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- Product number
- 66387-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- GSDMD antibody
- Antibody type
- Monoclonal
- Description
- GSDMD antibody (Cat. #66387-1-Ig) is a mouse monoclonal antibody that shows reactivity with human and has been validated for the following applications: IF, WB, ELISA.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 2E6C7
- Vial size
- 20ul, 150ul
Submitted references The NLRP3 inhibitor, MCC950, attenuates environmental pollutant PM(2.5)-induced acute lung injury by inhibiting alveolar macrophage pyroptosis.
Combined single-cell transcriptome and immune repertoire analysis reveals hepatic and renal immune injury by heat stroke.
VDAC1-mediated cytosolic leakage of mtDNA triggers pyroptosis of nucleus pulposus cells by activating the TLR9 signaling pathway.
Xue-Jie-San alleviates Crohn's disease through suppressing endothelial cell pyroptosis via the TLR4/NF-κB/NLRP3 pathway.
Pyroptosis Drives the Impairment of Colonic Barrier Integrity During Toxoplasma Gondii Chronic Infection.
pH-Activatable engineered nanoparticle-based selective hexokinase 2 degrader provokes GSDME-dependent pyroptosis for cancer therapy.
Engineered Akkermansia muciniphila vesicles for targeted pyroptosis and trained immunity to enhance immunotherapy in hepatocellular carcinoma.
Tooth loss impairs cognitive function in SAMP8 mice by aggravating pyroptosis of microglia via the cGAS/STING pathway.
Tetramethylpyrazine alleviates acute pancreatitis inflammation by inhibiting pyroptosis via the NRF2 pathway.
FZD6 promotes 5-fluorouracil resistance through inhibiting pyroptosis in colorectal cancer.
Effects of and mechanisms underlying qingwen baidu decoction in sepsis-associated acute kidney injury.
Picroside II-Encapsulated Nanoformulations as Pyroptosis Inhibitor Alleviate Cytokine Storms and Remodel Gut Microbiota Disturbances.
Methamphetamine and HIV-1 Tat Synergistically Induce Microglial Pyroptosis Via Activation of the AIM2 Inflammasome.
Targeting RelA/NLRP3/CCL3 axis mitigates microglia inflammatory response and promotes recovery after spinal cord injury.
Ligilactobacillus Murinus and Lactobacillus Johnsonii Suppress Macrophage Pyroptosis in Atherosclerosis through Butyrate-GPR109A-GSDMD Axis.
Saccharomyces boulardii Alleviates Ovalbumin-Induced Pyroptosis Through Cyba and IL-17 Signaling Pathway.
Juglone promotes spinal cord injury recovery by suppressing pyroptosis and necroptosis through FOS/USP53/ubiquitination.
Tong-Qiao-Huo-Xue Decoction mitigates post-stroke inflammatory response via suppression of the FIB-NLRP3 signaling pathway.
Engineered macrophage membrane-coated nanoparticles attenuate calcium oxalate nephrocalcinosis-induced kidney injury by reducing oxidative stress and pyroptosis.
Oxygen/sulfate radicals-generating CaS(2)O(8) nanosonosensitizers induce PANoptosis and calcium overload for enhanced peritoneal metastasis immunotherapy.
Butyrate attenuates SA-AKI by inhibiting pyroptosis via the STING-GSDMD axis.
Integrative analysis of immunogenic PANoptosis and experimental validation of cinobufagin-induced activation to enhance glioma immunotherapy.
PD-1 Attenuates Neuropathic Pain by Ameliorating NLRP3 Inflammasome-Mediated Microglia Pyroptosis.
Long non-coding RNA NEAT1 mediated lupus nephritis induced podocytes pyroptosis through DNMT1-STING axis.
The Synergistic Role of P2rx7 and Panx1 in Regulating Alveolar Macrophage Pyroptosis and Exosome-Mediated Ferroptosis of Alveolar Epithelial Cells in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome.
β-Hydroxybutyric Acid-Induced Bovine Endometrial Epithelial Cell Pyroptosis via Activating P2X7R.
TLR4-mediated endoplasmic reticulum stress regulates pyroptosis in macrophages infected with the Bacillus Calmette-Guérin mycobacterial.
SIRT2 Promotes NLRP3-Mediated Microglia Pyroptosis and Neuroinflammation via FOXO3a Pathway After Subarachnoid Hemorrhage.
Run-Mu-Ling Granules Mitigate Ocular Surface Inflammatory Injury Associated with Dry Eye by Suppressing the NLRP3/GSDMD-Mediated Pyroptosis Pathway.
Corilagin alleviates atherosclerosis by inhibiting NLRP3 inflammasome activation via the Olfr2 signaling pathway in vitro and in vivo.
Neuregulin-1, a member of the epidermal growth factor family, mitigates STING-mediated pyroptosis and necroptosis in ischaemic flaps.
GSDMD suppresses keratinocyte differentiation by inhibiting FLG expression and attenuating KCTD6-mediated HDAC1 degradation in atopic dermatitis.
WIP1-mediated regulation of p38 MAPK signaling attenuates pyroptosis in sepsis-associated acute kidney injury.
Mefunidone alleviates silica-induced inflammation and fibrosis by inhibiting the TLR4-NF-κB/MAPK pathway and attenuating pyroptosis in murine macrophages.
Andrographolide ameliorates sepsis-induced acute lung injury by promoting autophagy in alveolar macrophages via the RAGE/PI3K/AKT/mTOR pathway.
Diosgenin attenuates metabolic-associated fatty liver disease through the hepatic NLRP3 inflammasome-dependent signaling pathway.
LINC00365 promotes miR-221-5p to inhibit pyroptosis via Dicer in colorectal cancer.
RSPO3 regulates the radioresistance of Non-Small cell lung cancer cells via NLRP3 Inflammasome-Mediated pyroptosis.
Microglia-derived ADAM9 promote GHRH neurons pyroptosis by Mad2L2-JNK-caspase-1 pathway in subarachnoid hemorrhage.
A palmitoylation-depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis.
Transcutaneous electrical acupoint stimulation attenuated neuroinflammation and oxidative stress by activating SIRT1-induced signaling pathway in MCAO/R rat models.
Deficiency of purinergic P2X4 receptor alleviates experimental autoimmune hepatitis in mice.
Platycodon D protects human nasal epithelial cells from pyroptosis through the Nrf2/HO-1/ROS signaling cascade in chronic rhinosinusitis.
Xiaoqinglong decoction improves allergic rhinitis by inhibiting NLRP3-mediated pyroptosis in BALB/C mice.
Revealing the Mechanism of NLRP3 Inflammatory Pathway Activation through K(+) Efflux Induced by PLO via Signal Point Mutations.
Regulation of cardiac ferroptosis in diabetic human heart failure: uncovering molecular pathways and key targets.
Long Non-coding RNA ZFAS1 Regulates Fibrosis and Scortosis in the Cell Model of Diabetic Nephropathy Through miR-525-5p/SGK1 Axis.
Penthorum chinense Pursh extract ameliorates hepatic steatosis by suppressing pyroptosis via the NLRP3/Caspase-1/GSDMD pathway.
Infant feces-derived Lactobacillus gasseri FWJL-4 mitigates experimental necrotizing enterocolitis via acetate production.
A High MCT-Based Ketogenic Diet Suppresses Th1 and Th17 Responses to Ameliorate Experimental Autoimmune Encephalomyelitis in Mice by Inhibiting GSDMD and JAK2-STAT3/4 Pathways.
Serabelisib regulates GSDMD-mediated pyroptosis, apoptosis and migration of hepatoma cells via the PI3K/Akt/E-cadherin signaling pathway.
VNP20009-Abvec-Igκ-MIIP suppresses ovarian cancer progression by modulating Ras/MEK/ERK signaling pathway.
Mesenchymal stem cell-loaded hydrogel to inhibit inflammatory reaction in surgical brain injury via mitochondria transfer.
TMAO promotes vascular endothelial cell pyroptosis via the LPEAT-mitophagy pathway.
Bone marrow-derived mesenchymal stem cell-conditioned medium ameliorates diabetic foot ulcers in rats.
Mesenchymal stem cell-derived exosomal miR-548x-3p inhibits pyroptosis of vascular endothelial cells through HMGB1 in heat stroke.
GSK2656157, a PERK Inhibitor, Alleviates Pyroptosis of Macrophages Induced by Mycobacterium Bacillus Calmette-Guerin Infection.
CBL0137 activates ROS/BAX signaling to promote caspase-3/GSDME-dependent pyroptosis in ovarian cancer cells.
Tongxinluo promotes endothelium-dependent arteriogenesis to attenuate diabetic peripheral arterial disease.
Metal-enriched HSP90 nanoinhibitor overcomes heat resistance in hyperthermic intraperitoneal chemotherapy used for peritoneal metastases.
ASC/inflammasome-independent pyroptosis in ovarian cancer cells through translational augmentation of caspase-1.
Growth differentiation factor 5 inhibits lipopolysaccharide-mediated pyroptosis of nucleus pulposus mesenchymal stem cells via RhoA signaling pathway.
Hyperuricemia promotes the progression of atherosclerosis by activating endothelial cell pyroptosis via the ROS/NLRP3 pathway.
MALAT1 knockdown alleviates the pyroptosis of microglias in diabetic cerebral ischemia via regulating STAT1 mediated NLRP3 transcription.
Pyroptosis correlates with tumor immunity and prognosis.
HIV-induced bystander cell death in astrocytes requires cell-to-cell viral transmission.
Isoxanthohumol, a component of Sophora flavescens, promotes the activation of the NLRP3 inflammasome and induces idiosyncratic hepatotoxicity.
Involvement of pyroptosis pathway in epicardial adipose tissue - myocardium axis in experimental heart failure with preserved ejection fraction.
Acquiring high expression of suilysin enable non-epidemic Streptococccus suis to cause streptococcal toxic shock-like syndrome (STSLS) through NLRP3 inflammasome hyperactivation.
An NLRP3 inflammasome-triggered cytokine storm contributes to Streptococcal toxic shock-like syndrome (STSLS).
Cell Death Is Counteracted by Mitophagy in HIV-Productively Infected Astrocytes but Is Promoted by Inflammasome Activation Among Non-productively Infected Cells.
Han Z, Han Y, Li R, Fan K, Zhang X, Sun T, Li Y, Qiao H
Current research in toxicology 2026;10:100282
Current research in toxicology 2026;10:100282
Combined single-cell transcriptome and immune repertoire analysis reveals hepatic and renal immune injury by heat stroke.
Zhang M, Wang B, Sun D, Chen X, Zhou Y, Yao J, Du L, Zhang Z, Li H, Qu Z, Chen L, Luo Q, Zhang J, Jin X, Cheng X, Niu J, Xing Q, Tan X, Wang T, Liu J, Li L, Song Q, Chen X, Chen Y
JCI insight 2026 Mar 23;11(6)
JCI insight 2026 Mar 23;11(6)
VDAC1-mediated cytosolic leakage of mtDNA triggers pyroptosis of nucleus pulposus cells by activating the TLR9 signaling pathway.
Hu T, Yan M, Chen Y, Chen S, Song Z, Jing X, Hu B, Liu H
Cellular signalling 2026 Jun;142:112387
Cellular signalling 2026 Jun;142:112387
Xue-Jie-San alleviates Crohn's disease through suppressing endothelial cell pyroptosis via the TLR4/NF-κB/NLRP3 pathway.
Gao Y, Zhu YQ, Liu KH, Wu D, Wang Z, Zheng HY, Yang X, Wen K, Sun XL
Journal of ethnopharmacology 2026 Jul 15;366:121648
Journal of ethnopharmacology 2026 Jul 15;366:121648
Pyroptosis Drives the Impairment of Colonic Barrier Integrity During Toxoplasma Gondii Chronic Infection.
Tian X, Xing Y, Zhou Y, Huang Y, Zhang Y, Guo J, Wang Q, Fu L, Shi Z, Yang X, Pan W, Sun F
Immunology 2026 Jan;177(1):70-82
Immunology 2026 Jan;177(1):70-82
pH-Activatable engineered nanoparticle-based selective hexokinase 2 degrader provokes GSDME-dependent pyroptosis for cancer therapy.
Gong L, Li S, Sun J, Liu K, Wang S, Ji M, Hou P, Yan L, Yang D, Liu D
Acta pharmaceutica Sinica. B 2026 Jan;16(1):539-554
Acta pharmaceutica Sinica. B 2026 Jan;16(1):539-554
Engineered Akkermansia muciniphila vesicles for targeted pyroptosis and trained immunity to enhance immunotherapy in hepatocellular carcinoma.
Huang L, Rong Y, Guo M, Liu M, Long F, Zhong W, Hu Y, He X, He J, Zheng D, Yuan C, Wang F
Cell reports. Medicine 2026 Jan 20;7(1):102524
Cell reports. Medicine 2026 Jan 20;7(1):102524
Tooth loss impairs cognitive function in SAMP8 mice by aggravating pyroptosis of microglia via the cGAS/STING pathway.
Sun X, Lu Y, Hu J, Meng S, Wang X, Jiang Q
Frontiers in aging neuroscience 2025;17:1628520
Frontiers in aging neuroscience 2025;17:1628520
Tetramethylpyrazine alleviates acute pancreatitis inflammation by inhibiting pyroptosis via the NRF2 pathway.
Li H, Gao Y, Huang M, Zhang H, Wu Q, Huang Y, Ye X, Chen W
Frontiers in pharmacology 2025;16:1557681
Frontiers in pharmacology 2025;16:1557681
FZD6 promotes 5-fluorouracil resistance through inhibiting pyroptosis in colorectal cancer.
He Z, Yang J, Zhang Y, Zhang T, Guo T, Jin L, Mao Y, Wang T
Carcinogenesis 2025 Sep 4;46(3)
Carcinogenesis 2025 Sep 4;46(3)
Effects of and mechanisms underlying qingwen baidu decoction in sepsis-associated acute kidney injury.
Zhao Y, Zhang M, Dong L, Zhang Q, Bai J, Hao Y, Yi Z, Zhou Y
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120310
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120310
Picroside II-Encapsulated Nanoformulations as Pyroptosis Inhibitor Alleviate Cytokine Storms and Remodel Gut Microbiota Disturbances.
Wu Q, Tang AL, Dong QQ, Chen BQ, Shi Y, Xu XL, Chen W, Chen W
ACS nano 2025 Sep 16;19(36):32569-32584
ACS nano 2025 Sep 16;19(36):32569-32584
Methamphetamine and HIV-1 Tat Synergistically Induce Microglial Pyroptosis Via Activation of the AIM2 Inflammasome.
Miao L, Wang H, Yang X, Xu L, Xu R, Teng H, Zhang Y, Zhao Y, Yang G, Zeng X
Inflammation 2025 Oct;48(5):3300-3313
Inflammation 2025 Oct;48(5):3300-3313
Targeting RelA/NLRP3/CCL3 axis mitigates microglia inflammatory response and promotes recovery after spinal cord injury.
Song W, Fu R, Yuan Z, Liu Y, Kao Y, Zhang R, Gu G, Zhu H, Liu H, Zhang Z, Kong X, Feng S
Brain, behavior, and immunity 2025 Oct;129:801-817
Brain, behavior, and immunity 2025 Oct;129:801-817
Ligilactobacillus Murinus and Lactobacillus Johnsonii Suppress Macrophage Pyroptosis in Atherosclerosis through Butyrate-GPR109A-GSDMD Axis.
Hua R, Ding N, Hua Y, Wang X, Xu Y, Qiao X, Shi X, Bai T, Xiong Y, Zhuo X, Fan C, Zhou J, Wu Y, Liu J, Yuan Z, Li T
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e01707
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e01707
Saccharomyces boulardii Alleviates Ovalbumin-Induced Pyroptosis Through Cyba and IL-17 Signaling Pathway.
Chen Z, Hu L, Yang Y, Wang Y, Li Y, Su J, Wang G, Gong S
Molecular nutrition & food research 2025 Nov;69(21):e70194
Molecular nutrition & food research 2025 Nov;69(21):e70194
Juglone promotes spinal cord injury recovery by suppressing pyroptosis and necroptosis through FOS/USP53/ubiquitination.
Chen L, Chang Y, Zhang S, Wang Z, Liu H, Wang H, Shi L, Li N, Feng S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157341
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157341
Tong-Qiao-Huo-Xue Decoction mitigates post-stroke inflammatory response via suppression of the FIB-NLRP3 signaling pathway.
Huang P, Sun H, Wang Y, Wang N
Metabolic brain disease 2025 May 17;40(5):206
Metabolic brain disease 2025 May 17;40(5):206
Engineered macrophage membrane-coated nanoparticles attenuate calcium oxalate nephrocalcinosis-induced kidney injury by reducing oxidative stress and pyroptosis.
Ba X, Ye T, He Y, Tong Y, Shang H, Wu J, Deng W, Zhong Z, Yang X, Wang K, Xie Y, Jiang K, Guo X, Tang K
Acta biomaterialia 2025 Mar 15;195:479-495
Acta biomaterialia 2025 Mar 15;195:479-495
Oxygen/sulfate radicals-generating CaS(2)O(8) nanosonosensitizers induce PANoptosis and calcium overload for enhanced peritoneal metastasis immunotherapy.
Wang Q, Wen Y, Bi B, Li K, Liu Y, Li B, Zhou S, Li Z, Xu J, Qiu M, Li Y, Wu M, Chen Y, Wu W, Zhao J
Science bulletin 2025 Jun 15;70(11):1804-1821
Science bulletin 2025 Jun 15;70(11):1804-1821
Butyrate attenuates SA-AKI by inhibiting pyroptosis via the STING-GSDMD axis.
Tian X, Yuan L, Zeng Y
Biochemical and biophysical research communications 2025 Jan;743:151143
Biochemical and biophysical research communications 2025 Jan;743:151143
Integrative analysis of immunogenic PANoptosis and experimental validation of cinobufagin-induced activation to enhance glioma immunotherapy.
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Journal of experimental & clinical cancer research : CR 2025 Feb 3;44(1):35
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PD-1 Attenuates Neuropathic Pain by Ameliorating NLRP3 Inflammasome-Mediated Microglia Pyroptosis.
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Molecular neurobiology 2025 Dec;62(12):15478-15493
Molecular neurobiology 2025 Dec;62(12):15478-15493
Long non-coding RNA NEAT1 mediated lupus nephritis induced podocytes pyroptosis through DNMT1-STING axis.
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Renal failure 2025 Dec;47(1):2595372
Renal failure 2025 Dec;47(1):2595372
The Synergistic Role of P2rx7 and Panx1 in Regulating Alveolar Macrophage Pyroptosis and Exosome-Mediated Ferroptosis of Alveolar Epithelial Cells in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome.
Rao H, Ding Q, Liu A, Qiu H, Luo J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 31;39(16):e70904
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 31;39(16):e70904
β-Hydroxybutyric Acid-Induced Bovine Endometrial Epithelial Cell Pyroptosis via Activating P2X7R.
Mu J, Sun Q, Lin N, Yue C, Zhu J, Zou H, Zhao H, Song R, Liu Z, Ma Y
Journal of agricultural and food chemistry 2025 Aug 27;73(34):21296-21308
Journal of agricultural and food chemistry 2025 Aug 27;73(34):21296-21308
TLR4-mediated endoplasmic reticulum stress regulates pyroptosis in macrophages infected with the Bacillus Calmette-Guérin mycobacterial.
Nie X, Miao S, Hou Y, Ma Y, Li M, Liu Y, Yang Y, Xu J, Wang Y
International immunopharmacology 2025 Apr 16;152:114346
International immunopharmacology 2025 Apr 16;152:114346
SIRT2 Promotes NLRP3-Mediated Microglia Pyroptosis and Neuroinflammation via FOXO3a Pathway After Subarachnoid Hemorrhage.
Sun JQ, Sheng B, Gao S, Liu XZ, Cui Y, Peng Z, Chen XX, Ding PF, Zhuang Z, Wu LY, Hang CH, Li W
Journal of inflammation research 2024;17:11679-11698
Journal of inflammation research 2024;17:11679-11698
Run-Mu-Ling Granules Mitigate Ocular Surface Inflammatory Injury Associated with Dry Eye by Suppressing the NLRP3/GSDMD-Mediated Pyroptosis Pathway.
Luo D, Ji HJ, Yan XQ, Wang ZM, Li LJ, Shi L, Gao WP, Li K
Journal of inflammation research 2024;17:10769-10784
Journal of inflammation research 2024;17:10769-10784
Corilagin alleviates atherosclerosis by inhibiting NLRP3 inflammasome activation via the Olfr2 signaling pathway in vitro and in vivo.
Mao J, Chen Y, Zong Q, Liu C, Xie J, Wang Y, Fisher D, Hien NTT, Pronyuk K, Musabaev E, Li Y, Zhao L, Dang Y
Frontiers in immunology 2024;15:1364161
Frontiers in immunology 2024;15:1364161
Neuregulin-1, a member of the epidermal growth factor family, mitigates STING-mediated pyroptosis and necroptosis in ischaemic flaps.
Zhu X, Yu G, Lv Y, Yang N, Zhao Y, Li F, Zhao J, Chen Z, Lai Y, Chen L, Wang X, Xiao J, Cai Y, Feng Y, Ding J, Gao W, Zhou K, Xu H
Burns & trauma 2024;12:tkae035
Burns & trauma 2024;12:tkae035
GSDMD suppresses keratinocyte differentiation by inhibiting FLG expression and attenuating KCTD6-mediated HDAC1 degradation in atopic dermatitis.
Zhong Y, Huang T, Li X, Luo P, Zhang B
PeerJ 2024;12:e16768
PeerJ 2024;12:e16768
WIP1-mediated regulation of p38 MAPK signaling attenuates pyroptosis in sepsis-associated acute kidney injury.
Wang Y, Cui C, Zhao W, Tian X, Liu P, Wei L, Zhu Z, Liu M, Fu R, Jia L
Immunobiology 2024 Sep;229(5):152832
Immunobiology 2024 Sep;229(5):152832
Mefunidone alleviates silica-induced inflammation and fibrosis by inhibiting the TLR4-NF-κB/MAPK pathway and attenuating pyroptosis in murine macrophages.
Long L, Dai X, Yao T, Zhang X, Jiang G, Cheng X, Jiang M, He Y, Peng Z, Hu G, Tao L, Meng J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117216
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117216
Andrographolide ameliorates sepsis-induced acute lung injury by promoting autophagy in alveolar macrophages via the RAGE/PI3K/AKT/mTOR pathway.
Qin Y, Li W, Liu J, Wang F, Zhou W, Xiao L, Zhou P, Wu F, Chen X, Xu S, Liu L, Xiao X, Zhang D
International immunopharmacology 2024 Sep 30;139:112719
International immunopharmacology 2024 Sep 30;139:112719
Diosgenin attenuates metabolic-associated fatty liver disease through the hepatic NLRP3 inflammasome-dependent signaling pathway.
Yu W, Yin G, Chen S, Zhang X, Meng D, Wang L, Liu H, Jiang W, Sun Y, Zhang F
International immunopharmacology 2024 Sep 10;138:112581
International immunopharmacology 2024 Sep 10;138:112581
LINC00365 promotes miR-221-5p to inhibit pyroptosis via Dicer in colorectal cancer.
Yang W, Huang X, Lv W, Jin Y, Zhu Y
Acta biochimica et biophysica Sinica 2024 Oct 22;57(4):529-541
Acta biochimica et biophysica Sinica 2024 Oct 22;57(4):529-541
RSPO3 regulates the radioresistance of Non-Small cell lung cancer cells via NLRP3 Inflammasome-Mediated pyroptosis.
Li H, Zhang J, Yu B, Yang T, Liu B, Li F, Jin X, Li Q
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2024 Nov;200:110528
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2024 Nov;200:110528
Microglia-derived ADAM9 promote GHRH neurons pyroptosis by Mad2L2-JNK-caspase-1 pathway in subarachnoid hemorrhage.
Mao J, Bao Y, Liu F, Ye Q, Peng J, Nie J, Huang L, Liao Y, Xing Y, Wu D, Wang K, Feng W, Qi S, Pan J, Qiu B
Journal of neuroinflammation 2024 Nov 19;21(1):302
Journal of neuroinflammation 2024 Nov 19;21(1):302
A palmitoylation-depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis.
Zhang N, Zhang J, Yang Y, Shan H, Hou S, Fang H, Ma M, Chen Z, Tan L, Xu D
Nature cell biology 2024 May;26(5):757-769
Nature cell biology 2024 May;26(5):757-769
Transcutaneous electrical acupoint stimulation attenuated neuroinflammation and oxidative stress by activating SIRT1-induced signaling pathway in MCAO/R rat models.
Tan Z, Dong F, Wu L, Xu G, Zhang F
Experimental neurology 2024 Mar;373:114658
Experimental neurology 2024 Mar;373:114658
Deficiency of purinergic P2X4 receptor alleviates experimental autoimmune hepatitis in mice.
Liu Z, Sun M, Liu W, Feng F, Li X, Jin C, Zhang Y, Wang J
Biochemical pharmacology 2024 Mar;221:116033
Biochemical pharmacology 2024 Mar;221:116033
Platycodon D protects human nasal epithelial cells from pyroptosis through the Nrf2/HO-1/ROS signaling cascade in chronic rhinosinusitis.
Wang R, Wang Y, Liu H, Zhu J, Fang C, Xu W, Lu Z, Yan Y, He W, Ruan Y, Zhou M
Chinese medicine 2024 Mar 4;19(1):40
Chinese medicine 2024 Mar 4;19(1):40
Xiaoqinglong decoction improves allergic rhinitis by inhibiting NLRP3-mediated pyroptosis in BALB/C mice.
Wang R, Wang Y, Yang Q, Liu J, Lu Z, Xu W, Zhu J, Liu H, He W, Yan Y, Ruan Y, Zhou M
Journal of ethnopharmacology 2024 Mar 1;321:117490
Journal of ethnopharmacology 2024 Mar 1;321:117490
Revealing the Mechanism of NLRP3 Inflammatory Pathway Activation through K(+) Efflux Induced by PLO via Signal Point Mutations.
Shan Q, Ma W, Li B, Li Q, Wang X, Li Y, Wang J, Zhu Y, Liu N
International journal of molecular sciences 2024 Jun 18;25(12)
International journal of molecular sciences 2024 Jun 18;25(12)
Regulation of cardiac ferroptosis in diabetic human heart failure: uncovering molecular pathways and key targets.
Gawargi FI, Mishra PK
Cell death discovery 2024 Jun 1;10(1):268
Cell death discovery 2024 Jun 1;10(1):268
Long Non-coding RNA ZFAS1 Regulates Fibrosis and Scortosis in the Cell Model of Diabetic Nephropathy Through miR-525-5p/SGK1 Axis.
Zhuang L, Jin G, Wang Q, Ge X, Pei X
Applied biochemistry and biotechnology 2024 Jul;196(7):3731-3746
Applied biochemistry and biotechnology 2024 Jul;196(7):3731-3746
Penthorum chinense Pursh extract ameliorates hepatic steatosis by suppressing pyroptosis via the NLRP3/Caspase-1/GSDMD pathway.
Luo R, Hu Y, Wang L, Ke Z, Wang W, Wang P, Tian W
Food science & nutrition 2024 Jul;12(7):5176-5187
Food science & nutrition 2024 Jul;12(7):5176-5187
Infant feces-derived Lactobacillus gasseri FWJL-4 mitigates experimental necrotizing enterocolitis via acetate production.
Pan LL, Sun Y, Dong X, Ren Z, Li B, Yang P, Zhang L, Sun J
Gut microbes 2024 Jan-Dec;16(1):2430541
Gut microbes 2024 Jan-Dec;16(1):2430541
A High MCT-Based Ketogenic Diet Suppresses Th1 and Th17 Responses to Ameliorate Experimental Autoimmune Encephalomyelitis in Mice by Inhibiting GSDMD and JAK2-STAT3/4 Pathways.
Zhang Q, Sun W, Wang Q, Zheng X, Zhang R, Zhang N
Molecular nutrition & food research 2024 Feb;68(3):e2300602
Molecular nutrition & food research 2024 Feb;68(3):e2300602
Serabelisib regulates GSDMD-mediated pyroptosis, apoptosis and migration of hepatoma cells via the PI3K/Akt/E-cadherin signaling pathway.
Li M, Huang Z, Zhou Y
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 Feb;33(2):171-181
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 Feb;33(2):171-181
VNP20009-Abvec-Igκ-MIIP suppresses ovarian cancer progression by modulating Ras/MEK/ERK signaling pathway.
Wang Q, Tang Y, Dai A, Li T, Pei Y, Zhang Z, Hu X, Chen T, Chen Q
Applied microbiology and biotechnology 2024 Feb 19;108(1):218
Applied microbiology and biotechnology 2024 Feb 19;108(1):218
Mesenchymal stem cell-loaded hydrogel to inhibit inflammatory reaction in surgical brain injury via mitochondria transfer.
Wang Y, Yang X, Liu M, Yan Y, Kong F, Wang J, Zhang Z, Chen Y, Chen L, Liang Z, Peng X, Liu F
Journal of controlled release : official journal of the Controlled Release Society 2024 Dec;376:231-240
Journal of controlled release : official journal of the Controlled Release Society 2024 Dec;376:231-240
TMAO promotes vascular endothelial cell pyroptosis via the LPEAT-mitophagy pathway.
Chen Y, Yuan C, Qin W, Yu B, Wei D, Wu P
Biochemical and biophysical research communications 2024 Apr 9;703:149667
Biochemical and biophysical research communications 2024 Apr 9;703:149667
Bone marrow-derived mesenchymal stem cell-conditioned medium ameliorates diabetic foot ulcers in rats.
Xu YF, Wu YX, Wang HM, Gao CH, Xu YY, Yan Y
Clinics (Sao Paulo, Brazil) 2023;78:100181
Clinics (Sao Paulo, Brazil) 2023;78:100181
Mesenchymal stem cell-derived exosomal miR-548x-3p inhibits pyroptosis of vascular endothelial cells through HMGB1 in heat stroke.
Pei Y, Ma W, Wang H, Chen F, Xiao W, Fan M, Han X, Cao Y
Genomics 2023 Nov;115(6):110719
Genomics 2023 Nov;115(6):110719
GSK2656157, a PERK Inhibitor, Alleviates Pyroptosis of Macrophages Induced by Mycobacterium Bacillus Calmette-Guerin Infection.
Ma B, Nie X, Liu L, Li M, Chen Q, Liu Y, Hou Y, Yang Y, Xu J
International journal of molecular sciences 2023 Nov 12;24(22)
International journal of molecular sciences 2023 Nov 12;24(22)
CBL0137 activates ROS/BAX signaling to promote caspase-3/GSDME-dependent pyroptosis in ovarian cancer cells.
Yang C, Wang ZQ, Zhang ZC, Lou G, Jin WL
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114529
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114529
Tongxinluo promotes endothelium-dependent arteriogenesis to attenuate diabetic peripheral arterial disease.
Gu JJ, Hou YL, Yan YH, Li J, Wei YR, Ma K, Wang XQ, Zhang JH, Wang DD, Li CR, Li DQ, Sun LL, Gao HL
World journal of diabetes 2023 Mar 15;14(3):234-254
World journal of diabetes 2023 Mar 15;14(3):234-254
Metal-enriched HSP90 nanoinhibitor overcomes heat resistance in hyperthermic intraperitoneal chemotherapy used for peritoneal metastases.
Wang Q, Liu P, Wen Y, Li K, Bi B, Li BB, Qiu M, Zhang S, Li Y, Li J, Chen H, Yin Y, Zeng L, Zhang C, He Y, Zhao J
Molecular cancer 2023 Jun 14;22(1):95
Molecular cancer 2023 Jun 14;22(1):95
ASC/inflammasome-independent pyroptosis in ovarian cancer cells through translational augmentation of caspase-1.
Calbay O, Padia R, Akter M, Sun L, Li B, Qian N, Guo J, Fu Z, Jin L, Huang S
iScience 2023 Dec 15;26(12):108408
iScience 2023 Dec 15;26(12):108408
Growth differentiation factor 5 inhibits lipopolysaccharide-mediated pyroptosis of nucleus pulposus mesenchymal stem cells via RhoA signaling pathway.
Zhu C, Zhou Q, Wang Z, Zhang J, Xu C, Ruan D
Molecular biology reports 2023 Aug;50(8):6337-6347
Molecular biology reports 2023 Aug;50(8):6337-6347
Hyperuricemia promotes the progression of atherosclerosis by activating endothelial cell pyroptosis via the ROS/NLRP3 pathway.
He B, Nie Q, Wang F, Wang X, Zhou Y, Wang C, Guo J, Fan X, Ye Z, Liu P, Wen J
Journal of cellular physiology 2023 Aug;238(8):1808-1822
Journal of cellular physiology 2023 Aug;238(8):1808-1822
MALAT1 knockdown alleviates the pyroptosis of microglias in diabetic cerebral ischemia via regulating STAT1 mediated NLRP3 transcription.
Zhao N, Hua W, Liu Q, Wang Y, Liu Z, Jin S, Wang B, Pang Y, Qi J, Song Y
Molecular medicine (Cambridge, Mass.) 2023 Apr 3;29(1):44
Molecular medicine (Cambridge, Mass.) 2023 Apr 3;29(1):44
Pyroptosis correlates with tumor immunity and prognosis.
Lou X, Li K, Qian B, Li Y, Zhang D, Cui W
Communications biology 2022 Sep 6;5(1):917
Communications biology 2022 Sep 6;5(1):917
HIV-induced bystander cell death in astrocytes requires cell-to-cell viral transmission.
Cevallos C, Ojeda DS, Sánchez L, Urquiza J, Delpino MV, Quarleri J
Journal of neurochemistry 2022 Nov;163(4):338-356
Journal of neurochemistry 2022 Nov;163(4):338-356
Isoxanthohumol, a component of Sophora flavescens, promotes the activation of the NLRP3 inflammasome and induces idiosyncratic hepatotoxicity.
Lin L, Chen Y, Li Q, Xu G, Ding K, Ren L, Shi W, Wang Y, Li Z, Dai W, Wei Z, Yang Y, Bai Z, Xiao X
Journal of ethnopharmacology 2022 Mar 1;285:114796
Journal of ethnopharmacology 2022 Mar 1;285:114796
Involvement of pyroptosis pathway in epicardial adipose tissue - myocardium axis in experimental heart failure with preserved ejection fraction.
Xia YY, Shi Y, Li Z, Li H, Wu LD, Zhou WY, Gu Y, Ling ZY, Zhang JX, Chen SL
Biochemical and biophysical research communications 2022 Dec 25;636(Pt 2):62-70
Biochemical and biophysical research communications 2022 Dec 25;636(Pt 2):62-70
Acquiring high expression of suilysin enable non-epidemic Streptococccus suis to cause streptococcal toxic shock-like syndrome (STSLS) through NLRP3 inflammasome hyperactivation.
Xu L, Lin L, Lu X, Xiao P, Liu R, Wu M, Jin M, Zhang A
Emerging microbes & infections 2021 Dec;10(1):1309-1319
Emerging microbes & infections 2021 Dec;10(1):1309-1319
An NLRP3 inflammasome-triggered cytokine storm contributes to Streptococcal toxic shock-like syndrome (STSLS).
Lin L, Xu L, Lv W, Han L, Xiang Y, Fu L, Jin M, Zhou R, Chen H, Zhang A
PLoS pathogens 2019 Jun;15(6):e1007795
PLoS pathogens 2019 Jun;15(6):e1007795
Cell Death Is Counteracted by Mitophagy in HIV-Productively Infected Astrocytes but Is Promoted by Inflammasome Activation Among Non-productively Infected Cells.
Ojeda DS, Grasso D, Urquiza J, Till A, Vaccaro MI, Quarleri J
Frontiers in immunology 2018;9:2633
Frontiers in immunology 2018;9:2633
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