10275-1-AP

antibody from Proteintech Group

Targeting: SNX17 KIAA0064

Provider product page for 10275-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [18]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 10275-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10275-1-AP, RRID:AB_2192394
Product name: SNX17 antibody
Antibody type: Polyclonal
Description: KD/KO validated SNX17 antibody (Cat. #10275-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SNX17 protein structure - 10275-1-AP shown in red.

Submitted references SNX17 Mediates Dendritic Spine Maturation via p140Cap.

Cui Q, Liang S, Li H, Guo Y, Lv J, Wang X, Qin P, Xu H, Huang TY, Lu Y, Tian Q, Zhang T
Molecular neurobiology 2024 Mar;61(3):1346-1362

Sorting nexin 17 increases low-density lipoprotein receptor-related protein 4 membrane expression: A novel mechanism of acetylcholine receptor aggregation in myasthenia gravis.

He X, Zhou S, Ji Y, Zhang Y, Lv J, Quan S, Zhang J, Zhao X, Cui W, Li W, Liu P, Zhang L, Shen T, Fang H, Yang J, Zhang Y, Cui X, Zhang Q, Gao F
Frontiers in immunology 2022;13:916098

Molecular determinants of αVβ5 localization in flat clathrin lattices - role of αVβ5 in cell adhesion and proliferation.

Zuidema A, Wang W, Kreft M, Bleijerveld OB, Hoekman L, Aretz J, Böttcher RT, Fässler R, Sonnenberg A
Journal of cell science 2022 Jun 1;135(11)

New insights into the phosphorylation of the threonine motif of the β1 integrin cytoplasmic domain.

Böttcher RT, Strohmeyer N, Aretz J, Fässler R
Life science alliance 2022 Apr;5(4)

Recycling of autophagosomal components from autolysosomes by the recycler complex.

Zhou C, Wu Z, Du W, Que H, Wang Y, Ouyang Q, Jian F, Yuan W, Zhao Y, Tian R, Li Y, Chen Y, Gao S, Wong CCL, Rong Y
Nature cell biology 2022 Apr;24(4):497-512

The Role of Sorting Nexin 17 in Cardiac Development.

Wu Y, Zhou Y, Huang J, Ma K, Yuan T, Jiang Y, Ye M, Li J
Frontiers in cardiovascular medicine 2021;8:748891

SNX17 protects the heart from doxorubicin-induced cardiotoxicity by modulating LMOD2 degradation.

Zhang Y, Ni L, Lin B, Hu L, Lin Z, Yang J, Wang J, Ma H, Liu Y, Yang J, Lin J, Xu L, Wu L, Shi D
Pharmacological research 2021 Jul;169:105642

A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry.

Zhu Y, Feng F, Hu G, Wang Y, Yu Y, Zhu Y, Xu W, Cai X, Sun Z, Han W, Ye R, Qu D, Ding Q, Huang X, Chen H, Xu W, Xie Y, Cai Q, Yuan Z, Zhang R
Nature communications 2021 Feb 11;12(1):961

Suppression of Membranous LRP5 Recycling, Wnt/β-Catenin Signaling, and Colon Carcinogenesis by 15-LOX-1 Peroxidation of Linoleic Acid in PI3P.

Liu F, Zuo X, Liu Y, Deguchi Y, Moussalli MJ, Chen W, Yang P, Wei B, Tan L, Lorenzi PL, Gao S, Jaoude JC, Mehdizadeh A, Valentin LA, Wei D, Shureiqi I
Cell reports 2020 Aug 18;32(7):108049

TFEB controls retromer expression in response to nutrient availability.

Curnock R, Calcagni A, Ballabio A, Cullen PJ
The Journal of cell biology 2019 Dec 2;218(12):3954-3966

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.

McNally KE, Faulkner R, Steinberg F, Gallon M, Ghai R, Pim D, Langton P, Pearson N, Danson CM, Nägele H, Morris LL, Singla A, Overlee BL, Heesom KJ, Sessions R, Banks L, Collins BM, Berger I, Billadeau DD, Burstein E, Cullen PJ
Nature cell biology 2017 Oct;19(10):1214-1225

Regulation of Cell Migration and β1 Integrin Trafficking by the Endosomal Adaptor GGA3.

Ratcliffe CD, Sahgal P, Parachoniak CA, Ivaska J, Park M
Traffic (Copenhagen, Denmark) 2016 Jun;17(6):670-88

A phosphoinositide conversion mechanism for exit from endosomes.

Ketel K, Krauss M, Nicot AS, Puchkov D, Wieffer M, Müller R, Subramanian D, Schultz C, Laporte J, Haucke V
Nature 2016 Jan 21;529(7586):408-12

SNX17 affects T cell activation by regulating TCR and integrin recycling.

Osborne DG, Piotrowski JT, Dick CJ, Zhang JS, Billadeau DD
Journal of immunology (Baltimore, Md. : 1950) 2015 May 1;194(9):4555-66

Sorting nexin 31 binds multiple β integrin cytoplasmic domains and regulates β1 integrin surface levels and stability.

Tseng HY, Thorausch N, Ziegler T, Meves A, Fässler R, Böttcher RT
Journal of molecular biology 2014 Sep 9;426(18):3180-3194

LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins.

Schorch B, Song S, van Diemen FR, Bock HH, May P, Herz J, Brummelkamp TR, Papatheodorou P, Aktories K
Proceedings of the National Academy of Sciences of the United States of America 2014 Apr 29;111(17):6431-6

Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail.

Böttcher RT, Stremmel C, Meves A, Meyer H, Widmaier M, Tseng HY, Fässler R
Nature cell biology 2012 May 6;14(6):584-92

Adaptor protein sorting nexin 17 interacts with the scavenger receptor FEEL-1/stabilin-1 and modulates its expression on the cell surface.

Adachi H, Tsujimoto M
Biochimica et biophysica acta 2010 May;1803(5):553-63

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human brain tissue were subjected to SDS PAGE followed by western blot with 10275-1-AP(SNX17 antibody) at dilution of 1:300
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using SNX17 antibody 10275-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
Sample type: cell line