66387-1-Ig

antibody from Proteintech Group

Targeting: GSDMD DF5L, FLJ12150, GSDMDC1

Provider product page for 66387-1-Ig

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Immunocytochemistry

Antibody data

Antibody Data
Antigen structure
References [29]
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Product number: 66387-1-Ig - Provider product page
Provider: Proteintech Group
Product name: GSDMD antibody
Antibody type: Monoclonal
Description: GSDMD antibody (Cat. #66387-1-Ig) is a mouse monoclonal antibody that shows reactivity with human and has been validated for the following applications: IF, WB, ELISA.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 2E6C7
Vial size: 20ul, 150ul

GSDMD protein structure - 66387-1-Ig shown in red.

Submitted references GSDMD suppresses keratinocyte differentiation by inhibiting FLG expression and attenuating KCTD6-mediated HDAC1 degradation in atopic dermatitis.

Zhong Y, Huang T, Li X, Luo P, Zhang B
PeerJ 2024;12:e16768

A palmitoylation-depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis.

Zhang N, Zhang J, Yang Y, Shan H, Hou S, Fang H, Ma M, Chen Z, Tan L, Xu D
Nature cell biology 2024 May;26(5):757-769

Transcutaneous electrical acupoint stimulation attenuated neuroinflammation and oxidative stress by activating SIRT1-induced signaling pathway in MCAO/R rat models.

Tan Z, Dong F, Wu L, Xu G, Zhang F
Experimental neurology 2024 Mar;373:114658

Deficiency of purinergic P2X4 receptor alleviates experimental autoimmune hepatitis in mice.

Liu Z, Sun M, Liu W, Feng F, Li X, Jin C, Zhang Y, Wang J
Biochemical pharmacology 2024 Mar;221:116033

Platycodon D protects human nasal epithelial cells from pyroptosis through the Nrf2/HO-1/ROS signaling cascade in chronic rhinosinusitis.

Wang R, Wang Y, Liu H, Zhu J, Fang C, Xu W, Lu Z, Yan Y, He W, Ruan Y, Zhou M
Chinese medicine 2024 Mar 4;19(1):40

Xiaoqinglong decoction improves allergic rhinitis by inhibiting NLRP3-mediated pyroptosis in BALB/C mice.

Wang R, Wang Y, Yang Q, Liu J, Lu Z, Xu W, Zhu J, Liu H, He W, Yan Y, Ruan Y, Zhou M
Journal of ethnopharmacology 2024 Mar 1;321:117490

Revealing the Mechanism of NLRP3 Inflammatory Pathway Activation through K(+) Efflux Induced by PLO via Signal Point Mutations.

Shan Q, Ma W, Li B, Li Q, Wang X, Li Y, Wang J, Zhu Y, Liu N
International journal of molecular sciences 2024 Jun 18;25(12)

Long Non-coding RNA ZFAS1 Regulates Fibrosis and Scortosis in the Cell Model of Diabetic Nephropathy Through miR-525-5p/SGK1 Axis.

Zhuang L, Jin G, Wang Q, Ge X, Pei X
Applied biochemistry and biotechnology 2024 Jul;196(7):3731-3746

A High MCT-Based Ketogenic Diet Suppresses Th1 and Th17 Responses to Ameliorate Experimental Autoimmune Encephalomyelitis in Mice by Inhibiting GSDMD and JAK2-STAT3/4 Pathways.

Zhang Q, Sun W, Wang Q, Zheng X, Zhang R, Zhang N
Molecular nutrition & food research 2024 Feb;68(3):e2300602

Serabelisib regulates GSDMD-mediated pyroptosis, apoptosis and migration of hepatoma cells via the PI3K/Akt/E-cadherin signaling pathway.

Li M, Huang Z, Zhou Y
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 Feb;33(2):171-181

VNP20009-Abvec-Igκ-MIIP suppresses ovarian cancer progression by modulating Ras/MEK/ERK signaling pathway.

Wang Q, Tang Y, Dai A, Li T, Pei Y, Zhang Z, Hu X, Chen T, Chen Q
Applied microbiology and biotechnology 2024 Feb 19;108(1):218

TMAO promotes vascular endothelial cell pyroptosis via the LPEAT-mitophagy pathway.

Chen Y, Yuan C, Qin W, Yu B, Wei D, Wu P
Biochemical and biophysical research communications 2024 Apr 9;703:149667

Bone marrow-derived mesenchymal stem cell-conditioned medium ameliorates diabetic foot ulcers in rats.

Xu YF, Wu YX, Wang HM, Gao CH, Xu YY, Yan Y
Clinics (Sao Paulo, Brazil) 2023;78:100181

Mesenchymal stem cell-derived exosomal miR-548x-3p inhibits pyroptosis of vascular endothelial cells through HMGB1 in heat stroke.

Pei Y, Ma W, Wang H, Chen F, Xiao W, Fan M, Han X, Cao Y
Genomics 2023 Nov;115(6):110719

GSK2656157, a PERK Inhibitor, Alleviates Pyroptosis of Macrophages Induced by Mycobacterium Bacillus Calmette-Guerin Infection.

Ma B, Nie X, Liu L, Li M, Chen Q, Liu Y, Hou Y, Yang Y, Xu J
International journal of molecular sciences 2023 Nov 12;24(22)

CBL0137 activates ROS/BAX signaling to promote caspase-3/GSDME-dependent pyroptosis in ovarian cancer cells.

Yang C, Wang ZQ, Zhang ZC, Lou G, Jin WL
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114529

Tongxinluo promotes endothelium-dependent arteriogenesis to attenuate diabetic peripheral arterial disease.

Gu JJ, Hou YL, Yan YH, Li J, Wei YR, Ma K, Wang XQ, Zhang JH, Wang DD, Li CR, Li DQ, Sun LL, Gao HL
World journal of diabetes 2023 Mar 15;14(3):234-254

Metal-enriched HSP90 nanoinhibitor overcomes heat resistance in hyperthermic intraperitoneal chemotherapy used for peritoneal metastases.

Wang Q, Liu P, Wen Y, Li K, Bi B, Li BB, Qiu M, Zhang S, Li Y, Li J, Chen H, Yin Y, Zeng L, Zhang C, He Y, Zhao J
Molecular cancer 2023 Jun 14;22(1):95

ASC/inflammasome-independent pyroptosis in ovarian cancer cells through translational augmentation of caspase-1.

Calbay O, Padia R, Akter M, Sun L, Li B, Qian N, Guo J, Fu Z, Jin L, Huang S
iScience 2023 Dec 15;26(12):108408

Growth differentiation factor 5 inhibits lipopolysaccharide-mediated pyroptosis of nucleus pulposus mesenchymal stem cells via RhoA signaling pathway.

Zhu C, Zhou Q, Wang Z, Zhang J, Xu C, Ruan D
Molecular biology reports 2023 Aug;50(8):6337-6347

Hyperuricemia promotes the progression of atherosclerosis by activating endothelial cell pyroptosis via the ROS/NLRP3 pathway.

He B, Nie Q, Wang F, Wang X, Zhou Y, Wang C, Guo J, Fan X, Ye Z, Liu P, Wen J
Journal of cellular physiology 2023 Aug;238(8):1808-1822

MALAT1 knockdown alleviates the pyroptosis of microglias in diabetic cerebral ischemia via regulating STAT1 mediated NLRP3 transcription.

Zhao N, Hua W, Liu Q, Wang Y, Liu Z, Jin S, Wang B, Pang Y, Qi J, Song Y
Molecular medicine (Cambridge, Mass.) 2023 Apr 3;29(1):44

Pyroptosis correlates with tumor immunity and prognosis.

Lou X, Li K, Qian B, Li Y, Zhang D, Cui W
Communications biology 2022 Sep 6;5(1):917

HIV-induced bystander cell death in astrocytes requires cell-to-cell viral transmission.

Cevallos C, Ojeda DS, Sánchez L, Urquiza J, Delpino MV, Quarleri J
Journal of neurochemistry 2022 Nov;163(4):338-356

Isoxanthohumol, a component of Sophora flavescens, promotes the activation of the NLRP3 inflammasome and induces idiosyncratic hepatotoxicity.

Lin L, Chen Y, Li Q, Xu G, Ding K, Ren L, Shi W, Wang Y, Li Z, Dai W, Wei Z, Yang Y, Bai Z, Xiao X
Journal of ethnopharmacology 2022 Mar 1;285:114796

Involvement of pyroptosis pathway in epicardial adipose tissue - myocardium axis in experimental heart failure with preserved ejection fraction.

Xia YY, Shi Y, Li Z, Li H, Wu LD, Zhou WY, Gu Y, Ling ZY, Zhang JX, Chen SL
Biochemical and biophysical research communications 2022 Dec 25;636(Pt 2):62-70

Acquiring high expression of suilysin enable non-epidemic Streptococccus suis to cause streptococcal toxic shock-like syndrome (STSLS) through NLRP3 inflammasome hyperactivation.

Xu L, Lin L, Lu X, Xiao P, Liu R, Wu M, Jin M, Zhang A
Emerging microbes & infections 2021 Dec;10(1):1309-1319

An NLRP3 inflammasome-triggered cytokine storm contributes to Streptococcal toxic shock-like syndrome (STSLS).

Lin L, Xu L, Lv W, Han L, Xiang Y, Fu L, Jin M, Zhou R, Chen H, Zhang A
PLoS pathogens 2019 Jun;15(6):e1007795

Cell Death Is Counteracted by Mitophagy in HIV-Productively Infected Astrocytes but Is Promoted by Inflammasome Activation Among Non-productively Infected Cells.

Ojeda DS, Grasso D, Urquiza J, Till A, Vaccaro MI, Quarleri J
Frontiers in immunology 2018;9:2633

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