ABCC12

This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer. [provided by RefSeq, Jul 2008]

Description

ATP binding cassette subfamily C member 12

Tissue specificity

Tissue enriched (testis)

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

16 (48081006 - 48156018)

Ensembl ID

ENSG00000140798  (ver. 103.38)

Orthologs

Mouse Abcc12: ENSMUSG00000036872

UniProt

Q96J65

neXtProt

NX_Q96J65

Human splice variants
Mouse splice variants

Protein structure