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LRRFIP2
LRR binding FLII interacting protein 2HUFI-2
The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]
Top validated antibodies |
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| LSBio |  LS-C144340 |
Polyclonal |
WB
EL
ICC
IHC
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| GeneTex | GTX31429 |
Polyclonal |
WB
EL
ICC
IHC
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| Boster Biological Technology | A08734 |
Polyclonal |
WB
EL
ICC
IHC
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| antibodies-online | ABIN2448524 |
Polyclonal |
WB
EL
ICC
IHC
|
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| Novus Biologicals | 43620002 |
2 references | Polyclonal |
WB
EL
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