BS61294

antibody from Bioworld Technology, Inc
Targeting: WNK2 KIAA1760, NY-CO-43, PRKWNK2, SDCCAG43
Provider product page for BS61294

Antibody data

Product number
BS61294 - Provider product page
Provider
Bioworld Technology, Inc
Product name
WNK2 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human WNK2.
Description
The protein kinase superfamily contains over a thousand proteins in 57 subfamilies that all share a catalytic core of 250ÿ300 amino acids organized in two domains. WNK, for ¡ùwith no lysine (K)¡ì, kinases are serine-threonine protein kinases that contain a cysteine residue in place of a lysine residue in a family of proteins that traditionally contain a lysine following a short string of hydrophobic residues. WNK kinases contain a lysine upstream of the traditional position, within a glycine string. This lysine functions as an anchor and orients ATP through interactions with the ? and ¡Â phosphoryl groups. The catalytic domains of WNK2, WNK3 and WNK4 are 95% homologous to WNK1. The human WNK1 gene encodes a 2,382 amino acid protein that is primarily expressed in heart, kidney, muscle and distal nephron. The human WNK3 gene encodes a protein that is primarily expressed in brain; the human WNK4 gene encodes a 1,243 amino acid protein that is expressed in kidney. Aberrant function of WNK kinases and their associated signaling pathways are implicated in hypertension, increased renal salt reabsorption and impaired K+ and H+ excretion.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
WNK2 protein structure - BS61294 shown in red.