BS8135

antibody from Bioworld Technology, Inc
Targeting: ZWINT KNTC2AP, SIP30, Zwint1
Provider product page for BS8135
Western blot
Immunohistochemistry

Antibody data

Product number
BS8135 - Provider product page
Provider
Bioworld Technology, Inc
Product name
ZWINT polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human ZWINT.
Description
ZWINT (ZW10 interactor), also known as KNTC2AP or HZwint-1, is a 277 amino acid protein that is involved in kinetochore function. Localized to the cytoplasm during interphase and to kinetochores from late prophase to anaphase, ZWINT interacts with ZW10 (Zeste White 10) and functions to regulate the association between ZW10 and kinetochores. Additionally, ZWINT is part of a kinetochore complex composed of proteins such as MIS12 (MIND kinetochore complex component) and PMF-1 (polyamine-modulated factor 1) that work in concert to ensure proper kinetochore formation and spindle checkpoint activity. Defects in the gene encoding ZWINT are associated with the pathogenesis of Roberts syndrome, an autosomal recessive disorder characterized by growth retardation due to premature chromosome separation.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
ZWINT protein structure - BS8135 shown in red.