AP3B2

Adaptor protein complex 3 (AP-3 complex) is a heterotrimeric protein complex involved in the formation of clathrin-coated synaptic vesicles. The protein encoded by this gene represents the beta subunit of the neuron-specific AP-3 complex and was first identified as the target antigen in human paraneoplastic neurologic disorders. The encoded subunit binds clathrin and is phosphorylated by a casein kinase-like protein, which mediates synaptic vesicle coat assembly. Defects in this gene are a cause of early-onset epileptic encephalopathy. [provided by RefSeq, Feb 2017]

Description

Adaptor related protein complex 3 subunit beta 2

Tissue specificity

Tissue enhanced (brain, pituitary gland, retina)

Subcell location

Nucleoplasm, Golgi apparatus, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

15 (82659281 - 82710112)

Ensembl ID

ENSG00000103723  (ver. 103.38)

Orthologs

Mouse Ap3b2: ENSMUSG00000062444

UniProt

Q13367

neXtProt

NX_Q13367

Human splice variants
Mouse splice variants

Protein structure