ABIN251659

antibody from antibodies-online

Targeting: NOD2 BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, PSORAS1

Provider product page for ABIN251659

Western blot

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [13]
Comments [0]
Validations
Western blot [5]
Immunohistochemistry [1]
Flow cytometry [2]

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Product number: ABIN251659 - Provider product page
Provider: antibodies-online
Product name: anti-Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) (AA 28-301) antibody
Antibody type: Monoclonal
Description: Protein G purified
Reactivity: Human, Mouse
Host: Mouse
Epitope: AA 28-301
Isotype: IgG
Antibody clone number: 2D9
Vial size: 0.025 mL
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Handling: Avoid freeze-thaw cycles

NOD2 protein structure - ABIN251659 shown in red.

Submitted references Vitamin D Promotes Pneumococcal Killing and Modulates Inflammatory Responses in Primary Human Neutrophils.

Subramanian K, Bergman P, Henriques-Normark B
Journal of innate immunity 2017;9(4):375-386

Activation of nucleotide oligomerization domain 2 (NOD2) by human cytomegalovirus initiates innate immune responses and restricts virus replication.

Kapoor A, Forman M, Arav-Boger R
PloS one 2014;9(3):e92704

RNAi screening identifies mediators of NOD2 signaling: implications for spatial specificity of MDP recognition.

Lipinski S, Grabe N, Jacobs G, Billmann-Born S, Till A, Häsler R, Aden K, Paulsen M, Arlt A, Kraemer L, Hagemann N, Erdmann KS, Schreiber S, Rosenstiel P
Proceedings of the National Academy of Sciences of the United States of America 2012 Dec 26;109(52):21426-31

Functional expression of NOD2 in freshly isolated human peripheral blood γδ T cells.

Marischen L, Wesch D, Oberg HH, Rosenstiel P, Trad A, Shomali M, Grötzinger J, Janssen O, Tchikov V, Schütze S, Kabelitz D
Scandinavian journal of immunology 2011 Aug;74(2):126-34

Genome-wide expression profiling identifies an impairment of negative feedback signals in the Crohn's disease-associated NOD2 variant L1007fsinsC.

Billmann-Born S, Till A, Arlt A, Lipinski S, Sina C, Latiano A, Annese V, Häsler R, Kerick M, Manke T, Seegert D, Hanidu A, Schäfer H, van Heel D, Li J, Schreiber S, Rosenstiel P
Journal of immunology (Baltimore, Md. : 1950) 2011 Apr 1;186(7):4027-38

Caspase recruitment domain-containing protein 8 (CARD8) negatively regulates NOD2-mediated signaling.

von Kampen O, Lipinski S, Till A, Martin SJ, Nietfeld W, Lehrach H, Schreiber S, Rosenstiel P
The Journal of biological chemistry 2010 Jun 25;285(26):19921-6

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation.

Cooney R, Baker J, Brain O, Danis B, Pichulik T, Allan P, Ferguson DJ, Campbell BJ, Jewell D, Simmons A
Nature medicine 2010 Jan;16(1):90-7

DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses.

Lipinski S, Till A, Sina C, Arlt A, Grasberger H, Schreiber S, Rosenstiel P
Journal of cell science 2009 Oct 1;122(Pt 19):3522-30

NOD2 plays an important role in the inflammatory responses of microglia and astrocytes to bacterial CNS pathogens.

Chauhan VS, Sterka DG Jr, Furr SR, Young AB, Marriott I
Glia 2009 Mar;57(4):414-23

Altered host:pathogen interactions conferred by the Blau syndrome mutation of NOD2.

Kim TH, Payne U, Zhang X, Iwanaga Y, Davey MP, Rosenbaum JT, Inman RD
Rheumatology international 2007 Jan;27(3):257-62

A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling.

McDonald C, Chen FF, Ollendorff V, Ogura Y, Marchetto S, Lécine P, Borg JP, Nuñez G
The Journal of biological chemistry 2005 Dec 2;280(48):40301-9

Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis.

Ogura Y, Lala S, Xin W, Smith E, Dowds TA, Chen FF, Zimmermann E, Tretiakova M, Cho JH, Hart J, Greenson JK, Keshav S, Nuñez G
Gut 2003 Nov;52(11):1591-7

Crohn's disease and the NOD2 gene: a role for paneth cells.

Lala S, Ogura Y, Osborne C, Hor SY, Bromfield A, Davies S, Ogunbiyi O, Nuñez G, Keshav S
Gastroenterology 2003 Jul;125(1):47-57

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Supportive validation

Submitted by: antibodies-online (provider)
Main image
Experimental details: Detection of NOD2 in 20ug of NOD2 transfected 293T cell lysate using ABIN151959. ECL detection in 10 seconds.