Explore
Validate
Learn55160-1-AP
antibody from Proteintech Group
Targeting: RPGRIP1L
CORS3, FTM, JBTS7, KIAA1005, MKS5, NPHP8, PPP1R134
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [25]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 55160-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#55160-1-AP, RRID:AB_10860269
- Product name
- RPGRIP1L antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated RPGRIP1L antibody (Cat. #55160-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Unraveling cellular complexity with transient adapters in highly multiplexed super-resolution imaging.
TTLL12 is required for primary ciliary axoneme formation in polarized epithelial cells.
INPP5E regulates CD3ζ enrichment at the immune synapse by phosphoinositide distribution control.
Disease-associated mutations in WDR34 lead to diverse impacts on the assembly and function of dynein-2.
The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling.
Analyzing Centrioles and Cilia by Expansion Microscopy.
Differential requirement of NPHP1 for compartmentalized protein localization during photoreceptor outer segment development and maintenance.
Case Report: Novel RPGRIP1L Gene Mutations Identified by Whole Exome Sequencing in a Patient With Multiple Primary Tumors.
The Major Ciliary Isoforms of RPGR Build Different Interaction Complexes with INPP5E and RPGRIP1L.
Ciliopathy protein HYLS1 coordinates the biogenesis and signaling of primary cilia by activating the ciliary lipid kinase PIPKIγ.
RAB19 Directs Cortical Remodeling and Membrane Growth for Primary Ciliogenesis.
Comparative Super-Resolution Mapping of Basal Feet Reveals a Modular but Distinct Architecture in Primary and Motile Cilia.
661W Photoreceptor Cell Line as a Cell Model for Studying Retinal Ciliopathies.
Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding.
Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport.
Disruption of RPGR protein interaction network is the common feature of RPGR missense variations that cause XLRP.
Expansion microscopy for the analysis of centrioles and cilia.
Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function.
Super-Resolution Imaging Reveals TCTN2 Depletion-Induced IFT88 Lumen Leakage and Ciliary Weakening.
Loss of OCRL increases ciliary PI(4,5)P(2) in Lowe oculocerebrorenal syndrome.
In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations.
Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.
Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.
TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone.
Mutations in CSPP1, encoding a core centrosomal protein, cause a range of ciliopathy phenotypes in humans.
Schueder F, Rivera-Molina F, Su M, Marin Z, Kidd P, Rothman JE, Toomre D, Bewersdorf J
Cell 2024 Mar 28;187(7):1769-1784.e18
Cell 2024 Mar 28;187(7):1769-1784.e18
TTLL12 is required for primary ciliary axoneme formation in polarized epithelial cells.
Ceglowski J, Hoffman HK, Neumann AJ, Hoff KJ, McCurdy BL, Moore JK, Prekeris R
EMBO reports 2024 Jan;25(1):198-227
EMBO reports 2024 Jan;25(1):198-227
INPP5E regulates CD3ζ enrichment at the immune synapse by phosphoinositide distribution control.
Chiu TY, Lo CH, Lin YH, Lai YD, Lin SS, Fang YT, Huang WS, Huang SY, Tsai PY, Yang FH, Chong WM, Wu YC, Tsai HC, Liu YW, Hsu CL, Liao JC, Wang WJ
Communications biology 2023 Sep 5;6(1):911
Communications biology 2023 Sep 5;6(1):911
Disease-associated mutations in WDR34 lead to diverse impacts on the assembly and function of dynein-2.
Shak C, Vuolo L, Uddin B, Katoh Y, Brown T, Mukhopadhyay AG, Heesom K, Roberts AJ, Stevenson N, Nakayama K, Stephens DJ
Journal of cell science 2023 Mar 1;136(5)
Journal of cell science 2023 Mar 1;136(5)
The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling.
Schembs L, Willems A, Hasenpusch-Theil K, Cooper JD, Whiting K, Burr K, Bøstrand SMK, Selvaraj BT, Chandran S, Theil T
Cell reports 2022 May 17;39(7):110811
Cell reports 2022 May 17;39(7):110811
Analyzing Centrioles and Cilia by Expansion Microscopy.
Kong D, Loncarek J
Methods in molecular biology (Clifton, N.J.) 2021;2329:249-263
Methods in molecular biology (Clifton, N.J.) 2021;2329:249-263
Differential requirement of NPHP1 for compartmentalized protein localization during photoreceptor outer segment development and maintenance.
Datta P, Cribbs JT, Seo S
PloS one 2021;16(5):e0246358
PloS one 2021;16(5):e0246358
Case Report: Novel RPGRIP1L Gene Mutations Identified by Whole Exome Sequencing in a Patient With Multiple Primary Tumors.
Guo J, Yang Y, Ji Z, Yao M, Xia X, Sha X, Huang M
Frontiers in genetics 2021;12:620472
Frontiers in genetics 2021;12:620472
The Major Ciliary Isoforms of RPGR Build Different Interaction Complexes with INPP5E and RPGRIP1L.
Vössing C, Atigbire P, Eilers J, Markus F, Stieger K, Song F, Neidhardt J
International journal of molecular sciences 2021 Mar 30;22(7)
International journal of molecular sciences 2021 Mar 30;22(7)
Ciliopathy protein HYLS1 coordinates the biogenesis and signaling of primary cilia by activating the ciliary lipid kinase PIPKIγ.
Chen C, Xu Q, Zhang Y, Davies BA, Huang Y, Katzmann DJ, Harris PC, Hu J, Ling K
Science advances 2021 Jun;7(26)
Science advances 2021 Jun;7(26)
RAB19 Directs Cortical Remodeling and Membrane Growth for Primary Ciliogenesis.
Jewett CE, Soh AWJ, Lin CH, Lu Q, Lencer E, Westlake CJ, Pearson CG, Prekeris R
Developmental cell 2021 Feb 8;56(3):325-340.e8
Developmental cell 2021 Feb 8;56(3):325-340.e8
Comparative Super-Resolution Mapping of Basal Feet Reveals a Modular but Distinct Architecture in Primary and Motile Cilia.
Nguyen QPH, Liu Z, Albulescu A, Ouyang H, Zlock L, Coyaud E, Laurent E, Finkbeiner W, Moraes TJ, Raught B, Mennella V
Developmental cell 2020 Oct 26;55(2):209-223.e7
Developmental cell 2020 Oct 26;55(2):209-223.e7
661W Photoreceptor Cell Line as a Cell Model for Studying Retinal Ciliopathies.
Wheway G, Nazlamova L, Turner D, Cross S
Frontiers in genetics 2019;10:308
Frontiers in genetics 2019;10:308
Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding.
Mirvis M, Siemers KA, Nelson WJ, Stearns TP
PLoS biology 2019 Jul;17(7):e3000381
PLoS biology 2019 Jul;17(7):e3000381
Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport.
Insinna C, Lu Q, Teixeira I, Harned A, Semler EM, Stauffer J, Magidson V, Tiwari A, Kenworthy AK, Narayan K, Westlake CJ
Nature communications 2019 Jan 25;10(1):428
Nature communications 2019 Jan 25;10(1):428
Disruption of RPGR protein interaction network is the common feature of RPGR missense variations that cause XLRP.
Zhang Q, Giacalone JC, Searby C, Stone EM, Tucker BA, Sheffield VC
Proceedings of the National Academy of Sciences of the United States of America 2019 Jan 22;116(4):1353-1360
Proceedings of the National Academy of Sciences of the United States of America 2019 Jan 22;116(4):1353-1360
Expansion microscopy for the analysis of centrioles and cilia.
Sahabandu N, Kong D, Magidson V, Nanjundappa R, Sullenberger C, Mahjoub MR, Loncarek J
Journal of microscopy 2019 Dec;276(3):145-159
Journal of microscopy 2019 Dec;276(3):145-159
Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function.
Vuolo L, Stevenson NL, Heesom KJ, Stephens DJ
eLife 2018 Oct 16;7
eLife 2018 Oct 16;7
Super-Resolution Imaging Reveals TCTN2 Depletion-Induced IFT88 Lumen Leakage and Ciliary Weakening.
Weng RR, Yang TT, Huang CE, Chang CW, Wang WJ, Liao JC
Biophysical journal 2018 Jul 17;115(2):263-275
Biophysical journal 2018 Jul 17;115(2):263-275
Loss of OCRL increases ciliary PI(4,5)P(2) in Lowe oculocerebrorenal syndrome.
Prosseda PP, Luo N, Wang B, Alvarado JA, Hu Y, Sun Y
Journal of cell science 2017 Oct 15;130(20):3447-3454
Journal of cell science 2017 Oct 15;130(20):3447-3454
In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations.
Shimada H, Lu Q, Insinna-Kettenhofen C, Nagashima K, English MA, Semler EM, Mahgerefteh J, Cideciyan AV, Li T, Brooks BP, Gunay-Aygun M, Jacobson SG, Cogliati T, Westlake CJ, Swaroop A
Cell reports 2017 Jul 11;20(2):384-396
Cell reports 2017 Jul 11;20(2):384-396
Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.
Lu Q, Insinna C, Ott C, Stauffer J, Pintado PA, Rahajeng J, Baxa U, Walia V, Cuenca A, Hwang YS, Daar IO, Lopes S, Lippincott-Schwartz J, Jackson PK, Caplan S, Westlake CJ
Nature cell biology 2015 Mar;17(3):228-240
Nature cell biology 2015 Mar;17(3):228-240
Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.
Lu Q, Insinna C, Ott C, Stauffer J, Pintado PA, Rahajeng J, Baxa U, Walia V, Cuenca A, Hwang YS, Daar IO, Lopes S, Lippincott-Schwartz J, Jackson PK, Caplan S, Westlake CJ
Nature cell biology 2015 Apr;17(4):531
Nature cell biology 2015 Apr;17(4):531
TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone.
Roberson EC, Dowdle WE, Ozanturk A, Garcia-Gonzalo FR, Li C, Halbritter J, Elkhartoufi N, Porath JD, Cope H, Ashley-Koch A, Gregory S, Thomas S, Sayer JA, Saunier S, Otto EA, Katsanis N, Davis EE, Attié-Bitach T, Hildebrandt F, Leroux MR, Reiter JF
The Journal of cell biology 2015 Apr 13;209(1):129-42
The Journal of cell biology 2015 Apr 13;209(1):129-42
Mutations in CSPP1, encoding a core centrosomal protein, cause a range of ciliopathy phenotypes in humans.
Shaheen R, Shamseldin HE, Loucks CM, Seidahmed MZ, Ansari S, Ibrahim Khalil M, Al-Yacoub N, Davis EE, Mola NA, Szymanska K, Herridge W, Chudley AE, Chodirker BN, Schwartzentruber J, Majewski J, Katsanis N, Poizat C, Johnson CA, Parboosingh J, Boycott KM, Innes AM, Alkuraya FS
American journal of human genetics 2014 Jan 2;94(1):73-9
American journal of human genetics 2014 Jan 2;94(1):73-9
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 55160-1-AP(RPGRIP1L antibody) at dilution of 1:800
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas using 55160-1-AP(RPGRIP1L antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The RPGRIP1L antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human RPGRIP1L. This antibody recognizes human antigen. The RPGRIP1L antibody has been validated for the following applications: ELISA, WB, IHC analysis.
