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- Antigen structure
- References [18]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 15104-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15104-1-AP, RRID:AB_2207757
- Product name
- TNIP1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TNIP1 antibody (Cat. #15104-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Deletion of ABIN1-LIR motifs impairs hepatic lipid homeostasis and mitophagy via AMPK-TFEB axis in mice.
Protocol Development for CRISPR/Cas9 Knockout of the Anti-inflammatory Protein TNIP1 in HaCaT Keratinocytes.
STING induces HOIP-mediated synthesis of M1 ubiquitin chains to stimulate NF-κB signaling.
LncRNA-Gm17586 inhibits S.typhimurium mediated pyroptosis by promoting NLRP3 and Tnip1 binding.
TNFAIP3-interacting protein 1 (ABIN-1) negatively regulates caspase-8/FADD-dependent pyroptosis.
TNIP1 and Autophagy Receptors regulate STING Signaling.
Macrophage biomimetic nanoparticle-targeted functional extracellular vesicle micro-RNAs revealed via multiomics analysis alleviate sepsis-induced acute lung injury.
ABIN1 (Q478) is Required to Prevent Hematopoietic Deficiencies through Regulating Type I IFNs Expression.
TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.
A20 binding and inhibitor of nuclear factor kappa B (NF-κB)-1 (ABIN-1): a novel modulator of mitochondrial autophagy.
Ubiquitin-binding domain in ABIN1 is critical for regulating cell death and inflammation during development.
ABIN-1 is a key regulator in RIPK1-dependent apoptosis (RDA) and necroptosis, and ABIN-1 deficiency potentiates necroptosis-based cancer therapy in colorectal cancer.
S100A6 promotes proliferation and migration of HepG2 cells via increased ubiquitin-dependent degradation of p53.
ABIN-1 protects chondrocytes from lipopolysaccharide-induced inflammatory injury through the inactivation of NF-κB signalling.
A20 and ABIN1 Suppression of a Keratinocyte Inflammatory Program with a Shared Single-Cell Expression Signature in Diverse Human Rashes.
ABIN1 inhibits HDAC1 ubiquitination and protects it from both proteasome- and lysozyme-dependent degradation.
Immune regulator ABIN1 suppresses HIV-1 transcription by negatively regulating the ubiquitination of Tat.
A functional genomics screen for microRNA regulators of NF-kappaB signaling.
Huber LS, Merline R, Zeng-Brouwers J, Vutukuri R, Kraus N, Ortiz C, Guenther S, Buhl EM, Hahnefeld L, Gurke R, Bein J, Karimova M, Wurzel P, Boor P, Welsch C, Wild P, Pfeilschifter J, Kögel D, Wygrecka M, Trebicka J, Bartoszewski R, Dikic I, Schaefer L
American journal of physiology. Cell physiology 2025 Nov 1;329(5):C1360-C1379
American journal of physiology. Cell physiology 2025 Nov 1;329(5):C1360-C1379
Protocol Development for CRISPR/Cas9 Knockout of the Anti-inflammatory Protein TNIP1 in HaCaT Keratinocytes.
Carman LE, Samulevich ML, Aneskievich BJ
Methods in molecular biology (Clifton, N.J.) 2025 Mar 20;
Methods in molecular biology (Clifton, N.J.) 2025 Mar 20;
STING induces HOIP-mediated synthesis of M1 ubiquitin chains to stimulate NF-κB signaling.
Fischer TD, Bunker EN, Zhu PP, Le Guerroué F, Hadjian M, Dominguez-Martin E, Scavone F, Cohen R, Yao T, Wang Y, Werner A, Youle RJ
The EMBO journal 2025 Jan;44(1):141-165
The EMBO journal 2025 Jan;44(1):141-165
LncRNA-Gm17586 inhibits S.typhimurium mediated pyroptosis by promoting NLRP3 and Tnip1 binding.
An Z, Ding W
Scientific reports 2025 Feb 25;15(1):6713
Scientific reports 2025 Feb 25;15(1):6713
TNFAIP3-interacting protein 1 (ABIN-1) negatively regulates caspase-8/FADD-dependent pyroptosis.
Li X, Wang D, Su Z, Mao X
The FEBS journal 2025 Apr;292(8):1972-1990
The FEBS journal 2025 Apr;292(8):1972-1990
TNIP1 and Autophagy Receptors regulate STING Signaling.
Bunker EN, Fischer TD, Zhu PP, Le Guerroué F, Youle RJ
bioRxiv : the preprint server for biology 2025 Apr 23;
bioRxiv : the preprint server for biology 2025 Apr 23;
Macrophage biomimetic nanoparticle-targeted functional extracellular vesicle micro-RNAs revealed via multiomics analysis alleviate sepsis-induced acute lung injury.
Wang G, Ma X, Huang W, Wang S, Lou A, Wang J, Tu Y, Cui W, Zhou W, Zhang W, Li Y, Geng S, Meng Y, Li X
Journal of nanobiotechnology 2024 Jun 23;22(1):362
Journal of nanobiotechnology 2024 Jun 23;22(1):362
ABIN1 (Q478) is Required to Prevent Hematopoietic Deficiencies through Regulating Type I IFNs Expression.
Wu X, Wang Y, Chen B, Liu Y, Li F, Ou Y, Zhang H, Wu X, Li X, Wang L, Rong W, Liu J, Xing M, Zhao X, Liu H, Ge L, Lv A, Wang L, Wang Z, Li M, Zhang H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jan;11(3):e2303555
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jan;11(3):e2303555
TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.
Le Guerroué F, Bunker EN, Rosencrans WM, Nguyen JT, Basar MA, Werner A, Chou TF, Wang C, Youle RJ
Molecular cell 2023 Mar 16;83(6):927-941.e8
Molecular cell 2023 Mar 16;83(6):927-941.e8
A20 binding and inhibitor of nuclear factor kappa B (NF-κB)-1 (ABIN-1): a novel modulator of mitochondrial autophagy.
Merline R, Rödig H, Zeng-Brouwers J, Poluzzi C, Tascher G, Michaelis J, Lopez-Mosqueda J, Rhiner A, Huber LS, Diehl V, Dikic I, Kögel D, Münch C, Wygrecka M, Schaefer L
American journal of physiology. Cell physiology 2023 Feb 1;324(2):C339-C352
American journal of physiology. Cell physiology 2023 Feb 1;324(2):C339-C352
Ubiquitin-binding domain in ABIN1 is critical for regulating cell death and inflammation during development.
Li M, Liu Y, Xu C, Zhao Q, Liu J, Xing M, Li X, Zhang H, Wu X, Wang L, Ou Y, Wu X, Zhao X, Liu H, Qiu L, Li F, Li J, Rong W, Luo Y, Deng J, Wang X, Wang Z, Zhao Y, Lv A, Li Q, Zhang H
Cell death and differentiation 2022 Oct;29(10):2034-2045
Cell death and differentiation 2022 Oct;29(10):2034-2045
ABIN-1 is a key regulator in RIPK1-dependent apoptosis (RDA) and necroptosis, and ABIN-1 deficiency potentiates necroptosis-based cancer therapy in colorectal cancer.
Cai J, Hu D, Sakya J, Sun T, Wang D, Wang L, Mao X, Su Z
Cell death & disease 2021 Feb 1;12(2):140
Cell death & disease 2021 Feb 1;12(2):140
S100A6 promotes proliferation and migration of HepG2 cells via increased ubiquitin-dependent degradation of p53.
Song D, Xu B, Shi D, Li S, Cai Y
Open medicine (Warsaw, Poland) 2020;15(1):317-326
Open medicine (Warsaw, Poland) 2020;15(1):317-326
ABIN-1 protects chondrocytes from lipopolysaccharide-induced inflammatory injury through the inactivation of NF-κB signalling.
Peng K, Li Y, Lu C, Hu S
Clinical and experimental pharmacology & physiology 2020 Jul;47(7):1212-1220
Clinical and experimental pharmacology & physiology 2020 Jul;47(7):1212-1220
A20 and ABIN1 Suppression of a Keratinocyte Inflammatory Program with a Shared Single-Cell Expression Signature in Diverse Human Rashes.
Harirchian P, Lee J, Hilz S, Sedgewick AJ, Perez White BE, Kesling MJ, Mully T, Golovato J, Gray M, Mauro TM, Purdom E, Kim EA, Sbitany H, Bhutani T, Vaske CJ, Benz SC, Cho RJ, Cheng JB
The Journal of investigative dermatology 2019 Jun;139(6):1264-1273
The Journal of investigative dermatology 2019 Jun;139(6):1264-1273
ABIN1 inhibits HDAC1 ubiquitination and protects it from both proteasome- and lysozyme-dependent degradation.
Ma Y, Yuan S, Tian X, Lin S, Wei S, Hu T, Chen S, Li X, Chen S, Wu D, Wang M, Guo D
Journal of cellular biochemistry 2018 Apr;119(4):3030-3043
Journal of cellular biochemistry 2018 Apr;119(4):3030-3043
Immune regulator ABIN1 suppresses HIV-1 transcription by negatively regulating the ubiquitination of Tat.
Chen S, Yang X, Cheng W, Ma Y, Shang Y, Cao L, Chen S, Chen Y, Wang M, Guo D
Retrovirology 2017 Feb 13;14(1):12
Retrovirology 2017 Feb 13;14(1):12
A functional genomics screen for microRNA regulators of NF-kappaB signaling.
Olarerin-George AO, Anton L, Hwang YC, Elovitz MA, Hogenesch JB
BMC biology 2013 Feb 28;11:19
BMC biology 2013 Feb 28;11:19
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 15104-1-AP(TNIP1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using TNIP1 antibody 15104-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lymphoma using 15104-1-AP(TNIP1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lymphoma using 15104-1-AP(TNIP1 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
