27226-1-AP

antibody from Proteintech Group

Targeting: FTO ALKBH9, KIAA1752, MGC5149

Provider product page for 27226-1-AP

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Product number: 27226-1-AP - Provider product page
Provider: Proteintech Group
Product name: FTO antibody
Antibody type: Polyclonal
Description: KD/KO validated FTO antibody (Cat. #27226-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

FTO protein structure - 27226-1-AP shown in red.

Submitted references YTHDF2 promotes arsenic carcinogenesis through m(6)A-dependent SMAD7 decay and PRR5 escape from decay.

Zhang Q, Man J, Cai J, Zhao T, Zhang Z
International journal of biological macromolecules 2026 Mar;348:150816

Integrative Multi-Analysis Identifies METTL3-Regulated FGF19 and H6PD as Candidate Targets in Diabetic Cognitive Impairment.

Fu J, Wang H, Yan J, Chen W, Wang R, Gao H, Li C
Biomolecules 2026 Mar 20;16(3)

LncRNA IGF2AS Regulates Bovine Adipocyte Differentiation by Stabilizing the ILF3/FTO Complex and Activating PI3K/AKT Signaling.

Song C, Chen J, Jiang X, Chen B, Pan Y, Su C, Ren J, Li X, Chen X, Wang Y, Fang X, Zhang C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 15;40(5):e71618

N(6)-methyladenosine modification of MRP7 mRNA modulates its expression and paclitaxel sensitivity in lung cancer-derived A549 cells.

Inamoto T, Nakano M, Fukami T, Nakajima M
Drug metabolism and pharmacokinetics 2026 Jun;68:101519

FTO Upregulates GLG1 Expression via m(6)A Methylation Modification to Facilitate Gastric Cancer Cell Migration and Invasion.

Deng X, Hu Y, Yang X, Luo X, Peng Y, Luo M
Journal of gastroenterology and hepatology 2026 Jan;41(1):215-230

m(6)A modification in the 3'‑leader region of EBOV genome antagonizes ISG20 to facilitate viral replication.

Zhao B, Cao Z, Zhang K, Xiao S, Shen X, Li F, Wu Y, Zhang B, Wang Q, Zhang H, Chuai X, Chiu S
International journal of biological macromolecules 2026 Jan;339(Pt 2):149804

FTO-mediated m6A demethylation of CSF3 suppresses NETosis via downregulation of RLN2 expression in colorectal cancer.

Xu J, Zhang J, Li R, Chen S, Duan C, Ma X, Wang X, Liu X, Gu L, Meng K, Li M
Cell biology and toxicology 2026 Jan 7;42(1):4

Irisin inhibits adipogenic differentiation of bone marrow mesenchymal stem cells through the SIRT1/RANBP2/FTO signaling axis and protects against osteoporosis.

Chen J, Liu J, Fu Q, Xu M, Zhai X, Li L, Xu W, Wu X, Wang K, Si H
Cell death discovery 2026 Feb 25;12(1)

FTO mediates m6A demethylation of HNF1A and drives hepatic steatosis in metabolic dysfunction-associated steatotic liver disease.

Tan J, Shi C, Wang G, Zhang L, Li F, Yan G, Jin Y, Ding H, Jiang F, Li X
Biochimica et biophysica acta. Molecular and cell biology of lipids 2026 Apr;1871(3):159732

FTO-mediated m(6)A depletion drives prenatal prednisone exposure-induced cortical neurogenesis deficits and long-term anxiety-depression-like behaviors in offspring.

Qi C, Guo J, Zhu S, Liu K, Liu Y, Luo M, Jin X, Dai G, Yang P, Wang S, Chen X, Chen H, Wang H, Xu D
Acta pharmaceutica Sinica. B 2026 Apr;16(4):2375-2395

FTO-mediated m6A demethylation of TRIM21 regulates macrophage polarization and attenuates myocardial ischemia-reperfusion injury.

Wan Z, Ding Y
Immunologic research 2026 Apr 25;74(1)

m(6)A demethylase FTO promotes the progression of abdominal aortic aneurysm through PDK4-mediated apoptosis.

Gong W, Yang X, Fan N, Wang H, Fu S, Tian Y, Li L
Scientific reports 2026 Apr 18;

Chronic Psychological Stress Activates TRP/TAM/CXCL1 Signaling to Promote Breast Cancer Adipocyte Lipolysis via KEAP1 m(6)A Demethylation.

Zhan D, She Y, Zhang X, Zhang J, Wang S, Hong S, Zheng Y, Wang N, Wang Z
Research (Washington, D.C.) 2025;8:0980

FTO Alleviates Hepatic Ischemia-Reperfusion Injury by Regulating Apoptosis and Autophagy.

Wang PX, Zhu L, Xiang M, Zhang R, Zheng X, Zheng Z, Li K
Gastroenterology research and practice 2025;2025:5587859

m6A epigenetic signature in necrotizing enterocolitis: insights from murine to neonatal studies.

Chen Y, Wei Q, Gan Y, Wei B, Huang Q, Pan S, Chen Y
Frontiers in immunology 2025;16:1709677

Changes of N6-methyladenosine and ferroptosis in cadmium-induced reproductive toxicity of male mice fed a high fat and high sugar diet.

Liu D, Zhao Y, Dai J, Li R, Yuan J, Shen K, He Z, Gu S
Toxicology 2025 Sep;516:154172

FTO promotes weight gain via altering Kif1a splicing and axonal vesicle trafficking in AgRP neurons.

Kohno D, Kawabata-Iwakawa R, Ichinose S, Suyama S, Ohashi K, Ariyani W, Sadakata T, Yokota-Hashimoto H, Kobayashi R, Horii T, Susanti VY, Konno A, Tsuneoka H, Yoshikawa C, Matsui S, Harada A, Yada T, Hatada I, Hirai H, Nishiyama M, Sasaki T, Kitamura T
The EMBO journal 2025 Sep;44(18):4919-4961

The splicing factor SRSF6 mediates ferroptosis resistance in head and neck squamous cell carcinoma through induction of stearoyl-CoA desaturase.

Yan L, Wang J, Li B, Guo J, Jia R
The Journal of biological chemistry 2025 Sep;301(9):110509

METTL3 Silencing Suppresses Cardiac Fibrosis Post Myocardial Infarction via m6A Modification of SMOC2.

He Y, Pan X, Liu Z, Zuo P, Sheng Z, Hao C, Tao Z, Chen Z, Song J, Ma G, Ling S
Journal of cellular and molecular medicine 2025 Sep;29(17):e70829

m6A demethylase FTO/ALKBH5 promotes diabetes-induced endothelial cell dysfunction by negatively regulating lncRNA H19.

Luo Y, Luo W, Cao Y, Wang Z
Experimental and molecular pathology 2025 Sep;143:104970

Alpha-ketoglutarate protects against myocardial infarction via FTO-mediated anti-inflammatory macrophage activation.

Lin Z, He H, Chen P, Dong X, Jiang J, Huang W, Pan Z, Guan Z, Lu L, Li H, Huang Y, Wang Z, Luo T, Wang L, Chen Z
Basic research in cardiology 2025 Oct;120(5):889-912

Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation.

Zhang H, Li Z, Zhu Y, Lyu W, Wei W, Wang H, Tian S, Yue W, Zhong J, Sun QY, Guan Y
Nature communications 2025 Oct 8;16(1):8955

ADAP-METTL3 modulates the inflammatory responses of macrophages via m(6)A modification of Spry1.

Dong A, Zhang P, Yang F, Wang Y, Liu H
Cell death & disease 2025 Oct 7;16(1):708

IGF2BP3 redirects glycolytic flux to promote one-carbon metabolism and RNA methylation.

Sharma G, Gutierrez M, Jones AE, Kapoor S, Jaiswal AK, Neeb ZT, Rios A, Dorairaj P, Thaxton ML, Lin TL, Tran TM, Kabbani LES, Ritter AJ, Scherer GM, Sorrentino JP, Stiles L, Hoeve JT, Damoiseaux RD, Garg NK, Divakaruni AS, Sanford JR, Rao DS
Cell reports 2025 Oct 28;44(10):116330

SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m6A Modification.

Zuo X, Xu J, Yang D, Yang C, Liu X, Chen N, Wang H, Luo X, Luo Q, Wang Y, Wei Q, Yang Y, Zhao H, Xu J, Wang W, Liu T, Yi P
Cancer research 2025 Oct 15;85(20):3894-3909

Changes of N(6)-methyladenosine modification and unfolded protein response in renal cell injury induced by cadmium.

Wang N, Dai J, Li R, Li W, Liu D, Liu X, Mei Z, Lu H, He Z, Gu S
Ecotoxicology and environmental safety 2025 Oct 15;305:119228

WTAP-mediated m(6)A modification promotes drug sensitivity by regulating NR3C1 in prostate cancer.

Wang H, Zhang D, Ouyang Y, Li J, Pang G, Xie X, Huang H, Yan T, Pang X, Zhou Q, Xie B, Wang F, An S, Hu Y
Science China. Life sciences 2025 Nov;68(11):3151-3166

Deregulation and delocalization of the m(6)A demethylase FTO and aberrant m(6)A levels in ccRCC tissue samples.

Tito C, Rosa P, Sorrentino V, Magnanti M, Innocenti A, Zaccaria L, Costantini M, Iaiza A, Bastianelli D, Masciarelli S, Pastore AL, Simone G, Carbone A, Fatica A, Petrozza V, Fazi F
Histology and histopathology 2025 Nov;40(11):1747-1756

Hyperactivation of the m(6)A demethylase FTO to down-regulate SLC7A11/xCT-mediated redox homeostasis and epigenetic remodeling in facial infiltrating lipomatosis.

Chen H, Gao W, Huang Z, Chang SJ, Qiu Y, Sun B, Lin X, Hua C
Free radical biology & medicine 2025 Nov;239:432-448

Gambogic acid induces ferroptosis and suppresses colorectal cancer progression by modulating the m6A modification of p62.

Wang J, Deng J, Sun B, Qiao G, Yang J, Gao Z, Zhang Q, Dong M, Qu P, Wang Z
Cellular signalling 2025 Nov;135:112024

The m(6)A demethylase FTO links TLR7 to mitochondrial oxidation driving age-associated B cell formation in systemic lupus erythematosus.

Zeng Q, Li L, Li X, Qin L, Feng T, Zhu Y, Wang J, Zou Y, Su J, Dong G, Xia W, Xu T, Zhang G, Cui Y, Lin H, Li X, Li Y
Science translational medicine 2025 Nov 5;17(823):eadu6015

m(6)A demethylase FTO drives pancreatic ductal adenocarcinoma tumorigenesis and metastasis through remodeling PFKM mediated glycolysis.

Tan Z, Yang J, Chen Y, Zhu H, Liu X, Xu H, Meng Q, Xiao M, Tang R, Rong Z, Yu X, Liang C, Xu J
Cell death & disease 2025 Nov 3;16(1):784

FTO Suppresses Dental Pulp Stem Cell Senescence by Destabilizing NOLC1 mRNA.

Li B, Xu M, Huang J, Jia R
Biomolecules 2025 Nov 19;15(11)

FTO-mediated m6A modification elevates the MFN2 mRNA stability to suppress ovarian granulosa cell senescence.

Li Q, Shen H, Liu A, Yu L, Wang L, Zhang X
International journal of biological macromolecules 2025 May;307(Pt 4):142181

The Impact of METTL3 on MDM2 Promotes Podocytes Injury During Diabetic Kidney Disease.

Wu H, Yu Z, Yang Y, Han Z, Pan Q, Chen Y, Yu H, Shen S, Xu L
Journal of cellular and molecular medicine 2025 May;29(10):e70627

YTHDF1 shapes immune-mediated hepatitis via regulating inflammatory cell recruitment and response.

Li H, Yu K, Zhang X, Li J, Hu H, Deng X, Zeng S, Dong X, Zhao J, Zhang Y
Genes & diseases 2025 May;12(3):101327

FTO regulates ELK3-mediated metabolic rewiring and represents a unique therapeutic target in T cell leukemia.

Huang H, Li X, Luo J, Gao C, Yang M, Xu J, Xie T, Chen Z, Wang D, Wang Y, Li HB, Huang J, Liu Y, Zhang H, Ntziachristos P, Zhao Y, Qing G, Liu H
Science advances 2025 May 30;11(22):eadq3052

Metabolite-dependent m(6)A methylation driven by mechanotransduction-metabolism-epitranscriptomics axis promotes bone development and regeneration.

Li Z, Guo Z, Yang Z, Yang B, Hu Y, Xie X, Zong Z, Chen Z, Zhang K, Zhao P, Li G, Yang X, Bian L
Cell reports 2025 May 27;44(5):115611

Genome-wide profiling of N6-methyladenosine-modified pseudogene-derived long noncoding RNAs reveals the tumour-promoting and innate immune-restraining function of RPS15AP12 in ovarian cancer.

Xu J, Ren Y, Lu J, Qin F, Yang D, Tang C, Yang Y, Xu J, Liu T, Yi P
Clinical and translational medicine 2025 Mar;15(3):e70249

FTO/miR-503-5p/USP10 axis regulates neuronal endoplasmic reticulum stress-mediated apoptosis in ischemic stroke.

Peng Q, Wang S, Huang S, Deng Y, Li Z, Liu C, Hong Y, Duan R, Xue X, Ge P
International immunopharmacology 2025 Mar 6;149:114150

Electroacupuncture regulates FTO/Nrf2/NLRP3 axis-mediated pyroptosis in cerebral ischemia-reperfusion injury.

Li C, Ji H, Mao W, Zhang L, Tong T, Wang J, Cai L, Wang H, Sun T, Yi H, Li S, Tu Y, Zhang J, Wang H, Wu H, Han W, Wang Y
Neuroreport 2025 Mar 19;36(5):257-266

The Flip Side of the Coin: METTL3 Serves as a Novel Cellular Senescence Accelerator via Negative Regulation of ITGA9.

Li Y, Huang L, Fang M, Ye L, Yang H, Wu W, Yuan Y, Cao K, Zheng HL, Sun X, Wu Y, Xiong XD, Liu X, Xu S
Aging and disease 2025 Mar 18;17(2):1034-1051

Bisphenol F induces spermatogenic cell ferroptosis via FTO-mediated m6A regulation of FTH1.

Zhou SM, Shi Y, Li JY, Wang N, Zeng Y, Chen HQ, Tan YP, Deng SW, Liu QQ, Huang XQ, Wang YQ, Zhou ZY, Liu WB
Free radical biology & medicine 2025 Mar 1;229:364-373

Targeting m(6)A demethylase FTO to heal diabetic wounds with ROS-scavenging nanocolloidal hydrogels.

Zheng X, Deng S, Li Y, Luo Z, Gan Z, Zheng Z, Xu R, Xiao S, Cai Y, Meng J, Li L, Li C, Xue X, Dai W, Qin S, Wang M, Zeng K, Xiao Z, Xia L
Biomaterials 2025 Jun;317:123065

Strain-Divergent m6A Landscapes Modulate Nipah Virus Replication and METTL3 Inhibition Attenuates Virulence.

Luo T, Chen Z, Zhang F, Liu H, Huang F, Zhang X, Feng J, Ding S, Liu L, Guan W, Zeng A, Hao H
Viruses 2025 Jun 9;17(6)

Mitigation of Ferroptosis in Diabetic Kidney Disease Through Mesenchymal Stem Cell Intervention via the Smad2/3/METTL3/S1PR1 Axis.

Huang LL, Hou YY, Yang J, Liao XN, Ma JS, Wang WC, Quan YX, Jiang HY, Bai YH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 30;39(12):e70714

Berbamine inhibits cell proliferation and invasion by increasing FTO expression in renal cell carcinoma cells.

Xu J, Cheng X, Xu M, Zhang J, Yang T, Shuai L, Deng L, Zhang Y
BMC cancer 2025 Jun 2;25(1):987

NRF2 maintains redox balance via ME1 and NRF2 inhibitor synergizes with venetoclax in NPM1-mutated acute myeloid leukemia.

Hu J, Yuan Z, Shu Y, Ren J, Yang J, Tang L, Wei X, Liu Y, Jin F, Xiao Q, Chen X, Wu N, Zhao W, Li Z, Zhang L
Cancer & metabolism 2025 Jun 18;13(1):32

m6A reader IGF2BP2-stabilized lncRNA LHX1-DT inhibits renal cell carcinoma (RCC) cell proliferation and invasion by sponging miR-590-5p.

Zhu C, Li R, You X, Xu J, Wang J, Dong D, Chen X, Wang K
NPJ precision oncology 2025 Jun 17;9(1):193

FTO-mediated m(6)A demethylation regulates IGFBP3 expression and AKT activation through IMP3-dependent P-body re-localisation in lung cancer.

Wang H, Peng H, Zhang Z, Abulimiti Y, Hu J, Zhou Y, Ji P, Li D
Clinical and translational medicine 2025 Jul;15(7):e70392

FTO triggers NLRP3/GSDMD-dependent pyroptosis to enhance cisplatin-sensitivity in ovarian cancer.

Zhang F, Zhu T, Gan L, Du Y, Liu L, Ding H, Chen X, Guan Y
Cellular signalling 2025 Jul;131:111698

ALKBH5-mediated NPC2 mRNA m(6)A demethylation promotes resistance to oxaliplatin in colorectal cancer.

Wan P, Ren Y, Li HT
Functional & integrative genomics 2025 Jul 19;25(1):158

Exosome-derived long non-coding RNA AC010789.1 modified by FTO and hnRNPA2B1 accelerates growth of hair follicle stem cells against androgen alopecia by activating S100A8/Wnt/β-catenin signalling.

Chu S, Jia L, Li Y, Xiong J, Sun Y, Zhou Q, Du D, Li Z, Huang X, Jiang H, Wu B, Li Y
Clinical and translational medicine 2025 Jan;15(1):e70152

hnRNPU-mediated pathogenic alternative splicing drives gastric cancer progression.

Jin G, Song Y, Fang S, Yan M, Yang Z, Shao Y, Zhao K, Liu M, Wang Z, Guo Z, Dong Z
Journal of experimental & clinical cancer research : CR 2025 Jan 7;44(1):8

IDO1 inhibits ferroptosis by regulating FTO-mediated m6A methylation and SLC7A11 mRNA stability during glioblastoma progression.

Tian Q, Dan G, Wang X, Zhu J, Chen C, Tang D, Wang Z, Chen D, Lei S, Yang C, Wang H, Guo B, Jin B, Chen T, Tang L
Cell death discovery 2025 Jan 25;11(1):22

O-GlcNAcylated FTO promotes m6A modification of SOX4 to enhance MDS/AML cell proliferation.

Gou J, Bi J, Wang K, Lei L, Feng Y, Tan Z, Gao J, Song Y, Kang E, Guan F, Li X
Cell communication and signaling : CCS 2025 Jan 23;23(1):43

Comprehensive Analysis Reveals Midnolin as a Potential Prognostic, Therapeutic, and Immunological Cancer Biomarker.

Zhang XG, Li WT, Jin X, Fu C, Jiang W, Bai J, Shi ZZ
Biomedicines 2025 Jan 23;13(2)

ALKBH5 alleviates lower extremity arteriosclerosis by regulating ITGB1 demethylation and influencing macrophage polarization.

Guan Z, Wang X, Xu C, Lu R
Heliyon 2025 Jan 15;11(1):e41495

RNA m(6)A involves in regulation of oxidative stress and apoptosis may via NF-kB pathway in cadmium-induced lung cells.

Zhang N, Yang J, Zhao Y, Li W, Zhao B, Li R, He Z, Gu S
Cell death discovery 2025 Jan 10;11(1):4

N 6-Methyladenosine Demethylase FTO Controls Macrophage Homeostasis in Diabetic Vasculopathy.

Feng S, Zhang Q, Liu Q, Huang C, Zhang H, Wang F, Zhu Y, Jian Q, Chen X, Jiang Q, Yan B
Diabetes 2025 Jan 1;74(1):82-95

Bioinformatic Analysis of m6A Regulator-Mediated RNA Methylation Modification Patterns and Immune Microenvironment Characterization in Endometriosis.

Zheng W, Fu Z, Tan X, Liang X, Cao L
Biochemical genetics 2025 Feb;63(1):433-464

Organophosphate flame retardant triphenyl phosphate (TPhP) induced colonic fibrosis by bringing about epithelial-mesenchymal transition.

Peng C, Wang M, Zheng C, Zhang X, Chen Y, Wang L
Ecotoxicology and environmental safety 2025 Feb;291:117913

m6A Demethylase FTO-Mediated Upregulation of BAP1 Induces Neuronal Ferroptosis via the p53/SLC7A11 Axis in the MPP(+)/MPTP-Induced Parkinson's Disease Model.

Li Z, Chen X, Xiang W, Tang T, Gan L
ACS chemical neuroscience 2025 Feb 5;16(3):405-416

Liver ALKBH5 regulates glucose and lipid homeostasis independently through GCGR and mTORC1 signaling.

Ding K, Zhang Z, Han Z, Shi L, Li X, Liu Y, Li Z, Zhao C, Cui Y, Zhou L, Xu B, Zhou W, Zhao Y, Wang Z, Huang H, Xie L, Chen XW, Chen Z
Science (New York, N.Y.) 2025 Feb 28;387(6737):eadp4120

The pseudorabies virus UL13 protein kinase triggers phosphorylation of the RNA demethylase FTO, which is associated with FTO-dependent suppression of interferon-stimulated gene expression.

Verhamme R, Jansens RJJ, Liu J, Van Raemdonck F, Van Waesberghe C, Nicholson L, Jaffrey SR, Favoreel HW
Journal of virology 2025 Feb 25;99(2):e0201924

m6A regulator-based molecular classification and hub genes associated with immune infiltration characteristics and clinical outcomes in diffuse gliomas.

Lu J, Chen S, Hu W, Sai K, Li D, Jiang P
BMC medical genomics 2025 Feb 24;18(1):37

FTO-associated osteoclastogenesis promotes alveolar bone resorption in apical periodontitis male rat via the HK1/USP14/RANK pathway.

Qian Y, Wu J, Yang W, Lyu R, You Q, Li J, He Q, Zhuang Y, Wang W, Wang Y, Zhu Y, Wu Z, Chen D
Nature communications 2025 Feb 11;16(1):1519

METTL3 alleviates renal tubular mitochondrial dysfunction by regulating the TUG1/PGC-1a axis in an IGF2BP2-dependent manner in diabetic nephropathy.

Chen T, Wang J, Xu Y, Zhu Y, Jin Y, Fan Q
Renal failure 2025 Dec;47(1):2521455

M6a demethylase FTO regulates the oxidative stress, mitochondrial biogenesis of cardiomyocytes and PGC-1a stability in myocardial ischemia-reperfusion injury.

Jiang Q, Chen X, Gong K, Xu Z, Chen L, Zhang F
Redox report : communications in free radical research 2025 Dec;30(1):2454892

Novel role of FTO in regulation of gut-brain communication via Desulfovibrio fairfieldensis-produced hydrogen sulfide under arsenic exposure.

Chen R, Chai X, Zhang Y, Zhou T, Xia Y, Jiang X, Lv B, Zhang J, Zhou L, Tian X, Wang R, Mao L, Zhao F, Zhang H, Hu J, Qiu J, Zou Z, Chen C
Gut microbes 2025 Dec;17(1):2438471

SARS-CoV-2 and HCoV-OC43 regulate host m6A modification via activation of the mTORC1 signalling pathway to facilitate viral replication.

Zhou S, Hui X, Wang W, Zhao C, Jin M, Qin Y, Chen M
Emerging microbes & infections 2025 Dec;14(1):2447620

FTO-mediated m6A modification regulates the osteogenic differentiation of ADSCs by targeting FOXO1.

Wang Z, Wen S, Li H, Wang X, Guo S, Yang S
Stem cell research & therapy 2025 Dec 17;17(1):39

The m6A modification-mediated upregulation of ETS2 translation drives arsenic-induced spermatogonial senescence.

Zhang XY, Zhang YH, Liang NN, Xu SS, Li QS, Song YP, Zhang WW, Wang B, Wang H, Huang YC, Xu DX
Free radical biology & medicine 2025 Dec 1;240:384-396

FTO curbs trophoblast cell biological behaviors through repressing ALDH1A1 expression.

Liu L, Liu H, Jia R, Zhang X, Lu X
Cytotechnology 2025 Aug;77(4):124

FTO promotes breast cancer development via inhibiting CYP27B1 /1,25-dihydroxyvitamin D3 asis in m6A-dependent manner.

Qin Y, Zeng H, Dong Z, Zhu C, Bian Q, Zhai X, Tang H, Zhou F, Yang L, Zhang J
International journal of biological macromolecules 2025 Aug;319(Pt 3):145464

A novel FTO-targeting nanodrug induces disulfidptosis and ameliorates the suppressive tumor immune environment to treat uveal melanoma.

Tian H, Deng H, Liu X, Liu C, Zhang C, Leong KW, Fan X, Ruan J
Biomaterials 2025 Aug;319:123168

FTO-mediated the destabilization of RASGRF1 mRNA impedes thyroid cancer progression and suppresses macrophage M2 polarization.

Li Z, Ma J, Guan H, Lai J, Xu F, Cao G
Cell biology and toxicology 2025 Aug 4;41(1):123

Demethylase FTO in the cerebrospinal fluid-contacting nucleus of mice contributes to neuropathic pain via mediating m6A demethylation of P2rx4 mRNA.

Zhang YT, Huang WL, Zhang YJ, Zhang LC
Neuropharmacology 2025 Aug 1;273:110462

Nuclear accumulation of YTHDF1 regulates mRNA splicing in the DNA damage response.

Hou J, Gao Y, Han B, Yan S, Wei S, Gao X
Science advances 2025 Apr 18;11(16):eado7660

METTL3 Plays Regulatory Roles in Acute Pneumonia during Staphylococcus aureus Infection.

Wu M, Nie Q, Zhang Y, Qin J, Ye L, Zhao R, Dai M, Wu M
ACS infectious diseases 2025 Apr 11;11(4):905-916

Branch Chain Amino Acid Metabolism Promotes Brain Metastasis of NSCLC through EMT Occurrence by Regulating ALKBH5 activity.

Mao L, Wang L, Lyu Y, Zhuang Q, Li Z, Zhang J, Gu Z, Lu S, Wang X, Guan Y, Xiong J, Wang Y, Mao Y, Yang H, Liu Y
International journal of biological sciences 2024;20(9):3285-3301

The Effect Mechanism of N6-adenosine Methylation (m6A) in Melatonin Regulated LPS-induced Colon Inflammation.

Li Y, Ma B, Wang Z, Chen Y, Dong Y
International journal of biological sciences 2024;20(7):2491-2506

m(6)A modification enhances the stability of CDC25A promotes tumorigenicity of esophagogastric junction adenocarcinoma via cell cycle.

Pan Y, Feng H, Zhou J, Zhang W, Liu Y, Zheng J, Wang J, Gao S, Li Y
International journal of biological sciences 2024;20(11):4209-4221

METTL3-mediated methylation of CYP2C19 mRNA may aggravate clopidogrel resistance in ischemic stroke patients.

Tan Q, Yang L, Yuan S, Zheng D, Lin Y, Chen K, He Y, Chen S, Hao J, Dai J, He S, Mao F, Leng X, Jiang H, Yang J
Open medicine (Warsaw, Poland) 2024;19(1):20240899

FTO Stabilizes MIS12 to Inhibit Vascular Smooth Muscle Cell Senescence in Atherosclerotic Plaque.

Sun J, Wang M, Jia F, Song J, Ren J, Hu B
Journal of inflammation research 2024;17:1857-1871

FTO diversely influences sensitivity of neuroblastoma cells to various chemotherapeutic drugs.

Lin M, Hua Z, Li Z
Frontiers in pharmacology 2024;15:1384141

N6-methyladenosine-modified circ_0000337 sustains bortezomib resistance in multiple myeloma by regulating DNA repair.

Jiang S, Gao L, Li J, Zhang F, Zhang Y, Liu J
Frontiers in cell and developmental biology 2024;12:1383232

Comprehensive analysis of the expression patterns and function of the FTO-LINE1 axis in yak tissues and muscle satellite cells.

Ma Z, Chai Z, Yang H, Zhang X, Zhao H, Luo X, Zhong J, Wu Z
Frontiers in veterinary science 2024;11:1448587

Changes of m(6)A Regulatory Proteins and Nrf2 Signaling Molecules in Liver Tissue of Type 2 Diabetes Mellitus Rats.

Wang N, Yang J, Liu X, Liu G, He Z, Gu S
Cell biochemistry and biophysics 2024 Sep;82(3):2217-2226

Fluoride exposure-induced gut microbiota alteration mediates colonic ferroptosis through N(6)-methyladenosine (m(6)A) mediated silencing of SLC7A11.

Huang H, Lin Y, Xin J, Sun N, Zhao Z, Wang H, Duan L, Zhou Y, Liu X, Fang J, Jing B, Pan K, Zeng Y, Zeng D, Li H, Ma H, Bai Y, Wei L, Ni X
Ecotoxicology and environmental safety 2024 Sep 15;283:116816

Fat Mass- and Obesity-Associated Protein (FTO) Promotes the Proliferation of Goat Skeletal Muscle Satellite Cells by Stabilizing DAG1 mRNA in an IGF2BP1-Related m(6)A Manner.

Yao J, Xu L, Zhao Z, Dai D, Zhan S, Cao J, Guo J, Zhong T, Wang L, Li L, Zhang H
International journal of molecular sciences 2024 Sep 11;25(18)

N6-Methyladenosine Positively Regulates Coxsackievirus B3 Replication.

Zhao H, Gao Z, Sun J, Qiao H, Zhao Y, Cui Y, Zhao B, Wang W, Chiu S, Chuai X
Viruses 2024 Sep 11;16(9)

FTO-mediated SMAD2 m6A modification protects cartilage against Osteoarthritis.

Zhou H, Xie Z, Qian Y, Ni W, Cui L, Fang X, Wan S, Zhao X, Qin A, Fan S, Wu Y
Experimental & molecular medicine 2024 Oct;56(10):2283-2295

LncRNA HOTAIRM1 promotes radioresistance in nasopharyngeal carcinoma by modulating FTO acetylation-dependent alternative splicing of CD44.

Mi J, Wang Y, He S, Qin X, Li Z, Zhang T, Huang W, Wang R
Neoplasia (New York, N.Y.) 2024 Oct;56:101034

IGFBP7 regulates cell proliferation and migration through JAK/STAT pathway in gastric cancer and is regulated by DNA and RNA methylation.

Mo W, Deng L, Cheng Y, Ge S, Wang J
Journal of cellular and molecular medicine 2024 Oct;28(19):e70080

FTO alleviated ferroptosis in septic cardiomyopathy via mediating the m6A modification of BACH1.

Zeng H, Xu J, Wu R, Wang X, Jiang Y, Wang Q, Guo J, Xiao F
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167307

FTO/IGF2BP2-mediated N6 methyladenosine modification in invasion and metastasis of thyroid carcinoma via CDH12.

Chen Z, Zhong X, Xia M, Liu C, Tang W, Liu G, Yi Y, Guo Y, Jiang Q, Zu X, Zhong J
Cell death & disease 2024 Oct 8;15(10):733

HSV-1-induced N6-methyladenosine reprogramming via ICP0-mediated suppression of METTL14 potentiates oncolytic activity in glioma.

Chen Y, Bian S, Zhang J, Luan Y, Yin B, Dai W, Wang H, Chen X, Dong Y, Cai Y, Dong R, Yu L, Shu M
Cell reports 2024 Oct 22;43(10):114756

TGF-β Promotes Hepatocellular Carcinoma Metastasis Through Through m6A Modification of PCDHGA9.

Wang H, Guan W, Zhang X, Wu Y, Ou Y, Zhang Y, Zeng Z, Yao H
Cancer biotherapy & radiopharmaceuticals 2024 Nov;39(9):644-653

Fat Mass and Obesity-Associated Protein Regulates Granulosa Cell Aging by Targeting Matrix Metalloproteinase-2 Gene Via an N6-Methyladenosine-YT521-B Homology Domain Family Member 2-Dependent Pathway in Aged Mice.

Li L, Yang L, Shen L, Zhao Y, Wang L, Zhang H
Reproductive sciences (Thousand Oaks, Calif.) 2024 Nov;31(11):3498-3511

The methyltransferase METTL3 regulates endothelial cell proliferation and inflammation via m(6)A RNA methylation-mediated TRAF1 expression.

Chen D, Xu W, Zheng H, Zhang Y, Lin Y, Han Y, Yao F, Shen H
Biochemical and biophysical research communications 2024 Nov 5;732:150399

METTL3 and IGF2BP2 coordinately regulate FOSL1 mRNA via m6A modification, suppressing trophoblast invasion and contributing to fetal growth restriction.

Chen R, Wang T, Tong H, Zhang X, Ruan J, Qi H, Liu X, He G
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Nov 30;38(22):e70154

Downregulated KLF4, induced by m6A modification, aggravates intestinal barrier dysfunction in inflammatory bowel disease.

Zhu X, Wang J, Zhang H, Yue H, Zhu J, Li J, Wang K, Shen K, Yang K, Leng X, Xi Q, Shi T
Cellular and molecular life sciences : CMLS 2024 Nov 29;81(1):470

METTL14 suppresses the expression of YAP1 and the stemness of triple-negative breast cancer.

Bai X, Liu J, Zhou S, Wu L, Feng X, Zhang P
Journal of experimental & clinical cancer research : CR 2024 Nov 20;43(1):307

RNA reading protein YTHDF2 mediates Benzo(k)fluoranthene induced male reproductive injury by regulating the stability of BCL2.

Li YW, Wang DD, Chen HQ, Zeng Y, Wang N, Shi Y, Li JY, Zhou NY, Wang DP, Chen Q, Han X, Cao J, Liu WB
Environmental pollution (Barking, Essex : 1987) 2024 Nov 15;361:124889

Dynamic multilayered control of m(6)A RNA demethylase activity.

Jaafar C, Aguiar RCT
Proceedings of the National Academy of Sciences of the United States of America 2024 Nov 12;121(46):e2317847121

Epstein-Barr virus suppresses N(6)-methyladenosine modification of TLR9 to promote immune evasion.

Zhang X, Li Z, Peng Q, Liu C, Wu Y, Wen Y, Zheng R, Xu C, Tian J, Zheng X, Yan Q, Wang J, Ma J
The Journal of biological chemistry 2024 May;300(5):107226

METTL14 affects UVB-induced human dermal fibroblasts photoaging via miR-100-3p biogenesis in an m(6)A-dependent manner.

Chen L, Hu Y, Zhang M, Liu L, Ma J, Xu Z, Zhang J, Gu H, Chen K
Aging cell 2024 May;23(5):e14123

Manganese induces podocyte injury through regulating MTDH/ALKBH5/NLRP10 axis: Combined analysis at epidemiology and molecular biology levels.

Liang Q, Jing J, He H, Huang X, Liu J, Wang M, Qi Z, Zhang L, Huang Z, Yan Y, Liu S, Gao M, Zou Y
Environment international 2024 May;187:108672

GnRH-driven FTO-mediated RNA m(6)A modification promotes gonadotropin synthesis and secretion.

Wang HQ, Ma YR, Zhang YX, Wei FH, Zheng Y, Ji ZH, Guo HX, Wang T, Zhang JB, Yuan B
BMC biology 2024 May 3;22(1):104

l-2-Hydroxyglutarate remodeling of the epigenome and epitranscriptome creates a metabolic vulnerability in kidney cancer models.

Kundu A, Brinkley GJ, Nam H, Karki S, Kirkman R, Pandit M, Shim E, Widden H, Liu J, Heidarian Y, Mahmoudzadeh NH, Fitt AJ, Absher D, Ding HF, Crossman DK, Placzek WJ, Locasale JW, Rakheja D, McConathy JE, Ramachandran R, Bae S, Tennessen JM, Sudarshan S
The Journal of clinical investigation 2024 May 14;134(13)

Palmatine inhibits expression fat mass and obesity associated protein (FTO) and exhibits a curative effect in dextran sulfate sodium (DSS)-induced experimental colitis.

Ji W, Huo Y, Zhang Y, Qian X, Ren Y, Hu C, Zhang J
International immunopharmacology 2024 May 10;132:111968

Dynamics of N6-methyladenosine modification during aging and their potential roles in the degeneration of intervertebral disc.

Liu L, Sun H, Zhang Y, Liu C, Zhuang Y, Liu M, Ai X, Long D, Huang B, Li C, Zhou Y, Dong S, Feng C
JOR spine 2024 Mar;7(1):e1316

IGF2BP3-stabilized CAMK1 regulates the mitochondrial dynamics of renal tubule to alleviate diabetic nephropathy.

Yuan D, Li H, Dai W, Zhou X, Zhou W, He L
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167022

METTL3-mediated m(6)A modification of SOX4 regulates osteoblast proliferation and differentiation via YTHDF3 recognition.

Feng ZW, Peng B, Wang SH, Zhao DC, Wang YB, Yang A, Zhan HW, Sheng XY, Xu LH, Ren XJ, Yang F, Geng B, Xia YY
Cellular signalling 2024 Mar;115:111038

RNA m6A dynamic modification mediated by nucleus-localized FTO is involved in follicular reserve.

Zhang JN, Wang RT, Klinger FG, Cheng SF, Shen W, Sun XF
Zoological research 2024 Mar 18;45(2):415-428

FTO-mediated m6A mRNA demethylation aggravates renal fibrosis by targeting RUNX1 and further enhancing PI3K/AKT pathway.

Wang DX, Bao SY, Song NN, Chen WZ, Ding XQ, Walker RJ, Fang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 15;38(5):e23436

FTO-mediated autophagy inhibition promotes non-small cell lung cancer progression by reducing the stability of SESN2 mRNA.

Wang K, Mei Z, Zheng M, Liu X, Li D, Wang H
Heliyon 2024 Mar 15;10(5):e27571

FTO demethylates regulates cell-cycle progression by controlling CCND1 expression in luteinizing goat granulosa cells.

Li D, Zhou L, Liu Z, Zhang Z, Mao W, Shi W, Zhu M, Wang F, Wan Y
Theriogenology 2024 Mar 1;216:20-29

Changes of RNA m(6)A/m(5)C Modification Regulatory Molecules in Ferroptosis of T2DM Rat Pancreas.

Liu X, Wang N, Gu S, He Z
Cell biochemistry and biophysics 2024 Jun;82(2):1279-1289

Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through directly regulating contactin-associated protein-like 4 (CNTNAP4) transcription: An experimental study.

Hu W, Wang M, Sun G, Zhang L, Lu H
Cellular signalling 2024 Jun;118:111139

WTAP and m(6)A-modified circRNAs modulation during stress response in acute myeloid leukemia progenitor cells.

Iaiza A, Mazzanti G, Goeman F, Cesaro B, Cortile C, Corleone G, Tito C, Liccardo F, De Angelis L, Petrozza V, Masciarelli S, Blandino G, Fanciulli M, Fatica A, Fontemaggi G, Fazi F
Cellular and molecular life sciences : CMLS 2024 Jun 23;81(1):276

Demethylase FTO-mediated m6A modification of SIK1 modulates placental cytotrophoblast syncytialization in type 2 diabetes mellitus.

Ning J, Yan J, Wang S, Cui Z, Xue Y, Juan J, Yang H
iScience 2024 Jun 21;27(6):109900

ZFHX3 acts as a tumor suppressor in prostate cancer by targeting FTO-mediated m(6)A demethylation.

Hu Q, Yin J, Zhao S, Wang Y, Shi R, Yan K, Huang S
Cell death discovery 2024 Jun 13;10(1):284

LncRNA CARMN m6A demethylation by ALKBH5 inhibits mutant p53-driven tumour progression through miR-5683/FGF2.

Liu N, Jiang X, Zhang G, Long S, Li J, Jiang M, Jia G, Sun R, Zhang L, Zhang Y
Clinical and translational medicine 2024 Jul;14(7):e1777

PXR Activation Relieves Deoxynivalenol-Induced Liver Oxidative Stress Via Malat1 LncRNA m(6)A Demethylation.

Feng Y, Shen J, Lin Z, Chen Z, Zhou M, Ma X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(25):e2308742

The demethylase ALKBH5 mediates ZKSCAN3 expression through the m(6)A modification to activate VEGFA transcription and thus participates in MNNG-induced gastric cancer progression.

Wang Q, Huang Y, Jiang M, Tang Y, Wang Q, Bai L, Yu C, Yang X, Ding K, Wang W, Bai J, Chen Y
Journal of hazardous materials 2024 Jul 15;473:134690

Characterization of m6A Modifiers and RNA Modifications in Uterine Fibroids.

George JW, Cancino RA, Griffin Miller JL, Qiu F, Lin Q, Rowley MJ, Chennathukuzhi VM, Davis JS
Endocrinology 2024 Jul 1;165(8)

YTHDC1 delays cellular senescence and pulmonary fibrosis by activating ATR in an m6A-independent manner.

Zhang C, Chen L, Xie C, Wang F, Wang J, Zhou H, Liu Q, Zeng Z, Li N, Huang J, Zhao Y, Liu H
The EMBO journal 2024 Jan;43(1):61-86

Melatonin Alleviates Lipopolysaccharide-Induced Abnormal Pregnancy through MTNR1B Regulation of m6A.

Zhao S, Dong Y, Li Y, Wang Z, Chen Y, Dong Y
International journal of molecular sciences 2024 Jan 5;25(2)

Circular RNA-circPan3 attenuates cardiac hypertrophy via miR-320-3p/HSP20 axis.

Fang X, Ao X, Xiao D, Wang Y, Jia Y, Wang P, Li M, Wang J
Cellular & molecular biology letters 2024 Jan 3;29(1):3

Exploring the prognostic potential of m6A methylation regulators in low-grade glioma: implications for tumor microenvironment modulation.

Wu H, Chen S, Hu Z, Ge R, Ma L, You C, Huang Y
European journal of medical research 2024 Jan 3;29(1):19

The m(6)A demethylases FTO and ALKBH5 aggravate the malignant progression of nasopharyngeal carcinoma by coregulating ARHGAP35.

Yang Z, Zhang S, Xiong J, Xia T, Zhu R, Miao M, Li K, Chen W, Zhang L, You Y, You B
Cell death discovery 2024 Jan 23;10(1):43

Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma.

Dai W, Tian R, Yu L, Bian S, Chen Y, Yin B, Luan Y, Chen S, Fan Z, Yan R, Pan X, Hou Y, Li R, Chen J, Shu M
Nature communications 2024 Jan 2;15(1):131

Demethylase FTO-Mediated m6A Modification of lncRNA MEG3 Activates Neuronal Pyroptosis via NLRP3 Signaling in Cerebral Ischemic Stroke.

Yan H, Huang W, Rao J, Yan D, Yuan J
Molecular neurobiology 2024 Feb;61(2):1023-1043

N6-methyladenosine regulates metabolic remodeling in kidney aging through transcriptional regulator GLIS1.

Xu L, Chen S, Fan Q, Zhu Y, Mei H, Wang J, Yu H, Chen Y, Liu F
BMC biology 2024 Dec 31;22(1):302

FTO-mediated demethylation of MTUS1/ATIP1 promotes tumor progression in head and neck squamous cell carcinoma.

Tang D, Cao C, Li W, Wang A
BMC cancer 2024 Dec 3;24(1):1489

WTAP and METTL14 regulate the m6A modification of DKK3 in renal tubular epithelial cells of diabetic nephropathy.

Fu K, Jing C, Shi J, Mao S, Lu R, Yang M, Chen Y, Qian B, Wang Y, Li L
Biochemical and biophysical research communications 2024 Dec 17;738:150524

High WTAP expression level as a promising biomarker for poor prognosis in colorectal cancer: a pilot study.

Relucenti M, Tito C, Mercantini P, Pilozzi E, Barbaranelli C, Cristiano L, Savarese D, Bastianelli D, Fazi F, Petrozza V, Li X, Chen R, Miglietta S, Familiari G
European journal of histochemistry : EJH 2024 Dec 16;68(4)

Chronic social isolation leads to abnormal behavior in male mice through the hippocampal METTL14 mediated epitranscriptomic RNA m6A modifications.

Xu XF, Chen J, Long LH, Zhang AM, Yang JW, Li YJ, Chen L, Zhong XL, Xu Y, Cao WY
Journal of affective disorders 2024 Dec 1;366:262-272

FTO blocks RNA translational activity via the loss of N6-methyladenosine methylation at 5' UTR regulated by RBM5 in cisplatin-resistant NSCLC.

Li L, Qu D, Wang B, Yuan S, Zhao Y, Liu N, Huo F, Zhang D, Zhang L
Journal of cellular physiology 2024 Aug;239(8):e31296

Alteration of N6-methyladenosine modification profiles in the neutrophilic RNAs following ischemic stroke.

Fan J, Zhong L, Yan F, Li X, Li L, Zhao H, Han Z, Wang R, Tao Z, Zheng Y, Ma Q, Luo Y
Neuroscience 2024 Aug 16;553:56-73

The RNA Demethylases ALKBH5 and FTO Regulate the Translation of ATF4 mRNA in Sorafenib-Treated Hepatocarcinoma Cells.

Adjibade P, Di-Marco S, Gallouzi IE, Mazroui R
Biomolecules 2024 Aug 1;14(8)

FTO ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via P53-P21/Nrf2 activation in a HuR-dependent m6A manner.

Yang Y, Ren J, Zhang J, Shi H, Wang J, Yan Y
Redox biology 2024 Apr;70:103067

A novel PDIA3/FTO/USP20 positive feedback regulatory loop induces osteogenic differentiation of preosteoblast in osteoporosis.

Zhang F, Liu C, Chen Z, Zhao C
Cell biology international 2024 Apr;48(4):541-550

Highly pathogenic PRRSV upregulates IL-13 production through nonstructural protein 9-mediated inhibition of N6-methyladenosine demethylase FTO.

Gong X, Liang Y, Wang J, Pang Y, Wang F, Chen X, Zhang Q, Song C, Wang Y, Zhang C, Fang X, Chen X
The Journal of biological chemistry 2024 Apr;300(4):107199

RBMS1 Coordinates with the m(6)A Reader YTHDF1 to Promote NSCLC Metastasis through Stimulating S100P Translation.

Sun Y, Chen D, Sun S, Ren M, Zhou L, Chen C, Zhao J, Wei H, Zhao Q, Qi Y, Zhang J, Zhang G, Liu H, Yang Q, Liu Q, Wang Y, Zhang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(15):e2307122

FTO Positively Regulates Odontoblastic Differentiation via SMOC2 in Human Stem Cells from the Apical Papilla under Inflammatory Microenvironment.

Huang Q, Sun Y, Huang W, Zhang F, He H, He Y, Huang F
International journal of molecular sciences 2024 Apr 5;25(7)

CHOP regulated by METTL14-m6A affects cell cycle arrest and regorafenib sensitivity in HCC cells.

Pan Y, You B, Zhao X, Zhang S, Li W
BMC cancer 2024 Apr 25;24(1):525

A LATS2 and ALKBH5 positive feedback loop supports their oncogenic roles.

Cao L, Han R, Zhao Y, Qin X, Li Q, Xiong H, Kong Y, Liu Z, Li Z, Dong F, Li T, Zhao X, Lei L, Zhao Q, Liu D, Wang B, Wu X
Cell reports 2024 Apr 23;43(4):114032

FTO promotes gastric cancer progression by modulating MAP4K4 expression via demethylation in an m6A-dependent manner.

Yin Z, Guo X, Liang X, Wang Z
Medical oncology (Northwood, London, England) 2024 Apr 20;41(5):120

Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expression.

Qiao Y, Su M, Zhao H, Liu H, Wang C, Dai X, Liu L, Liu G, Sun H, Sun M, Wang J, Li Z, Fan J, Zhang Q, Li C, Situ F, Xue J, Jia Z, Zhang C, Zhang S, Shan C
Journal of experimental & clinical cancer research : CR 2024 Apr 10;43(1):108

ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression.

An X, Wu W, Yang L, Dong J, Liu B, Guo J, Chen J, Guo B, Cao W, Jiang Q
Translational research : the journal of laboratory and clinical medicine 2023 Sep;259:62-71

HPV E7-drived ALKBH5 promotes cervical cancer progression by modulating m6A modification of PAK5.

Huo FC, Zhu ZM, Du WQ, Pan YJ, Jiang X, Kang MJ, Liu BW, Mou J, Pei DS
Pharmacological research 2023 Sep;195:106863

PIAS1 upregulation confers protection against Cerulein-induced acute pancreatitis via FTO downregulation by enhancing sumoylation of Foxa2.

Zhou J, Tan Q, Tong J, Tong Z, Wang C, Sun B, Fang M, Lv J
Genomics 2023 Sep;115(5):110693

Comprehensive analysis of transcriptome-wide N6-methyladenosine methylomes in the Barrett's esophagus in rats.

Zou K, Dong H, Li M, Zhang Y, Zhang K, Song D, Chu C
Genomics 2023 Sep;115(5):110687

FTO alleviates cerebral ischemia/reperfusion-induced neuroinflammation by decreasing cGAS mRNA stability in an m6A-dependent manner.

Yu Z, Zheng L, Geng Y, Zhang Y, Wang Y, You G, Cai M, Li M, Cheng X, Zan J
Cellular signalling 2023 Sep;109:110751

Comprehensive analysis of N6-methyladenosine-related RNA methylation in the mouse hippocampus after acquired hearing loss.

Zhou X, Jin L, Li Y, Wang Y, Li W, Shen X
BMC genomics 2023 Sep 27;24(1):577

FTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson's disease via m6A-dependent regulation of ATM mRNA.

Geng Y, Long X, Zhang Y, Wang Y, You G, Guo W, Zhuang G, Zhang Y, Cheng X, Yuan Z, Zan J
Journal of translational medicine 2023 Sep 22;21(1):652

The predictive significance of a 5-m6A RNA methylation regulator signature in colorectal cancer.

Zhang D, Wu G, Yang L, Wu Q, Yuan L
Heliyon 2023 Oct;9(10):e20172

AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance.

Qiu T, Wu C, Yao X, Han Q, Wang N, Yuan W, Zhang J, Shi Y, Jiang L, Liu X, Yang G, Sun X
Cell biology and toxicology 2023 Oct;39(5):2165-2181

Differential epitranscriptome and proteome modulation in the brain of neonatal mice exposed to isoflurane or sevoflurane.

Wu Y, Yang Z, Su S, Xu X, Li Y, Li X, Gao Y, Sun D, Wan S, Pen M, Jin W, Ke C
Cell biology and toxicology 2023 Oct;39(5):2133-2148

m(6) A demethylase Fto regulates the TNF-α-induced inflammatory response in cementoblasts.

Li B, Du M, Sun Q, Cao Z, He H
Oral diseases 2023 Oct;29(7):2806-2815

N6-methyladenosine demethylase FTO related to hyperandrogenism in PCOS via AKT pathway.

Jing YX, Li HX, Yue F, Li YM, Yu X, He JJ, Zhang XH
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2023 Oct 26;39(1):2276167

Comprehensive Transcriptomic Profiling of m6A Modification in Age-Related Hearing Loss.

Feng M, Zhou X, Hu Y, Zhang J, Yang T, Chen Z, Yuan W
Biomolecules 2023 Oct 18;13(10)

METTL3/IGF2BP2 axis affects the progression of colorectal cancer by regulating m6A modification of STAG3.

Yi J, Peng F, Zhao J, Gong X
Scientific reports 2023 Oct 12;13(1):17292

Targeting histone deacetylase suppresses tumor growth through eliciting METTL14-modified m(6) A RNA methylation in ocular melanoma.

Zhuang A, Gu X, Ge T, Wang S, Ge S, Chai P, Jia R, Fan X
Cancer communications (London, England) 2023 Nov;43(11):1185-1206

Altered m6A RNA methylation governs denervation-induced muscle atrophy by regulating ubiquitin proteasome pathway.

Sun J, Zhou H, Chen Z, Zhang H, Cao Y, Yao X, Chen X, Liu B, Gao Z, Shen Y, Qi L, Sun H
Journal of translational medicine 2023 Nov 23;21(1):845

The hippocampal FTO-BDNF-TrkB pathway is required for novel object recognition memory reconsolidation in mice.

Chang R, Zhu S, Peng J, Lang Z, Zhou X, Liao H, Zou J, Zeng P, Tan S
Translational psychiatry 2023 Nov 14;13(1):349

A druggable copper-signalling pathway that drives inflammation.

Solier S, Müller S, Cañeque T, Versini A, Mansart A, Sindikubwabo F, Baron L, Emam L, Gestraud P, Pantoș GD, Gandon V, Gaillet C, Wu TD, Dingli F, Loew D, Baulande S, Durand S, Sencio V, Robil C, Trottein F, Péricat D, Näser E, Cougoule C, Meunier E, Bègue AL, Salmon H, Manel N, Puisieux A, Watson S, Dawson MA, Servant N, Kroemer G, Annane D, Rodriguez R
Nature 2023 May;617(7960):386-394

Hypericin Ameliorates Depression-like Behaviors via Neurotrophin Signaling Pathway Mediating m6A Epitranscriptome Modification.

Lei C, Li N, Chen J, Wang Q
Molecules (Basel, Switzerland) 2023 May 3;28(9)

Ectopic endometriotic stromal cells-derived lactate induces M2 macrophage polarization via Mettl3/Trib1/ERK/STAT3 signalling pathway in endometriosis.

Gou Y, Wang H, Wang T, Wang H, Wang B, Jiao N, Yu Y, Cao Y, Wang H, Zhang Z
Immunology 2023 Mar;168(3):389-402

Demethylase FTO enhances the PI3K/Akt signaling to promote gastric cancer malignancy.

Zhu Y, Yang J, Li Y, Xu J, Fang Z
Medical oncology (Northwood, London, England) 2023 Mar 27;40(5):130

RNA binding protein YTHDF1 mediates bisphenol S-induced Leydig cell damage by regulating the mitochondrial pathway of BCL2 and the expression of CDK2-CyclinE1.

Li JZ, Zhou SM, Yuan WB, Chen HQ, Zeng Y, Fan J, Zhang Z, Wang N, Cao J, Liu WB
Environmental pollution (Barking, Essex : 1987) 2023 Mar 15;321:121144

The differences in biological behavior and gene expression characteristics between pure and mixed early gastric signet ring cell carcinomas.

Wang X, Li X, Yang P, Qin X, Yu J, Cheng Y, Zhang G, Tang L
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2023 Jun;55(6):815-822

Fat mass and obesity-associated factor (FTO)-mediated N6-methyladenosine regulates spermatogenesis in an age-dependent manner.

Wu Y, Li J, Li C, Lu S, Wei X, Li Y, Xia W, Qian C, Wang Z, Liu M, Gu Y, Huang B, Tan Y, Hu Z
The Journal of biological chemistry 2023 Jun;299(6):104783

Newcastle disease virus activates methylation-related enzymes to reprogram m(6)A methylation in infected cells.

Yuan W, Hou Y, Wang Q, Lv T, Ren J, Fan L, Cai J, Xiang B, Lin Q, Liao M, Ding C, Chen L, Ren T
Veterinary microbiology 2023 Jun;281:109747

FTO-dependent m(6)A regulates muscle fiber remodeling in an NFATC1-YTHDF2 dependent manner.

Wang W, Du X, Luo M, Yang N
Clinical epigenetics 2023 Jul 5;15(1):109

ALKBH5 causes retinal pigment epithelium anomalies and choroidal neovascularization in age-related macular degeneration via the AKT/mTOR pathway.

Sun RX, Zhu HJ, Zhang YR, Wang JN, Wang Y, Cao QC, Ji JD, Jiang C, Yuan ST, Chen X, Liu QH
Cell reports 2023 Jul 25;42(7):112779

m6A demethylase FTO renders radioresistance of nasopharyngeal carcinoma via promoting OTUB1-mediated anti-ferroptosis.

Huang WM, Li ZX, Wu YH, Shi ZL, Mi JL, Hu K, Wang RS
Translational oncology 2023 Jan;27:101576

5'-tRF-GlyGCC promotes breast cancer metastasis by increasing fat mass and obesity-associated protein demethylase activity.

Chen F, Song C, Meng F, Zhu Y, Chen X, Fang X, Ma D, Wang Y, Zhang C
International journal of biological macromolecules 2023 Jan 31;226:397-409

FTO-dependent m(6)A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke.

Li B, Xi W, Bai Y, Liu X, Zhang Y, Li L, Bian L, Liu C, Tang Y, Shen L, Yang L, Gu X, Xie J, Zhou Z, Wang Y, Yu X, Wang J, Chao J, Han B, Yao H
Nature communications 2023 Jan 30;14(1):489

The miR-27a-3p/FTO axis modifies hypoxia-induced malignant behaviors of glioma cells.

Du P, Meng L, Liao X, Liu Y, Mo X, Gong M, Liao Y
Acta biochimica et biophysica Sinica 2023 Jan 25;55(1):103-116

The m6A demethylase FTO promotes keloid formation by up-regulating COL1A1.

Ren S, Ji Y, Wang M, Ye M, Huang L, Cai X
Annals of translational medicine 2023 Jan 15;11(1):15

Cross-Talk between N6-Methyladenosine and Their Related RNAs Defined a Signature and Confirmed m6A Regulators for Diagnosis of Endometriosis.

Wang X, Zhao X, Wang J, Wu H, Cheng Y, Guo Q, Liang T, Zhang G
International journal of molecular sciences 2023 Jan 14;24(2)

ALKBH1-mediated m(1) A demethylation of METTL3 mRNA promotes the metastasis of colorectal cancer by downregulating SMAD7 expression.

Chen W, Wang H, Mi S, Shao L, Xu Z, Xue M
Molecular oncology 2023 Feb;17(2):344-364

Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner.

Chen Y, Liu X, Li L, He X, Zheng F, Zhang Y, Gao H, Jin Z, Wu D, Wang Q, Tao H, Zhao Y, Liu W, Zou L
Molecular medicine (Cambridge, Mass.) 2023 Feb 6;29(1):19

Novel RNA N6-methyladenosine regulator related signature for predicting clinical and immunological characteristics in breast cancer.

Zhang J, Liu G, Dai Z, Xie F, Zheng R, Yuan B, Guo L
Gene 2023 Feb 15;853:147095

The N6-methyladenosine demethylase FTO is required for odontoblast differentiation in vitro and dentine formation in mice by promoting RUNX2 exon 5 inclusion through RBM4.

Xu M, Li B, Huang J, Jia R, Guo J
International endodontic journal 2023 Dec;56(12):1534-1549

Downregulation of ALKBH5 rejuvenates aged human mesenchymal stem cells and enhances their therapeutic efficacy in myocardial infarction.

Gao X, Liang X, Liu B, Hong Y, He H, Shen Y, Chen J, Huang X, Hu B, Li W, Li X, Zhang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23294

EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma.

Lv D, Zhong C, Dixit D, Yang K, Wu Q, Godugu B, Prager BC, Zhao G, Wang X, Xie Q, Bao S, He C, Heiland DH, Rosenfeld MG, Rich JN
Molecular cell 2023 Dec 7;83(23):4334-4351.e7

Targeting AKT induced Ferroptosis through FTO/YTHDF2-dependent GPX4 m6A methylation up-regulating and degradating in colorectal cancer.

Zhang G, Mi W, Wang C, Li J, Zhang Y, Liu N, Jiang M, Jia G, Wang F, Yang G, Zhang L, Wang J, Fu Y, Zhang Y
Cell death discovery 2023 Dec 15;9(1):457

Profile of N6-methyladenosine of Pb-exposed neurons presents epitranscriptomic alterations in PI3K-AKT pathway-associated genes.

Ai S, Li D, Gu X, Xu Y, Wang Y, Wang HL, Chen XT
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Aug;178:113821

Maternal tamoxifen exposure leads to abnormal primordial follicle assembly.

Zhao J, Zhang J, Sun Y, Wang R, Shi D, Shen W, Sun X
Histochemistry and cell biology 2023 Aug;160(2):97-111

Genetic and pharmacological inhibition of METTL3 alleviates renal fibrosis by reducing EVL m6A modification through an IGF2BP2-dependent mechanism.

Ni WJ, Zhou H, Lu H, Ma NN, Hou BB, Li W, Kong FX, Yu JT, Hou R, Jin J, Wen JG, Zhang T, Meng XM
Clinical and translational medicine 2023 Aug;13(8):e1359

WTAP-mediated m6A modification of IFNE is required for antiviral defense in condyloma acuminata.

Gu Z, Liu J, Qin L, Zhang Y, Cui W, Huang H, Liu L, Cao Y, Zhang H
Journal of dermatological science 2023 Aug;111(2):43-51

Characterization of m(6)A modifiers and RNA modifications in uterine fibroids.

George JW, Cancino RA, Miller JLG, Qiu F, Lin Q, Rowley MJ, Chennathukuzhi VM, Davis JS
bioRxiv : the preprint server for biology 2023 Aug 9;

METTL3-mediated m6A mRNA modification was involved in cadmium-induced liver injury.

Li W, Tan M, Wang H, Wang Z, Pang Y, Yang R, Zhong S, Pan X, Chen S, Wang Q, Li D, Xiao Y, Chen W, Chen L
Environmental pollution (Barking, Essex : 1987) 2023 Aug 15;331(Pt 2):121887

METTL14 reverses liver fibrosis by inhibiting NOVA2 through an m6A-YTHDF2-dependent mechanism.

Hou X, Li Y, Song J, Peng L, Zhang W, Liu R, Yuan H, Feng T, Li J, Li W, Zhu C
Hepatology communications 2023 Aug 1;7(8)

FTO regulates the DNA damage response via effects on cell-cycle progression.

Liu W, Yasui M, Sassa A, You X, Wan J, Cao Y, Xi J, Zhang X, Honma M, Luan Y
Mutation research. Genetic toxicology and environmental mutagenesis 2023 Apr;887:503608

FTO demethylates m6A modifications in CDKAL1 mRNA and promotes gastric cancer chemoresistance by altering mitochondrial dynamics.

Liu N, Liu C, Wang Z, Wang L, Wang J, Kong J
Clinical and experimental pharmacology & physiology 2023 Apr;50(4):307-315

Effects of Helicobacter pylori on the expression of the FTO gene and its biological role in gastric cancer.

Gui S, Wang Q, Bao L, He X, Wang Z, Liu L, Wu L, Zhao Y, Zhou J, Xie Y
Oncology letters 2023 Apr;25(4):143

Comprehensive analyses of molecular features, prognostic values, and regulatory functionalities of m(6)A-modified long non-coding RNAs in lung adenocarcinoma.

Ping Y, Huang J, Zhu J, Sun Z, Shang A, Chen C, Liu W, Li D
Clinical epigenetics 2023 Apr 7;15(1):60

Epitranscriptic regulation of HRAS by N(6)-methyladenosine drives tumor progression.

Pan Y, Gu Y, Liu T, Zhang Q, Yang F, Duan L, Cheng S, Zhu X, Xi Y, Chang X, Ye Q, Gao S
Proceedings of the National Academy of Sciences of the United States of America 2023 Apr 4;120(14):e2302291120

Demethylase FTO inhibits the development of prostate cancer by upregulating EGR2 expression in an m6A manner.

Wang Z, Sun H, Zhu H, Gu D, Chen X, Pan Y, Zheng B, Yang D
Turkish journal of biology = Turk biyoloji dergisi 2022;46(6):426-438

GSK3β Exacerbates Myocardial Ischemia/Reperfusion Injury by Inhibiting Myc.

Wen C, Lan M, Tan X, Wang X, Zheng Z, Lv M, Zhao X, Luo H, Liu Y, Wei P, Yue R, Hu H, Guo L
Oxidative medicine and cellular longevity 2022;2022:2588891

Role of the Demethylase AlkB Homolog H5 in the Promotion of Dentinogenesis.

Tian C, Chai J, Liu W, Zhang X, Li Y, Zuo H, Yuan G, Zhang H, Liu H, Chen Z
Frontiers in physiology 2022;13:923185

m(6)A mRNA Methylation Was Associated With Gene Expression and Lipid Metabolism in Liver of Broilers Under Lipopolysaccharide Stimulation.

Guo F, Zhang Y, Ma J, Yu Y, Wang Q, Gao P, Wang L, Xu Z, Wei X, Jing M
Frontiers in genetics 2022;13:818357

Identification and experimental validation of key m6A modification regulators as potential biomarkers of osteoporosis.

Qiao Y, Li J, Liu D, Zhang C, Liu Y, Zheng S
Frontiers in genetics 2022;13:1072948

The Maternal Microbiome Programs the m(6)A Epitranscriptome of the Mouse Fetal Brain and Intestine.

Xiao Z, Liu S, Li Z, Cui J, Wang H, Wang Z, Ren Q, Xia L, Wang Z, Li Y
Frontiers in cell and developmental biology 2022;10:882994

PIKE-A Modulates Mitochondrial Metabolism through Increasing SDHA Expression Mediated by STAT3/FTO Axis.

Sun M, Yan Q, Qiao Y, Zhao H, Wang Y, Shan C, Zhang S
International journal of molecular sciences 2022 Sep 25;23(19)

FTO Inhibits Epithelial Ovarian Cancer Progression by Destabilising SNAI1 mRNA through IGF2BP2.

Sun M, Zhang X, Bi F, Wang D, Zhou X, Li X, Yang Q
Cancers 2022 Oct 25;14(21)

m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-β-induced epithelial-mesenchymal transition of lung cancer cells.

Suphakhong K, Terashima M, Wanna-Udom S, Takatsuka R, Ishimura A, Takino T, Suzuki T
The Journal of biological chemistry 2022 Nov;298(11):102554

N6-methyladenosine reader YTHDF3 regulates melanoma metastasis via its 'executor'LOXL3.

Shi HZ, Xiong JS, Gan L, Zhang Y, Zhang CC, Kong YQ, Miao QJ, Tian CC, Li R, Liu JQ, Zhang EJ, Bu WB, Wang Y, Cheng XF, Sun JF, Chen H
Clinical and translational medicine 2022 Nov;12(11):e1075

Systematic analysis of the expression profile and prognostic significance of m6A regulators and PD-L1 in hepatocellular carcinoma.

Kong F, Wang K, Wang L
Discover oncology 2022 Nov 25;13(1):131

Therapeutic targeting m6A-guided miR-146a-5p signaling contributes to the melittin-induced selective suppression of bladder cancer.

Yan R, Dai W, Wu R, Huang H, Shu M
Cancer letters 2022 May 28;534:215615

m6A demethylase FTO promotes tumor progression via regulation of lipid metabolism in esophageal cancer.

Duan X, Yang L, Wang L, Liu Q, Zhang K, Liu S, Liu C, Gao Q, Li L, Qin G, Zhang Y
Cell & bioscience 2022 May 14;12(1):60

MiR-155 regulates m(6)A level and cell progression by targeting FTO in clear cell renal cell carcinoma.

Yang W, Xie L, Wang P, Zhuang C
Cellular signalling 2022 Mar;91:110217

Protective role of mRNA demethylase FTO on axon guidance molecules of nigro-striatal projection system in manganese-induced parkinsonism.

Qi Z, Wang S, Li J, Wen Y, Cui R, Zhang K, Liu Y, Yang X, Zhang L, Xu B, Liu W, Xu Z, Deng Y
Journal of hazardous materials 2022 Mar 15;426:128099

Fusobacterium nucleatum reduces METTL3-mediated m(6)A modification and contributes to colorectal cancer metastasis.

Chen S, Zhang L, Li M, Zhang Y, Sun M, Wang L, Lin J, Cui Y, Chen Q, Jin C, Li X, Wang B, Chen H, Zhou T, Wang L, Hsu CH, Zhuo W
Nature communications 2022 Mar 10;13(1):1248

Long noncoding RNA lnc-H2AFV-1 promotes cell growth by regulating aberrant m6A RNA modification in head and neck squamous cell carcinoma.

Chen X, Liu Y, Sun D, Sun R, Wang X, Li M, Song N, Ying J, Guo T, Jiang Y
Cancer science 2022 Jun;113(6):2071-2084

PDGF signaling inhibits mitophagy in glioblastoma stem cells through N(6)-methyladenosine.

Lv D, Gimple RC, Zhong C, Wu Q, Yang K, Prager BC, Godugu B, Qiu Z, Zhao L, Zhang G, Dixit D, Lee D, Shen JZ, Li X, Xie Q, Wang X, Agnihotri S, Rich JN
Developmental cell 2022 Jun 20;57(12):1466-1481.e6

Increased m6A-RNA methylation and FTO suppression is associated with myocardial inflammation and dysfunction during endotoxemia in mice.

Dubey PK, Patil M, Singh S, Dubey S, Ahuja P, Verma SK, Krishnamurthy P
Molecular and cellular biochemistry 2022 Jan;477(1):129-141

Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.

Li Z, Xu Q, Huangfu N, Chen X, Zhu J
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019

Intermittent Fasting Improves High-Fat Diet-Induced Obesity Cardiomyopathy via Alleviating Lipid Deposition and Apoptosis and Decreasing m6A Methylation in the Heart.

Xu Z, Qin Y, Lv B, Tian Z, Zhang B
Nutrients 2022 Jan 7;14(2)

The expression of m6A enzymes in the hippocampus of diabetic cognitive impairment mice and the possible improvement of YTHDF1.

Li M, Zhong X, Zhao Z, Zeng Z, Yuan Q, Xiao X, Zu X, Liu J
Brain research 2022 Feb 15;1777:147766

FTO/RUNX2 signaling axis promotes cementoblast differentiation under normal and inflammatory condition.

Sun Q, Zhao T, Li B, Li M, Luo P, Zhang C, Chen G, Cao Z, Li Y, Du M, He H
Biochimica et biophysica acta. Molecular cell research 2022 Dec;1869(12):119358

The landscape of m6A regulators in esophageal cancer: molecular characteristics, immuno-oncology features, and clinical relevance.

Li Z, Zheng C, Huang L, Yin X, Wang Z, Liu C, Li B
Annals of translational medicine 2022 Dec;10(24):1347

FTO mediated ERBB2 demethylation promotes tumor progression in esophageal squamous cell carcinoma cells.

Zhao F, Ge F, Xie M, Li Z, Zang C, Kong L, Pu Y, Zheng X, Tan Y
Clinical & experimental metastasis 2022 Aug;39(4):623-639

PGE(2) -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase.

Tao X, Du R, Guo S, Feng X, Yu T, OuYang Q, Chen Q, Fan X, Wang X, Guo C, Li X, Xue F, Chen S, Tong M, Lazarus M, Zuo S, Yu Y, Shen Y
The EMBO journal 2022 Aug 16;41(16):e110439

Fat mass and obesity associated (FTO)-mediated N6-methyladenosine modification of Krüppel-like factor 3 (KLF3) promotes osteosarcoma progression.

Shan HJ, Gu WX, Duan G, Chen HL
Bioengineered 2022 Apr;13(4):8038-8050

Downregulated fat mass and obesity-associated protein inhibits bone resorption and osteoclastogenesis by nuclear factor-kappa B inactivation.

Zhuang J, Ning H, Wang M, Zhao W, Jing Y, Liu X, Zu J, Kong P, Wang X, Sun C, Yan J
Cellular signalling 2021 Nov;87:110137

Human umbilical cord-derived mesenchymal stem cell-exosomal miR-627-5p ameliorates non-alcoholic fatty liver disease by repressing FTO expression.

Cheng L, Yu P, Li F, Jiang X, Jiao X, Shen Y, Lai X
Human cell 2021 Nov;34(6):1697-1708

m(6)A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 2.

Takemoto S, Nakano M, Fukami T, Nakajima M
Biochemical pharmacology 2021 Nov;193:114766

Decreased expression of m(6)A demethylase FTO in ovarian aging.

Sun X, Zhang Y, Hu Y, An J, Li L, Wang Y, Zhang X
Archives of gynecology and obstetrics 2021 May;303(5):1363-1369

mTORC1 stimulates cell growth through SAM synthesis and m(6)A mRNA-dependent control of protein synthesis.

Villa E, Sahu U, O'Hara BP, Ali ES, Helmin KA, Asara JM, Gao P, Singer BD, Ben-Sahra I
Molecular cell 2021 May 20;81(10):2076-2093.e9

AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation.

Bian X, Shi D, Xing K, Zhou H, Lu L, Yu D, Wu W
Clinical and translational medicine 2021 Mar;11(3):e352

The N(6)-methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression.

Ondo K, Isono M, Nakano M, Hashiba S, Fukami T, Nakajima M
Biochemical pharmacology 2021 Jul;189:114402

METTL14-regulated PI3K/Akt signaling pathway via PTEN affects HDAC5-mediated epithelial-mesenchymal transition of renal tubular cells in diabetic kidney disease.

Xu Z, Jia K, Wang H, Gao F, Zhao S, Li F, Hao J
Cell death & disease 2021 Jan 4;12(1):32

Increased m6A modification of RNA methylation related to the inhibition of demethylase FTO contributes to MEHP-induced Leydig cell injury(☆).

Zhao T, Wang J, Wu Y, Han L, Chen J, Wei Y, Shen L, Long C, Wu S, Wei G
Environmental pollution (Barking, Essex : 1987) 2021 Jan 1;268(Pt A):115627

Upregulation of METTL3 expression and m6A RNA methylation in placental trophoblasts in preeclampsia.

Gu Y, Chu X, Morgan JA, Lewis DF, Wang Y
Placenta 2021 Jan 1;103:43-49

The tumor-suppressive effects of alpha-ketoglutarate-dependent dioxygenase FTO via N6-methyladenosine RNA methylation on bladder cancer patients.

Yi W, Yu Y, Li Y, Yang J, Gao S, Xu L
Bioengineered 2021 Dec;12(1):5323-5333

Exploration of the potential roles of m6A regulators in the uterus in pregnancy and infertility.

Zhao S, Lu J, Chen Y, Wang Z, Cao J, Dong Y
Journal of reproductive immunology 2021 Aug;146:103341

Identification of a robust signature for clinical outcomes and immunotherapy response in gastric cancer: based on N6-methyladenosine related long noncoding RNAs.

Han T, Xu D, Zhu J, Li J, Liu L, Deng Y
Cancer cell international 2021 Aug 16;21(1):432

Vascular Smooth Muscle FTO Promotes Aortic Dissecting Aneurysms via m6A Modification of Klf5.

Ma D, Liu X, Zhang JJ, Zhao JJ, Xiong YJ, Chang Q, Wang HY, Su P, Meng J, Zhao YB
Frontiers in cardiovascular medicine 2020;7:592550

Resveratrol Attenuates High-Fat Diet Induced Hepatic Lipid Homeostasis Disorder and Decreases m(6)A RNA Methylation.

Wu J, Li Y, Yu J, Gan Z, Wei W, Wang C, Zhang L, Wang T, Zhong X
Frontiers in pharmacology 2020;11:568006

N(6)-Methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2.

Li Y, Xia L, Tan K, Ye X, Zuo Z, Li M, Xiao R, Wang Z, Liu X, Deng M, Cui J, Yang M, Luo Q, Liu S, Cao X, Zhu H, Liu T, Hu J, Shi J, Xiao S, Xia L
Nature genetics 2020 Sep;52(9):870-877

FTO accelerates ovarian cancer cell growth by promoting proliferation, inhibiting apoptosis, and activating autophagy.

Zhao L, Kong X, Zhong W, Wang Y, Li P
Pathology, research and practice 2020 Sep;216(9):153042

The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N(6)-methyladenosine methylation of Parp10 mRNA.

Gao XQ, Zhang YH, Liu F, Ponnusamy M, Zhao XM, Zhou LY, Zhai M, Liu CY, Li XM, Wang M, Shan C, Shan PP, Wang Y, Dong YH, Qian LL, Yu T, Ju J, Wang T, Wang K, Chen XZ, Wang YH, Zhang J, Li PF, Wang K
Nature cell biology 2020 Nov;22(11):1319-1331

Alteration of N(6)-methyladenosine epitranscriptome profile in unilateral ureteral obstructive nephropathy.

Li X, Fan X, Yin X, Liu H, Yang Y
Epigenomics 2020 Jul;12(14):1157-1173

YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.

Sheng H, Li Z, Su S, Sun W, Zhang X, Li L, Li J, Liu S, Lu B, Zhang S, Shan C
Carcinogenesis 2020 Jul 10;41(5):541-550

Resveratrol Attenuates Aflatoxin B(1)-Induced ROS Formation and Increase of m(6)A RNA Methylation.

Wu J, Gan Z, Zhuo R, Zhang L, Wang T, Zhong X
Animals : an open access journal from MDPI 2020 Apr 13;10(4)

FTO promotes cell proliferation and migration in esophageal squamous cell carcinoma through up-regulation of MMP13.

Liu S, Huang M, Chen Z, Chen J, Chao Q, Yin X, Quan M
Experimental cell research 2020 Apr 1;389(1):111894

Glucose Is Involved in the Dynamic Regulation of m6A in Patients With Type 2 Diabetes.

Yang Y, Shen F, Huang W, Qin S, Huang JT, Sergi C, Yuan BF, Liu SM
The Journal of clinical endocrinology and metabolism 2019 Mar 1;104(3):665-673

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