HPA038237

antibody from Atlas Antibodies

Targeting: TCOF1 TCS, treacle

Western blot (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

HPA038237

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA038237, RRID:AB_10670660

Product name

Anti-TCOF1

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human TCOF1, Gene description: Treacher Collins-Franceschetti syndrome 1, Alternative Gene Names: TCS, treacle, Validated applications: ICC, IHC, WB, Uniprot ID: Q13428, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.2 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

FOSL1 is a key regulator of a super-enhancer driving TCOF1 expression in triple-negative breast cancer

He Q, Hu J, Huang H, Wu T, Li W, Ramakrishnan S, Pan Y, Chan K, Zhang L, Yang M, Wang X, Chin Y
Epigenetics & Chromatin 2024;17(1)

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Ribosome biosynthesis and Hedgehog activity are cooperative actionable signaling mechanisms in breast cancer following radiotherapy

Metge B, Alsheikh H, Chen D, Elhamamsy A, Hinshaw D, Chen B, Sleckman B, Samant R, Shevde L
npj Precision Oncology 2023;7(1)

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Nucleolar Protein Treacle Is Important for the Efficient Growth of Mumps Virus

Wakata A, Katoh H, Kato F, Takeda M, Dutch R
Journal of Virology 2022;96(19)

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53BP1-mediated recruitment of RASSF1A to ribosomal DNA breaks promotes local ATM signaling.

Tsaridou S, Velimezi G, Willenbrock F, Chatzifrangkeskou M, Elsayed W, Panagopoulos A, Karamitros D, Gorgoulis V, Lygerou Z, Roukos V, O'Neill E, Pefani DE
EMBO reports 2022 Aug 3;23(8):e54483

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Treacle and TOPBP1 control replication stress response in the nucleolus

Velichko A, Ovsyannikova N, Petrova N, Luzhin A, Vorobjeva M, Gavrikov A, Mishin A, Kireev I, Razin S, Kantidze O
Journal of Cell Biology 2021;220(8)

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TCOF1 upregulation in triple-negative breast cancer promotes stemness and tumour growth and correlates with poor prognosis

Hu J, Lai Y, Huang H, Ramakrishnan S, Pan Y, Ma V, Cheuk W, So G, He Q, Geoffrey Lau C, Zhang L, Cho W, Chan K, Wang X, Rebecca Chin Y
British Journal of Cancer 2021;126(1):57-71

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Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation

Mooser C, Symeonidou I, Leimbacher P, Ribeiro A, Shorrocks A, Jungmichel S, Larsen S, Knechtle K, Jasrotia A, Zurbriggen D, Jeanrenaud A, Leikauf C, Fink D, Nielsen M, Blackford A, Stucki M
Nature Communications 2020;11(1)

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Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

Lambert J, Picaud S, Fujisawa T, Hou H, Savitsky P, Uusküla-Reimand L, Gupta G, Abdouni H, Lin Z, Tucholska M, Knight J, Gonzalez-Badillo B, St-Denis N, Newman J, Stucki M, Pelletier L, Bandeira N, Wilson M, Filippakopoulos P, Gingras A
Molecular Cell 2019;73(3):621-638.e17

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Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repair

Korsholm L, Gál Z, Lin L, Quevedo O, Ahmad D, Dulina E, Luo Y, Bartek J, Larsen D
Nucleic Acids Research 2019;47(15):8019-8035

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Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription

Velichko A, Petrova N, Luzhin A, Strelkova O, Ovsyannikova N, Kireev I, Petrova N, Razin S, Kantidze O
Nucleic Acids Research 2019;47(13):6811-6825

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The NBS1–Treacle complex controls ribosomal RNA transcription in response to DNA damage

Larsen D, Hari F, Clapperton J, Gwerder M, Gutsche K, Altmeyer M, Jungmichel S, Toledo L, Fink D, Rask M, Grøfte M, Lukas C, Nielsen M, Smerdon S, Lukas J, Stucki M
Nature Cell Biology 2014;16(8):792-803