Antibody data
- Antibody Data
- Antigen structure
- References [61]
- Comments [0]
- Validations
- Immunohistochemistry [1]
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- Product number
- 22524-1-AP - Provider product page

- Provider
- Proteintech Group
- Product name
- DAT antibody
- Antibody type
- Polyclonal
- Description
- DAT antibody (Cat. #22524-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The engineered probiotic strain Lactococcus lactis MG1363-pMG36e-GLP-1 regulates microglial polarization and gut dysbiosis in a transgenic mouse model of Parkinson's disease.
Microengineering of the capillary interface of midbrain dopaminergic neurons to study Parkinson's disease vascular alterations.
NAD+-Boosters Improve Mitochondria Quality Control In Parkinson's Disease Models Via Mitochondrial UPR.
Brain insulin signaling restores deficits in striatal dopamine release in overweight male mice with preexisting low D2-receptor expression.
The selenocysteine-containing protein SELENOT maintains dopamine signaling in the midbrain to protect mice from hyperactivity disorder.
Disruption of axonal transport in Parkinson's disease: the role of pathological α-Syn and AMPK/p38 MAPK signaling.
Propagation of pathologic α-synuclein from kidney to brain may contribute to Parkinson's disease.
α-Conotoxin TxIB Reversed Nicotine-Induced Locomotor Sensitization and Nicotine-Enhanced Dopaminergic Activity in Mice.
Alpha-synuclein Fibrils Inhibit Activation of the BDNF/ERK Signaling Loop in the mPFC to Induce Parkinson's Disease-like Alterations with Depression.
GDF15 attenuates Parkinson's disease progression via suppressing the activation of cGAS-STING pathway.
A nanoparticle-based wireless deep brain stimulation system that reverses Parkinson's disease.
Chronic adulthood exposure to bisphenol A causes behavioral changes via suppressing dopamine transporter trafficking.
Identification of novel biomarkers to distinguish clear cell and non-clear cell renal cell carcinoma using bioinformatics and machine learning.
Comparative analysis of uninduced and neuronally-induced human dental pulp stromal cells in a 6-OHDA model of Parkinson's disease.
Gastrodin relieves Parkinson's disease-related motor deficits by facilitating the MEK-dependent VMAT2 to maintain dopamine homeostasis.
An accelerated Parkinson's disease monkey model using AAV-α-synuclein plus poly(ADP-ribose).
Dopamine loss alters glutamate synapses and transporters in the medial prefrontal cortex and anxiety-related behaviour in a male MPTP rodent model of Parkinson's disease.
Ablation of NAMPT in dopaminergic neurons leads to neurodegeneration and induces Parkinson's disease in mouse.
Scoulerine: A natural isoquinoline alkaloid targeting SLC6A3 to treat RCC.
Effects of latroeggtoxin-VI on dopamine and α-synuclein in PC12 cells and the implications for Parkinson's disease.
Impaired Response to Mismatch Novelty in the Li(2+)-Pilocarpine Rat Model of TLE: Correlation with Hippocampal Monoaminergic Inputs.
Sleep and Pain: A Role for the Anterior Cingulate Cortex, Nucleus Accumbens, and Dopamine in the Increased Pain Sensitivity Following Sleep Restriction.
Dopamine regulates colonic glial cell-derived neurotrophic factor secretion through cholinergic dependent and independent pathways.
BL-918 activates PINK1/Parkin signaling pathway to ameliorate the progression of Parkinson's disease.
Phosphoglycerate kinase is a central leverage point in Parkinson's disease-driven neuronal metabolic deficits.
Electroacupuncture alleviated depression-like behaviors in ventromedial prefrontal cortex of chronic unpredictable mild stress-induced rats: Increasing synaptic transmission and phosphorylating dopamine transporter.
Recovery of motor function is associated with rescue of glutamate biomarkers in the striatum and motor cortex following treatment with Mucuna pruriens in a murine model of Parkinsons disease.
Low-dose Cu exposure enhanced α-synuclein accumulation associates with mitochondrial impairments in mice model of Parkinson's disease.
Effectiveness of exercise and pramipexole in the treatment of restless leg syndrome: Implications on the dopaminergic system and PTPRD.
Phosphoglycerate kinase is a central leverage point in Parkinson's Disease driven neuronal metabolic deficits.
Socially Mediated Shift in Neural Circuits Activation Regulated by Synergistic Neuromodulatory Signaling.
Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons.
Dysregulation of striatal dopamine D2/D3 receptor-mediated by hypocretin induces depressive behaviors in rats.
Components of the sympathetic nervous system as targets to modulate inflammation - rheumatoid arthritis synovial fibroblasts as neuron-like cells?
Multi-omics analysis reveals BDE47 induces depression-like behaviors in mice by interfering with the 2-arachidonoyl glycerol-associated microbiota-gut-brain axis.
Exendin-4 and linagliptin attenuate neuroinflammation in a mouse model of Parkinson's disease.
Focused Ultrasound Promotes the Delivery of Gastrodin and Enhances the Protective Effect on Dopaminergic Neurons in a Mouse Model of Parkinson's Disease.
Fine Particulate Matter Triggers α-Synuclein Fibrillization and Parkinson-like Neurodegeneration.
Sleep Disturbance Alters Cocaine-Induced Locomotor Activity: Involvement of Striatal Neuroimmune and Dopamine Signaling.
Dopamine-related oxidative stress and mitochondrial dysfunction in dopaminergic neurons differentiated from deciduous teeth-derived stem cells of children with Down syndrome.
FMR1 deletion in rats induces hyperactivity with no changes in striatal dopamine transporter availability.
Reconstituting neurovascular unit with primary neural stem cells and brain microvascular endothelial cells in three-dimensional matrix.
Exposure to Melamine cyanuric acid in adolescent mice caused emotional disorder and behavioral disorder.
Asparagine endopeptidase cleaves synaptojanin 1 and triggers synaptic dysfunction in Parkinson's disease.
The neuroprotective effects of isoquercitrin purified from apple pomace by high-speed countercurrent chromatography in the MPTP acute mouse model of Parkinson's disease.
Iron deficiency in pregnancy: Influence on sleep, behavior, and molecular markers of adult male offspring.
Gait Deficits and Loss of Striatal Tyrosine Hydroxlase/Trk-B are Restored Following 7,8-Dihydroxyflavone Treatment in a Progressive MPTP Mouse Model of Parkinson's Disease.
Reversing a model of Parkinson's disease with in situ converted nigral neurons.
PLRP2 selectively localizes synaptic membrane proteins via acyl-chain remodeling of phospholipids.
Catalpol Exerts a Neuroprotective Effect in the MPTP Mouse Model of Parkinson's Disease.
Differentiation of adult human retinal pigment epithelial cells into dopaminergic-like cells in vitro and in the recipient monkey brain.
Effects of sleep disruption on stress, nigrostriatal markers, and behavior in a chronic/progressive MPTP male mouse model of parkinsonism.
Andrographolide alleviates Parkinsonism in MPTP-PD mice via targeting mitochondrial fission mediated by dynamin-related protein 1.
The loss of dopaminergic neurons in DEC1 deficient mice potentially involves the decrease of PI3K/Akt/GSK3β signaling.
Glatiramer Acetate Reverses Motor Dysfunction and the Decrease in Tyrosine Hydroxylase Levels in a Mouse Model of Parkinson's Disease.
Downregulation of DEC1 contributes to the neurotoxicity induced by MPP(+) by suppressing PI3K/Akt/GSK3β pathway.
Exercise in an animal model of Parkinson's disease: Motor recovery but not restoration of the nigrostriatal pathway.
Echinacoside's nigrostriatal dopaminergic protection against 6-OHDA-Induced endoplasmic reticulum stress through reducing the accumulation of Seipin.
Exercise intervention increases spontaneous locomotion but fails to attenuate dopaminergic system loss in a progressive MPTP model in aged mice.
Intervention with exercise restores motor deficits but not nigrostriatal loss in a progressive MPTP mouse model of Parkinson's disease.
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Effectiveness of exercise and pramipexole in the treatment of restless leg syndrome: Implications on the dopaminergic system and PTPRD.
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Phosphoglycerate kinase is a central leverage point in Parkinson's Disease driven neuronal metabolic deficits.
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Neural regeneration research 2023 Aug;18(8):1818-1826
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Biomedicines 2022 May 18;10(5)
Dopamine-related oxidative stress and mitochondrial dysfunction in dopaminergic neurons differentiated from deciduous teeth-derived stem cells of children with Down syndrome.
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FASEB bioAdvances 2022 Jul;4(7):454-467
FASEB bioAdvances 2022 Jul;4(7):454-467
FMR1 deletion in rats induces hyperactivity with no changes in striatal dopamine transporter availability.
D'Elia A, Schiavi S, Manduca A, Rava A, Buzzelli V, Ascone F, Orsini T, Putti S, Soluri A, Galli F, Soluri A, Mattei M, Cicconi R, Massari R, Trezza V
Scientific reports 2022 Dec 29;12(1):22535
Scientific reports 2022 Dec 29;12(1):22535
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Brain pathology (Zurich, Switzerland) 2021 Sep;31(5):e12940
Brain pathology (Zurich, Switzerland) 2021 Sep;31(5):e12940
Exposure to Melamine cyanuric acid in adolescent mice caused emotional disorder and behavioral disorder.
Wang S, Zhang J, Zhang S, Shi F, Feng D, Feng X
Ecotoxicology and environmental safety 2021 Mar 15;211:111938
Ecotoxicology and environmental safety 2021 Mar 15;211:111938
Asparagine endopeptidase cleaves synaptojanin 1 and triggers synaptic dysfunction in Parkinson's disease.
Zou L, Zhang X, Xiong M, Meng L, Tian Y, Pan L, Yuan X, Chen G, Wang Z, Bu L, Yao Z, Zhang Z, Ye K, Zhang Z
Neurobiology of disease 2021 Jul;154:105326
Neurobiology of disease 2021 Jul;154:105326
The neuroprotective effects of isoquercitrin purified from apple pomace by high-speed countercurrent chromatography in the MPTP acute mouse model of Parkinson's disease.
Liu C, Wang W, Li H, Liu J, Zhang P, Cheng Y, Qin X, Hu Y, Wei Y
Food & function 2021 Jul 7;12(13):6091-6101
Food & function 2021 Jul 7;12(13):6091-6101
Iron deficiency in pregnancy: Influence on sleep, behavior, and molecular markers of adult male offspring.
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Journal of neuroscience research 2021 Dec;99(12):3325-3338
Journal of neuroscience research 2021 Dec;99(12):3325-3338
Gait Deficits and Loss of Striatal Tyrosine Hydroxlase/Trk-B are Restored Following 7,8-Dihydroxyflavone Treatment in a Progressive MPTP Mouse Model of Parkinson's Disease.
Massaquoi MS, Liguore WA, Churchill MJ, Moore C, Melrose HL, Meshul CK
Neuroscience 2020 May 1;433:53-71
Neuroscience 2020 May 1;433:53-71
Reversing a model of Parkinson's disease with in situ converted nigral neurons.
Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD
Nature 2020 Jun;582(7813):550-556
Nature 2020 Jun;582(7813):550-556
PLRP2 selectively localizes synaptic membrane proteins via acyl-chain remodeling of phospholipids.
Kuge H, Miyamoto I, Yagyu KI, Honke K
Journal of lipid research 2020 Dec;61(12):1747-1763
Journal of lipid research 2020 Dec;61(12):1747-1763
Catalpol Exerts a Neuroprotective Effect in the MPTP Mouse Model of Parkinson's Disease.
Wang LY, Yu X, Li XX, Zhao YN, Wang CY, Wang ZY, He ZY
Frontiers in aging neuroscience 2019;11:316
Frontiers in aging neuroscience 2019;11:316
Differentiation of adult human retinal pigment epithelial cells into dopaminergic-like cells in vitro and in the recipient monkey brain.
Li S, Zhang H, Wang A, Liu Y, Liu H, Yue F, Abulaiti X, Zhang C, Li L
Molecular medicine (Cambridge, Mass.) 2019 Mar 29;25(1):9
Molecular medicine (Cambridge, Mass.) 2019 Mar 29;25(1):9
Effects of sleep disruption on stress, nigrostriatal markers, and behavior in a chronic/progressive MPTP male mouse model of parkinsonism.
Xu M, Bohlen JK, Moore C, Nipper MA, Finn DA, Jones CE, Lim MM, Meshul CK
Journal of neuroscience research 2019 Dec;97(12):1706-1719
Journal of neuroscience research 2019 Dec;97(12):1706-1719
Andrographolide alleviates Parkinsonism in MPTP-PD mice via targeting mitochondrial fission mediated by dynamin-related protein 1.
Geng J, Liu W, Gao J, Jiang C, Fan T, Sun Y, Qin ZH, Xu Q, Guo W, Gao J
British journal of pharmacology 2019 Dec;176(23):4574-4591
British journal of pharmacology 2019 Dec;176(23):4574-4591
The loss of dopaminergic neurons in DEC1 deficient mice potentially involves the decrease of PI3K/Akt/GSK3β signaling.
Zhu Z, Yichen W, Ziheng Z, Dinghao G, Ming L, Wei L, Enfang S, Gang H, Honda H, Jian Y
Aging 2019 Dec 28;11(24):12733-12753
Aging 2019 Dec 28;11(24):12733-12753
Glatiramer Acetate Reverses Motor Dysfunction and the Decrease in Tyrosine Hydroxylase Levels in a Mouse Model of Parkinson's Disease.
Churchill MJ, Cantu MA, Kasanga EA, Moore C, Salvatore MF, Meshul CK
Neuroscience 2019 Aug 21;414:8-27
Neuroscience 2019 Aug 21;414:8-27
Downregulation of DEC1 contributes to the neurotoxicity induced by MPP(+) by suppressing PI3K/Akt/GSK3β pathway.
Zhu Z, Wang YW, Ge DH, Lu M, Liu W, Xiong J, Hu G, Li XP, Yang J
CNS neuroscience & therapeutics 2017 Sep;23(9):736-747
CNS neuroscience & therapeutics 2017 Sep;23(9):736-747
Exercise in an animal model of Parkinson's disease: Motor recovery but not restoration of the nigrostriatal pathway.
Churchill MJ, Pflibsen L, Sconce MD, Moore C, Kim K, Meshul CK
Neuroscience 2017 Sep 17;359:224-247
Neuroscience 2017 Sep 17;359:224-247
Echinacoside's nigrostriatal dopaminergic protection against 6-OHDA-Induced endoplasmic reticulum stress through reducing the accumulation of Seipin.
Zhang Y, Long H, Zhou F, Zhu W, Ruan J, Zhao Y, Lu Y
Journal of cellular and molecular medicine 2017 Dec;21(12):3761-3775
Journal of cellular and molecular medicine 2017 Dec;21(12):3761-3775
Exercise intervention increases spontaneous locomotion but fails to attenuate dopaminergic system loss in a progressive MPTP model in aged mice.
Hood RL, Liguore WA, Moore C, Pflibsen L, Meshul CK
Brain research 2016 Sep 1;1646:535-542
Brain research 2016 Sep 1;1646:535-542
Intervention with exercise restores motor deficits but not nigrostriatal loss in a progressive MPTP mouse model of Parkinson's disease.
Sconce MD, Churchill MJ, Greene RE, Meshul CK
Neuroscience 2015 Jul 23;299:156-74
Neuroscience 2015 Jul 23;299:156-74
Protective effects of cholecystokinin-8 on methamphetamine-induced behavioral changes and dopaminergic neurodegeneration in mice.
Gou H, Wen D, Ma C, Li M, Li Y, Zhang W, Liu L, Cong B
Behavioural brain research 2015 Apr 15;283:87-96
Behavioural brain research 2015 Apr 15;283:87-96
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The DAT antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human DAT. This antibody recognizes human, mouse, rat antigen. The DAT antibody has been validated for the following applications: ELISA, WB, IHC analysis.