Antibody data
- Antibody Data
- Antigen structure
- References [59]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 55084-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#55084-1-AP, RRID:AB_10859941
- Product name
- DRD2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DRD2 antibody (Cat. #55084-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Tetrahydrocoptisine alleviates postoperative delirium with sleep disturbances by modulating the TH/NLRP3 Inflammasome pathway.
Pharmacologic targeting of the dopamine D2 receptor impacts the efficacy of immune checkpoint blockade in melanoma.
Perinatal hyperandrogenization and immune activation in rodents model subtypes of autism.
Increased social reward behavior in adolescent male and female rats exposed prenatally to alcohol is associated with altered dopamine receptor expression.
The effect of clavulanic acid on the development of tolerance and dependence induced by morphine in mice: role of DRD2 and NR1 genes, oxidative stress, and GDNF protein.
Extracellular Vesicles Derived from FGF2-Primed Astrocytes Against Mitochondrial and Synaptic Toxicities in Parkinson's Disease.
Dopamine D2S/D2L Receptor Regulation of Alcohol-Induced Reward and Signalling.
Transcriptomic analysis and experiment to verify the mechanism of Xiaoyao san in the treatment of irritable bowel syndrome with depression.
Distinct Transcriptomic Profiles of Cultured Anterior and Posterior Populations of Human Infant Scleral Fibroblasts: Including Dopamine Receptors.
Co-Expression of Tardive Dyskinesia and Drug-Induced Parkinsonism in Rats Chronically Treated With Haloperidol.
Repurposing Caffeine, Metformin, and Furosemide to Target Schizophrenia-Related Impairments in a Triple-Hit Rat Model.
Repeated treatment with JWH-018 progressively increases motor activity and aggressiveness in male mice: involvement of CB(1) cannabinoid and D(1)/D(2) dopaminergic receptors.
Chaihu Guizhi Decoction prevents cognitive, memory impairments and sensorimotor gating deficit induced by N-methyl-d-aspartate receptor antibody in mice.
Interrogation of RNA-bound proteome with XRNAX illuminates molecular alterations in the mouse brain affected with dysmyelination.
Neuroligin 1 Regulates Autistic-Like Repetitive Behavior through Modulating the Activity of Striatal D2 Receptor-Expressing Medium Spiny Neurons.
The neurons in NAc core receiving ACC excitatory afferents contribute to chronic postoperative pain.
Optogenetic-induced α-synuclein accumulation reveals early synaptic dysfunction in experimental models of Parkinson's disease.
A piperidinyl indole derivative, potential complement factor B inhibitor, plays a renoprotective role in diabetic nephropathy.
Dopaminergic neurons in the ventral periaqueductal gray projecting to the dorsal lateral septum regulate comorbid pain and anxiety.
Cholesterol-activated stress granules reduce the membrane localization of DRD2 and promote prolactinoma dopamine agonists resistance.
Total Alkaloid Extract of Nelumbinis Plumula Promoted Sleep in PCPA-Induced Insomnia Rats by Affecting Neurotransmitters and Their Receptor Activities.
Long-life triclosan exposure induces ADHD-like behavior in rats via prefrontal cortex dopaminergic deficiency.
Theobromine improves hyperactivity, inattention, and working memory via modulation of dopaminergic neural function in the frontal cortex of spontaneously hypertensive rats.
Dopamine D2 Receptor Activation Blocks GluA2/ROS Positive Feedback Loop to Alienate Chronic-Migraine-Associated Pain Sensitization.
Pramipexole improves depression-like behavior in diabetes mellitus with depression rats by inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing impaired neuroplasticity.
Non-canonical interplay between glutamatergic NMDA and dopamine receptors shapes synaptogenesis.
Intranasal Delivery of Near-Infrared and Magnetic Dual-Response Nanospheres to Rapidly Produce Antidepressant-Like and Cognitive Enhancement Effects.
Pathological characteristics of axons and alterations of proteomic and lipidomic profiles in midbrain dopaminergic neurodegeneration induced by WDR45-deficiency.
Dopamine D2-receptor neurons in nucleus accumbens regulate sevoflurane anesthesia in mice.
Neuropathological features of levodopa-responsive parkinsonism in multiple system atrophy: an autopsy case report and comparative neuropathological study.
Network pharmacology, molecular docking, and experimental validation to explore the potential mechanism of Long Mu Qing Xin mixture for the treatment of attention deficit hyperactivity disorder.
Amphiregulin blockade decreases the levodopa-induced dyskinesia in a 6-hydroxydopamine Parkinson's disease mouse model.
Dopaminergic Projections from the Hypothalamic A11 Nucleus to the Spinal Trigeminal Nucleus Are Involved in Bidirectional Migraine Modulation.
Deep learning-based image analysis identifies a DAT-negative subpopulation of dopaminergic neurons in the lateral Substantia nigra.
5-HT4 Receptor is Protective for MPTP-induced Parkinson's Disease Mice Via Altering Gastrointestinal Motility or Gut Microbiota.
Thrombospondin1 mimics rapidly relieve depression via Shank3 dependent uncoupling between dopamine D1 and D2 receptors.
Knockout of Dopamine D3 Receptor Gene Blocked Methamphetamine-Induced Distinct Changes of Dopaminergic and Glutamatergic Synapse in the Nucleus Accumbens Shell of Mice.
Total Barley Maiya Alkaloids Prevent Increased Prolactin Levels Caused by Antipsychotic Drugs and Reduce Dopamine Receptor D2 via Epigenetic Mechanisms.
Electroacupuncture Alleviates Anxiety-Like Behaviors Induced by Chronic Neuropathic Pain via Regulating Different Dopamine Receptors of the Basolateral Amygdala.
Biochemical Neuroadaptations in the Rat Striatal Dopaminergic System after Prolonged Exposure to Methamphetamine Self-Administration.
ZBTB20 Regulates Prolactin Expression and Lactotrope Function in Adult Mice.
Mechanistic analysis of erectile dysfunction in a depression rat model.
Dopamine D2 receptors in the nucleus accumbens modulate erectile function in a rat model of nonorganic erectile dysfunction.
Xiaoyao San ameliorates high-fat diet-induced anxiety and depression via regulating gut microbiota in mice.
Dopamine receptor D2 regulates GLUA1-containing AMPA receptor trafficking and central sensitization through the PI3K signaling pathway in a male rat model of chronic migraine.
The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas.
Dopamine receptor D2 inhibition alleviates diabetic hepatic stellate cells fibrosis by regulating the TGF-β1/Smads and NFκB pathways.
ZFP804A mutant mice display sex-dependent schizophrenia-like behaviors.
Total barley maiya alkaloids inhibit prolactin secretion by acting on dopamine D2 receptor and protein kinase A targets.
Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons.
A high-throughput screen identifies inhibitors of lung cancer stem cells.
Targeting Cancer Stem Cells with Differentiation Agents as an Alternative to Genotoxic Chemotherapy for the Treatment of Malignant Testicular Germ Cell Tumors.
The ancient Chinese formula Longdan Xiegan Tang improves antipsychotic-induced hyperprolactinemia by repairing the hypothalamic and pituitary TGF-β1 signaling in rats.
Paeoniflorin ameliorates antipsychotic-induced hyperprolactinemia in rats by attenuating impairment of the dopamine D2 receptor and TGF-β1 signaling pathways in the hypothalamus and pituitary.
Targeting Dopamine Receptor D2 by Imipridone Suppresses Uterine Serous Cancer Malignant Phenotype.
Dopamine D2 receptors in the basolateral amygdala modulate erectile function in a rat model of nonorganic erectile dysfunction.
Development of a peptide targeting dopamine transporter to improve ADHD-like deficits.
Protective Effect of Curcumin by Modulating BDNF/DARPP32/CREB in Arsenic-Induced Alterations in Dopaminergic Signaling in Rat Corpus Striatum.
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Cholesterol-activated stress granules reduce the membrane localization of DRD2 and promote prolactinoma dopamine agonists resistance.
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Long-life triclosan exposure induces ADHD-like behavior in rats via prefrontal cortex dopaminergic deficiency.
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Dopamine D2 Receptor Activation Blocks GluA2/ROS Positive Feedback Loop to Alienate Chronic-Migraine-Associated Pain Sensitization.
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Pramipexole improves depression-like behavior in diabetes mellitus with depression rats by inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing impaired neuroplasticity.
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Frontiers in molecular neuroscience 2023;16:1287160
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International journal of molecular sciences 2023 Nov 28;24(23)
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iScience 2023 Apr 21;26(4):106488
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Frontiers in cellular neuroscience 2022;16:893190
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Frontiers in pharmacology 2022;13:888522
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Molecular neurobiology 2022 Sep;59(9):5299-5311
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International journal of molecular sciences 2022 Sep 3;23(17)
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Endocrinology 2022 Oct 23;163(12)
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The Journal of international medical research 2022 May;50(5):3000605221100334
Dopamine D2 receptors in the nucleus accumbens modulate erectile function in a rat model of nonorganic erectile dysfunction.
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Andrology 2022 May;10(4):808-817
Andrology 2022 May;10(4):808-817
Xiaoyao San ameliorates high-fat diet-induced anxiety and depression via regulating gut microbiota in mice.
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Dec;156:113902
Dopamine receptor D2 regulates GLUA1-containing AMPA receptor trafficking and central sensitization through the PI3K signaling pathway in a male rat model of chronic migraine.
Zhang W, Lei M, Wen Q, Zhang D, Qin G, Zhou J, Chen L
The journal of headache and pain 2022 Aug 10;23(1):98
The journal of headache and pain 2022 Aug 10;23(1):98
The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas.
Wang S, Wang A, Zhang Y, Zhu K, Wang X, Chen Y, Wu J
BMC endocrine disorders 2021 Nov 23;21(1):235
BMC endocrine disorders 2021 Nov 23;21(1):235
Dopamine receptor D2 inhibition alleviates diabetic hepatic stellate cells fibrosis by regulating the TGF-β1/Smads and NFκB pathways.
Zhao B, Li S, Guo Z, Chen Z, Zhang X, Xu C, Chen J, Wei C
Clinical and experimental pharmacology & physiology 2021 Mar;48(3):370-380
Clinical and experimental pharmacology & physiology 2021 Mar;48(3):370-380
ZFP804A mutant mice display sex-dependent schizophrenia-like behaviors.
Huang Y, Huang J, Zhou QX, Yang CX, Yang CP, Mei WY, Zhang L, Zhang Q, Hu L, Hu YQ, Song NN, Wu SX, Xu L, Ding YQ
Molecular psychiatry 2021 Jun;26(6):2514-2532
Molecular psychiatry 2021 Jun;26(6):2514-2532
Total barley maiya alkaloids inhibit prolactin secretion by acting on dopamine D2 receptor and protein kinase A targets.
Gong X, Tao J, Wang Y, Wu J, An J, Meng J, Wang X, Chen Y, Zou J
Journal of ethnopharmacology 2021 Jun 12;273:113994
Journal of ethnopharmacology 2021 Jun 12;273:113994
Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons.
Kawahata I, Sekimori T, Wang H, Wang Y, Sasaoka T, Bousset L, Melki R, Mizobata T, Kawata Y, Fukunaga K
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Biomedicines 2021 Jan 8;9(1)
A high-throughput screen identifies inhibitors of lung cancer stem cells.
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Aug;140:111748
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Aug;140:111748
Targeting Cancer Stem Cells with Differentiation Agents as an Alternative to Genotoxic Chemotherapy for the Treatment of Malignant Testicular Germ Cell Tumors.
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Cancers 2021 Apr 23;13(9)
Cancers 2021 Apr 23;13(9)
The ancient Chinese formula Longdan Xiegan Tang improves antipsychotic-induced hyperprolactinemia by repairing the hypothalamic and pituitary TGF-β1 signaling in rats.
Ren L, Liu W, Wang C, Yang Y, Huang X, Wang C, Li Y
Journal of ethnopharmacology 2020 May 23;254:112572
Journal of ethnopharmacology 2020 May 23;254:112572
Paeoniflorin ameliorates antipsychotic-induced hyperprolactinemia in rats by attenuating impairment of the dopamine D2 receptor and TGF-β1 signaling pathways in the hypothalamus and pituitary.
Huang X, Ren L, Hou L, Fan H, Wang C, Wang C, Li Y
Journal of ethnopharmacology 2020 Jul 15;257:112862
Journal of ethnopharmacology 2020 Jul 15;257:112862
Targeting Dopamine Receptor D2 by Imipridone Suppresses Uterine Serous Cancer Malignant Phenotype.
Hu W, Zhang L, Ferri-Borgogno S, Kwan SY, Lewis KE, Cun HT, Yeung TL, Soliman PT, Tarapore RS, Allen JE, Guan X, Lu KH, Mok SC, Au-Yeung CL
Cancers 2020 Aug 27;12(9)
Cancers 2020 Aug 27;12(9)
Dopamine D2 receptors in the basolateral amygdala modulate erectile function in a rat model of nonorganic erectile dysfunction.
Chen G, Chen J, Yang B, Yu W, Chen Y, Dai Y
Andrologia 2019 Feb;51(1):e13160
Andrologia 2019 Feb;51(1):e13160
Development of a peptide targeting dopamine transporter to improve ADHD-like deficits.
Lai TKY, Su P, Zhang H, Liu F
Molecular brain 2018 Nov 9;11(1):66
Molecular brain 2018 Nov 9;11(1):66
Protective Effect of Curcumin by Modulating BDNF/DARPP32/CREB in Arsenic-Induced Alterations in Dopaminergic Signaling in Rat Corpus Striatum.
Srivastava P, Dhuriya YK, Gupta R, Shukla RK, Yadav RS, Dwivedi HN, Pant AB, Khanna VK
Molecular neurobiology 2018 Jan;55(1):445-461
Molecular neurobiology 2018 Jan;55(1):445-461
Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome.
Yan Y, Jiang W, Liu L, Wang X, Ding C, Tian Z, Zhou R
Cell 2015 Jan 15;160(1-2):62-73
Cell 2015 Jan 15;160(1-2):62-73
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The DRD2 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human DRD2. This antibody recognizes human, mouse, rat antigen. The DRD2 antibody has been validated for the following applications: ELISA, WB analysis.