HPA038608

antibody from Atlas Antibodies

Targeting: GLS2 GA, GLS, hLGA, LGA

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

HPA038608

Provider

Atlas Antibodies

Product name

Anti-GLS2

Antibody type

Polyclonal

Antigen

Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence

Description

Affinity purified using the PrEST antigen as affinity ligand

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Antigen sequence

MRSMKALQKALSRAGSHCGRGGWGHPSRSPLLGGG
VRHHLSEAAAQGRETPHSHQPQHQDHDSSESGMLS
RLGDLLFY


Isotype

IgG

Vial size

100 µl

Storage

Store at +4°C for short term storage (1-2 days). Long time storage is recommended at -20°C. If stored at lower temperature, aliquot to avoid repeated freezing and thawing. Working dilution samples should be discarded if not used within 12 hours.

References

Submitted references

Targeting hepatic glutaminase activity to ameliorate hyperglycemia

Miller R, Shi Y, Lu W, Pirman D, Jatkar A, Blatnik M, Wu H, Cárdenas C, Wan M, Foskett J, Park J, Zhang Y, Holland W, Rabinowitz J, Birnbaum M
Nature Medicine 2018;24(4):518-524

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Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition

Jacque N, Ronchetti A, Larrue C, Meunier G, Birsen R, Willems L, Saland E, Decroocq J, Maciel T, Lambert M, Poulain L, Hospital M, Sujobert P, Joseph L, Chapuis N, Lacombe C, Moura I, Demo S, Sarry J, Recher C, Mayeux P, Tamburini J, Bouscary D
Blood 2015;126(11):1346-1356

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Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis

Xiang Y, Stine Z, Xia J, Lu Y, O’Connor R, Altman B, Hsieh A, Gouw A, Thomas A, Gao P, Sun L, Song L, Yan B, Slusher B, Zhuo J, Ooi L, Lee C, Mancuso A, McCallion A, Le A, Milone M, Rayport S, Felsher D, Dang C
Journal of Clinical Investigation 2015;125(6):2293-2306

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Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment

Tanaka K, Sasayama T, Irino Y, Takata K, Nagashima H, Satoh N, Kyotani K, Mizowaki T, Imahori T, Ejima Y, Masui K, Gini B, Yang H, Hosoda K, Sasaki R, Mischel P, Kohmura E
Journal of Clinical Investigation 2015;125(4):1591-1602