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- Antibody Data
- Antigen structure
- References [17]
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- Immunohistochemistry [2]
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- Product number
- 14590-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14590-1-AP, RRID:AB_2104394
- Product name
- FBXO2 antibody
- Antibody type
- Polyclonal
- Description
- FBXO2 antibody (Cat. #14590-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references p53 and fatty acids collaborate to trigger ferroptosis via the FBXO2-FABP5 axis in colorectal cancer.
FBXO2-mediated KPTN ubiquitination promotes amino acid-dependent mTORC1 signaling and tumor growth.
FBXO2 promotes hepatocellular carcinoma progression and sorafenib resistance by targeting USP49 for proteasomal degradation.
Fbxo2 inhibits cell proliferation, migration and invasion by the ubiquitin-mediated degradation of WEE1 in renal cell carcinoma.
Integrated mendelian randomization and bioinformatics approach unveiling the immunological and prognostic significance of FBXO2 in breast cancer.
FBXO2 as a switch guides a special fate of tumor clones evolving into a highly malignant transcriptional subtype in oral squamous cell carcinoma.
Fbxo2 suppresses prostate cancer progression by regulating YTHDF2 ubiquitination and degradation.
γδ T-cell autoresponses to ectopic membrane proteins: a new type of pattern recognition.
Muscle-derived small extracellular vesicles induce liver fibrosis during overtraining.
FBXO2 promotes the progression of papillary thyroid carcinoma through the p53 pathway.
Data-independent acquisition combined with liquid chromatography mass spectrometry technique to detect prognostic protein markers in type I gastric neuroendocrine neoplasm.
F-box only protein 2 exacerbates non-alcoholic fatty liver disease by targeting the hydroxyl CoA dehydrogenase alpha subunit.
Inhibition of histone methyltransferase Smyd3 rescues NMDAR and cognitive deficits in a tauopathy mouse model.
Early Wnt Signaling Activation Promotes Inner Ear Differentiation via Cell Caudalization in Mouse Stem Cell-Derived Organoids.
Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis.
FBXO2, a novel marker for metastasis in human gastric cancer.
Quantitative proteomics by SWATH-MS reveals sophisticated metabolic reprogramming in hepatocellular carcinoma tissues.
Tong J, Han T, Deng J, Gan Y, Ruan R, Zhao W, Xiong C, Liao Q, Chen S, Bu H, Xiong J, Zhou X, Hao Q
Redox biology 2026 Mar;90:104043
Redox biology 2026 Mar;90:104043
FBXO2-mediated KPTN ubiquitination promotes amino acid-dependent mTORC1 signaling and tumor growth.
Gao J, Qing J, Li X, Luo Y, Huang L, Li H, Zhang H, Zhang J, Xiao P, Li J, Li T, He S
The Journal of clinical investigation 2026 Feb 16;136(4)
The Journal of clinical investigation 2026 Feb 16;136(4)
FBXO2 promotes hepatocellular carcinoma progression and sorafenib resistance by targeting USP49 for proteasomal degradation.
Hang S, Wang Q, Zhang J, Dong Y, Hu B, Wang P, Xu L
Frontiers in immunology 2025;16:1660034
Frontiers in immunology 2025;16:1660034
Fbxo2 inhibits cell proliferation, migration and invasion by the ubiquitin-mediated degradation of WEE1 in renal cell carcinoma.
Wang L, Zang Y, Yang C, Xu M, Dai G, Xiang H, Ma J, Wang Z, Liu X, Xue B
Cellular oncology (Dordrecht, Netherlands) 2025 Oct;48(5):1495-1511
Cellular oncology (Dordrecht, Netherlands) 2025 Oct;48(5):1495-1511
Integrated mendelian randomization and bioinformatics approach unveiling the immunological and prognostic significance of FBXO2 in breast cancer.
Huang R, Chen Z, Mao M, Lai S, Li J
Discover oncology 2025 Nov 22;16(1):2187
Discover oncology 2025 Nov 22;16(1):2187
FBXO2 as a switch guides a special fate of tumor clones evolving into a highly malignant transcriptional subtype in oral squamous cell carcinoma.
Cheng J, Liu O, Bin X, Tang Z
Apoptosis : an international journal on programmed cell death 2025 Feb;30(1-2):167-184
Apoptosis : an international journal on programmed cell death 2025 Feb;30(1-2):167-184
Fbxo2 suppresses prostate cancer progression by regulating YTHDF2 ubiquitination and degradation.
Xu X, Dai G, Liu CL, Yao Q, Cai X, Wang Y, Chen Z, Liu K, Zhu J, Ma J, Wang Z, Xue B, Wang L
Cell death & disease 2025 Dec 29;17(1):153
Cell death & disease 2025 Dec 29;17(1):153
γδ T-cell autoresponses to ectopic membrane proteins: a new type of pattern recognition.
You H, Zhang X, Chen H, Liu C, Teng D, Han J, Chen M, Pang Y, Zhang J, Cai M, Zhao Y, Dong Q, Wang S, Xu Y, Hu Y, Dong P, He W
Cellular & molecular immunology 2025 Apr;22(4):356-370
Cellular & molecular immunology 2025 Apr;22(4):356-370
Muscle-derived small extracellular vesicles induce liver fibrosis during overtraining.
Liu Y, Zhou R, Guo Y, Hu B, Xie L, An Y, Wen J, Liu Z, Zhou M, Kuang W, Xiao Y, Wang M, Xie G, Zhou H, Lu R, Peng H, Huang Y
Cell metabolism 2025 Apr 1;37(4):824-841.e8
Cell metabolism 2025 Apr 1;37(4):824-841.e8
FBXO2 promotes the progression of papillary thyroid carcinoma through the p53 pathway.
Guo W, Ren Y, Qiu X
Scientific reports 2024 Sep 29;14(1):22574
Scientific reports 2024 Sep 29;14(1):22574
Data-independent acquisition combined with liquid chromatography mass spectrometry technique to detect prognostic protein markers in type I gastric neuroendocrine neoplasm.
Zhang M, Zheng X, Wang C, Li S
Rapid communications in mass spectrometry : RCM 2024 Aug 30;38(16):e9849
Rapid communications in mass spectrometry : RCM 2024 Aug 30;38(16):e9849
F-box only protein 2 exacerbates non-alcoholic fatty liver disease by targeting the hydroxyl CoA dehydrogenase alpha subunit.
Liu Z, Chen NY, Zhang Z, Zhou S, Hu SY
World journal of gastroenterology 2023 Jul 28;29(28):4433-4450
World journal of gastroenterology 2023 Jul 28;29(28):4433-4450
Inhibition of histone methyltransferase Smyd3 rescues NMDAR and cognitive deficits in a tauopathy mouse model.
Williams JB, Cao Q, Wang W, Lee YH, Qin L, Zhong P, Ren Y, Ma K, Yan Z
Nature communications 2023 Jan 6;14(1):91
Nature communications 2023 Jan 6;14(1):91
Early Wnt Signaling Activation Promotes Inner Ear Differentiation via Cell Caudalization in Mouse Stem Cell-Derived Organoids.
Tang PC, Chen L, Singh S, Groves AK, Koehler KR, Liu XZ, Nelson RF
Stem cells (Dayton, Ohio) 2023 Jan 30;41(1):26-38
Stem cells (Dayton, Ohio) 2023 Jan 30;41(1):26-38
Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis.
El Shikh MEM, El Sayed R, Aly NAR, Prediletto E, Hands R, Fossati-Jimack L, Bombardieri M, Lewis MJ, Pitzalis C
Frontiers in medicine 2022;9:1013660
Frontiers in medicine 2022;9:1013660
FBXO2, a novel marker for metastasis in human gastric cancer.
Sun X, Wang T, Guan ZR, Zhang C, Chen Y, Jin J, Hua D
Biochemical and biophysical research communications 2018 Jan 15;495(3):2158-2164
Biochemical and biophysical research communications 2018 Jan 15;495(3):2158-2164
Quantitative proteomics by SWATH-MS reveals sophisticated metabolic reprogramming in hepatocellular carcinoma tissues.
Gao Y, Wang X, Sang Z, Li Z, Liu F, Mao J, Yan D, Zhao Y, Wang H, Li P, Ying X, Zhang X, He K, Wang H
Scientific reports 2017 Apr 5;7:45913
Scientific reports 2017 Apr 5;7:45913
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 14590-1-AP(FBXO2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The FBXO2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human FBXO2. This antibody recognizes human, mouse, rat antigen. The FBXO2 antibody has been validated for the following applications: ELISA, IHC analysis.
