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- Antibody Data
- Antigen structure
- References [11]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 10310-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10310-1-AP, RRID:AB_2144642
- Product name
- MPV17 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MPV17 antibody (Cat. #10310-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Mitochondrial protein MPV17 promotes β-cell apoptosis in diabetogenesis.
MPV17 does not control cancer cell proliferation.
Inner mitochondrial membrane protein MPV17 mutant mice display increased myocardial injury after ischemia/reperfusion.
Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model.
MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria.
A monoclonal antibody raised against bacterially expressed MPV17 sequences shows peroxisomal, endosomal and lysosomal localisation in U2OS cells.
Mpv17 in mitochondria protects podocytes against mitochondrial dysfunction and apoptosis in vivo and in vitro.
MPV17L2 is required for ribosome assembly in mitochondria.
AAV-mediated liver-specific MPV17 expression restores mtDNA levels and prevents diet-induced liver failure.
Lethal hepatopathy and leukodystrophy caused by a novel mutation in MPV17 gene: description of an alternative MPV17 spliced form.
MPV17 encodes an inner mitochondrial membrane protein and is mutated in infantile hepatic mitochondrial DNA depletion.
Tang Q, Shi W, Liu M, Tang L, Ren W, Shi S
Clinical science (London, England : 1979) 2023 Aug 14;137(15):1195-1208
Clinical science (London, England : 1979) 2023 Aug 14;137(15):1195-1208
MPV17 does not control cancer cell proliferation.
Canonne M, Wanet A, Nguyen TTA, Khelfi A, Ayama-Canden S, Van Steenbrugge M, Fattaccioli A, Sokal E, Najimi M, Arnould T, Renard P
PloS one 2020;15(3):e0229834
PloS one 2020;15(3):e0229834
Inner mitochondrial membrane protein MPV17 mutant mice display increased myocardial injury after ischemia/reperfusion.
Madungwe NB, Feng Y, Imam Aliagan A, Tombo N, Kaya F, Bopassa JC
American journal of translational research 2020;12(7):3412-3428
American journal of translational research 2020;12(7):3412-3428
Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model.
Moss CF, Dalla Rosa I, Hunt LE, Yasukawa T, Young R, Jones AWE, Reddy K, Desai R, Virtue S, Elgar G, Voshol P, Taylor MS, Holt IJ, Reijns MAM, Spinazzola A
Nucleic acids research 2017 Dec 15;45(22):12808-12815
Nucleic acids research 2017 Dec 15;45(22):12808-12815
MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria.
Dalla Rosa I, Cámara Y, Durigon R, Moss CF, Vidoni S, Akman G, Hunt L, Johnson MA, Grocott S, Wang L, Thorburn DR, Hirano M, Poulton J, Taylor RW, Elgar G, Martí R, Voshol P, Holt IJ, Spinazzola A
PLoS genetics 2016 Jan;12(1):e1005779
PLoS genetics 2016 Jan;12(1):e1005779
A monoclonal antibody raised against bacterially expressed MPV17 sequences shows peroxisomal, endosomal and lysosomal localisation in U2OS cells.
Weiher H, Pircher H, Jansen-Dürr P, Hegenbarth S, Knolle P, Grunau S, Vapola M, Hiltunen JK, Zwacka RM, Schmelzer E, Reumann K, Will H
BMC research notes 2016 Feb 27;9:128
BMC research notes 2016 Feb 27;9:128
Mpv17 in mitochondria protects podocytes against mitochondrial dysfunction and apoptosis in vivo and in vitro.
Casalena G, Krick S, Daehn I, Yu L, Ju W, Shi S, Tsai SY, D'Agati V, Lindenmeyer M, Cohen CD, Schlondorff D, Bottinger EP
American journal of physiology. Renal physiology 2014 Jun 1;306(11):F1372-80
American journal of physiology. Renal physiology 2014 Jun 1;306(11):F1372-80
MPV17L2 is required for ribosome assembly in mitochondria.
Dalla Rosa I, Durigon R, Pearce SF, Rorbach J, Hirst EM, Vidoni S, Reyes A, Brea-Calvo G, Minczuk M, Woellhaf MW, Herrmann JM, Huynen MA, Holt IJ, Spinazzola A
Nucleic acids research 2014 Jul;42(13):8500-15
Nucleic acids research 2014 Jul;42(13):8500-15
AAV-mediated liver-specific MPV17 expression restores mtDNA levels and prevents diet-induced liver failure.
Bottani E, Giordano C, Civiletto G, Di Meo I, Auricchio A, Ciusani E, Marchet S, Lamperti C, d'Amati G, Viscomi C, Zeviani M
Molecular therapy : the journal of the American Society of Gene Therapy 2014 Jan;22(1):10-7
Molecular therapy : the journal of the American Society of Gene Therapy 2014 Jan;22(1):10-7
Lethal hepatopathy and leukodystrophy caused by a novel mutation in MPV17 gene: description of an alternative MPV17 spliced form.
Navarro-Sastre A, Martín-Hernández E, Campos Y, Quintana E, Medina E, de Las Heras RS, Lluch M, Muñoz A, del Hoyo P, Martín R, Gort L, Briones P, Ribes A
Molecular genetics and metabolism 2008 Jun;94(2):234-9
Molecular genetics and metabolism 2008 Jun;94(2):234-9
MPV17 encodes an inner mitochondrial membrane protein and is mutated in infantile hepatic mitochondrial DNA depletion.
Spinazzola A, Viscomi C, Fernandez-Vizarra E, Carrara F, D'Adamo P, Calvo S, Marsano RM, Donnini C, Weiher H, Strisciuglio P, Parini R, Sarzi E, Chan A, DiMauro S, Rötig A, Gasparini P, Ferrero I, Mootha VK, Tiranti V, Zeviani M
Nature genetics 2006 May;38(5):570-5
Nature genetics 2006 May;38(5):570-5
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse kidney tissue were subjected to SDS PAGE followed by western blot with 10310-1-AP(MPV17 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas cancer using 10310-1-AP(MPV17 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MPV17 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MPV17. This antibody recognizes human, mouse antigen. The MPV17 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
