Antibody data
- Antibody Data
- Antigen structure
- References [39]
- Comments [0]
- Validations [0]
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- Product number
- 67487-1-Ig - Provider product page

- Provider
- Proteintech Group
- Product name
- MFN2 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated MFN2 antibody (Cat. #67487-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, Mouse, Rat and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 5F3B3
- Vial size
- 20ul, 150ul
Submitted references Chronic intermittent hypoxia increases Parkinson's disease susceptibility via PPARα-mediated lipid droplet-mitochondrial dysfunction.
A modular design of two-pronged sub-organelle targeting strategy disrupting mitochondria-endoplasmic reticulum crosstalk for mitigating rheumatoid arthritis.
Caveolin-1 deficiency exacerbates liver fibrosis by driving lipid metabolic reprogramming in hepatic stellate cells via DRP1-mediated mitochondrial fission.
TCDD Induces Hepatocytes Lipid Deposition via Downregulation of MFN2.
Mitofusin 2 Alleviates Liver Fibrogenesis by Suppressing β-Catenin Nuclear Translocation.
Fasting Enhances Cardiomyocyte Hypoxia Tolerance by Regulating Ca(2+) Transport at Mitochondria-Endoplasmic Reticulum Contact Sites.
Di-(2-Ethylhexyl) phthalate causes testicular ferroptosis though deficiency of androgen receptor and disruption of mitochondrial quality control.
E3 Ubiquitin Ligase Nedd4-2 Exacerbates Seizure-Induced Mitochondrial Defects in an Alzheimer's Disease Mouse Model.
Cardioprotective effect of Yiqi Huoxue decoction on post-myocardial infarction injury mediated by Ca(2+) flux through MAMs.
Sex-specific impact of selective reduced uterine placental perfusion model of preeclampsia on fetal cardiac maturation and mitochondrial function.
Mitochondrial homeostasis dysfunctions during the epithelial-mesenchymal transition process in lens epithelial cells.
Lactoferrin alleviates doxorubicin-induced myocardial injury in mice: Associations with gut microbiota and microbial metabolites.
Activin A protects against lipopolysaccharide/TNF-α induced damage of dopaminergic neurons both in vivo and in vitro by regulating mitochondrial fusion.
Ginsenoside Rg5 alleviates radiation-induced acute lung vascular endothelium injury by reducing mitochondrial apoptosis via Sirt1.
PINK1 affects mitochondrial oxidative phosphorylation by regulating MFN2 to alleviate diabetic kidney disease.
Icariin mitigates depressive-like behavior in rats by regulating mitochondrial function.
circRNA-79530 regulates Twist-mediated mitochondrial damage via sponging miR-214 affecting hypoxia/reoxygenation-induced injury in H9c2 cardiomyocytes.
Brevilin A, a novel BNIP3 inhibitor suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss via impairing mitophagy and mitochondrial metabolism.
VPS13B recruits lipid vesicles to promote mitochondrial fission and quality control.
Drp1 Promotes Macrophage M1 Polarization and Inflammatory Response in Autoimmune Myocarditis by Driving Mitochondrial Fission.
Fibroblast growth factor 7 protects osteoblasts against oxidative damage through targeting mitochondria.
MFN2 coordinates mitochondria motility with α-tubulin acetylation and this regulation is disrupted in CMT2A.
Mitofusin2 Ameliorated Endoplasmic Reticulum Stress and Mitochondrial Reactive Oxygen Species Through Maintaining Mitochondria-Associated Endoplasmic Reticulum Membrane Integrity in Cisplatin-Induced Acute Kidney Injury.
Sirtuin 7 ameliorates cuproptosis, myocardial remodeling and heart dysfunction in hypertension through the modulation of YAP/ATP7A signaling.
IDH1/MDH1 deacetylation promotes NETosis by regulating OPA1 and autophagy.
VDR regulates mitochondrial function as a protective mechanism against renal tubular cell injury in diabetic rats.
Schisandrin B Alleviates LPS Induced Mitochondrial Damage in C28I2 Cells.
Moderate replacement of fish oil with palmitic acid-stimulated mitochondrial fusion promotes β-oxidation by Mfn2 interacting with Cpt1α via its GTPase-domain.
Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1.
Schisandrin B Alleviates Renal Tubular Cell Epithelial-Mesenchymal Transition and Mitochondrial Dysfunction by Kielin/Chordin-like Protein Upregulation via Akt Pathway Inactivation and Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase Pathway Activation in Diabetic Kidney Disease.
Cardiolipin and OPA1 Team up for Methamphetamine-Induced Locomotor Activity by Promoting Neuronal Mitochondrial Fusion in the Nucleus Accumbens of Mice.
Myricetin improves pathological changes in 3×Tg-AD mice by regulating the mitochondria-NLRP3 inflammasome-microglia channel by targeting P38 MAPK signaling pathway.
Multi-Targeting Intranasal Nanoformulation as a Therapeutic for Alzheimer's Disease.
Loganin alleviated cognitive impairment in 3×Tg-AD mice through promoting mitophagy mediated by optineurin.
Mitochonic Acid-5 Inhibits Reactive Oxygen Species Production and Improves Human Chondrocyte Survival by Upregulating SIRT3-Mediated, Parkin-dependent Mitophagy.
Roles of HIF-1α/BNIP3 mediated mitophagy in mitochondrial dysfunction of letrozole-induced PCOS rats.
Diosgenin Ameliorated Type II Diabetes-Associated Nonalcoholic Fatty Liver Disease through Inhibiting De Novo Lipogenesis and Improving Fatty Acid Oxidation and Mitochondrial Function in Rats.
Cardioprotective responses to aerobic exercise-induced physiological hypertrophy in zebrafish heart.
Nujiangexanthone A Inhibits Cervical Cancer Cell Proliferation by Promoting Mitophagy.
Zhai MR, Pan J, Wu ZH, He YY, Zhang KR, Ren L, Wang YR, Li YB, Gao J, Xiao L, Liu YH
Theranostics 2026;16(5):2466-2487
Theranostics 2026;16(5):2466-2487
A modular design of two-pronged sub-organelle targeting strategy disrupting mitochondria-endoplasmic reticulum crosstalk for mitigating rheumatoid arthritis.
Ren J, Tang Y, Liao Z, Wen X, Hua Y, Li Y, Wang Q
Biomaterials 2026 Oct;333:124212
Biomaterials 2026 Oct;333:124212
Caveolin-1 deficiency exacerbates liver fibrosis by driving lipid metabolic reprogramming in hepatic stellate cells via DRP1-mediated mitochondrial fission.
Wang Y, Wang X, Lin J, Zhang W, Sun Y, Geng Q, Chen S, Zhang C, Jin L, Hu C
Free radical biology & medicine 2026 Jul;250:203-215
Free radical biology & medicine 2026 Jul;250:203-215
TCDD Induces Hepatocytes Lipid Deposition via Downregulation of MFN2.
Xing C, Ai Y, Wu Y, Wang X, Ding H, Wei C, Xu G, Sun W
Journal of applied toxicology : JAT 2026 Jan;46(1):250-258
Journal of applied toxicology : JAT 2026 Jan;46(1):250-258
Mitofusin 2 Alleviates Liver Fibrogenesis by Suppressing β-Catenin Nuclear Translocation.
Zeng CM, Shao B, He LL, Lin Y, Lai XJ, Ding GS
Current medical science 2026 Feb;46(1):173-185
Current medical science 2026 Feb;46(1):173-185
Fasting Enhances Cardiomyocyte Hypoxia Tolerance by Regulating Ca(2+) Transport at Mitochondria-Endoplasmic Reticulum Contact Sites.
Chen X, Jiao B, Xue T, Xie M, Yu Z
International journal of molecular sciences 2026 Feb 24;27(5)
International journal of molecular sciences 2026 Feb 24;27(5)
Di-(2-Ethylhexyl) phthalate causes testicular ferroptosis though deficiency of androgen receptor and disruption of mitochondrial quality control.
Tian Q, Yan X, Xu J, Ma J, Sun X, Li J, Wang N, Yao X, Qiu T, Zhang C, Deng H, Yang G
Free radical biology & medicine 2026 Apr;247:348-360
Free radical biology & medicine 2026 Apr;247:348-360
E3 Ubiquitin Ligase Nedd4-2 Exacerbates Seizure-Induced Mitochondrial Defects in an Alzheimer's Disease Mouse Model.
Wang Y, Zhu J, Lizarazo S, Lee KY, Wong O, Azim S, Yook Y, Kumar V, Tsai NP
Journal of neurochemistry 2026 Apr;170(4):e70440
Journal of neurochemistry 2026 Apr;170(4):e70440
Cardioprotective effect of Yiqi Huoxue decoction on post-myocardial infarction injury mediated by Ca(2+) flux through MAMs.
Li Y, Du T, Zhang Y, Lu Y, Li X, Xie W, Guo S
Frontiers in cardiovascular medicine 2025;12:1596757
Frontiers in cardiovascular medicine 2025;12:1596757
Sex-specific impact of selective reduced uterine placental perfusion model of preeclampsia on fetal cardiac maturation and mitochondrial function.
Chatterjee P, Molberg R, Kirschenman R, Holody CD, Quon A, Spaans F, Bourque SL, Lemieux H, Davidge ST
American journal of physiology. Regulatory, integrative and comparative physiology 2025 Sep 1;329(3):R474-R486
American journal of physiology. Regulatory, integrative and comparative physiology 2025 Sep 1;329(3):R474-R486
Mitochondrial homeostasis dysfunctions during the epithelial-mesenchymal transition process in lens epithelial cells.
Xie H, Huang R, Xu K, Du L, Yang X, Xu W, Guo X, Lu G, Fan T, Chen C
Experimental eye research 2025 Nov;260:110583
Experimental eye research 2025 Nov;260:110583
Lactoferrin alleviates doxorubicin-induced myocardial injury in mice: Associations with gut microbiota and microbial metabolites.
Wu X, Yang J, Suo H, Song J
Journal of dairy science 2025 Nov;108(11):11853-11870
Journal of dairy science 2025 Nov;108(11):11853-11870
Activin A protects against lipopolysaccharide/TNF-α induced damage of dopaminergic neurons both in vivo and in vitro by regulating mitochondrial fusion.
Zhang Y, Tian S, Niu M, Yang H, Liu L, Kang Y, Yin Y
Neuroscience 2025 Nov 10;587:108-122
Neuroscience 2025 Nov 10;587:108-122
Ginsenoside Rg5 alleviates radiation-induced acute lung vascular endothelium injury by reducing mitochondrial apoptosis via Sirt1.
Li C, Zhao B, Xiong J, Li L, Pang D, Unger K, Jung M, Lyu J, Kuang H, Liang L, Li T, Chen L, Bai H
Journal of ginseng research 2025 May;49(3):260-270
Journal of ginseng research 2025 May;49(3):260-270
PINK1 affects mitochondrial oxidative phosphorylation by regulating MFN2 to alleviate diabetic kidney disease.
Pei X, Liu J, Wei Y, Zhu Y, Li Y, Wang Q, Zhuang L, Jin G
International immunopharmacology 2025 Jun 5;157:114786
International immunopharmacology 2025 Jun 5;157:114786
Icariin mitigates depressive-like behavior in rats by regulating mitochondrial function.
Zhao H, Zhang S, Gong Z, Chen T, Guo H, Yang M, Wang L, Zhou X, Xie J, Li H, Lu Y, Zhu Z
Journal of ethnopharmacology 2025 Jun 26;350:120036
Journal of ethnopharmacology 2025 Jun 26;350:120036
circRNA-79530 regulates Twist-mediated mitochondrial damage via sponging miR-214 affecting hypoxia/reoxygenation-induced injury in H9c2 cardiomyocytes.
Yu Z, Xu W, Teng Y, Li T, Guo R, Li J, Li X, Li Y, Hao Y
European journal of histochemistry : EJH 2025 Jun 17;69(3)
European journal of histochemistry : EJH 2025 Jun 17;69(3)
Brevilin A, a novel BNIP3 inhibitor suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss via impairing mitophagy and mitochondrial metabolism.
Zhou R, Wang Y, Liu S, Su Y, Liu Z, Yang B, Li X, Zhao J, Xu J, Liu Q, Song F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156774
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156774
VPS13B recruits lipid vesicles to promote mitochondrial fission and quality control.
Lee SK, Ham HJ, Park S, Lee HE, Mun JY, Jang DJ, Lee JA
Nature communications 2025 Dec 16;17(1):747
Nature communications 2025 Dec 16;17(1):747
Drp1 Promotes Macrophage M1 Polarization and Inflammatory Response in Autoimmune Myocarditis by Driving Mitochondrial Fission.
Lin L, Wei J, Xue J, Fan G, Zhu W, Zhu Y, Wu R
Journal of cardiovascular translational research 2025 Apr;18(2):237-246
Journal of cardiovascular translational research 2025 Apr;18(2):237-246
Fibroblast growth factor 7 protects osteoblasts against oxidative damage through targeting mitochondria.
Liu X, Hu X, Niu C, Yang Y, Huang Z, Xie J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 15;38(5):e23524
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 15;38(5):e23524
MFN2 coordinates mitochondria motility with α-tubulin acetylation and this regulation is disrupted in CMT2A.
Kumar A, Larrea D, Pero ME, Infante P, Conenna M, Shin GJ, Van Elias V, Grueber WB, Di Marcotullio L, Area-Gomez E, Bartolini F
iScience 2024 Jun 21;27(6):109994
iScience 2024 Jun 21;27(6):109994
Mitofusin2 Ameliorated Endoplasmic Reticulum Stress and Mitochondrial Reactive Oxygen Species Through Maintaining Mitochondria-Associated Endoplasmic Reticulum Membrane Integrity in Cisplatin-Induced Acute Kidney Injury.
Liu YT, Zhang H, Duan SB, Wang JW, Chen H, Zhan M, Zhang W, Li AM, Liu Y, Yang Y, Yang S
Antioxidants & redox signaling 2024 Jan;40(1-3):16-39
Antioxidants & redox signaling 2024 Jan;40(1-3):16-39
Sirtuin 7 ameliorates cuproptosis, myocardial remodeling and heart dysfunction in hypertension through the modulation of YAP/ATP7A signaling.
Chen YF, Qi RQ, Song JW, Wang SY, Dong ZJ, Chen YH, Liu Y, Zhou XY, Li J, Liu XY, Zhong JC
Apoptosis : an international journal on programmed cell death 2024 Dec;29(11-12):2161-2182
Apoptosis : an international journal on programmed cell death 2024 Dec;29(11-12):2161-2182
IDH1/MDH1 deacetylation promotes NETosis by regulating OPA1 and autophagy.
Wang Y, Guo J, Zhang D, Shi C, Zhang X, Gong Z
International immunopharmacology 2024 Dec 25;143(Pt 1):113270
International immunopharmacology 2024 Dec 25;143(Pt 1):113270
VDR regulates mitochondrial function as a protective mechanism against renal tubular cell injury in diabetic rats.
Chen H, Zhang H, Li AM, Liu YT, Liu Y, Zhang W, Yang C, Song N, Zhan M, Yang S
Redox biology 2024 Apr;70:103062
Redox biology 2024 Apr;70:103062
Schisandrin B Alleviates LPS Induced Mitochondrial Damage in C28I2 Cells.
Hu F, Hu W, Xu H
The Journal of membrane biology 2024 Apr;257(1-2):107-114
The Journal of membrane biology 2024 Apr;257(1-2):107-114
Moderate replacement of fish oil with palmitic acid-stimulated mitochondrial fusion promotes β-oxidation by Mfn2 interacting with Cpt1α via its GTPase-domain.
Song YF, Wang LJ, Luo Z, Hogstrand C, Lai XH, Zheng FF
The Journal of nutritional biochemistry 2024 Apr;126:109559
The Journal of nutritional biochemistry 2024 Apr;126:109559
Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1.
Liu Y, Zhang H, Liu Y, Zhang S, Su P, Wang L, Li Y, Liang Y, Wang X, Zhao W, Chen B, Luo D, Zhang N, Yang Q
Autophagy 2023 Sep;19(9):2443-2463
Autophagy 2023 Sep;19(9):2443-2463
Schisandrin B Alleviates Renal Tubular Cell Epithelial-Mesenchymal Transition and Mitochondrial Dysfunction by Kielin/Chordin-like Protein Upregulation via Akt Pathway Inactivation and Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase Pathway Activation in Diabetic Kidney Disease.
Liu W, Li F, Guo D, Du C, Zhao S, Li J, Yan Z, Hao J
Molecules (Basel, Switzerland) 2023 Nov 29;28(23)
Molecules (Basel, Switzerland) 2023 Nov 29;28(23)
Cardiolipin and OPA1 Team up for Methamphetamine-Induced Locomotor Activity by Promoting Neuronal Mitochondrial Fusion in the Nucleus Accumbens of Mice.
Wang L, Wei Q, Xu R, Chen Y, Li S, Bu Q, Zhao Y, Li H, Zhao Y, Jiang L, Chen Y, Dai Y, Zhao Y, Cen X
ACS chemical neuroscience 2023 May 3;14(9):1585-1601
ACS chemical neuroscience 2023 May 3;14(9):1585-1601
Myricetin improves pathological changes in 3×Tg-AD mice by regulating the mitochondria-NLRP3 inflammasome-microglia channel by targeting P38 MAPK signaling pathway.
Liu P, Zhou Y, Shi J, Wang F, Yang X, Zheng X, Wang Y, He Y, Xie X, Pang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul;115:154801
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul;115:154801
Multi-Targeting Intranasal Nanoformulation as a Therapeutic for Alzheimer's Disease.
Fihurka O, Wang Y, Hong Y, Lin X, Shen N, Yang H, Brown B, Mommer M, Zieneldien T, Li Y, Kim J, Li M, Cai J, Zhou Q, Cao C
Biomolecules 2023 Jan 25;13(2)
Biomolecules 2023 Jan 25;13(2)
Loganin alleviated cognitive impairment in 3×Tg-AD mice through promoting mitophagy mediated by optineurin.
Zhou Y, Luo D, Shi J, Yang X, Xu W, Gao W, Guo Y, Zhao Q, Xie X, He Y, Du G, Pang X
Journal of ethnopharmacology 2023 Aug 10;312:116455
Journal of ethnopharmacology 2023 Aug 10;312:116455
Mitochonic Acid-5 Inhibits Reactive Oxygen Species Production and Improves Human Chondrocyte Survival by Upregulating SIRT3-Mediated, Parkin-dependent Mitophagy.
Xin R, Xu Y, Long D, Mao G, Liao H, Zhang Z, Kang Y
Frontiers in pharmacology 2022;13:911716
Frontiers in pharmacology 2022;13:911716
Roles of HIF-1α/BNIP3 mediated mitophagy in mitochondrial dysfunction of letrozole-induced PCOS rats.
Wang F, Han J, Wang X, Liu Y, Zhang Z
Journal of molecular histology 2022 Oct;53(5):833-842
Journal of molecular histology 2022 Oct;53(5):833-842
Diosgenin Ameliorated Type II Diabetes-Associated Nonalcoholic Fatty Liver Disease through Inhibiting De Novo Lipogenesis and Improving Fatty Acid Oxidation and Mitochondrial Function in Rats.
Zhong Y, Li Z, Jin R, Yao Y, He S, Lei M, Wang X, Shi C, Gao L, Peng X
Nutrients 2022 Nov 24;14(23)
Nutrients 2022 Nov 24;14(23)
Cardioprotective responses to aerobic exercise-induced physiological hypertrophy in zebrafish heart.
Chen Z, Zhou Z, Peng X, Sun C, Yang D, Li C, Zhu R, Zhang P, Zheng L, Tang C
The journal of physiological sciences : JPS 2021 Nov 8;71(1):33
The journal of physiological sciences : JPS 2021 Nov 8;71(1):33
Nujiangexanthone A Inhibits Cervical Cancer Cell Proliferation by Promoting Mitophagy.
Feng J, Mansouripour A, Xi Z, Zhang L, Xu G, Zhou H, Xu H
Molecules (Basel, Switzerland) 2021 May 12;26(10)
Molecules (Basel, Switzerland) 2021 May 12;26(10)
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