APR00158G

antibody from Leading Biology

Targeting: FKBP8 FKBP38, FKBPr38

Western blot (Recommended by provider)

Antibody Data

Product number

APR00158G

Provider

Leading Biology

Product name

FKBP38 Antibody

Antibody type

Polyclonal

Description

FK506-binding protein 38 (FKBP38), a member of the immunophilin family, has been implicated to play an important role in apoptosis thro μgh its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane (OMM). Suppression of endogenous FKBP38 by RNAi or transfection of a mutant FKBK38 missing the transmembrane domain necessary for mitochondrial insertion, resulted in the translocation of Bcl-2 and Bcl-xL from the OMM to the cytosol. It has also been s μggested that FKBP38 may play a role in the cross-talk between the Bcl-2 and the Calcineurin/NF-AT apoptosis signaling pathways and in cell size regulation thro μgh interactions with tuberous sclerosis genes.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.