HPA013993

antibody from Atlas Antibodies

Targeting: RBM7

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

HPA013993

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA013993, RRID:AB_1856137

Product name

Anti-RBM7

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human RBM7, Gene description: RNA binding motif protein 7, Validated applications: IHC, ICC, Uniprot ID: Q9Y580, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.2 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

The MTR4/hnRNPK complex surveils aberrant polyadenylated RNAs with multiple exons

Taniue K, Sugawara A, Zeng C, Han H, Gao X, Shimoura Y, Ozeki A, Onoguchi-Mizutani R, Seki M, Suzuki Y, Hamada M, Akimitsu N
Nature Communications 2024;15(1)

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RBM7 deficiency promotes breast cancer metastasis by coordinating MFGE8 splicing switch and NF-kB pathway

Wang K, Yu J, Dai Z, Huang F, Chen C, Chen D, Zhang J, Zhao J, Li M, Zhang W, Li X, Qi Y, Wang Y
eLife 2024;13

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Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome

Gerlach P, Garland W, Lingaraju M, Salerno-Kochan A, Bonneau F, Basquin J, Jensen T, Conti E
Molecular Cell 2022;82(13):2505-2518.e7

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hnRNPH1-MTR4 complex-mediated regulation of NEAT1v2 stability is critical for IL8 expression.

Tanu T, Taniue K, Imamura K, Onoguchi-Mizutani R, Han H, Jensen TH, Akimitsu N
RNA biology 2021 Oct 15;18(sup1):537-547

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P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress

Bugai A, Quaresma A, Friedel C, Lenasi T, Düster R, Sibley C, Fujinaga K, Kukanja P, Hennig T, Blasius M, Geyer M, Ule J, Dölken L, Barborič M
Molecular Cell 2019;74(2):254-267.e10

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ZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation

Gable D, Gaysinskaya V, Atik C, Talbot C, Kang B, Stanley S, Pugh E, Amat-Codina N, Schenk K, Arcasoy M, Brayton C, Florea L, Armanios M
Genes & Development 2019;33(19-20):1381-1396

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The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs

Lingaraju M, Johnsen D, Schlundt A, Langer L, Basquin J, Sattler M, Heick Jensen T, Falk S, Conti E
Nature Communications 2019;10(1)

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The RNA exosome contributes to gene expression regulation during stem cell differentiation

Lloret-Llinares M, Karadoulama E, Chen Y, Wojenski L, Villafano G, Bornholdt J, Andersson R, Core L, Sandelin A, Jensen T
Nucleic Acids Research 2018;46(21):11502-11513

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The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity

Rialdi A, Hultquist J, Jimenez-Morales D, Peralta Z, Campisi L, Fenouil R, Moshkina N, Wang Z, Laffleur B, Kaake R, McGregor M, Haas K, Pefanis E, Albrecht R, Pache L, Chanda S, Jen J, Ochando J, Byun M, Basu U, García-Sastre A, Krogan N, van Bakel H, Marazzi I
Cell 2017;169(4):679-692.e14

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Structure of the RBM7–ZCCHC8 core of the NEXT complex reveals connections to splicing factors

Falk S, Finogenova K, Melko M, Benda C, Lykke-Andersen S, Jensen T, Conti E
Nature Communications 2016;7(1)