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- Antibody Data
- Antigen structure
- References [34]
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- Validations
- Immunohistochemistry [1]
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- Product number
- 10734-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10734-1-AP, RRID:AB_2297660
- Product name
- MGP antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MGP antibody (Cat. #10734-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Complement Regulatory Protein CD46 Manifests a Unique Role in Promoting the Migration of Bladder Cancer Cells.
The effect of ET1-CTGF mediated pathway on the accumulation of extracellular matrix in the trabecular meshwork and its contribution to the increase in IOP.
Evidence that pyrophosphate acts as an extracellular signalling molecule to exert direct functional effects in primary cultures of osteoblasts and osteoclasts.
Matrix Gla Protein drives stemness and tumor initiation in ovarian cancer.
A novel epithelial-mesenchymal transition (EMT)-related gene signature of predictive value for the survival outcomes in lung adenocarcinoma.
Attenuating effect of magnesium on pulmonary arterial calcification in rodent models of pulmonary hypertension.
Inflammation promotes erythropoietin induced vascular calcification by activating p38 pathway.
The regenerating skeletal muscle niche drives satellite cell return to quiescence.
MGP Regulates Perivascular Adipose-Derived Stem Cells Differentiation Toward Smooth Muscle Cells Via BMP2/SMAD Pathway Enhancing Neointimal Formation.
Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease.
Drug resistance evaluation in novel 3D in vitro model.
Plasma Exosomes Derived From Patients With End-Stage Renal Disease and Renal Transplant Recipients Have Different Effects on Vascular Calcification.
Identification of Chemoresistance-Associated Key Genes and Pathways in High-Grade Serous Ovarian Cancer by Bioinformatics Analyses.
Generation of a Matrix Gla (Mgp) floxed mouse, followed by conditional knockout, uncovers a new Mgp function in the eye.
Calciprotein particle inhibition explains magnesium-mediated protection against vascular calcification.
Silencing of tumor-suppressive NR_023387 in renal cell carcinoma via promoter hypermethylation and HNF4A deficiency.
Intermedin(1-53) attenuates aging-associated vascular calcification in rats by upregulating sirtuin 1.
The Effect of Dietary Vitamin K1 Supplementation on Trabecular Meshwork and Retina in a Chronic Ocular Hypertensive Rat Model.
Differentially expressed microRNA profiles in exosomes from vascular smooth muscle cells associated with coronary artery calcification.
Indoxyl sulfate promotes osteogenic differentiation of vascular smooth muscle cells by miR-155-5p-dependent downregulation of matrix Gla protein via ROS/NF-κB signaling.
2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes injury-induced vascular neointima formation in mice.
Expression analysis of the osteoarthritis genetic susceptibility mapping to the matrix Gla protein gene MGP.
High Concentration of Calcium Promotes Mineralization in NRK-52E Cells Via Inhibiting the Expression of Matrix Gla Protein.
The Role of Matrix Gla Protein (MGP) Expression in Paclitaxel and Topotecan Resistant Ovarian Cancer Cell Lines.
Matrix gla protein: An extracellular matrix protein regulates myostatin expression in the muscle developmental program.
Matrix Gla protein repression by miR-155 promotes oncogenic signals in breast cancer MCF-7 cells.
Noggin inhibits hypoxia-induced proliferation by targeting store-operated calcium entry and transient receptor potential cation channels.
Differential gene expression analysis of human entorhinal cortex support a possible role of some extracellular matrix proteins in the onset of Alzheimer disease.
Can lineage-specific markers be identified to characterize mesenchyme-derived cell populations in the human airways?
Characterization of dystrophic calcification induced in mice by cardiotoxin.
Using gene expression to predict the secretome of differentiating human preadipocytes.
Prognostic value of matrix Gla protein in breast cancer.
Juvenile dermatomyositis calcifications selectively displayed markers of bone formation.
Bone morphogenic protein antagonists are coexpressed with bone morphogenic protein 4 in endothelial cells exposed to unstable flow in vitro in mouse aortas and in human coronary arteries: role of bone morphogenic protein antagonists in inflammation and atherosclerosis.
Nguyen TT, Thanh HD, Do MH, Jung C
Chonnam medical journal 2023 Sep;59(3):160-166
Chonnam medical journal 2023 Sep;59(3):160-166
The effect of ET1-CTGF mediated pathway on the accumulation of extracellular matrix in the trabecular meshwork and its contribution to the increase in IOP.
Wang J, Rong Y, Liu Y, Zhu M, Chen W, Chen Z, Guo J, Deng C, Manyande A, Wang P, Zhang H, Xiang Y
International ophthalmology 2023 Sep;43(9):3297-3307
International ophthalmology 2023 Sep;43(9):3297-3307
Evidence that pyrophosphate acts as an extracellular signalling molecule to exert direct functional effects in primary cultures of osteoblasts and osteoclasts.
Bourne LE, Davies BK, Millan JL, Arnett TR, Wheeler-Jones CPD, Keen JAC, Roberts SJ, Orriss IR
Bone 2023 Nov;176:116868
Bone 2023 Nov;176:116868
Matrix Gla Protein drives stemness and tumor initiation in ovarian cancer.
Nieddu V, Melocchi V, Battistini C, Franciosa G, Lupia M, Stellato C, Bertalot G, Olsen JV, Colombo N, Bianchi F, Cavallaro U
Cell death & disease 2023 Mar 28;14(3):220
Cell death & disease 2023 Mar 28;14(3):220
A novel epithelial-mesenchymal transition (EMT)-related gene signature of predictive value for the survival outcomes in lung adenocarcinoma.
Cui Y, Wang X, Zhang L, Liu W, Ning J, Gu R, Cui Y, Cai L, Xing Y
Frontiers in oncology 2022;12:974614
Frontiers in oncology 2022;12:974614
Attenuating effect of magnesium on pulmonary arterial calcification in rodent models of pulmonary hypertension.
Chuang KH, Yao RH, Jiang YN, Gui LX, Zheng SY, Lin MJ
Journal of hypertension 2022 Oct 1;40(10):1979-1993
Journal of hypertension 2022 Oct 1;40(10):1979-1993
Inflammation promotes erythropoietin induced vascular calcification by activating p38 pathway.
Li X, Liu C, Li Y, Xiong W, Zuo D
Bioengineered 2022 Mar;13(3):5277-5291
Bioengineered 2022 Mar;13(3):5277-5291
The regenerating skeletal muscle niche drives satellite cell return to quiescence.
Cutler AA, Pawlikowski B, Wheeler JR, Dalla Betta N, Elston T, O'Rourke R, Jones K, Olwin BB
iScience 2022 Jun 17;25(6):104444
iScience 2022 Jun 17;25(6):104444
MGP Regulates Perivascular Adipose-Derived Stem Cells Differentiation Toward Smooth Muscle Cells Via BMP2/SMAD Pathway Enhancing Neointimal Formation.
Ni H, Liu C, Chen Y, Lu Y, Ji Y, Xiang M, Xie Y
Cell transplantation 2022 Jan-Dec;31:9636897221075747
Cell transplantation 2022 Jan-Dec;31:9636897221075747
Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease.
Eshraghi M, Karunadharma PP, Blin J, Shahani N, Ricci EP, Michel A, Urban NT, Galli N, Sharma M, Ramírez-Jarquín UN, Florescu K, Hernandez J, Subramaniam S
Nature communications 2021 Mar 5;12(1):1461
Nature communications 2021 Mar 5;12(1):1461
Drug resistance evaluation in novel 3D in vitro model.
Nowacka M, Sterzynska K, Andrzejewska M, Nowicki M, Januchowski R
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111536
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111536
Plasma Exosomes Derived From Patients With End-Stage Renal Disease and Renal Transplant Recipients Have Different Effects on Vascular Calcification.
Lin X, Zhu T, Xu F, Zhong JY, Li F, Shan SK, Wu F, Guo B, Zheng MH, Wang Y, Xu QS, Liao XB, Lu HY, Xie XB, Yuan LQ
Frontiers in cell and developmental biology 2020;8:618228
Frontiers in cell and developmental biology 2020;8:618228
Identification of Chemoresistance-Associated Key Genes and Pathways in High-Grade Serous Ovarian Cancer by Bioinformatics Analyses.
Wu Y, Xia L, Guo Q, Zhu J, Deng Y, Wu X
Cancer management and research 2020;12:5213-5223
Cancer management and research 2020;12:5213-5223
Generation of a Matrix Gla (Mgp) floxed mouse, followed by conditional knockout, uncovers a new Mgp function in the eye.
Borrás T, Cowley DO, Asokan P, Pandya K
Scientific reports 2020 Oct 29;10(1):18583
Scientific reports 2020 Oct 29;10(1):18583
Calciprotein particle inhibition explains magnesium-mediated protection against vascular calcification.
Ter Braake AD, Eelderink C, Zeper LW, Pasch A, Bakker SJL, de Borst MH, Hoenderop JGJ, de Baaij JHF
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2020 May 1;35(5):765-773
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2020 May 1;35(5):765-773
Silencing of tumor-suppressive NR_023387 in renal cell carcinoma via promoter hypermethylation and HNF4A deficiency.
Zhou H, Guo L, Yao W, Shi R, Yu G, Xu H, Ye Z
Journal of cellular physiology 2020 Mar;235(3):2113-2128
Journal of cellular physiology 2020 Mar;235(3):2113-2128
Intermedin(1-53) attenuates aging-associated vascular calcification in rats by upregulating sirtuin 1.
Chen Y, Zhang LS, Ren JL, Zhang YR, Wu N, Jia MZ, Yu YR, Ning ZP, Tang CS, Qi YF
Aging 2020 Mar 31;12(7):5651-5674
Aging 2020 Mar 31;12(7):5651-5674
The Effect of Dietary Vitamin K1 Supplementation on Trabecular Meshwork and Retina in a Chronic Ocular Hypertensive Rat Model.
Deng C, Yao K, Peng F, Zhao B, Chen Z, Chen W, Zhao Y, Zhang H, Wang J
Investigative ophthalmology & visual science 2020 Jul 1;61(8):40
Investigative ophthalmology & visual science 2020 Jul 1;61(8):40
Differentially expressed microRNA profiles in exosomes from vascular smooth muscle cells associated with coronary artery calcification.
Pan W, Liang J, Tang H, Fang X, Wang F, Ding Y, Huang H, Zhang H
The international journal of biochemistry & cell biology 2020 Jan;118:105645
The international journal of biochemistry & cell biology 2020 Jan;118:105645
Indoxyl sulfate promotes osteogenic differentiation of vascular smooth muscle cells by miR-155-5p-dependent downregulation of matrix Gla protein via ROS/NF-κB signaling.
He X, Wang Z, Wei L, Cheng X, Chen L, Gao F, Jiang H
Experimental cell research 2020 Dec 1;397(1):112301
Experimental cell research 2020 Dec 1;397(1):112301
2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes injury-induced vascular neointima formation in mice.
Guo S, Zhang R, Liu Q, Wan Q, Wang Y, Yu Y, Liu G, Shen Y, Yu Y, Zhang J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Sep;33(9):10207-10217
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Sep;33(9):10207-10217
Expression analysis of the osteoarthritis genetic susceptibility mapping to the matrix Gla protein gene MGP.
Shepherd C, Reese AE, Reynard LN, Loughlin J
Arthritis research & therapy 2019 Jun 18;21(1):149
Arthritis research & therapy 2019 Jun 18;21(1):149
High Concentration of Calcium Promotes Mineralization in NRK-52E Cells Via Inhibiting the Expression of Matrix Gla Protein.
Wang Q, Hu H, Dirie NI, Lu Y, Zhang J, Cui L, Qin B, Wang Y, Zhu J, Xun Y, Zhu Y, Wu Y, Wang S
Urology 2018 Sep;119:161.e1-161.e7
Urology 2018 Sep;119:161.e1-161.e7
The Role of Matrix Gla Protein (MGP) Expression in Paclitaxel and Topotecan Resistant Ovarian Cancer Cell Lines.
Sterzyńska K, Klejewski A, Wojtowicz K, Świerczewska M, Andrzejewska M, Rusek D, Sobkowski M, Kędzia W, Brązert J, Nowicki M, Januchowski R
International journal of molecular sciences 2018 Sep 25;19(10)
International journal of molecular sciences 2018 Sep 25;19(10)
Matrix gla protein: An extracellular matrix protein regulates myostatin expression in the muscle developmental program.
Ahmad S, Jan AT, Baig MH, Lee EJ, Choi I
Life sciences 2017 Mar 1;172:55-63
Life sciences 2017 Mar 1;172:55-63
Matrix Gla protein repression by miR-155 promotes oncogenic signals in breast cancer MCF-7 cells.
Tiago DM, Conceição N, Caiado H, Laizé V, Cancela ML
FEBS letters 2016 Apr;590(8):1234-41
FEBS letters 2016 Apr;590(8):1234-41
Noggin inhibits hypoxia-induced proliferation by targeting store-operated calcium entry and transient receptor potential cation channels.
Yang K, Lu W, Jia J, Zhang J, Zhao M, Wang S, Jiang H, Xu L, Wang J
American journal of physiology. Cell physiology 2015 Jun 1;308(11):C869-78
American journal of physiology. Cell physiology 2015 Jun 1;308(11):C869-78
Differential gene expression analysis of human entorhinal cortex support a possible role of some extracellular matrix proteins in the onset of Alzheimer disease.
Santa-Maria I, Avila J, Rabano A
Neuroscience letters 2010 Jan 14;468(3):225-8
Neuroscience letters 2010 Jan 14;468(3):225-8
Can lineage-specific markers be identified to characterize mesenchyme-derived cell populations in the human airways?
Singh SR, Billington CK, Sayers I, Hall IP
American journal of physiology. Lung cellular and molecular physiology 2010 Aug;299(2):L169-83
American journal of physiology. Lung cellular and molecular physiology 2010 Aug;299(2):L169-83
Characterization of dystrophic calcification induced in mice by cardiotoxin.
Zhao Y, Urganus AL, Spevak L, Shrestha S, Doty SB, Boskey AL, Pachman LM
Calcified tissue international 2009 Sep;85(3):267-75
Calcified tissue international 2009 Sep;85(3):267-75
Using gene expression to predict the secretome of differentiating human preadipocytes.
Mutch DM, Rouault C, Keophiphath M, Lacasa D, Clément K
International journal of obesity (2005) 2009 Mar;33(3):354-63
International journal of obesity (2005) 2009 Mar;33(3):354-63
Prognostic value of matrix Gla protein in breast cancer.
Yoshimura K, Takeuchi K, Nagasaki K, Ogishima S, Tanaka H, Iwase T, Akiyama F, Kuroda Y, Miki Y
Molecular medicine reports 2009 Jul-Aug;2(4):549-53
Molecular medicine reports 2009 Jul-Aug;2(4):549-53
Juvenile dermatomyositis calcifications selectively displayed markers of bone formation.
Urganus AL, Zhao YD, Pachman LM
Arthritis and rheumatism 2009 Apr 15;61(4):501-8
Arthritis and rheumatism 2009 Apr 15;61(4):501-8
Bone morphogenic protein antagonists are coexpressed with bone morphogenic protein 4 in endothelial cells exposed to unstable flow in vitro in mouse aortas and in human coronary arteries: role of bone morphogenic protein antagonists in inflammation and atherosclerosis.
Chang K, Weiss D, Suo J, Vega JD, Giddens D, Taylor WR, Jo H
Circulation 2007 Sep 11;116(11):1258-66
Circulation 2007 Sep 11;116(11):1258-66
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MGP antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MGP. This antibody recognizes human,mouse,rat antigen. The MGP antibody has been validated for the following applications: ELISA, IHC analysis.
