through Activating the NLR Family Pyrin Domain Containing 3 Inflammasome.
Hu X, Zeng Q, Xiao J, Qin S, Wang Y, Shan T, Hu D, Zhu Y, Liu K, Zheng K, Wang Y, Ren Z
Frontiers in microbiology 2022;13:838808
Frontiers in microbiology 2022;13:838808
Cochlear Marginal Cell Pyroptosis Is Induced by Cisplatin via NLRP3 Inflammasome Activation.
Yu W, Zong S, Zhou P, Wei J, Wang E, Ming R, Xiao H
Frontiers in immunology 2022;13:823439
Frontiers in immunology 2022;13:823439
Fucoidan Alleviates Renal Fibrosis in Diabetic Kidney Disease via Inhibition of NLRP3 Inflammasome-Mediated Podocyte Pyroptosis.
Wang MZ, Wang J, Cao DW, Tu Y, Liu BH, Yuan CC, Li H, Fang QJ, Chen JX, Fu Y, Wan BY, Wan ZY, Wan YG, Wu GW
Frontiers in pharmacology 2022;13:790937
Frontiers in pharmacology 2022;13:790937
Pyroptosis relates to tumor microenvironment remodeling and prognosis: A pan-cancer perspective.
Khan M, Ai M, Du K, Song J, Wang B, Lin J, Ren A, Chen C, Huang Z, Qiu W, Zhang J, Tian Y, Yuan Y
Frontiers in immunology 2022;13:1062225
Frontiers in immunology 2022;13:1062225
Prognostic value and immune infiltration of the gasdermin family in lung adenocarcinoma.
Peng LS, Duan SL, Li RQ, Wang D, Han YY, Huang T, Yu YP, Ou CL, Wang JP
Frontiers in oncology 2022;12:1043862
Frontiers in oncology 2022;12:1043862
Lactobacillus rhamnosus GR-1 attenuates foodborne Bacillus cereus-induced NLRP3 inflammasome activity in bovine mammary epithelial cells by protecting intercellular tight junctions.
Shan Q, Liu N, Wang X, Zhu Y, Yin J, Wang J
Journal of animal science and biotechnology 2022 Sep 9;13(1):101
Journal of animal science and biotechnology 2022 Sep 9;13(1):101
Gasdermin D is involved in switching from apoptosis to pyroptosis in TLR4-mediated renal tubular epithelial cells injury in diabetic kidney disease.
Yuan S, Wang Y, Li Z, Chen X, Song P, Chen A, Qu Z, Wen S, Liu H, Zhu X
Archives of biochemistry and biophysics 2022 Sep 30;727:109347
Archives of biochemistry and biophysics 2022 Sep 30;727:109347
Bisdemethoxycurcumin Alleviates Dextran Sodium Sulfate-Induced Colitis via Inhibiting NLRP3 Inflammasome Activation and Modulating the Gut Microbiota in Mice.
Zhang J, Li Q, Zhang X, Chen Y, Lu Y, Wang X, Zhang L, Wang T
Antioxidants (Basel, Switzerland) 2022 Oct 7;11(10)
Antioxidants (Basel, Switzerland) 2022 Oct 7;11(10)
Nuclear translocation of Gasdermin D sensitizes colorectal cancer to chemotherapy in a pyroptosis-independent manner.
Peng X, Na R, Zhou W, Meng X, Yang Y, Amini S, Song L
Oncogene 2022 Nov;41(47):5092-5106
Oncogene 2022 Nov;41(47):5092-5106
S100A8-Mediated NLRP3 Inflammasome-Dependent Pyroptosis in Macrophages Facilitates Liver Fibrosis Progression.
Liu Y, Kong X, You Y, Xiang L, Zhang Y, Wu R, Zhou L, Duan L
Cells 2022 Nov 12;11(22)
Cells 2022 Nov 12;11(22)
The role of discoid domain receptor 1 on renal tubular epithelial pyroptosis in diabetic nephropathy.
Zhao W, He C, Jiang J, Zhao Z, Yuan H, Wang F, Shen B
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2022 Nov 1;26(6):427-438
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2022 Nov 1;26(6):427-438
Anti‑β(2)GPI/β(2)GPI induces neutrophil pyroptosis and thereby enhances ICAM‑1 and IL‑8 expression in endothelial cells.
Luo J, Zhang M, Wang Z, Yan L, Liu Y
International journal of molecular medicine 2022 May;49(5)
International journal of molecular medicine 2022 May;49(5)
Silica nanoparticles induce pyroptosis and cardiac hypertrophy via ROS/NLRP3/Caspase-1 pathway.
Wang F, Liang Q, Ma Y, Sun M, Li T, Lin L, Sun Z, Duan J
Free radical biology & medicine 2022 Mar;182:171-181
Free radical biology & medicine 2022 Mar;182:171-181
The TLR-chaperone CNPY3 is a critical regulator of NLRP3-inflammasome activation.
Ghait M, Husain RA, Duduskar SN, Haack TB, Rooney M, Göhrig B, Bauer M, Rubio I, Deshmukh SD
European journal of immunology 2022 Jun;52(6):907-923
European journal of immunology 2022 Jun;52(6):907-923
3,4,5-O-tricaffeoylquinic acid with anti-radiation activity suppresses LPS-induced NLRP3 inflammasome activation via autophagy in THP-1 macrophages.
Liu J, Chen J, Xu B, Lin L, Liu S, Ma X, Liu J
Molecular immunology 2022 Jul;147:187-198
Molecular immunology 2022 Jul;147:187-198
Crosstalk Between RPE Cells and Choroidal Endothelial Cells via the ANXA1/FPR2/SHP2/NLRP3 Inflammasome/Pyroptosis Axis Promotes Choroidal Neovascularization.
Zhu M, Wang Y, Zhu L, Du S, Wang Z, Zhang Y, Guo Y, Tu Y, Song E
Inflammation 2022 Feb;45(1):414-427
Inflammation 2022 Feb;45(1):414-427
ATG5-Mediated Autophagy May Inhibit Pyroptosis to Ameliorate Oleic Acid-Induced Hepatocyte Steatosis.
Tang Q, Liu W, Yang X, Tian Y, Chen J, Hu Y, Fu N
DNA and cell biology 2022 Dec;41(12):1038-1052
DNA and cell biology 2022 Dec;41(12):1038-1052
Elsholtzia bodinieri Vaniot Ameliorated Acute Lung Injury by NQO1, BCL2 and PTGS2 In Silico and In Vitro Analyses.
Sun J, Jiang X, Chen Y, Guo S, Zhao Z, Cao J, Liu Y, Cheng G, Li Y, Tian L
International journal of molecular sciences 2022 Dec 9;23(24)
International journal of molecular sciences 2022 Dec 9;23(24)
Extracellular traps from activated vascular smooth muscle cells drive the progression of atherosclerosis.
Zhai M, Gong S, Luan P, Shi Y, Kou W, Zeng Y, Shi J, Yu G, Hou J, Yu Q, Jian W, Zhuang J, Feinberg MW, Peng W
Nature communications 2022 Dec 6;13(1):7500
Nature communications 2022 Dec 6;13(1):7500
Curcumin activates NLRC4, AIM2, and IFI16 inflammasomes and induces pyroptosis by up-regulated ISG3 transcript factor in acute myeloid leukemia cell lines.
Zhou Y, Kong Y, Jiang M, Kuang L, Wan J, Liu S, Zhang Q, Yu K, Li N, Le A, Zhang Z
Cancer biology & therapy 2022 Dec 31;23(1):328-335
Cancer biology & therapy 2022 Dec 31;23(1):328-335
The selective NLRP3 inflammasome inhibitor MCC950 improves isoproterenol-induced cardiac dysfunction by inhibiting cardiomyocyte senescence.
Shi Y, Zhao L, Wang J, Liu S, Zhang Y, Qin Q
European journal of pharmacology 2022 Dec 15;937:175364
European journal of pharmacology 2022 Dec 15;937:175364
NLRP6 Induces Lung Injury and Inflammation Early in Brucella and Influenza Coinfection.
Shi B, Han H, Li H, Tan L, Li X, Wang K, Li B, He W, Tian C, Yan F, Shi Y, Zheng Y, Zhao Z
Journal of personalized medicine 2022 Dec 14;12(12)
Journal of personalized medicine 2022 Dec 14;12(12)
Anti-depressant effects of acupuncture: The insights from NLRP3 mediated pyroptosis and inflammation.
Chen Y, Hao C, Chen W, Cheng W, Li P, Shen J, Tong T, Yan S, Huang S, He T, Huang Z, Meng X
Neuroscience letters 2022 Aug 10;785:136787
Neuroscience letters 2022 Aug 10;785:136787
Alda-1, an Activator of ALDH2, Improves Postresuscitation Cardiac and Neurological Outcomes by Inhibiting Pyroptosis in Swine.
Diao M, Xu J, Wang J, Zhang M, Wu C, Hu X, Zhu Y, Zhang M, Hu W
Neurochemical research 2022 Apr;47(4):1097-1109
Neurochemical research 2022 Apr;47(4):1097-1109
Tubastatin A Improves Post-Resuscitation Myocardial Dysfunction by Inhibiting NLRP3-Mediated Pyroptosis Through Enhancing Transcription Factor EB Signaling.
Xu J, Zhao X, Jiang X, He L, Wu X, Wang J, Chen Q, Li Y, Zhang M
Journal of the American Heart Association 2022 Apr 5;11(7):e024205
Journal of the American Heart Association 2022 Apr 5;11(7):e024205
Baclofen attenuates cognitive deficits in post-cardiac arrest brain injury.
Sun Y, Cong T, Li L, Li J, Wu H, Chen X, Zhou Y, Xiao Z
Biochemical and biophysical research communications 2022 Apr 30;602:135-141
Biochemical and biophysical research communications 2022 Apr 30;602:135-141
Dietary Tryptophan Supplementation Improves Antioxidant Status and Alleviates Inflammation, Endoplasmic Reticulum Stress, Apoptosis, and Pyroptosis in the Intestine of Piglets after Lipopolysaccharide Challenge.
Liu G, Tao J, Lu J, Jia G, Zhao H, Chen X, Tian G, Cai J, Zhang R, Wang J
Antioxidants (Basel, Switzerland) 2022 Apr 28;11(5)
Antioxidants (Basel, Switzerland) 2022 Apr 28;11(5)
Escin Sodium Improves the Prognosis of Acute Pancreatitis via Promoting Cell Apoptosis by Suppression of the ERK/STAT3 Signaling Pathway.
Zhang Q, Zhao C, Zhang L, Sun K, Yu L, Wang X, Ren L, Zhang N, Chen C, Liu J, Wang H, Tian H
Oxidative medicine and cellular longevity 2021;2021:9921839
Oxidative medicine and cellular longevity 2021;2021:9921839
Sodium Houttuyfonate Ameliorates β-amyloid(1-42)-Induced Memory Impairment and Neuroinflammation through Inhibiting the NLRP3/GSDMD Pathway in Alzheimer's Disease.
Zhao Y, Tian Y, Feng T
Mediators of inflammation 2021;2021:8817698
Mediators of inflammation 2021;2021:8817698
Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo.
Liao Z, Li S, Liu R, Feng X, Shi Y, Wang K, Li S, Zhang Y, Wu X, Yang C
Oxidative medicine and cellular longevity 2021;2021:5584447
Oxidative medicine and cellular longevity 2021;2021:5584447
Destructive Effects of Pyroptosis on Homeostasis of Neuron Survival Associated with the Dysfunctional BBB-Glymphatic System and Amyloid-Beta Accumulation after Cerebral Ischemia/Reperfusion in Rats.
Lyu Z, Chan Y, Li Q, Zhang Q, Liu K, Xiang J, Li X, Cai D, Li Y, Wang B, Yu Z
Neural plasticity 2021;2021:4504363
Neural plasticity 2021;2021:4504363
Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome-Induced Pyroptosis via Inhibiting the TLR4/NF-κB/PFKFB3 Signaling in Trophoblasts: Implication for a Potential Therapy of Preeclampsia.
Zhang Y, Liu W, Zhong Y, Li Q, Wu M, Yang L, Liu X, Zou L
Oxidative medicine and cellular longevity 2021;2021:1806344
Oxidative medicine and cellular longevity 2021;2021:1806344
Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3/caspase-1/GSDMD Pathway in Triple-Negative Breast Cancer.
Yan H, Luo B, Wu X, Guan F, Yu X, Zhao L, Ke X, Wu J, Yuan J
International journal of biological sciences 2021;17(10):2606-2621
International journal of biological sciences 2021;17(10):2606-2621
Ginsenoside Rg1 Inhibits Microglia Pyroptosis Induced by Lipopolysaccharide Through Regulating STAT3 Signaling.
Yao Y, Li C, Qian F, Zhao Y, Shi X, Hong D, Ai Q, Zhong L
Journal of inflammation research 2021;14:6619-6632
Journal of inflammation research 2021;14:6619-6632
Assessment of Pyroptosis-Related Indicators as Potential Biomarkers and Their Association with Severity in Patients with Liver Cirrhosis.
Wang D, Zhan X, Wu R, You Y, Chen W, Duan L
Journal of inflammation research 2021;14:3185-3196
Journal of inflammation research 2021;14:3185-3196
Mesenchymal Stem Cells Alleviate Post-resuscitation Cardiac and Cerebral Injuries by Inhibiting Cell Pyroptosis and Ferroptosis in a Swine Model of Cardiac Arrest.
Xu J, Zhang M, Liu F, Shi L, Jiang X, Chen C, Wang J, Diao M, Khan ZU, Zhang M
Frontiers in pharmacology 2021;12:793829
Frontiers in pharmacology 2021;12:793829
Metallothionein 3-Zinc Axis Suppresses Caspase-11 Inflammasome Activation and Impairs Antibacterial Immunity.
Chowdhury D, Gardner JC, Satpati A, Nookala S, Mukundan S, Porollo A, Landero Figueroa JA, Subramanian Vignesh K
Frontiers in immunology 2021;12:755961
Frontiers in immunology 2021;12:755961
CBD Alleviates Liver Injuries in Alcoholics With High-Fat High-Cholesterol Diet Through Regulating NLRP3 Inflammasome-Pyroptosis Pathway.
Jiang X, Gu Y, Huang Y, Zhou Y, Pang N, Luo J, Tang Z, Zhang Z, Yang L
Frontiers in pharmacology 2021;12:724747
Frontiers in pharmacology 2021;12:724747
siRNAs Targeting Mouse-Specific lncRNA AA388235 Induce Human Tumor Cell Pyroptosis/Apoptosis.
Chen YR, Feng WY, Cheng YX, Zhu H, Liu HJ, Gao Y, Zhou WJ
Frontiers in oncology 2021;11:662444
Frontiers in oncology 2021;11:662444
Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration.
Xing H, Zhang Z, Mao Q, Wang C, Zhou Y, Zhou X, Ying L, Xu H, Hu S, Zhang N
Journal of nanobiotechnology 2021 Sep 6;19(1):264
Journal of nanobiotechnology 2021 Sep 6;19(1):264
Engineering Extracellular Vesicles Restore the Impaired Cellular Uptake and Attenuate Intervertebral Disc Degeneration.
Liao Z, Liu H, Ma L, Lei J, Tong B, Li G, Ke W, Wang K, Feng X, Hua W, Li S, Yang C
ACS nano 2021 Sep 28;15(9):14709-14724
ACS nano 2021 Sep 28;15(9):14709-14724
Plasma exosomes derived from patients with intestinal Behçet's syndrome induce intestinal epithelial cell pyroptosis.
Hou CC, Ma HF, Ye JF, Luo D, Bao HF, Guan JL
Clinical rheumatology 2021 Oct;40(10):4143-4155
Clinical rheumatology 2021 Oct;40(10):4143-4155
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Zhao Y, Liu X, Zheng Y, Liu W, Ding C
Scientific reports 2021 Oct 18;11(1):20558
Scientific reports 2021 Oct 18;11(1):20558
(-)-Epicatechin ameliorates cigarette smoke-induced lung inflammation via inhibiting ROS/NLRP3 inflammasome pathway in rats with COPD.
Tian X, Xue Y, Xie G, Zhou Y, Xiao H, Ding F, Zhang M
Toxicology and applied pharmacology 2021 Oct 15;429:115674
Toxicology and applied pharmacology 2021 Oct 15;429:115674
The relationship between liver pathological inflammation degree and pyroptosis in chronic hepatitis B patients.
Wang Y, Li X, Chen Q, Jiao F, Shi C, Pei M, Wang L, Gong Z
Journal of medical virology 2021 Nov;93(11):6229-6235
Journal of medical virology 2021 Nov;93(11):6229-6235
Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway.
Hao W, Hao C, Wu C, Xu Y, Wu S, Lu X, Yang J, Jin C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112591
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112591
The balance between AIM2-associated inflammation and autophagy: the role of CHMP2A in brain injury after cardiac arrest.
Shao R, Wang X, Xu T, Xia Y, Cui D
Journal of neuroinflammation 2021 Nov 5;18(1):257
Journal of neuroinflammation 2021 Nov 5;18(1):257
Gasdermin D Is a Novel Prognostic Biomarker and Relates to TMZ Response in Glioblastoma.
Liu J, Gao L, Zhu X, Geng R, Tao X, Xu H, Chen Z
Cancers 2021 Nov 10;13(22)
Cancers 2021 Nov 10;13(22)
Mesenchymal stromal cells protect hepatocytes from lipotoxicity through alleviation of endoplasmic reticulum stress by restoring SERCA activity.
Li L, Zeng X, Liu Z, Chen X, Li L, Luo R, Liu X, Zhang J, Liu J, Lu Y, Cheng J, Chen Y
Journal of cellular and molecular medicine 2021 Mar;25(6):2976-2993
Journal of cellular and molecular medicine 2021 Mar;25(6):2976-2993
Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes.
Tsuchiya K, Hosojima S, Hara H, Kushiyama H, Mahib MR, Kinoshita T, Suda T
Cell reports 2021 Mar 23;34(12):108887
Cell reports 2021 Mar 23;34(12):108887
Macrophage membrane-mediated targeted drug delivery for treatment of spinal cord injury regardless of the macrophage polarization states.
Tang W, Yang Y, Yang L, Tang M, Chen Y, Li C
Asian journal of pharmaceutical sciences 2021 Jul;16(4):459-470
Asian journal of pharmaceutical sciences 2021 Jul;16(4):459-470
Suppressing ROS generation by apocynin inhibited cyclic stretch-induced inflammatory reaction in HPDLCs via a caspase-1 dependent pathway.
Wang Y, Song Y, Zhong Q, Wu Y, Zhuang J, Qu F, Xu C
International immunopharmacology 2021 Jan;90:107129
International immunopharmacology 2021 Jan;90:107129
Low shear stress induced vascular endothelial cell pyroptosis by TET2/SDHB/ROS pathway.
Chen J, Zhang J, Wu J, Zhang S, Liang Y, Zhou B, Wu P, Wei D
Free radical biology & medicine 2021 Jan;162:582-591
Free radical biology & medicine 2021 Jan;162:582-591
Histone deacetylase 2 regulates ULK1 mediated pyroptosis during acute liver failure by the K68 acetylation site.
Wang Y, Chen Q, Jiao F, Shi C, Pei M, Wang L, Gong Z
Cell death & disease 2021 Jan 11;12(1):55
Cell death & disease 2021 Jan 11;12(1):55
Gasdermin D: in vivo evidence of pyroptosis in spontaneous labor at term.
Gomez-Lopez N, Romero R, Panaitescu B, Miller D, Zou C, Gudicha DW, Tarca AL, Para R, Pacora P, Hassan SS, Hsu CD
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2021 Feb;34(4):569-579
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2021 Feb;34(4):569-579
Macrophages regulates the transition of pericyte to peritoneal fibrosis through the GSDMD/IL-1β axis.
Shao Q, Sun C, Zhang Q, Liu J, Xia Y, Jin B, Qian X
International immunopharmacology 2021 Dec;101(Pt A):108323
International immunopharmacology 2021 Dec;101(Pt A):108323
Isoorientin Attenuated the Pyroptotic Hepatocyte Damage Induced by Benzo[a]pyrene via ROS/NF-κB/NLRP3/Caspase-1 Signaling Pathway.
Li H, Yuan L, Li X, Luo Y, Zhang Z, Li J
Antioxidants (Basel, Switzerland) 2021 Aug 11;10(8)
Antioxidants (Basel, Switzerland) 2021 Aug 11;10(8)
Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP.
Ji Q, Wang L, Liu J, Wu Y, Lv H, Wen Y, Shi L, Qu B, Szentmáry N
Inflammation 2021 Apr;44(2):682-692
Inflammation 2021 Apr;44(2):682-692
CD147 Expression Is Associated with Tumor Proliferation in Bladder Cancer via GSDMD.
Peng J, Jiang H, Guo J, Huang J, Yuan Q, Xie J, Xiao K
BioMed research international 2020;2020:7638975
BioMed research international 2020;2020:7638975
Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis.
Zeng X, Zhu M, Liu X, Chen X, Yuan Y, Li L, Liu J, Lu Y, Cheng J, Chen Y
Nutrition & metabolism 2020;17:11
Nutrition & metabolism 2020;17:11
Overexpression of gasdermin D promotes invasion of adenoid cystic carcinoma.
Shen X, Zhang Q, He Z, Xiao S, Li H, Huang Z
International journal of clinical and experimental pathology 2020;13(7):1802-1811
International journal of clinical and experimental pathology 2020;13(7):1802-1811
Detection of proteins associated with the pyroptosis signaling pathway in breast cancer tissues and their significance.
Wu X, Mao X, Huang Y, Zhu Q, Guan J, Wu L
International journal of clinical and experimental pathology 2020;13(6):1408-1414
International journal of clinical and experimental pathology 2020;13(6):1408-1414
Tangshen Formula Attenuates Diabetic Kidney Injury by Imparting Anti-pyroptotic Effects via the TXNIP-NLRP3-GSDMD Axis.
Li N, Zhao T, Cao Y, Zhang H, Peng L, Wang Y, Zhou X, Wang Q, Li J, Yan M, Dong X, Zhao H, Li P
Frontiers in pharmacology 2020;11:623489
Frontiers in pharmacology 2020;11:623489
IFN regulatory Factor-1 induced macrophage pyroptosis by modulating m6A modification of circ_0029589 in patients with acute coronary syndrome.
Guo M, Yan R, Ji Q, Yao H, Sun M, Duan L, Xue Z, Jia Y
International immunopharmacology 2020 Sep;86:106800
International immunopharmacology 2020 Sep;86:106800
Trimethylamine N-oxide promotes apoE(-/-) mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway.
Wu P, Chen J, Chen J, Tao J, Wu S, Xu G, Wang Z, Wei D, Yin W
Journal of cellular physiology 2020 Oct;235(10):6582-6591
Journal of cellular physiology 2020 Oct;235(10):6582-6591
Type I Interferon Increases Inflammasomes Associated Pyroptosis in the Salivary Glands of Patients with Primary Sjögren's Syndrome.
Hong SM, Lee J, Jang SG, Lee J, Cho ML, Kwok SK, Park SH
Immune network 2020 Oct;20(5):e39
Immune network 2020 Oct;20(5):e39
MiR-124-3p promotes trophoblast cell HTR-8/SVneo pyroptosis by targeting placental growth factor.
Tao J, Xia LZ, Liang L, Chen Y, Wei D, Meng J, Wu S, Wang Z
Placenta 2020 Nov;101:176-184
Placenta 2020 Nov;101:176-184
Exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the NLRP3 inflammasome in mice.
Wang D, Weng Y, Zhang Y, Wang R, Wang T, Zhou J, Shen S, Wang H, Wang Y
The Science of the total environment 2020 Nov 25;745:141049
The Science of the total environment 2020 Nov 25;745:141049
HMGB1 mediates homocysteine-induced endothelial cells pyroptosis via cathepsin V-dependent pathway.
Leng Y, Chen R, Chen R, He S, Shi X, Zhou X, Zhang Z, Chen AF
Biochemical and biophysical research communications 2020 Nov 19;532(4):640-646
Biochemical and biophysical research communications 2020 Nov 19;532(4):640-646
NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology.
He X, Yang W, Zeng Z, Wei Y, Gao J, Zhang B, Li L, Liu L, Wan Y, Zeng Q, Gong Z, Liu L, Zhang H, Li Y, Yang S, Hu T, Wu L, Masliah E, Huang S, Cao H
Cellular & molecular immunology 2020 Mar;17(3):283-299
Cellular & molecular immunology 2020 Mar;17(3):283-299
TNF-α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury.
Wang Y, Zhang H, Chen Q, Jiao F, Shi C, Pei M, Lv J, Zhang H, Wang L, Gong Z
Cell proliferation 2020 Jun;53(6):e12829
Cell proliferation 2020 Jun;53(6):e12829
Discovery of novel TNNI3K inhibitor suppresses pyroptosis and apoptosis in murine myocardial infarction injury.
Pang H, Wang N, Chai J, Wang X, Zhang Y, Bi Z, Wu W, He G
European journal of medicinal chemistry 2020 Jul 1;197:112314
European journal of medicinal chemistry 2020 Jul 1;197:112314
Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer.
Teng JF, Mei QB, Zhou XG, Tang Y, Xiong R, Qiu WQ, Pan R, Law BY, Wong VK, Yu CL, Long HA, Xiao XL, Zhang F, Wu JM, Qin DL, Wu AG
Cancers 2020 Jan 13;12(1)
Cancers 2020 Jan 13;12(1)
Cyclin-Dependent Kinase 9 Inhibition Suppresses Necroptosis and Pyroptosis in the Progress of Endotoxemia.
Li J, Mao H, Pan Y, Li H, Lei L
Inflammation 2020 Dec;43(6):2061-2074
Inflammation 2020 Dec;43(6):2061-2074
Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis.
Zhang X, Zhang P, An L, Sun N, Peng L, Tang W, Ma D, Chen J
Acta pharmaceutica Sinica. B 2020 Aug;10(8):1397-1413
Acta pharmaceutica Sinica. B 2020 Aug;10(8):1397-1413
IFN Regulatory Factor 1 Mediates Macrophage Pyroptosis Induced by Oxidized Low-Density Lipoprotein in Patients with Acute Coronary Syndrome.
Guo M, Yan R, Yao H, Duan L, Sun M, Xue Z, Jia Y
Mediators of inflammation 2019;2019:2917128
Mediators of inflammation 2019;2019:2917128
HMGB1-induced endothelial cell pyroptosis is involved in systemic inflammatory response syndrome following radiofrequency ablation of hepatic hemangiomas.
Yang M, Yang X, Wang S, Xu L, Ke S, Ding X, Sun W, Gao J
American journal of translational research 2019;11(12):7555-7567
American journal of translational research 2019;11(12):7555-7567
Trichomonas vaginalis Induces NLRP3 Inflammasome Activation and Pyroptotic Cell Death in Human Macrophages.
Riestra AM, Valderrama JA, Patras KA, Booth SD, Quek XY, Tsai CM, Nizet V
Journal of innate immunity 2019;11(1):86-98
Journal of innate immunity 2019;11(1):86-98
TLR4/NF-κB Signaling Induces GSDMD-Related Pyroptosis in Tubular Cells in Diabetic Kidney Disease.
Wang Y, Zhu X, Yuan S, Wen S, Liu X, Wang C, Qu Z, Li J, Liu H, Sun L, Liu F
Frontiers in endocrinology 2019;10:603
Frontiers in endocrinology 2019;10:603
Neferine inhibits LPS-ATP-induced endothelial cell pyroptosis via regulation of ROS/NLRP3/Caspase-1 signaling pathway.
Tang YS, Zhao YH, Zhong Y, Li XZ, Pu JX, Luo YC, Zhou QL
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2019 Sep;68(9):727-738
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2019 Sep;68(9):727-738
Gasdermin D: Evidence of pyroptosis in spontaneous preterm labor with sterile intra-amniotic inflammation or intra-amniotic infection.
Gomez-Lopez N, Romero R, Tarca AL, Miller D, Panaitescu B, Schwenkel G, Gudicha DW, Hassan SS, Pacora P, Jung E, Hsu CD
American journal of reproductive immunology (New York, N.Y. : 1989) 2019 Dec;82(6):e13184
American journal of reproductive immunology (New York, N.Y. : 1989) 2019 Dec;82(6):e13184
Endothelial pyroptosis underlies systemic inflammatory response following radiofrequency ablation of hepatic hemangiomas.
Wang S, Yang M, Yang X, Xu L, Ke S, Ding X, Sun W, Gao J
Scandinavian journal of clinical and laboratory investigation 2019 Dec;79(8):619-628
Scandinavian journal of clinical and laboratory investigation 2019 Dec;79(8):619-628
Bacteroides fragilis Strain ZY-312 Defense against Cronobacter sakazakii-Induced Necrotizing Enterocolitis In Vitro and in a Neonatal Rat Model.
Fan H, Chen Z, Lin R, Liu Y, Wu X, Puthiyakunnon S, Wang Y, Zhu B, Zhang Q, Bai Y, Zhi F
mSystems 2019 Aug 6;4(4)
mSystems 2019 Aug 6;4(4)
Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis.
Guo Q, Wu Y, Hou Y, Liu Y, Liu T, Zhang H, Fan C, Guan H, Li Y, Shan Z, Teng W
Frontiers in immunology 2018;9:1197
Frontiers in immunology 2018;9:1197
Biological functions and clinical significance of the newly identified long non‑coding RNA RP1‑85F18.6 in colorectal cancer.
Ma Y, Chen Y, Lin C, Hu G
Oncology reports 2018 Nov;40(5):2648-2658
Oncology reports 2018 Nov;40(5):2648-2658
Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts.
Jun HK, Jung YJ, Ji S, An SJ, Choi BK
Cell death and differentiation 2018 Feb;25(2):380-391
Cell death and differentiation 2018 Feb;25(2):380-391
Atypical Gasdermin D and Mixed Lineage Kinase Domain-like Protein Leakage Aggravates Tetrachlorobenzoquinone-Induced Nod-like Receptor Protein 3 Inflammasome Activation.
Xia X, Lu B, Dong W, Yang B, Wang Y, Qin Q, Liu Z, Song E, Song Y
Chemical research in toxicology 2018 Dec 17;31(12):1418-1425
Chemical research in toxicology 2018 Dec 17;31(12):1418-1425
Protein kinase D at the Golgi controls NLRP3 inflammasome activation.
Zhang Z, Meszaros G, He WT, Xu Y, de Fatima Magliarelli H, Mailly L, Mihlan M, Liu Y, Puig Gámez M, Goginashvili A, Pasquier A, Bielska O, Neven B, Quartier P, Aebersold R, Baumert TF, Georgel P, Han J, Ricci R
The Journal of experimental medicine 2017 Sep 4;214(9):2671-2693
The Journal of experimental medicine 2017 Sep 4;214(9):2671-2693
Inflammasome activators induce fibronectin expression and release in macrophages.
Jun HK, Jung YJ, Choi BK
Cellular microbiology 2017 May;19(5)
Cellular microbiology 2017 May;19(5)
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.
Liu X, Zhang Z, Ruan J, Pan Y, Magupalli VG, Wu H, Lieberman J
Nature 2016 Jul 7;535(7610):153-8
Nature 2016 Jul 7;535(7610):153-8
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion.
He WT, Wan H, Hu L, Chen P, Wang X, Huang Z, Yang ZH, Zhong CQ, Han J
Cell research 2015 Dec;25(12):1285-98
Cell research 2015 Dec;25(12):1285-98
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 20770-1-AP(GSDMD antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using GSDMD antibody 20770-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human skin using 20770-1-AP(GSDMD antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human skin using 20770-1-AP(GSDMD antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
