TOX3

The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

Description

TOX high mobility group box family member 3

Tissue specificity

Tissue enhanced (intestine, retina, stomach)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Transcription factors

Chromosome

16 (52436417 - 52547802)

Ensembl ID

ENSG00000103460  (ver. 103.38)

Orthologs

Mouse Tox3: ENSMUSG00000043668

UniProt

O15405

neXtProt

NX_O15405

Human splice variants
Mouse splice variants

Protein structure